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53 条记录 (耗时 0.049 秒)

    Horizontal type blind
    43.
    发明授权
    Horizontal type blind 失效
    卧式盲

    公开(公告)号：US4327797A

    公开(公告)日：1982-05-04

    申请号：US77414

    申请日：1979-09-20

    申请人： Yukihiko Nakajima ,  Mitsuru Ohkubo ,  Tadakatsu Hashimoto ,  Shigeki Nakamura

    发明人： Yukihiko Nakajima ,  Mitsuru Ohkubo ,  Tadakatsu Hashimoto ,  Shigeki Nakamura

    IPC分类号： E06B9/32 ,  E06B9/324 ,  E06B9/322

    CPC分类号： E06B9/32 ,  E06B9/324

    摘要： A horizontal type blind having a novel mechanism for opening and closing slats which includes a pair of drive shafts juxtaposed in a housing fixed to a head box and adapted to be rotated in the same direction by pulling a slats-opening and closing cord and a pair of rollers connected to the drive shafts respectively and having two straps for holding the slats wound therearound respectively so as to feed either one of the straps while taking up the other according to the rotation of the rollers.

    摘要翻译： 一种具有用于打开和关闭板条的新型机构的水平式百叶窗，其包括一对驱动轴，该驱动轴并置在固定到头箱的壳体中，并且适于通过拉动板条开闭帘线和一对而沿相同方向旋转 的辊分别连接到驱动轴上，并具有两个带，用于分别缠绕在其上的板条，以便根据辊的旋转而进给另一个带。

    NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION
    45.
    发明申请
    NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION 有权
    具有选择性抑制作用的新型氨基吡啶衍生物

    公开(公告)号：US20120015969A1

    公开(公告)日：2012-01-19

    申请号：US13259620

    申请日：2010-03-15

    申请人： Hayley Binch ,  Masaya Hashimoto ,  Michael Mortimore ,  Mitsuru Ohkubo ,  Tomoko Sunami

    发明人： Hayley Binch ,  Masaya Hashimoto ,  Michael Mortimore ,  Mitsuru Ohkubo ,  Tomoko Sunami

    IPC分类号： A61K31/506 ,  C07D401/14 ,  A61P35/00 ,  C07D417/14

    CPC分类号： A61K31/535 ,  C07D401/14 ,  C07D417/14

    摘要： The present invention relates to a compound of Formula (I): wherein: R1 is H, —NHCOOR1a, C5-6 cycloalkyl, or phenyl; where the cycloalkyl and phenyl each independently may be substituted with one to three of the same or different substituents selected from R10; R1a is C1-3 alkyl which may be substituted with one to three of the same or different substituents selected from F and Cl; R2 is H, —COOH, —CH2 COOH, —COOR2a, or —CH2COOR2a; R2a is C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from halogen atoms; R3 is H, C1-6 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R11; R10 is F, Cl, CF3, or C1-2 alkyl; R11 is halogen atom, hydroxy, or cyano; W is selected from: W2a is H, halogen atom, cyano, C1-2 alkyl, or C3-5 cycloalkyl, or a pharmaceutically acceptable salt or ester thereof.

    摘要翻译： 本发明涉及式（I）的化合物：其中：R1是H，-NHCOOR1a，C5-6环烷基或苯基; 其中环烷基和苯基各自独立地可以被一至三个相同或不同的选自R 10的取代基取代; R 1a是可以被一至三个相同或不同的选自F和Cl的取代基取代的C 1-3烷基; R2是H，-COOH，-CH2COOH，-COOR2a或-CH2COOR2a; R2a是C1-2烷基，其中烷基可以被一至三个相同或不同的选自卤素原子的取代基取代; R3是H，C1-6烷基，其中烷基可以被一至三个相同或不同的选自R11的取代基取代; R 10是F，Cl，CF 3或C 1-2烷基; R11是卤素原子，羟基或氰基; W选自：W2a是H，卤素原子，氰基，C1-2烷基或C3-5环烷基，或其药学上可接受的盐或酯。

    Polynucleotide encoding a 35 KDA protein thats binds to WF00144
    47.
    发明授权
    Polynucleotide encoding a 35 KDA protein thats binds to WF00144 失效
    编码与WF00144结合的35KDa蛋白的多核苷酸

    公开(公告)号：US07371842B2

    公开(公告)日：2008-05-13

    申请号：US10511270

    申请日：2003-04-28

    申请人： Hidenori Nakajima ,  Mitsuru Ohkubo ,  Seiji Yoshimura ,  Nobuya Nishio ,  Kaori Nishio

    发明人： Hidenori Nakajima ,  Mitsuru Ohkubo ,  Seiji Yoshimura ,  Nobuya Nishio ,  Kaori Nishio

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N15/00 ,  C07K14/00

    CPC分类号： C12N9/88 ,  C07K14/4702 ,  G01N2500/00

    摘要： It is intended to provide a protein participating in the regulation of sugar production, a polynucleotide encoding the same, a method of screening a compound participating in the regulation of sugar production and a drug for treating or preventing diabetes which contains the compound participating in the regulation of sugar production. A polynucleotide encoding a protein specifically binding to a substance WF00144 is found out from rat liver cells and thus a protein participating in the regulation of sugar production and a polynucleotide encoding the same are provided. Moreover, a method and a substance relating to a method of treating and preventing diabetes are found out and thus a method of treating diabetes relating to the regulation of sugar production relating to the method of treating and preventing diabetes is provided.

    摘要翻译： 目的在于提供参与糖生产调节的蛋白质，编码糖蛋白的多核苷酸，筛选参与糖生产调节的化合物的方法和用于治疗或预防糖尿病的药物，其含有参与调节的化合物 的糖生产。 从大鼠肝细胞中发现编码与物质WF00144特异性结合的蛋白质的多核苷酸，因此提供了参与糖产​​生调节的蛋白质和编码该多核苷酸的多核苷酸。 此外，发现了与治疗和预防糖尿病的方法有关的方法和物质，因此提供了治疗和预防糖尿病的方法中关于糖生产调节的糖尿病的治疗方法。