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    METHOD FOR PRODUCING (METH) ACRYLATE ESTER COMPOUNDS
    3.
    发明申请
    METHOD FOR PRODUCING (METH) ACRYLATE ESTER COMPOUNDS 审中-公开

    公开(公告)号：US20180050975A1

    公开(公告)日：2018-02-22

    申请号：US15557232

    申请日：2016-03-07

    申请人： KURARAY CO., LTD.

    发明人： Yusuke TAKAHATA ,  Tsuyoshi KAJIYASHIKI

    IPC分类号： C07C67/03 ,  C07C69/54 ,  C07B41/12 ,  B01J31/16 ,  B01J31/18 ,  B01J31/40

    CPC分类号： C07C67/03 ,  B01J31/1616 ,  B01J31/183 ,  B01J31/403 ,  C07B41/12 ,  C07B61/00 ,  C07C67/54 ,  C07C69/54 ,  Y02P20/584

    摘要： An object of the invention is to provide a method for producing a (meth)acrylate ester compound by the transesterification of an alkyl (meth)acrylate with an alcohol compound having a tertiary hydroxyl group so as to esterify all the hydroxyl groups present in the alcohol compound with a high yield or, in a preferred embodiment, a method for esterifying a polyhydric alcohol compound having a tertiary hydroxyl group and also having a primary hydroxyl group and/or a secondary hydroxyl group by one-pot transesterification into a (meth)acrylate ester compound of the polyhydric alcohol. The method for producing a (meth)acrylate ester compound includes a step (I) of transesterifying an alkyl (meth)acrylate with an alcohol compound having a tertiary hydroxyl group using a transesterification catalyst including a complex of iron with a specific ligand, the water content in the transesterification reaction system being not more than 1000 ppm.

    Poly(citric acid) functionalized carbon nanotube drug delivery system
    8.
    发明授权
    Poly(citric acid) functionalized carbon nanotube drug delivery system 有权
    聚（柠檬酸）官能化碳纳米管药物递送系统

    公开(公告)号：US08460711B2

    公开(公告)日：2013-06-11

    申请号：US12870943

    申请日：2010-08-30

    申请人： Fatemeh Atyabi ,  Mohsen Adeli ,  Zahra Sobhani ,  Rassoul Dinarvand ,  Mohammad Hossein Ghahremani

    发明人： Fatemeh Atyabi ,  Mohsen Adeli ,  Zahra Sobhani ,  Rassoul Dinarvand ,  Mohammad Hossein Ghahremani

    IPC分类号： A61K9/51 ,  C07B41/12 ,  A61K9/00

    CPC分类号： A61K9/0092 ,  A61K47/6921 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/04 ,  C01B2202/34 ,  C01B2202/36 ,  C07B41/12 ,  C07D305/14 ,  Y10S977/742 ,  Y10S977/752 ,  Y10S977/906

    摘要： A method for synthesizing carbon nanotube drug carriers and the carbon nanotube drug carriers are disclosed. Initially, carbon nanotubes, nitric acid, and sulfuric acid are mixed to oxidize carbon nanotubes in a first mixture. The oxidized carbon nanotubes are then extracted from the first mixture. The oxidized carbon nanotubes and monohydrated citric acid are mixed to synthesize carbon nanotubes grafted with poly(citric acid) in a second mixture. The carbon nanotubes grafted with poly(citric acid) are then extracted from the second mixture. The carbon nanotubes grafted with poly(citric acid) and 4-(dimethylamino)pyridine are dissolved in anhydrous dimethylformamide in a third mixture. Next, a mixture that comprises a drug is added to the third mixture to synthesize the carbon nanotubes grafted with poly(citric acid) and the drug in a fourth mixture. Then, the carbon nanotubes grafted with poly(citric acid) and the drug are extracted from the fourth mixture.

    摘要翻译： 公开了碳纳米管药物载体和碳纳米管药物载体的合成方法。 首先，将碳纳米管，硝酸和硫酸混合以在第一混合物中氧化碳纳米管。 然后从第一混合物中提取氧化的碳纳米管。 将氧化的碳纳米管和一水合柠檬酸混合以合成在第二混合物中用聚（柠檬酸）接枝的碳纳米管。 然后从第二混合物中提取用聚（柠檬酸）接枝的碳纳米管。 用聚（柠檬酸）和4-（二甲基氨基）吡啶接枝的碳纳米管以第三混合物溶解在无水二甲基甲酰胺中。 接下来，将包含药物的混合物加入到第三混合物中，以合成在第四混合物中接枝有聚（柠檬酸）和药物的碳纳米管。 然后，从第四混合物中提取用聚（柠檬酸）和药物接枝的碳纳米管。

    Methods for synthesizing oligomers containing hydroxy acid units
    9.
    发明授权
    Methods for synthesizing oligomers containing hydroxy acid units 失效
    合成含有羟基酸单元的低聚物的方法

    公开(公告)号：US5625030A

    公开(公告)日：1997-04-29

    申请号：US561139

    申请日：1995-11-20

    申请人： Simon F. Williams ,  Oliver P. Peoples

    发明人： Simon F. Williams ,  Oliver P. Peoples

    IPC分类号： C07B41/12 ,  C07B43/06 ,  C07K1/04 ,  C07K11/02 ,  C08G63/06 ,  C08G63/685 ,  C08G63/91 ,  C08L77/00

    CPC分类号： C07K1/04 ,  C07B41/12 ,  C07B43/06 ,  C07K1/047 ,  C07K11/02

    摘要： Methods for synthesizing oligomers containing hydroxy acids, and optionally containing other types of monomers or oligomers such as amino acids, carbohydrates, nucleotides and peptides, are provided which are rapid, simple, and readily automated. The oligomers have a C-terminal and an O, S or N-terminal end. The starting hydroxy acid can be covalently bound at either the C-terminal or O, S or N-terminal end to a solid support. The bond to the solid support can be an amide, thioester, ester, phosphate, silyl ether, carbamate, benzyl ether, or other linkage that can be cleaved either chemically or enzymatically.

    摘要翻译： 提供了用于合成含有羟基酸的低聚物和任选地含有其它类型的单体或低聚物如氨基酸，碳水化合物，核苷酸和肽的方法，其是快速，简单且容易自动化的。 低聚物具有C末端和O，S或N-末端。 起始羟基酸可以在C末端或O，S或N-末端共价结合成固体支持物。 与固体支持物的键可以是酰胺，硫酯，酯，磷酸酯，甲硅烷基醚，氨基甲酸酯，苄基醚或可以化学或酶切割的其它连接。