公开(公告)号：US20100114236A1

公开(公告)日：2010-05-06

申请号：US12263348

申请日：2008-10-31

申请人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore

发明人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore

IPC分类号： A61N1/362 ,  H01M10/36

CPC分类号： A61N1/378 ,  A61N1/3956 ,  A61N1/3981 ,  H01M8/16 ,  H01M10/0525 ,  H01M10/425 ,  H01M10/44 ,  H01M16/006 ,  H02J7/0054 ,  H02J7/0063 ,  Y02E60/527

摘要： A system and method for powering an implantable cardiac therapy device (ICTD) via a hybrid battery system. The hybrid battery is comprised of a low voltage and low current bioelectric cell, a high voltage and high current rechargeable cell, and a charging means. Via the charging means, the bioelectric cell maintains the rechargeable cell at or near full power. The rechargeable cell is configured to power some or all operations of the ICTD. Some ICTD operations may be powered directly by the bioelectric cell. The rechargeable cell is further configured to be charged via a continuous charging process, reducing the complexity of the charging circuitry. In an embodiment, at least the bioelectric cell is external to the ICTD, enabling easy replacement of this power source. In an embodiment, a consumable anode of the bioelectric cell is external to the ICTD, enabling replacement of the power source by replacing only the anode.

摘要翻译： 通过混合电池系统为植入式心脏治疗装置（ICTD）供电的系统和方法。 混合电池包括低电压和低电流生物电池，高电压和高电流可再充电电池以及充电装置。 通过充电装置，生物电池将可再充电电池维持在或接近全功率。 可充电电池被配置为为ICTD的一些或所有操作供电。 一些ICTD操作可以由生物电池直接供电。 可再充电电池还被配置为经由连续充电过程进行充电，从而降低充电电路的复杂性。 在一个实施例中，至少生物电池在ICTD的外部，使得能够容易地更换该电源。 在一个实施例中，生物电池的消耗性阳极在ICTD的外部，能够通过仅替换阳极来替换电源。

公开(公告)号：US07630078B1

公开(公告)日：2009-12-08

申请号：US11683521

申请日：2007-03-08

申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

IPC分类号： G01B9/08

CPC分类号： A61B5/14542 ,  A61B5/02028 ,  A61B5/14535 ,  A61B5/1459 ,  A61B2560/0223 ,  A61N1/36557

摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

摘要翻译： 测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。 校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度 光源。 基于由校准光检测器产生的校准信号来补偿透射光强度的变化。 本说明书不是对本发明的完整描述或限制本发明的范围。 本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

公开(公告)号：US06804556B1

公开(公告)日：2004-10-12

申请号：US10036026

申请日：2001-12-21

申请人： Joseph J. Florio ,  Gene A. Bornzin ,  John W. Poore ,  Douglas T. Kurschinski

发明人： Joseph J. Florio ,  Gene A. Bornzin ,  John W. Poore ,  Douglas T. Kurschinski

IPC分类号： A61N1365

CPC分类号： A61N1/368

摘要： Techniques are described for overdrive pacing the heart using a pacemaker wherein the overdrive pacing rate only increases when at least two intrinsic beats are detected within a determined search period. In one specific technique, an increase in the pacing rate occurs only if two P-waves are detected within X cardiac cycles. In another specific technique, the overdrive pacing rate is increased only if at least two P-waves are detected within a block of N cardiac cycles. In both techniques, the overdrive pacing rate is decreased if no increase has occurred in the last Z cardiac cycles. By increasing the overdrive pacing rate only in response to detection of at least two P-waves within a determined number of cardiac cycles, an excessively high overdrive pacing rate is avoided. Other techniques are described for adaptively adjusting overdrive pacing parameters so as to achieve a determined target degree of pacing of, for example, 95% paced beats. By adaptively adjusting overdrive parameters to maintain a target degree of pacing, the average overdrive pacing rate is minimized while still maintaining a high number of paced beats, thereby reducing the risk of a tachyarrhythmia occurring within the patient.

摘要翻译： 描述了使用起搏器超速起搏心脏的技术，其中在确定的搜索周期内检测到至少两个固有节拍时，超速起搏速率仅增加。 在一种特定技术中，只有在X个心动周期内检测到两个P波时，起搏速率才会增加。 在另一个具体技术中，只有在N个心动周期的块内检测到至少两个P波时，才能增加超速起搏速率。 在两种技术中，如果在最后Z个心动周期中没有发生增加，则超速起搏速率将降低。 通过仅在确定的心跳周期内响应于至少两个P波的检测来增加超速起搏速率，避免了过高的超速起搏速率。 描述了用于自适应地调节过驱动起搏参数的其它技术，以便实现例如95％起搏节拍的确定的目标起搏程度。 通过自适应地调整过驱动参数以保持目标起搏程度，平均超速起搏速度最小化，同时仍然保持大量的起搏节奏，从而降低患者内出现快速性心律失常的风险。

公开(公告)号：US06766195B1

公开(公告)日：2004-07-20

申请号：US09686630

申请日：2000-10-10

申请人： Gene A. Bornzin ,  Peter Boileau ,  Joseph J. Florio ,  John W. Poore ,  Kelly H. McClure

发明人： Gene A. Bornzin ,  Peter Boileau ,  Joseph J. Florio ,  John W. Poore ,  Kelly H. McClure

IPC分类号： A61N0118

CPC分类号： A61N1/3962 ,  A61N1/395

摘要： Techniques are provided for detecting natural electrical coherence within the heart and for administering or adjusting therapy based upon whether natural electrical coherence is detected. In one example, an implantable cardioverter defibrillator (ICD), upon detecting atrial fibrillation, delays administering an atrial defibrillation pulse until a period of natural electrical coherence is detected between the left and the right atria of the heart. The ICD may further delay the pulse until the ventricles of the heart are refractory so as to help prevent triggering ventricular fibrillation. The pulses are administered at a time selected based upon the period of electrical coherence to reduce the amount of electrical energy required within the pulse to reliably defibrillate the heart. Other types of therapy besides defibrillation therapy such as anti-tachycardia pacing pulses may also be timed based upon detection periods of natural electrical coherence. Method and apparatus embodiments are described.

摘要翻译： 提供了用于检测心脏内的自然电连贯性的技术，并且用于基于是否检测到自然电连贯来施用或调整治疗。 在一个实例中，在检测心房颤动时，植入式心律转复除颤器（ICD）延迟施用心房除颤脉冲，直到在心脏的左心房和右心房之间检测到自然电相干的时间段。 ICD可以进一步延迟脉冲，直到心脏的心室难以耐受，以便有助于防止触发心室颤动。 在基于电相干周期选择的时间施加脉冲以减少脉冲内所需的电能量以可靠地除颤心脏。 除了除颤疗法之外的其他类型的治疗，如抗心动过速起搏脉冲也可以基于自然电连续性的检测周期来计时。 描述了方法和设备实施例。

公开(公告)号：US06731985B2

公开(公告)日：2004-05-04

申请号：US09981555

申请日：2001-10-16

申请人： John W. Poore ,  Kerry Bradley ,  Laurence S. Sloman ,  Gene A. Bornzin ,  Joseph J. Florio

发明人： John W. Poore ,  Kerry Bradley ,  Laurence S. Sloman ,  Gene A. Bornzin ,  Joseph J. Florio

IPC分类号： A61N1362

CPC分类号： A61N1/3712

摘要： An implantable cardiac stimulation device and associated method perform an automatic calibration procedure for evaluating whether automatic capture verification can be recommended. The calibration procedure calculates and displays a number of variables for use by a medical practitioner in programming automatic capture operating parameters. An average paced depolarization integral (PDI) is determined from the cardiac signals following delivery of multiple stimulation pulse below and above capture threshold such that both pure lead polarization signals and evoked response signals may be analyzed. From the paced depolarization integral data, a capture threshold, a stimulation response curve, a minimum evoked response, a maximum lead polarization, an evoked response sensitivity, an evoked response safety margin, and a polarization safety margin are determined. Based on these variables, the calibration procedure determines if automatic capture verification can be recommended. If so, the stimulation device calculates a capture detection threshold. The automatic capture verification recommendation and the estimated calibration variables are displayed.

摘要翻译： 可植入心脏刺激装置和相关方法执行自动校准程序，以评估是否可以推荐自动捕获验证。 校准程序计算并显示许多变量，供医生在编程自动捕获操作参数时使用。 平均节奏去极化积分（PDI）是在多次刺激脉冲传递后低于和高于捕获阈值的心脏信号确定的，以便可以分析纯铅极化信号和诱发响应信号。 从起搏去极化积分数据中，确定捕获阈值，刺激响应曲线，最小诱发响应，最大引线极化，诱发响应灵敏度，诱发响应安全裕度和极化安全裕度。 基于这些变量，校准过程确定是否可以推荐自动捕获验证。 如果是，则刺激装置计算捕获检测阈值。 显示自动捕获验证建议和估计的校准变量。

公开(公告)号：US09427579B2

公开(公告)日：2016-08-30

申请号：US13248818

申请日：2011-09-29

申请人： Eric S. Fain ,  Martin Cholette ,  Gary R. Dulak ,  Gene A. Bornzin ,  John W. Poore

发明人： Eric S. Fain ,  Martin Cholette ,  Gary R. Dulak ,  Gene A. Bornzin ,  John W. Poore

IPC分类号： A61B18/12 ,  A61N1/36 ,  A61B5/00 ,  A61B5/04 ,  A61N1/05 ,  A61B18/00 ,  A61B18/14

CPC分类号： A61B18/1492 ,  A61B5/04001 ,  A61B5/7203 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61N1/0551 ,  A61N1/36007

摘要： A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel; denervates at least some tissue proximate the renal vessel after performing the baseline measurement; performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating; and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel.

摘要翻译： 描述了肾去神经反馈方法，其执行肾血管的肾神经丛电活动的基线测量; 在进行基线测量后，至少接近肾血管的一些组织去神经细胞; 在去神经元后，对肾血管进行肾神经丛电活动的去神经后测量; 并且基于在肾血管上的肾神经丛电活动的基线测量和去神经后测量的比较来评估肾血管的去神经支配。

公开(公告)号：US09241638B2

公开(公告)日：2016-01-26

申请号：US13464590

申请日：2012-05-04

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

IPC分类号： A61B5/00 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/11 ,  A61B5/145

CPC分类号： A61B5/0205 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1116 ,  A61B5/14532

摘要： An implantable physiologic sensor assembly is configured to be implanted within a patient. The assembly includes a module that houses an internal operative chamber, and a flexible pressure-detecting member connected to the module. The module and the pressure-detecting member are separated before implantation into the patient. At least a first end of the pressure-detecting member is configured to be inserted into an artery of the patient and a second end of the pressure-detecting member is connected to the module. The module is configured to be subcutaneously positioned within the patient.

摘要翻译： 可植入生理传感器组件被配置为植入患者体内。 组件包括容纳内部操作室的模块和连接到模块的柔性压力检测构件。 模块和压力检测构件在植入之前被分离到患者体内。 压力检测构件的至少第一端构造成插入到患者的动脉中，并且压力检测构件的第二端连接到模块。 该模块被配置为皮下置于患者体内。

公开(公告)号：US08781605B2

公开(公告)日：2014-07-15

申请号：US13352167

申请日：2012-01-17

申请人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

发明人： Gene A. Bornzin ,  John W. Poore ,  Zoltan Somogyi

IPC分类号： A61N1/372 ,  A61N1/362 ,  A61B17/34 ,  A61N1/375 ,  A61N1/05 ,  A61N1/39

CPC分类号： A61N1/059 ,  A61B17/3468 ,  A61N1/0573 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3962

摘要： An assembly for introducing a leadless intra-cardiac medical device includes a sheath having an internal passage, wherein the sheath is configured to be maneuvered into the heart of the patient. A housing may be retained within the internal passage, wherein the housing is configured to be pushed out of the sheath, the housing having a first anchoring member configured to anchor the housing to a first implant location within the heart. The assembly may also include an electrode trailing the housing within the internal passage, wherein the electrode is also configured to be pushed out of the sheath. The electrode has a second anchoring member configured to anchor the electrode to a second implant location within the heart. A conductive wire connects the housing to the electrode, wherein movement of the housing out of the sheath causes the electrode to follow the movement to a distal end of the sheath.

摘要翻译： 用于引入无引线心脏内心脏医疗装置的组件包括具有内部通道的护套，其中护套构造成被操纵到患者的心脏中。 壳体可以被保持在内部通道内，其中壳体构造成被推出护套，壳体具有构造成将壳体锚定到心脏内的第一植入位置的第一锚定构件。 该组件还可以包括在内部通道内拖曳壳体的电极，其中电极还构造成被推出护套。 电极具有被配置为将电极锚定到心脏内的第二植入位置的第二锚定构件。 导电线将壳体连接到电极，其中壳体从鞘的移动导致电极跟随到鞘的远端的运动。

公开(公告)号：US08709631B1

公开(公告)日：2014-04-29

申请号：US11737307

申请日：2007-04-19

申请人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore ,  Sheldon Williams ,  Weiqun Yang ,  Taraneh Ghaffari Farazi

发明人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore ,  Sheldon Williams ,  Weiqun Yang ,  Taraneh Ghaffari Farazi

IPC分类号： H01M4/00 ,  H01M8/16

CPC分类号： A61N1/362 ,  A61N1/378 ,  H01M4/466 ,  H01M4/92 ,  H01M12/06 ,  H01M2220/30 ,  Y02E60/50

摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.

摘要翻译： 生物电池可用于为可植入装置供电。 生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得 管为阴极提供支撑。 生物电池还可以具有围绕阴极的膜以减少组织包封。 或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。 电解质设置在可渗透膜内，并且网围绕可渗透膜。 在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。

公开(公告)号：US08574737B2

公开(公告)日：2013-11-05

申请号：US13018140

申请日：2011-01-31

申请人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore ,  Sheldon Williams ,  Weiqun Yang ,  Taraneh Ghaffari Farazi

发明人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore ,  Sheldon Williams ,  Weiqun Yang ,  Taraneh Ghaffari Farazi

IPC分类号： H01M4/00 ,  H01M8/16 ,  H01M4/02 ,  H01M2/16

CPC分类号： A61N1/378 ,  H01M2/0275 ,  H01M2/1066 ,  H01M2/1653 ,  H01M2/18 ,  H01M2/361 ,  H01M4/12 ,  H01M4/366 ,  H01M4/48

摘要： A bioelectric battery may be used to power implantable devices. The bioelectric battery may have an anode electrode and a cathode electrode separated by an insulating member comprising a tube having a first end and a second end, wherein said anode is inserted into said first end of said tube and said cathode surrounds said tube such that the tube provides a support for the cathode electrode. The bioelectric battery may also have a membrane surrounding the cathode to reduce tissue encapsulation. Alternatively, an anode electrode, a cathode electrode surrounding the cathode electrode, a permeable membrane surrounding the cathode electrode. An electrolyte is disposed within the permeable membrane and a mesh surrounds the permeable membrane. In an alternative embodiment, a pacemaker housing acts as a cathode electrode for a bioelectric battery and an anode electrode is attached to the housing with an insulative adhesive.

摘要翻译： 生物电池可用于为可植入装置供电。 生物电池可以具有由包括具有第一端和第二端的管的绝缘构件分开的阳极电极和阴极电极，其中所述阳极插入所述管的所述第一端，所述阴极围绕所述管，使得 管为阴极提供支撑。 生物电池还可以具有围绕阴极的膜以减少组织包封。 或者，阳极电极，围绕阴极电极的阴极电极，围绕阴极电极的可渗透膜。 电解质设置在可渗透膜内，并且网围绕可渗透膜。 在替代实施例中，起搏器壳体用作生物电池的阴极电极，并且阳极通过绝缘粘合剂附接到壳体。