公开(公告)号：US11441049B2

公开(公告)日：2022-09-13

申请号：US17435654

申请日：2020-03-13

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Xiaojie Lin ,  Jonathan Himmelfarb ,  Buddy D. Ratner

IPC: C09D133/26 ,  C08J3/28 ,  A61L29/06 ,  A61L29/04 ,  A61L29/08 ,  A61L29/14

Abstract: Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.

公开(公告)号：US10828398B2

公开(公告)日：2020-11-10

申请号：US16398002

申请日：2019-04-29

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Tao Bai ,  Harihara Subramanian Sundaram ,  Andrew William Sinclair ,  Jean-René Ella-Menye ,  Priyesh Jain

IPC: A61K47/34 ,  A61K9/00 ,  A61L15/24 ,  A61L15/42 ,  A61L24/00 ,  A61L27/52 ,  A61L15/22 ,  A61K47/58 ,  A61L24/04 ,  A61L27/16 ,  A61L27/38 ,  A61L31/06 ,  A61L31/10 ,  C08F220/36 ,  C08G81/02 ,  C12N5/00 ,  A61L31/14

Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

公开(公告)号：US20200289712A1

公开(公告)日：2020-09-17

申请号：US16398002

申请日：2019-04-29

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Tao Bai ,  Harihara Subramanian Sundaram ,  Andrew William Sinclair ,  Jean-René Ella-Menye ,  Priyesh Jain

IPC: A61L27/52 ,  A61L31/14 ,  A61L15/22 ,  A61K9/00 ,  A61K47/58 ,  A61L15/24 ,  A61L15/42 ,  A61L24/00 ,  A61L24/04 ,  A61L27/16 ,  A61L27/38 ,  A61L31/06 ,  A61L31/10 ,  C08F220/36 ,  C08G81/02 ,  C12N5/00

Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.

公开(公告)号：US20190219570A1

公开(公告)日：2019-07-18

申请号：US16113918

申请日：2018-08-27

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Zheng Zhang ,  Shengfu Chen ,  Hana Vaisocherova

IPC: G01N33/545 ,  G01N33/543 ,  C08F122/22

CPC classification number: G01N33/545 ,  C08F122/22 ,  G01N33/54353

Abstract: Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.

公开(公告)号：US20190154683A1

公开(公告)日：2019-05-23

申请号：US16042883

申请日：2018-07-23

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Norman David Brault, JR. ,  Harihara S. Sundaram ,  Chun-Jen Huang ,  Qiuming Yu ,  Yuting Li

IPC: G01N33/543

Abstract: Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.

公开(公告)号：US10130716B2

公开(公告)日：2018-11-20

申请号：US14526846

申请日：2014-10-29

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Andrew Keefe ,  Hong Xue

IPC: A61K38/48 ,  A61K47/48

Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.

公开(公告)号：US20150157732A1

公开(公告)日：2015-06-11

申请号：US14526846

申请日：2014-10-29

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Andrew Keefe ,  Hong Xue

IPC: A61K47/48 ,  A61K38/48

CPC classification number: A61K47/48176 ,  A61K38/4826 ,  A61K47/58 ,  C12Y304/21001

Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.

Abstract translation: 两性离子聚合物和混合电荷共聚物生物共轭物，制备和使用生物共轭物的方法。

公开(公告)号：US20150133609A1

公开(公告)日：2015-05-14

申请号：US14539886

申请日：2014-11-12

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Tao Bai

IPC: C08G73/02

CPC classification number: C08G73/026 ,  C08G73/0266

Abstract: Zwitterionic and mixed charge conducting polymers, surfaces modified to include the polymers, bulk constructs that include the polymers, and methods for using the polymers.

Abstract translation: 两性离子和混合电荷导电聚合物，修饰成包括聚合物的表面，包括聚合物的本体构造物，以及使用该聚合物的方法。

公开(公告)号：US20140235803A1

公开(公告)日：2014-08-21

申请号：US14184540

申请日：2014-02-19

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Shengfu Chen ,  Yung Chang ,  Zheng Zhang

IPC: C08F126/02

CPC classification number: C08J3/075 ,  A61K49/18 ,  B82Y30/00 ,  C07C317/08 ,  C07C317/28 ,  C07C317/44 ,  C07C317/50 ,  C08F120/36 ,  C08F292/00 ,  C08F2220/365 ,  C08F2438/01 ,  C08K3/16 ,  C08K3/34 ,  C08K9/08 ,  C09D5/1637 ,  C09D7/62 ,  C09D7/67 ,  C09D7/68

Abstract: Nanoparticles zwitterionic polymers grafted thereto or grafted therefrom, and methods for making and using the nanoparticles. Zwitterionic nanogels, and methods for making and using the nanogels.

Abstract translation: 接枝到其上或从其接枝的纳米颗粒两性离子聚合物，以及制备和使用纳米颗粒的方法。 两性离子纳米凝胶，以及制造和使用纳米凝胶的方法。