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41.发明授权Synthetically produced tridecapeptide having the same activity as the hypothalamic substance, neurotensin 失效具有与下丘脑物质，神经降压素相同活性的合成产生的十三肽
公开(公告)号：US3929756A
公开(公告)日：1975-12-30
申请号：US41781673
申请日：1973-11-21
申请人： UNIV BRANDEIS
发明人： LEEMAN SUSAN E , CARRAWAY ROBERT E
IPC分类号： A61K38/00 , C07K7/08 , C07C103/52 , A61K37/00
摘要： A hypotensive peptide, designated neurotensin, has been discovered and isolated in pure form from acid-acetone extracts of bovine hypothalami by column chromatography and paper electrophoresis. Based upon this discovery, a tridecapeptide has been chemically synthesized having the activity of this hypothalamic substance.
摘要翻译： 已经通过柱层析和纸电泳，从牛下丘脑的酸 - 丙酮提取物中发现并分离出纯化形式的降血压肽，称为神经丝氨酸。 基于这一发现，已经化学合成了具有该下丘脑物质活性的十三肽。
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42.发明公开公开(公告)号：US20240318157A1
公开(公告)日：2024-09-26
申请号：US18575512
申请日：2022-07-01
发明人： Helen Eisenach , Steven Tuske
IPC分类号： C12N9/24 , C07K7/08 , C07K14/705
CPC分类号： C12N9/2402 , C07K7/083 , C07K14/70571 , C12Y302/0102 , C07K2319/06 , C07K2319/74
摘要： The disclosure provides amino acid sequences for neurotensin variants as well as recombinant proteins that contain neurotensin, sortilin propeptide, or variants thereof. The disclosure also provides method of production and method for determining cellular uptake for the recombinant proteins. Gene therapy compositions, pharmaceutical compositions, methods of treatment, and uses of the gene therapy compositions and the recombinant proteins are also disclosed.
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公开(公告)号：US20170020951A1
公开(公告)日：2017-01-26
申请号：US15183389
申请日：2016-06-15
发明人： H. Steve White , Brian Donald Klein , Cameron Spencer Metcalf , Daniel Ryan McDougle , Erika Adkins Scholl , Misty Danielle Smith , Grzegorz Bulaj , Liuyin Zhang
CPC分类号： A61K38/10 , A61K38/2271 , A61K38/31 , A61K47/60 , C07K7/083 , C07K14/57545 , C07K14/655
摘要： Neuropeptide analogs and compositions including neuropeptide analogs are described herein. Also provided are methods of producing and using the neuropeptide analogs and compositions including one or more neuropeptide analogs.
摘要翻译： 神经肽类似物和包含神经肽类似物的组合物在本文中描述。 还提供了产生和使用包含一种或多种神经肽类似物的神经肽类似物和组合物的方法。
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公开(公告)号：US20140113872A1
公开(公告)日：2014-04-24
申请号：US14114757
申请日：2012-05-03
CPC分类号： C07K5/10 , A61K38/2228 , A61K51/08 , A61K51/088 , C07K7/02 , C07K7/083 , C07K14/57509 , G01N33/5061 , G01N33/5088 , G01N2333/5751
摘要： Novel urotensin ll receptor (UT) agonists and antagonists are described herein. More specifically, novel derivatives of urotensin ll-related peptide (URP) are described herein.
摘要翻译： 本文描述了新型尿激素敏感素II受体（UT）激动剂和拮抗剂。 更具体地，本文描述了尿素调节素II相关肽（URP）的新型衍生物。
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公开(公告)号：US20130324467A1
公开(公告)日：2013-12-05
申请号：US13994675
申请日：2011-12-14
申请人： H. Steve White , Brian Donald Klein , Cameron Spencer Metcalf , Daniel Ryan McDougle , Erika Adkins Scholl , Misty Danielle Smith , Grzegorz Bulaj , Liuyin Zhang
发明人： H. Steve White , Brian Donald Klein , Cameron Spencer Metcalf , Daniel Ryan McDougle , Erika Adkins Scholl , Misty Danielle Smith , Grzegorz Bulaj , Liuyin Zhang
IPC分类号： C07K14/575 , C07K7/08 , C07K14/655
CPC分类号： A61K38/10 , A61K38/2271 , A61K38/31 , A61K47/60 , C07K7/083 , C07K14/57545 , C07K14/655
摘要： Neuropeptide analogs and compositions including neuropeptide analogs are described herein. Also provided are methods of producing and using the neuropeptide analogs and compositions including one or more neuropeptide analogs.
摘要翻译： 神经肽类似物和包含神经肽类似物的组合物在本文中描述。 还提供了产生和使用包含一种或多种神经肽类似物的神经肽类似物和组合物的方法。
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46.发明申请SHORT AND D-AMINO ACID-CONTAINING POLYPEPTIDES FOR THERAPEUTIC CONJUGATES AND USES THEREOF 审中-公开用于治疗结合物的短和含氨基酸的多肽及其用途公开(公告)号：US20130280281A1
公开(公告)日：2013-10-24
申请号：US13807640
申请日：2011-07-04
摘要： The present invention relates to short polypeptides (e.g., fewer than 19 amino acids in length) and longer polypeptides (e.g., 19 or more amino acids in length) having one or more D-amino acids as targeting moieties. These polypeptides, when conjugated to agents (e.g., therapeutic agents or transport vectors) are capable of transporting the agents across the BBB or into particular cell types. In particular, the short polypeptides can include one or more D-amino acids. These compounds are therefore particularly useful in the treatment of neurological diseases or diseases associated with particular cell types, organs, or tissues.
摘要翻译： 本发明涉及具有一个或多个D-氨基酸作为靶向部分的短多肽（例如，长度上少于19个氨基酸）和更长的多肽（例如，长度为19个或更多个的氨基酸）。 当与试剂（例如治疗剂或转运载体）缀合时，这些多肽能够将该药物转运穿过BBB或特定的细胞类型。 特别地，短多肽可以包括一个或多个D-氨基酸。 因此，这些化合物特别可用于治疗与特定细胞类型，器官或组织相关的神经疾病或疾病。
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公开(公告)号：US20120277158A1
公开(公告)日：2012-11-01
申请号：US13500852
申请日：2010-10-05
IPC分类号： A61K38/10 , C07K9/00 , C07K14/00 , C07K14/475 , C07K14/575 , A61K38/16 , A61P25/28 , A61P25/18 , A61P25/00 , A61P25/08 , A61P25/16 , A61P43/00 , A61P3/00 , A61P35/00 , A61P35/04 , C07K1/113 , C07K7/08 , B82Y5/00
CPC分类号： A61K47/62 , A61K47/64 , A61K47/6907 , A61K47/6911 , A61K47/6921 , A61K47/6929 , C07K7/083 , C07K14/475 , C07K14/5759 , C07K14/8117
摘要： The present invention is directed to conjugates that include a polypeptide capable of crossing the blood-brain barrier or entering one or more cell types attached to a transport vector, i.e., a composition capable of transporting an agent (e.g., a therapeutic agent). In certain cases, the polypeptides are directly conjugated to a lipid or polymeric vector to allow targeted application of a therapeutic agent to treat, for example, a cancer, a neurodegenerative disease, or a lysosomal storage disorder.
摘要翻译： 本发明涉及包含能够穿过血脑屏障或进入连接到转运载体的一种或多种细胞类型的多肽的缀合物，即能够转运药剂（例如治疗剂）的组合物。 在某些情况下，多肽直接与脂质或聚合载体缀合，以允许靶向施用治疗剂以治疗例如癌症，神经变性疾病或溶酶体贮积病症。
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48.发明申请PEPTIDE ANALOGS THAT ARE POTENT AND SELECTIVE FOR HUMAN NEUROTENSIN RECEPTOR SUBTYPE 2 审中-公开对于人神经递质受体亚型2的肽类型和选择性公开(公告)号：US20120178904A1
公开(公告)日：2012-07-12
申请号：US13177909
申请日：2011-07-07
IPC分类号： C07K7/06
摘要： Neurotensin analogs selective for neurotensin receptor subtype 2 are described. These include hexapeptides (NT(8-13)) and pentapeptides (NT(9-13)) having a D-3,1-naphthyl-alanine, D-3,2-naphthyl-alanine, an alanine derivative such as cyclohexylalanine, or 1,2,3,4-tetrahydroisoquinoline at position 11. Methods of treating pain by administering these neurotensin analogs are also described.
摘要翻译： 描述了对神经降压素受体亚型2有选择性的神经降压素类似物。 这些包括具有D-3,1-萘基 - 丙氨酸的六肽（NT（8-13））和五肽（NT（9-13）），D-3,2-萘基 - 丙氨酸，丙氨酸衍生物如环己基丙氨酸， 或1,2,3,4-四氢异喹啉。还描述了通过施用这些神经降压素类似物治疗疼痛的方法。
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公开(公告)号：US20110319339A1
公开(公告)日：2011-12-29
申请号：US13127346
申请日：2009-11-04
CPC分类号： C07K7/083 , A61K38/00 , A61K47/641 , A61K49/0002 , A61K49/0043 , A61K49/0056 , G01N33/574
摘要： The present invention relates to a multimeric molecule having the general formula A or B: and its use in the diagnosis and/or therapy of tumors.
摘要翻译： 本发明涉及具有通式A或B的多聚体分子及其在诊断和/或治疗肿瘤中的用途。
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公开(公告)号：US20080139481A1
公开(公告)日：2008-06-12
申请号：US11629806
申请日：2005-06-17
申请人： Thomas A. Dix
发明人： Thomas A. Dix
IPC分类号： A61K38/08 , C07D263/38 , A61K31/421 , C07C53/19 , A61K31/19 , C12Q1/02 , A61P29/00 , A61P25/18 , A61P35/00 , G01N33/68 , C07D233/02 , A61K31/4168 , C07K7/06
CPC分类号： C07C279/14 , A61K38/00 , C07C229/08 , C07C229/12 , C07C257/14 , C07D231/06 , C07D233/46 , C07D233/48 , C07D239/14 , C07K7/083
摘要： This invention relates to non-natural desamino alkyl amino acid compounds, methods of making, and peptides containing these compounds as their N-terminus moieties. A preferred example is neurotensin (8-13) in which the N terminus is an alpha desamino, alpha methyl N,N dimethyl homolysine residue.
摘要翻译： 本发明涉及非天然脱氨基烷基氨基酸化合物，制备方法以及含有这些化合物作为其N-末端部分的肽。 优选的实例是神经丝氨酸（8-13），其中N末端是α脱氨基，α甲基N，N二甲基均聚赖氨酸残基。
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