公开(公告)号：US20110189179A1

公开(公告)日：2011-08-04

申请号：US13086176

申请日：2011-04-13

申请人： Ugur Sahin ,  Özlzem Türeci ,  Michael Koslowski ,  Dirk Usener

发明人： Ugur Sahin ,  Özlzem Türeci ,  Michael Koslowski ,  Dirk Usener

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/30 ,  C12N5/10 ,  C12N15/63 ,  A61K39/00 ,  C12Q1/68 ,  A61K35/12 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K45/06 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/57 ,  A61K2039/572 ,  C07K14/4748 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/574

摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.

摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。

公开(公告)号：US20110104147A1

公开(公告)日：2011-05-05

申请号：US12765251

申请日：2010-04-22

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K39/00 ,  G01N33/53 ,  G01N33/574 ,  C07H21/00 ,  C07K16/18 ,  A61P35/00 ,  A61P37/04

CPC分类号： C12Q1/6886 ,  C07K14/4748 ,  C07K16/30 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.

摘要翻译： 本技术涉及与癌症疾病相关的遗传产物。 本技术还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。

公开(公告)号：US20090208498A1

公开(公告)日：2009-08-20

申请号：US12423153

申请日：2009-04-14

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： A61K39/395 ,  C07K16/30 ,  A61P35/00

CPC分类号： C07K16/3076 ,  A61K47/48569 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.

摘要翻译： 本技术涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本技术的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸 ，肽和蛋白质。

公开(公告)号：US20090202530A1

公开(公告)日：2009-08-13

申请号：US12066399

申请日：2006-09-06

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski ,  Dirk Usener

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski ,  Dirk Usener

IPC分类号： A61K39/395 ,  C12N15/11 ,  C07K16/18 ,  C12N5/06 ,  C12N15/00 ,  C07K14/00 ,  C12Q1/68 ,  C12Q1/02 ,  G01N33/574 ,  A61K31/7088 ,  A61K35/12 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K45/06 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/57 ,  A61K2039/572 ,  C07K14/4748 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/34 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/574

摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.

摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。

公开(公告)号：US07429461B2

公开(公告)日：2008-09-30

申请号：US10506443

申请日：2003-03-12

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： G01N33/574

CPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39558 ,  A61K48/00 ,  C07K14/4748 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/574

摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。

公开(公告)号：US20060035852A1

公开(公告)日：2006-02-16

申请号：US10537002

申请日：2003-11-21

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski

IPC分类号： A61K48/00

CPC分类号： C07K16/3076 ,  A61K47/48569 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for said products. Said invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for said polypeptides, peptides and proteins.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于编码所述产物的核酸。 所述发明还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码所述多肽，肽和蛋白质的核酸 。

公开(公告)号：US09637548B2

公开(公告)日：2017-05-02

申请号：US13201726

申请日：2010-02-18

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： G01N1/00 ,  G01N33/574 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/3046 ,  A61K2039/505 ,  C07K2317/34 ,  G01N33/57419 ,  G01N33/57446

摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of colorectal, in particular colonic, and gastric tumor tissues and colorectal, in particular colonic, and gastric tissues, and which represent targets for therapy or diagnosis of such tumor diseases in a subject.

公开(公告)号：US09216218B2

公开(公告)日：2015-12-22

申请号：US13636277

申请日：2011-03-10

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Rita Mitnachtkraus

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Rita Mitnachtkraus

IPC分类号： A61K39/395 ,  C07K16/30 ,  C12N5/20 ,  C07K16/46 ,  C12N5/16 ,  C12N15/113 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/462 ,  C07K16/464 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76 ,  C12N5/163 ,  C12N15/1138 ,  C12N2310/14

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.

摘要翻译： 本发明提供了可用作治疗和/或预防与表达GT468的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌，肝细胞癌，结肠癌，胰腺癌，食管癌 癌症，头颈癌，肾癌，特别是肾细胞癌，前列腺癌，肝癌，黑素瘤，肉瘤，骨髓瘤，成神经细胞瘤，胎盘绒毛膜癌，子宫颈癌和甲状腺癌及其转移形式。 在一个实施方案中，肿瘤疾病是肺中的转移性癌症。

公开(公告)号：US09090940B2

公开(公告)日：2015-07-28

申请号：US11886758

申请日：2006-03-23

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski ,  Gerd Helftenbein ,  Dirk Usener ,  Volker Schlüter

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski ,  Gerd Helftenbein ,  Dirk Usener ,  Volker Schlüter

IPC分类号： C12Q1/00 ,  G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57492 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G06F19/22

摘要： The invention relates to identifying tumor-associated genetic products and encoding nucleic acids thereof. A therapy and diagnosis of diseases in which the tumor-associated genetic products are aberrantly expressed, proteins, polypeptides and peptides which are expressed in association with tumor and the encoding nucleic acids for said proteins, polypeptides and peptides are also disclosed.

摘要翻译： 本发明涉及鉴定肿瘤相关基因产物并编码其核酸。 还公开了与肿瘤相关表达的肿瘤相关遗传产物异常表达的疾病的治疗和诊断，以及用于所述蛋白质，多肽和肽的编码核酸的蛋白质，多肽和肽。

公开(公告)号：US08946388B2

公开(公告)日：2015-02-03

申请号：US13119027

申请日：2009-09-16

申请人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Rita Mitnacht-Kraus

发明人： Ugur Sahin ,  Ozlem Tureci ,  Michael Koslowski ,  Rita Mitnacht-Kraus

IPC分类号： C07K16/00 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/73

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast Cancer, lung Cancer, gastric Cancer, ovarian Cancer, hepatocellular Cancer, colon Cancer, pancreatic Cancer, esophageal Cancer, head & neck Cancer, kidney Cancer, in particular renal cell Carcinoma, prostate Cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid Cancer, and the metastatic forms thereof. In one embodiment, the rumor disease is metastatic cancer in the lung.

摘要翻译： 本发明提供可用作治疗和/或预防与表达GT468的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌，肝细胞癌，结肠癌，胰腺癌，食管癌 癌症，头颈癌，肾癌，特别是肾细胞癌，前列腺癌，肝癌，黑素瘤，肉瘤，骨髓瘤，神经母细胞瘤，胎盘绒毛膜癌，子宫颈癌和甲状腺癌及其转移形式。 在一个实施方案中，谣言疾病是肺中的转移性癌症。