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41.发明授权公开(公告)号：US08835434B2
公开(公告)日：2014-09-16
申请号：US12811957
申请日：2009-01-09
Applicant: Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith Lee Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
Inventor： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith Lee Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
IPC: A61K31/517 , C07D403/04 , A61P35/00 , A61P25/28 , A61P9/00 , A61P29/00 , A61P15/00 , C07D239/70
CPC classification number: C07D239/70
Abstract: The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula (I): Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases, such as cancer.
Abstract translation: 本发明提供包含式（I）的化合物，包括其药学上可接受的盐：还提供使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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42.发明申请Debris Collection Device for Cutting Mechanism, LCD Panel Cutting Debris Suction Device 审中-公开用于切割机构的碎屑收集装置，LCD面板切割碎片吸引装置公开(公告)号：US20130104715A1
公开(公告)日：2013-05-02
申请号：US13375524
申请日：2011-11-03
Applicant: Junjie Huang , Hongqing Huang , Weiwei Zhang , Rui Xu , Huifang Duan , Jungmao Tsai , Yizhuang Zhuang , Xiaoxin Zhang
Inventor： Junjie Huang , Hongqing Huang , Weiwei Zhang , Rui Xu , Huifang Duan , Jungmao Tsai , Yizhuang Zhuang , Xiaoxin Zhang
IPC: B26D7/18
CPC classification number: B28D7/02 , B23Q11/006 , Y10T83/2066 , Y10T83/207
Abstract: The present invention discloses a debris collection device for cutting mechanism and an LCD panel cutting debris suction device. A debris collection device for cutting mechanism, wherein the debris collection device comprises a collection cap positioned behind the traveling direction of the cutting mechanism, and an air spray head positioned in front of the traveling direction of the cutting mechanism. The present invention can clear the debris produced in the LCD panel cutting process in time, and can reduce relevant defects such as line scratches, terminal scratches, short circuit, broken circuit, etc. which are generated because of debris. Thus, the yield and quality of products can be improved; the time of the subsequent cleaning process can be reduced; and the purposes of reducing risk, improving product yield and saving production cost can be achieved.
Abstract translation: 本发明公开了一种用于切割机构的碎片收集装置和一个LCD面板切屑碎屑抽吸装置。 一种用于切割机构的碎片收集装置，其中所述碎片收集装置包括位于所述切割机构的行进方向后面的收集帽和位于所述切割机构的行进方向前方的空气喷头。 本发明可以及时清除LCD面板切割过程中产生的碎屑，并且可以减少由于碎片而产生的线划痕，端子划伤，短路，断路等相关缺陷。 因此，可以提高产品的产量和质量; 可以减少后续清洗过程的时间; 可以实现降低风险，提高产品成本，节省生产成本的目的。
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43.发明申请Debris Collection Device for Cutting Mechanism and LCD Panel Cutting Debris Suction Device 有权用于切割机构的碎屑收集装置和LCD面板切割碎屑吸引装置公开(公告)号：US20130104336A1
公开(公告)日：2013-05-02
申请号：US13376187
申请日：2011-11-03
Applicant: Huifang Duan , Shaoyuan Zhang , Hao Jin , Rui Xu , Junjie Huang
Inventor： Huifang Duan , Shaoyuan Zhang , Hao Jin , Rui Xu , Junjie Huang
IPC: A47L9/02
CPC classification number: B26D7/1863 , B28D7/02 , G02F1/1303
Abstract: The present invention discloses a debris collection device for cutting mechanism and an LCD panel cutting debris suction device. A debris collection device for cutting mechanism comprises a debris collection cap and a suction spray head used for connecting with a suction device; the debris collection cap comprises a connecting part used for surrounding and fixing on the cutting mechanism, and the debris collection cap is provided with a through hole communicated with the suction spray head. The present invention can remove the debris produced in the cutting process in time, and can reduce relevant defects such as line scratches, terminal scratches, short circuit, broken circuit, etc. which are generated because of debris. Thus, the product yield and quality of LCD panels can be improved, and the time of the subsequent cleaning process can be reduced.
Abstract translation: 本发明公开了一种用于切割机构的碎片收集装置和一个LCD面板切屑碎屑抽吸装置。 用于切割机构的碎片收集装置包括碎片收集盖和用于与抽吸装置连接的抽吸喷头; 碎屑收集帽包括用于围绕和固定在切割机构上的连接部分，并且碎屑收集帽设置有与吸入喷头连通的通孔。 本发明可以及时去除切割过程中产生的碎屑，并且可以减少由于碎屑而产生的相关缺陷，例如线划痕，端子划痕，短路，断路等。 因此，可以提高LCD面板的产品产量和质量，并且可以减少后续清洁处理的时间。
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公开(公告)号：US20100292244A1
公开(公告)日：2010-11-18
申请号：US12811983
申请日：2009-01-09
Applicant: Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mtchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
Inventor： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mtchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang
IPC: A61K31/517 , C07D403/04 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/00 , A61P17/00 , A61P15/02
CPC classification number: C07D239/70
Abstract: The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了包含式I的化合物及其药学上可接受的盐。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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45.发明申请公开(公告)号：US20080058327A1
公开(公告)日：2008-03-06
申请号：US11773946
申请日：2007-07-05
Applicant: Ian Mitchell , James Blake , Rui Xu , Nicholas Kallan , Dengming Xiao , Keith Spencer , Josef Bencsik , Eli Wallace , Stephen Schlachter , Anna Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
Inventor： Ian Mitchell , James Blake , Rui Xu , Nicholas Kallan , Dengming Xiao , Keith Spencer , Josef Bencsik , Eli Wallace , Stephen Schlachter , Anna Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
IPC: A61K31/517 , A61K31/535 , A61P43/00 , C07D211/00 , C07D239/70
CPC classification number: C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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Patent Agency Ranking
公开(公告)号：US20220162193A1
公开(公告)日：2022-05-26
申请号：US17598389
申请日：2020-04-06
Applicant: Michelle Ann ESTRADA , Jonas GRINA , Paul WEHN , Rui XU , Peloton Therapeutics, Inc.
Inventor： Michelle Ann Estrada , Jonas Grina , Paul Wehn , Rui Xu
IPC: C07D403/12 , C07D405/14 , A61P35/00
Abstract: Compounds of formula I, that induce RBM39 protein degradation, pharmaceutical compositions containing these compounds, and methods of using these compounds for treating diseases associated with RBM39 protein activity are described herein.
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公开(公告)号：US09303040B2
公开(公告)日：2016-04-05
申请号：US12307526
申请日：2007-07-05
Applicant: Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik
Inventor： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik
IPC: A61K31/496 , C07D409/02 , C07D495/04
CPC classification number: C07D495/04
Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了包括分解对映异构体，非对映异构体，溶剂合物和其药学上可接受的盐的化合物，其包含式：还提供使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US09052342B2
公开(公告)日：2015-06-09
申请号：US13250756
申请日：2011-09-30
CPC classification number: G01R1/06727 , G01R1/06744
Abstract: An electrically conductive probe can comprise a post to which a beam structure is attached. The beam structure can comprise a cantilevered portion that extends away from the post to a free end to which a contact structure can be attached. The cantilevered portion of the beam can include both a solid section and a hollow section. Multiple such probes can be used in a test contactor to make electrical connections with an electronic device such as a semiconductor die or dies to be tested.
Abstract translation: 导电探针可以包括梁结构附接到的柱。 梁结构可以包括悬臂部分，该悬臂部分从支柱延伸到可以连接接触结构的自由端。 梁的悬臂部分可以包括固体部分和中空部分。 多个这样的探针可以用于测试接触器中，以与电子设备（例如半导体管芯或要测试的管芯）形成电连接。
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公开(公告)号：US08377937B2
公开(公告)日：2013-02-19
申请号：US12667850
申请日：2008-07-03
Applicant: Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Jun Liang , Brian S. Safina
Inventor： Josef R. Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mitchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Jun Liang , Brian S. Safina
IPC: C07D239/70 , A61K31/517
CPC classification number: C07D239/70 , C07D401/12 , C07D403/12 , C07D409/12
Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US08324221B2
公开(公告)日：2012-12-04
申请号：US12812384
申请日：2009-01-09
Applicant: Anna L. Banka , James F. Blake , Josef R. Bencsik , Kin Chiu Fong , Martin F. Hentemann , Douglas M. Sammond , Ian S. Mitchell , Rui Xu , Eli M. Wallace , Tony Tang
Inventor： Anna L. Banka , James F. Blake , Josef R. Bencsik , Kin Chiu Fong , Martin F. Hentemann , Douglas M. Sammond , Ian S. Mitchell , Rui Xu , Eli M. Wallace , Tony Tang
IPC: A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519 , C07D239/70
CPC classification number: C07D471/10 , C07D487/10
Abstract: The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供式（I）化合物，其包括互变异构体，拆分的对映异构体，拆分的非对映体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为Akt蛋白激酶抑制剂和治疗Akt介导的疾病例如过度增殖性疾病如癌症的方法。
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