公开(公告)号：US20100324037A1

公开(公告)日：2010-12-23

申请号：US12438504

申请日：2007-08-23

Applicant: Stewart Campbell ,  David Duffy ,  Michael Grogan ,  Steven Kates ,  Emanuele Ostuni ,  Olivier Schueller ,  Paul Sweetnam

Inventor： Stewart Campbell ,  David Duffy ,  Michael Grogan ,  Steven Kates ,  Emanuele Ostuni ,  Olivier Schueller ,  Paul Sweetnam

IPC: A61K31/5377 ,  C07D487/04 ,  A61K31/53 ,  A61P9/12 ,  A61P15/10

CPC classification number: C07D487/04

Abstract: A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

Abstract translation: 提供具有改善的非特异性结合特征和药代动力学性质的式A化合物：或其药学上可接受的盐，立体异构体或其水合物。

公开(公告)号：US20070166816A1

公开(公告)日：2007-07-19

申请号：US11637912

申请日：2006-12-13

Applicant: Stewart Campbell ,  Enoch Kim ,  Gregory Kirk ,  Emanuele Ostuni ,  Olivier Schueller ,  Rocco Casagrande ,  Evelyn Wang ,  Paul Sweetnam

Inventor： Stewart Campbell ,  Enoch Kim ,  Gregory Kirk ,  Emanuele Ostuni ,  Olivier Schueller ,  Rocco Casagrande ,  Evelyn Wang ,  Paul Sweetnam

IPC: C12M1/34

CPC classification number: B82Y30/00 ,  C12M23/12 ,  C12M23/16 ,  C12M25/02 ,  C12M29/10 ,  C12M35/08 ,  C12N2503/00 ,  C12N2503/02 ,  G01N33/5014

Abstract: This invention provides device for co-culturing at least two different cell types in a two-dimensional configuration, methods of patterning at least two different cell types in a two-dimensional co-culture configuration, and uses of these devices and methods for analyzing an effect of candidate compound on such cellular cocultures. Also provided is a transmigration and extravasation device. Assay devices for analyzing the absorption, permeability, metabolism and/or toxicity of a candidate compound by a cell are provided. A microfluidic network, which is adaptable for integration with a device for coculturing is provided.

Abstract translation: 本发明提供了用于以二维配置共培养至少两种不同细胞类型的装置，在二维共培养构型中构图至少两种不同细胞类型的方法，以及这些装置和方法用于分析 候选化合物对这种细胞共培养物的作用。 还提供了一种迁移和外渗装置。 提供了用于分析细胞的候选化合物的吸收，渗透性，代谢和/或毒性的测定装置。 提供了适用于与用于共同培养的装置集成的微流控网络。

公开(公告)号：US07169577B2

公开(公告)日：2007-01-30

申请号：US10206340

申请日：2002-07-29

Applicant: Evelyn Wang ,  Rocco Casagrande ,  Amar Kendale ,  Enoch Kim ,  Emanuele Ostuni ,  Olivier Schueller

Inventor： Evelyn Wang ,  Rocco Casagrande ,  Amar Kendale ,  Enoch Kim ,  Emanuele Ostuni ,  Olivier Schueller

IPC: C12Q1/24

CPC classification number: B01L3/5085 ,  B01J2219/00317 ,  B01J2219/00655 ,  B01J2219/00659 ,  B01J2219/00743 ,  B01L3/5088 ,  B01L2400/043 ,  C12M23/12 ,  C40B60/14 ,  G01N33/543 ,  G01N33/54326 ,  G01N35/0098

Abstract: The present invention provides methods and devices for screening a single cell or a small group of cells for a desired biological activity. In particular, the present invention provides for delivering cell(s) to a plurality of cell isolation regions of a cell isolation device, transferring cell(s) to a plurality of wells of a cell expansion device and then detecting the potential desired biological activity of the cell(s). Each of the receptacles comprise a recess sized to isolate a single cell or small group of cells and each of the wells encompass a cavity that provides sufficient volume for cell proliferation.

Abstract translation: 本发明提供用于筛选单细胞或小组细胞以获得所需生物活性的方法和装置。 特别地，本发明提供将细胞递送到细胞分离装置的多个细胞隔离区域，将细胞转移到细胞扩增装置的多个孔中，然后检测潜在的所需生物活性 电池。 每个细胞分离区域包括尺寸设计成分离单个细胞或小组细胞的凹陷，并且每个孔包括为细胞增殖提供足够体积的空腔。

公开(公告)号：US06982171B2

公开(公告)日：2006-01-03

申请号：US10385657

申请日：2003-03-12

Applicant: Enoch Kim ,  Gregory Kirk ,  Matthew Brown ,  Emanuele Ostuni

Inventor： Enoch Kim ,  Gregory Kirk ,  Matthew Brown ,  Emanuele Ostuni

IPC: C12N5/08

CPC classification number: B01L3/5025 ,  B01L2300/0829 ,  B01L2400/086

Abstract: The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member by being placed in substantially fluid-tight conformal contact with the support member. The support member and the top member are configured such that they together define a discrete chamber adapted to allow a monitoring of chemotaxis or chemoinvasion therein. The discrete chamber includes a first well region including at least one first well, the at least one first well configured to received a test agent therein; a second well region including at least one second well, the at least one second well configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region with one another. The second well region is preferably horizontally offset with respect to the first well region in a test orientation of the device.

公开(公告)号：US06937804B2

公开(公告)日：2005-08-30

申请号：US10336958

申请日：2003-01-06

Applicant: Christopher McCoy ,  John Tsen-Tao Chen

Inventor： Christopher McCoy ,  John Tsen-Tao Chen

IPC: G02B6/12 ,  G02B6/122 ,  G02B6/132 ,  G02B6/138 ,  G02B6/26 ,  G02F1/35 ,  G02F3/00 ,  G02F3/02

CPC classification number: B82Y20/00 ,  G02B6/1221 ,  G02B6/1225 ,  G02B6/132 ,  G02B6/138 ,  G02B6/26 ,  G02B2006/12145 ,  G02F1/3515 ,  G02F3/00 ,  G02F3/024 ,  G02F2201/346 ,  G02F2202/32

Abstract: A photonic switch according to the present invention may be formed using one of a selected group of non-linear optical materials. Each of the materials within this group has a refractive index that demonstrates a substantial peak as a function of wavelength, where the peak occurs at a wavelength distinct from the wavelength of the input signal. A method of producing a photonic switch according to the present invention includes fabricating source and drain waveguides using micro-molding or micro-contact printing processes, or MIMIC (micro-molding in capillaries) of a UV-curable polymer. If desired, a gate waveguide may also be formed in part by these processes. The photonic switch also includes a photonic crystal formed from non-linear optical material, which may be formed, for example, using a block copolymer and nanoparticle composite in a MIMIC or μfluidics process. Such a process may employ a functionalized mold material to align the blocks.

Abstract translation: 根据本发明的光子开关可以使用所选择的一组非线性光学材料之一来形成。 该组中的每种材料具有折射率，其表现出作为波长的函数的实质峰值，其中峰值出现在与输入信号的波长不同的波长处。 根据本发明的制造光子开关的方法包括使用微型成型或微接触印刷工艺或可UV固化聚合物的MIMIC（毛细管的微型成型）制造源极和漏极波导。 如果需要，也可以通过这些工艺部分地形成栅极波导。 光子开关还包括由非线性光学材料形成的光子晶体，其可以例如在MIMIC或微流体过程中使用嵌段共聚物和纳米颗粒复合材料形成。 这种方法可以使用官能化的模具材料来对准块体。

公开(公告)号：US06885790B2

公开(公告)日：2005-04-26

申请号：US10293752

申请日：2002-11-13

Applicant: Christopher McCoy ,  John Tsen-Tao Chen

Inventor： Christopher McCoy ,  John Tsen-Tao Chen

IPC: G02B6/122 ,  G02B6/34 ,  G02B6/35 ,  G02F1/01 ,  G02F1/35 ,  G02F2/00 ,  G02F3/02 ,  G02B26/00

CPC classification number: B82Y20/00 ,  G02B6/1225 ,  G02F1/0126 ,  G02F1/3515 ,  G02F2/004 ,  G02F3/024 ,  G02F2201/307 ,  G02F2202/32

Abstract: A photonic switch may be formed using one of a selected group of non-linear optical materials. Each of the materials within this group has a refractive index that demonstrates a substantial peak as a function of wavelength. The photonic switch includes a positive gain, and thus acts as a photonic transistor. In addition, a photonic switch is formed so that a gate signal is applied in a direction that is substantially perpendicular to the direction of the input signal so that there is no effective contamination of the input signal by the gate signal affecting the output signal.

Abstract translation: 可以使用所选择的一组非线性光学材料之一来形成光子开关。 该组中的每种材料具有折射率，其表现出作为波长的函数的实质峰值。 光子开关包括正增益，因此充当光子晶体管。 此外，形成光子开关，使得栅极信号被施加在基本上垂直于输入信号的方向的方向上，使得不影响输入信号的栅极信号对输入信号的有效污染。