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    Process for preparing porous polymer particles
    6.
    发明授权
    Process for preparing porous polymer particles 有权
    制备多孔聚合物颗粒的方法

    公开(公告)号：US08466206B1

    公开(公告)日：2013-06-18

    申请号：US13334199

    申请日：2011-12-22

    Applicant: Xiqiang Yang ,  James R. Bennett

    Inventor： Xiqiang Yang ,  James R. Bennett

    IPC: C08J9/00

    CPC classification number: C08J9/0066 ,  C08J9/28 ,  C08J2201/0482 ,  C08J2325/14 ,  C08J2367/00

    Abstract: A process for forming polymer particles with aligned pores and controlled narrow particle size distribution, including: a) forming an oil phase by dissolving a polymeric binder in a solvent; b) dispersing the oil phase into a water phase containing a controlled amount of particulate stabilizer and forming an oil-in-water emulsion of controlled narrow dispersed oil phase droplet size distribution; c) freezing the emulsion to freeze solvent in the oil droplets to form frozen solvent domains within the polymeric binder, and also the water in the continuous water phase; and d) removing the frozen solvent from the polymeric binder and the frozen water in the continuous water phase, thereby forming porous polymer particles of controlled narrow particle size distribution and containing directional aligned non-spherical pore structures. Optionally, the porous particles may contain encapsulated functional ingredients.

    Abstract translation: 一种用于形成具有排列孔和受控的窄粒度分布的聚合物颗粒的方法，包括：a）通过将聚合物粘合剂溶解在溶剂中形成油相; b）将油相分散到含有受控量的颗粒稳定剂的水相中并形成受控窄分散油相液滴尺寸分布的水包油乳液; c）冷冻乳液以在油滴中冷冻溶剂，以在聚合物粘合剂内形成冷冻溶剂结构域，以及连续水相中的水; 以及d）从连续水相中的聚合物粘合剂和冷冻水中除去冷冻的溶剂，从而形成受控窄粒度分布的多孔聚合物颗粒并且包含定向排列的非球形孔结构。 任选地，多孔颗粒可以含有包封的功能性成分。

    Polyhydroxyalkanoate compositions having controlled degradation rates
    9.
    发明授权
    Polyhydroxyalkanoate compositions having controlled degradation rates 有权
    具有受控降解速率的聚羟基链烷酸酯组合物

    公开(公告)号：US06878758B2

    公开(公告)日：2005-04-12

    申请号：US10403942

    申请日：2003-03-28

    Applicant: David P. Martin ,  Frank Skraly ,  Simon F. Williams

    Inventor： David P. Martin ,  Frank Skraly ,  Simon F. Williams

    IPC: A61K9/16 ,  A61K47/48 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L24/00 ,  A61L26/00 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/06 ,  A61L31/14 ,  C08G63/06 ,  C08G63/64 ,  C08G63/685 ,  C08G63/688 ,  C08G63/91 ,  C08K5/00 ,  C12N5/00 ,  C12P7/62 ,  C08L67/04

    CPC classification number: C08G63/912 ,  A61K9/1647 ,  A61K47/593 ,  A61K47/6957 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/64 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C12N5/0068 ,  C12N2533/30 ,  C12P7/625 ,  C08L67/04

    Abstract: Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.

    Abstract translation: 已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。 在一个实施方案中，聚羟基链烷酸酯含有改变降解速率的添加剂。 在另一个实施方案中，聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。 在另一个实施方案中，聚羟基链烷酸酯被化学改性。 用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。 例如，如通过实施例所证明的，多孔聚羟基链烷酸酯可以使用产生孔，空隙或间隙的方法，例如乳液或喷雾干燥技术，或者在聚合物内含有可浸出或可冷冻干燥的颗粒。 实例描述了包括泡沫，涂层，网格和微粒的聚（4HB）组合物。 如实施例所示，这些聚羟基链烷酸酯组合物具有非常有利的机械性能，并且在生理条件下在期望的时间范围内是生物相容的和降解的。 这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或可植入或注射的装置。

    Medical devices and applications of polyhydroxyalkanoate polymers
    10.
    发明申请
    Medical devices and applications of polyhydroxyalkanoate polymers 有权

    公开(公告)号：US20020173558A1

    公开(公告)日：2002-11-21

    申请号：US10136499

    申请日：2002-05-01

    Applicant: Metabolix, Inc.

    Inventor： Simon F. Williams ,  David P. Martin ,  Frank A. Skraly

    IPC: C08K003/00

    CPC classification number: A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

    Abstract: Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

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