利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

47 records (took 0.023 seconds)

    Automated pipette machine
    41.
    发明授权
    Automated pipette machine 有权
    自动移液器

    公开(公告)号：US07814805B2

    公开(公告)日：2010-10-19

    申请号：US12164209

    申请日：2008-06-30

    Applicant: Andrew Angus ,  Fred Davis ,  Adam Donath ,  Richard Grant ,  Dirk Kurpershoek

    Inventor： Andrew Angus ,  Fred Davis ,  Adam Donath ,  Richard Grant ,  Dirk Kurpershoek

    IPC: G01N1/14 ,  G01N35/10 ,  B01L3/02

    CPC classification number: B01L3/0279 ,  B01L2200/023 ,  B01L2200/0689 ,  G01N35/10

    Abstract: A pipette nozzle is provided for use on a movable arm on an automated pipette machine. The pipette nozzle includes a body defining a passage therethrough and having at least two seating surfaces provided on the body. The first seating surface is configured to receive and sealingly mate with a first size of pipette tip in a manner such that the first end of the passage is in fluid communication with the first size of pipette tip. The second seating surface is configured to correspondingly receive, sealingly mate and provide passage first end fluid communication with a second size of pipette tip. There is also provided an automated pipette machine which includes a tip ejector system including an arm that is movable between a first position and a second position wherein in the first position the arm is positioned to engage the tip during movement of the nozzle along a selected path and to prevent movement of the tip along the selected path while permitting the nozzle to move along the selected path, so that the movement of the nozzle along the selected path causes the nozzle and the tip to disengage from each other, and wherein in the second position the arm is positioned to avoid engagement with the tip during movement of the nozzle.

    Abstract translation: 提供移液管喷嘴用于自动移液管机上的可移动臂上。 移液管喷嘴包括限定穿过其中的通道的主体，并且具有设置在主体上的至少两个就座表面。 第一座面被构造成以使得通道的第一端与第一尺寸的移液管尖端流体连通的方式接收并密封地与第一尺寸的移液管尖端配合。 第二座面构造成相应地接收，密封地配合并提供与第二尺寸的移液管尖端的通道第一端流体连通。 还提供了一种自动移液器机器，其包括尖端喷射器系统，其包括可在第一位置和第二位置之间移动的臂，其中在第一位置中臂被定位成在沿着选定路径的喷嘴运动期间接合尖端 并且防止尖端沿着所选择的路径运动，同时允许喷嘴沿着所选择的路径移动，使得喷嘴沿着所选路径的移动导致喷嘴和尖端彼此脱离，并且其中在第二 位置是使臂被定位成避免在喷嘴运动期间与尖端接合。

    METHOD OF PIPETTING USING A PIPETTE TIP HOLDER
    42.
    发明申请
    METHOD OF PIPETTING USING A PIPETTE TIP HOLDER 有权
    使用管接头支架的方法

    公开(公告)号：US20100024575A1

    公开(公告)日：2010-02-04

    申请号：US12576936

    申请日：2009-10-09

    Applicant: Steven Woodside ,  Terry Thomas ,  Graeme Cross ,  Andrew Angus

    Inventor： Steven Woodside ,  Terry Thomas ,  Graeme Cross ,  Andrew Angus

    IPC: B01L3/02

    CPC classification number: B01L9/543 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2300/042 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

    Abstract: A method of pipetting comprises (a) providing a pipette tip holder having a plurality of segregated compartments and a tip support member for supporting a plurality of pipette tips in the pipette tip holder, the tip support member configured to support a single pipette in tip each segregated compartment; (b providing a plurality of pipette tips in the tip support member; (c) removing a first pipette tip from a first segregated compartment; (d) using the first pipette tip to complete a pipetting operation and placing the first pipette tip into a segregated compartment that has not contained a used pipette tip; (e) subsequently removing the first pipette tip from the segregated compartment and using the first pipette tip to complete another pipetting operation; and, (f) replacing the first pipette tip into the pipette tip holder, whereby the first pipette tip, when placed in the segregated compartment, is segregated in the pipette tip holder to reduce the possibility of a fluid from the first pipette tip contacting other pipette tips in the pipette tip holder.

    Abstract translation: 一种移液方法包括（a）提供具有多个隔离隔室的移液管末端保持器和用于将多个移液管末端支撑在吸头保持器中的末端支撑构件，该末端支撑构件构造成在每个端头中支撑单个移液管 分隔室 （b）在所述末梢支撑构件中提供多个移液管吸头;（c）从第一隔离隔间移除第一移液管末端;（d）使用所述第一移液管末端完成移液操作并将所述第一移液管吸头置于分离的 （e）随后从分离的隔室中移除第一移液管末端并使用第一移液管末端完成另一移液操作;以及（f）将第一移液管末端更换为移液管末端保持器 其中当放置在分隔室中时，第一移液管吸头被分离在移液管吸头保持器中，以减少来自第一移液管尖端的流体与移液器吸头保持器中的其它移液管吸头接触的可能性。

    Neural colony forming assay
    43.
    发明授权
    Neural colony forming assay 有权
    神经集落形成试验

    公开(公告)号：US07442545B2

    公开(公告)日：2008-10-28

    申请号：US10938579

    申请日：2004-09-13

    Applicant: Brent A. Reynolds ,  Sharon A. Louis

    Inventor： Brent A. Reynolds ,  Sharon A. Louis

    IPC: C12N5/00 ,  C12N5/06 ,  C12N5/08

    CPC classification number: G01N33/5073 ,  G01N33/56966

    Abstract: A neural colony forming cell (NCFC) assay is described. The assay allows one to distinguish neural stem cells from neural progenitor cells. In one embodiment, the present invention provides a method for identifying neural stem cells or neural progenitor cells comprising: (a) suspending neural cells in a semi-solid medium which supports the growth of neural cells; (b) plating the cells in the semi-solid medium at a density that allows for the production of colonies; (c) culturing the plated cells until size differences can be discerned between the colonies; and (d) estimating colony size wherein the larger colonies are likely produced by neural stem cells and wherein the small colonies are likely produced by neural progenitor cells In alternate embodiments, NSC can be distinguished from neural progenitor cells by determining the morphology or antigen expression of the colonies.

    Abstract translation: 描述了神经集落形成细胞（NCFC）测定。 该测定允许区分神经干细胞与神经祖细胞。 在一个实施方案中，本发明提供了用于鉴定神经干细胞或神经祖细胞的方法，包括：（a）将神经细胞悬浮于支持神经细胞生长的半固体培养基中; （b）以允许生产菌落的密度在半固体培养基中电镀细胞; （c）培养电镀细胞，直到在菌落之间可以看出尺寸差异; 和（d）估计集落大小，其中较大的菌落可能由神经干细胞产生，并且其中小菌落可能由神经祖细胞产生。在替代实施方案中，NSC可以通过确定神经祖细胞的形态或抗原表达来区分 殖民地

    Tetrameric antibody complexes for blocking non-specific labeling of antigens
    44.
    发明授权
    Tetrameric antibody complexes for blocking non-specific labeling of antigens 有权
    用于阻断抗原非特异性标记的四聚体抗体复合物

    公开(公告)号：US07387897B2

    公开(公告)日：2008-06-17

    申请号：US11524909

    申请日：2006-09-22

    Applicant: Albertus Wernerus Wognum ,  Peter Michael Lansdorp

    Inventor： Albertus Wernerus Wognum ,  Peter Michael Lansdorp

    IPC: G01N33/53

    CPC classification number: G01N33/5306 ,  G01N2333/70535 ,  Y10S435/962 ,  Y10S436/819 ,  Y10S436/825

    Abstract: A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody complexes that can bind to the antigen and are comprised of two monoclonal antibodies of a first animal species linked to two monoclonal antibodies of a second animal species that can bind the antibodies of the first animal species. Preferably, the antigen is an Fc Receptor and the method reduces the binding of a detection antibody with Fc receptors present on the surface of many cells.

    Abstract translation: 描述了在免疫测定中预防或抑制检测试剂和抗原之间的非特异性结合反应的方法。 该方法包括使用可与抗原结合的四聚体抗体复合物，并且由与可与第一动物物种结合的第二动物物种的两种单克隆抗体连接的第一动物物种的两种单克隆抗体组成。 优选地，抗原是Fc受体，并且该方法降低了检测抗体与许多细胞表面上存在的Fc受体的结合。

    Tetrameric antibody complexes for blocking non-specific labeling of antigens
    45.
    发明申请
    Tetrameric antibody complexes for blocking non-specific labeling of antigens 有权
    用于阻断抗原非特异性标记的四聚体抗体复合物

    公开(公告)号：US20070026468A1

    公开(公告)日：2007-02-01

    申请号：US11524909

    申请日：2006-09-22

    Applicant: Albertus Wognum ,  Peter Lansdorp

    Inventor： Albertus Wognum ,  Peter Lansdorp

    IPC: G01N33/567

    CPC classification number: G01N33/5306 ,  G01N2333/70535 ,  Y10S435/962 ,  Y10S436/819 ,  Y10S436/825

    Abstract: A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody complexes that can bind to the antigen and are comprised of two monoclonal antibodies of a first animal species linked to two monoclonal antibodies of a second animal species that can bind the antibodies of the first animal species. Preferably, the antigen is an Fc Receptor and the method reduces the binding of a detection antibody with Fc receptors present on the surface of many cells.

    Abstract translation: 描述了在免疫测定中预防或抑制检测试剂和抗原之间的非特异性结合反应的方法。 该方法包括使用可与抗原结合的四聚体抗体复合物，并且由与可与第一动物物种结合的第二动物物种的两种单克隆抗体连接的第一动物物种的两种单克隆抗体组成。 优选地，抗原是Fc受体，并且该方法降低了检测抗体与许多细胞表面上存在的Fc受体的结合。

Patent Agency Ranking