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公开(公告)号：US08273868B2
公开(公告)日：2012-09-25
申请号：US12631689
申请日：2009-12-04
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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公开(公告)号：US08253093B2
公开(公告)日：2012-08-28
申请号：US12849967
申请日：2010-08-04
申请人： Mirko Liedtke , Matthias John
发明人： Mirko Liedtke , Matthias John
CPC分类号： G02B21/362 , G01J1/02 , G01J1/0252 , G02B7/008 , G02B21/28
摘要： An optoelectronic detector and method of using same. In order to avoid any condensation on a surface, it has been known to heat such a surface. However, heating an optoelectronic detector will create a stronger hissing noise due to the greater dark current that is caused thereby. The invention is intended to avoid any condensation on an optoelectronic detector without airtight encapsulation. To this end, the detector is cooled and equipped with a sensor for the determination of a current value of one of the variables ambient humidity and ambient dew point temperature and a control unit that is connected with the sensor and designed to control the cooling device in dependence of such a value. By taking into account the ambient humidity or, respectively, the dew point temperature in the control of the cooling device, condensation on the detector can be avoided. An airtight encapsulation of the detector and the cooling device is not required.
摘要翻译： 一种光电检测器及其使用方法。 为了避免表面上的任何冷凝，已知加热这种表面。 然而，由于由此引起的较大的暗电流，加热光电检测器将产生更强的嘶嘶声。 本发明旨在避免在没有气密封装的情况下在光电检测器上的任何冷凝。 为此，检测器被冷却并配备有用于确定环境湿度和环境露点温度之一的变量的当前值的传感器，以及与传感器连接并被设计成控制冷却装置的控制单元 这种价值的依赖。 通过考虑环境湿度或分别控制冷却装置的露点温度，可以避免检测器上的冷凝。 不需要检测器和冷却装置的气密封装。
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公开(公告)号：US08232922B2
公开(公告)日：2012-07-31
申请号：US12355592
申请日：2009-01-16
申请人： Max Ammann , Matthias John
发明人： Max Ammann , Matthias John
IPC分类号： H01Q1/38
CPC分类号： H01Q9/30 , H01Q9/40 , H01Q9/42 , Y10T29/49016
摘要： The present application relates to microstrip-fed printed planar antennas and in particular to the geometry of same. More particularly an antenna is provided with a radiating or ground plane element having a generally continuous curved shape and being symmetrical about the longitudinal axis and non-symmetrical about an axis transverse to the longitudinal axis.
摘要翻译： 本申请涉及微带馈送印刷平面天线，特别涉及其几何形状。 更具体地说，天线设置有辐射或接地平面元件，其具有大致连续的弯曲形状并且围绕纵向轴线对称并且关于横向于纵向轴线的轴线是不对称的。
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公开(公告)号：US08099155B2
公开(公告)日：2012-01-17
申请号：US12229332
申请日：2008-08-21
申请人： Jan Boese , Estelle Camus , Matthias John
发明人： Jan Boese , Estelle Camus , Matthias John
IPC分类号： A61B5/00
CPC分类号： A61B8/00 , A61B6/4441 , A61B6/464 , A61B6/5247 , A61B8/0841 , A61B8/483 , A61B17/3403 , A61B90/37 , A61B2017/00694 , A61B2017/3413 , A61B2090/364 , A61B2090/365 , A61B2090/367 , A61B2090/376 , A61B2090/3762 , A61B2090/378 , G06T7/38 , G06T2207/10081 , G06T2207/10132 , G06T2207/20221 , G06T2207/30056
摘要： The present invention relates to a method for assisting with percutaneous interventions, wherein 2D x-ray images of an object region are recorded before the intervention using a C-arm x-ray system or a robot-based x-ray system at different projection angles and 3D x-ray image data of the object region is reconstructed from the 2D x-ray recordings. One or more 2D or 3D ultrasound images are recorded before and/or during the intervention using an external ultrasound system and registered with the 3D image data. The 2D or 3D ultrasound images are then overlaid with the 3D image data record or a target region segmented therefrom or displayed next to one another in the same perspective. The method allows a puncture or biopsy to be monitored with a low level of radiation.
摘要翻译： 本发明涉及一种辅助经皮干预的方法，其中使用C臂x射线系统或以不同投影角度的基于机器人的x射线系统在介入前记录对象区域的2D x射线图像 并且从2D X射线记录重建对象区域的3D X射线图像数据。 使用外部超声系统在干预之前和/或期间记录一个或多个2D或3D超声图像，并且与3D图像数据一起登记。 然后将2D或3D超声图像与3D图像数据记录或从其分割的目标区域或以相同的视角彼此相邻地显示。 该方法允许以低水平的辐射监测穿刺或活检。
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45.发明授权Device for merging a 2D radioscopy image with an image from a 3D image data record 有权用于将2D放射成像图像与来自3D图像数据记录的图像合并的装置公开(公告)号：US08045780B2
公开(公告)日：2011-10-25
申请号：US11904583
申请日：2007-09-27
申请人： Jan Boese , Matthias John , Norbert Rahn
发明人： Jan Boese , Matthias John , Norbert Rahn
IPC分类号： G06K9/00
CPC分类号： G06T15/08 , G06T7/38 , G06T11/008 , G06T2207/10072
摘要： The invention relates to a device for merging a 2D radioscopy image with an image obtained from a 3D image data record, having a memory unit that stores the 2D radioscopy image and the 3D image data record, a segmentation unit that segments an inner surface of a hollow organ from the 3D image data record, a registration unit that registers the 2D radioscopy image with the 3D image data record, a back-projection unit that back-projects the pixels of the 2D radioscopy image onto the segmented surface, taking account of the projection geometry of the 2D radioscopy image and the registration, and an image merger unit that generates a virtual endoscopy view of the surface from the segmented surface using the back-projected pixels. The device primarily allows 2D radioscopy images to be superimposed during interventional procedures with a fly display of the interior of an interesting organ.
摘要翻译： 本发明涉及一种用于将2D放射线图像与从3D图像数据记录获得的图像合并的装置，具有存储2D放射线图像和3D图像数据记录的存储单元，分割单元，其将 来自3D图像数据记录的空心器官，将2D放射线图像与3D图像数据记录注册的登记单元，将2D放射线图像的像素反投影到分割表面上的背投影单元，考虑到 2D放射线图像的投影几何图像和配准，以及图像合并单元，其使用后投影像素从分割表面生成表面的虚拟内窥镜视图。 该装置主要允许在介入手术过程中叠加2D放射成像图像，并显示有趣器官内部的飞行显示。
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公开(公告)号：US07924280B2
公开(公告)日：2011-04-12
申请号：US11526803
申请日：2006-09-26
申请人： Matthias John
发明人： Matthias John
IPC分类号： G06T17/00
CPC分类号： G06T19/00 , G06T7/0012 , G06T7/11 , G06T7/187 , G06T7/60 , G06T2207/10081 , G06T2207/10088 , G06T2207/30101 , G06T2210/41
摘要： A method is disclosed for processing of diagnostic image data. In one embodiment, the method includes determination of three-dimensional image information using an imaging medico-technical method, in which an examined volume is subdivided into a plurality of voxels and each voxel is allocated one measurement value, and selection of a subset of the voxels, with the measurement values which are associated with the selected voxels satisfying a specific relationship with a limit value. The method further includes identification of at least one cohesive volume area within the selected subset of the voxels, determination of a surface of the identified cohesive volume area, and determination of the distance between voxels within the cohesive volume area and the surface. Additionally, the method includes identification of volume elements within the cohesive volume area, with each volume element having a central voxel whose distance from the surface represents a local maximum, determination of a constriction within the cohesive volume area, which constriction separates identified volume elements from one another, and subdivision of the determined image information into a plurality of data subsets, with the constriction providing a boundary between the different data subsets.
摘要翻译： 公开了一种用于处理诊断图像数据的方法。 在一个实施例中，该方法包括使用成像医学技术方法来确定三维图像信息，其中检查的体积被细分为多个体素，并且每个体素被分配一个测量值，并且选择 体素，其中与所选择的体素相关联的测量值满足与极限值的特定关系。 该方法还包括识别体素的所选子集内的至少一个内聚体积区域，确定所识别的内聚体积区域的表面，以及确定内聚体积区域和表面之间的体素之间的距离。 此外，该方法包括识别内聚体积区域内的体积元素，其中每个体积元素具有中心体素，其距离表面的距离表示局部最大值，确定内聚体积区域内的收缩，该收缩将识别的体积元素与 并且将所确定的图像信息细分为多个数据子集，其中收缩部提供不同数据子集之间的边界。
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公开(公告)号：US20110032614A1
公开(公告)日：2011-02-10
申请号：US12849967
申请日：2010-08-04
申请人： Mirko LIEDTKE , Matthias John
发明人： Mirko LIEDTKE , Matthias John
CPC分类号： G02B21/362 , G01J1/02 , G01J1/0252 , G02B7/008 , G02B21/28
摘要： An optoelectronic detector and method of using same. In order to avoid any condensation on a surface, it has been known to heat such a surface. However, heating an optoelectronic detector will create a stronger hissing noise due to the greater dark current that is caused thereby. The invention is intended to avoid any condensation on an optoelectronic detector without airtight encapsulation. To this end, the detector is cooled and equipped with a sensor for the determination of a current value of one of the variables ambient humidity and ambient dew point temperature and a control unit that is connected with the sensor and designed to control the cooling device in dependence of such a value. By taking into account the ambient humidity or, respectively, the dew point temperature in the control of the cooling device, condensation on the detector can be avoided. An airtight encapsulation of the detector and the cooling device is not required.
摘要翻译： 一种光电检测器及其使用方法。 为了避免表面上的任何冷凝，已知加热这种表面。 然而，由于由此引起的较大的暗电流，加热光电检测器将产生更强的嘶嘶声。 本发明旨在避免光电检测器上没有气密封装的任何冷凝。 为此，检测器被冷却并配备有用于确定环境湿度和环境露点温度之一的变量的当前值的传感器，以及与传感器连接并被设计成控制冷却装置的控制单元 这种价值的依赖。 通过考虑环境湿度或分别控制冷却装置的露点温度，可以避免检测器上的冷凝。 不需要检测器和冷却装置的气密封装。
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48.发明申请DOUBLE-STRANDED RIBONUCLEIC ACID WITH INCREASED EFFECTIVENESS IN AN ORGANISM 审中-公开双重有效的抗坏血酸在有机体中具有更高的有效性公开(公告)号：US20100280102A1
公开(公告)日：2010-11-04
申请号：US12816994
申请日：2010-06-16
CPC分类号： C12N15/1135 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2330/30
摘要： The present invention relates to a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, wherein at least end of the dsRNA comprises a nucleotide overhang of 1 to 4 unpaired nucleotides in length; wherein the unpaired nucleotide adjacent to the terminal nucleotide pair comprises a purine base; and wherein the terminal nucleotide pair on both ends of the dsRNA is a G-C pair, or at least two of the last four consecutive terminal nucleotide pairs are G-C pairs.
摘要翻译： 本发明涉及一种靶向选择双链核糖核酸（dsRNA）的方法，所述双链核糖核酸（dsRNA）由两条单链组成，其通过RNA干扰显示增强的抑制靶基因表达的有效性，其中至少 dsRNA包含长度为1至4个不成对核苷酸的核苷酸突出端; 其中与所述末端核苷酸对相邻的未配对核苷酸包含嘌呤碱基; 并且其中dsRNA两端的末端核苷酸对是G-C对，或者最后四个连续的末端核苷酸对中的至少两个是G-C对。
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公开(公告)号：US07745418B2
公开(公告)日：2010-06-29
申请号：US11959936
申请日：2007-12-19
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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50.发明申请Method and apparatus for representing myocardial tissues in different states of damage 有权用于表示不同损伤状态的心肌组织的方法和装置公开(公告)号：US20080038197A1
公开(公告)日：2008-02-14
申请号：US11890400
申请日：2007-08-06
摘要： The invention relates to a method for differentially representing myocardial tissue in different states of damage, comprising the following steps: administering a myocardium-suitable contrast agent to a patient under examination; entering at least one patient-specific parameter affecting the speed of uptake by and elimination from the myocardium of said contrast agent; calculating a point in time after administration of the contrast agent at which a difference between a contrast agent content in necrotic myocardial tissue and a contrast agent content in non-necrotic myocardial tissue attains a maximum value, on the basis of the at least one patient-specific parameter, and carrying out, at the point in time calculated, a late-phase CT scan for accentuation of necrotic myocardial tissue compared to non-necrotic myocardial tissue. The invention likewise relates to apparatus, in particular for carrying out the method. A clean copy of the abstract that incorporates the above amendments is provided herewith on a separate page.
摘要翻译： 本发明涉及用于差异代表不同损伤状态的心肌组织的方法，包括以下步骤：向被检查的患者施用适合心肌的造影剂; 输入至少一个影响所述造影剂的心肌的摄取速度和消除速度的患者特异性参数; 计算施用造影剂之后的时间点，其中所述造影剂中的坏死心肌组织中的造影剂含量与非坏死性心肌组织中的造影剂含量之间的差异达到最大值，基于至少一个患者 - 具体参数，并且在计算的时间点进行与非坏死心肌组织相比的坏死心肌组织的晚期CT扫描。 本发明同样涉及装置，特别是用于实施该方法。 包含上述修订的摘要的干净的副本将提供在单独的页面上。
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