公开(公告)号：US07319031B2

公开(公告)日：2008-01-15

申请号：US10306416

申请日：2002-11-27

申请人： Albert Vent ,  Klaus D. Kraetzig

发明人： Albert Vent ,  Klaus D. Kraetzig

IPC分类号： C12M1/36

CPC分类号： G01N35/04 ,  G01N2035/00039

摘要： The invention is directed to a biological scanner for scanning biological growth plates. A biological growth plate can be loaded into the biological scanner. Upon loading of a biological growth plate, the biological scanner generates an image of the plate and may perform an analysis of the image. Various embodiments are directed to loading features that facilitate automated loading and proper positioning of a plate within the biological scanner, and ejection features that facilitate the automated ejection of the plate from the scanner. Additional embodiments are directed to features that allow a scanner unit of the biological scanner to be attached to a mounting platform of the scanner in different possible configurations.

摘要翻译： 本发明涉及用于扫描生物生长板的生物扫描仪。 生物生长板可以装载到生物扫描仪中。 在装载生物生长板时，生物扫描仪产生板的图像并且可以执行图像的分析。 各种实施例涉及便于自动加载和板在生物扫描仪内的适当定位的装载特征，以及促进板从扫描仪自动排出的弹射特征。 另外的实施例涉及允许生物扫描仪的扫描器单元以不同可能配置附接到扫描器的安装平台的特征。

公开(公告)号：US07318913B2

公开(公告)日：2008-01-15

申请号：US10696219

申请日：2003-10-29

申请人： Herbert H. Loeffler ,  Steven A. Bogen

发明人： Herbert H. Loeffler ,  Steven A. Bogen

IPC分类号： B01L1/00 ,  G01N35/10

CPC分类号： B01L3/502 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2400/049 ,  G01N1/312 ,  G01N35/00029 ,  G01N2035/00039 ,  G01N2035/0437 ,  G01N2035/1032 ,  G02B21/26 ,  G02B21/34 ,  Y10T436/112499 ,  Y10T436/25 ,  Y10T436/2575

摘要： A sample chamber is formed by a housing sealed against a microscope slide. The housing has fluid ports, including a well formed over at least one port. In a rinse station, rinse solution is drawn from a reservoir through the chamber to a waste reservoir. At a fill station, an aliquot of reagent already placed in the well is driven into the chamber. The reagent may be driven into the chamber by first drawing a vacuum on the chamber through the aliquot of reagent and then releasing the reagent to be drawn into the chamber by the vacuum.

公开(公告)号：US07273591B2

公开(公告)日：2007-09-25

申请号：US10639031

申请日：2003-08-12

申请人： James M. Sellers ,  Haydn B. Taylor ,  Lawrence M. Kuba

发明人： James M. Sellers ,  Haydn B. Taylor ,  Lawrence M. Kuba

IPC分类号： B01L3/00

CPC分类号： B01L9/52 ,  B01L2200/025 ,  B01L2300/0803 ,  B01L2300/0822 ,  G01N35/00029 ,  G01N35/025 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00138

摘要： A slide cartridge for use with a chemical analyzer includes an upper ring and a lower ring secured together but rotatable with respect to each other. The upper and lower rings define a plurality of reaction chambers between them, which receive dry analyte test slides. A gear track formed in the underside of the lower ring engages a pinion gear attached to a stepping motor of the chemical analyzer in order to rotate the slide cartridge. The slide cartridge is rotated under a sample fluid metering device, which deposits a sample fluid on the test slides through a plurality of spotter ports formed in the upper ring, and above a reflectometer, which performs a colorimetric measurement on the spotted test slides through viewing windows formed in the lower ring of the slide cartridge. A chemical analyzer with which the slide cartridge may be used includes a reflectometer, a sample fluid metering device and a stepping motor for rotating the slide cartridge.

摘要翻译： 用于化学分析器的滑动盒包括固定在一起但可相对于彼此旋转的上环和下环。 上下环在它们之间限定多个反应室，其接收干燥的分析物测试载玻片。 形成在下环的下侧的齿轮啮合附接到化学分析仪的步进电机的小齿轮，以便旋转滑动盒。 滑动盒在样品流体计量装置下旋转，样品流体计量装置将样品流体沉积在测试载玻片上，通过形成在上部环中的多个点样口和反射计上方，该反射计通过观察对被测试的载玻片进行比色测量 窗口形成在滑动盒的下环中。 可以使用滑动盒的化学分析器包括反射计，样品流体计量装置和用于旋转滑动盒的步进电机。

公开(公告)号：US20070103772A1

公开(公告)日：2007-05-10

申请号：US10562500

申请日：2004-02-27

申请人： Tibor Virag ,  Attila Laszlo ,  Viktor Varga ,  Bela Molnar

发明人： Tibor Virag ,  Attila Laszlo ,  Viktor Varga ,  Bela Molnar

IPC分类号： G02B21/06

CPC分类号： G02B21/34 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00138

摘要： A slide feeding unit for a microscope includes a slide magazine having a base plate; a toothed rack secured to a magazine side wall; and slide guiding elements perpendicular to an open magazine side. The unit further includes a magazine moving mechanism having a magazine-receiving trough including opposite side plates. Two rotary shafts supported by the trough extend along the trough side plates. Magazine-advancing feeding gears are supported by the side plates and may mesh with the toothed magazine rack. Lifting gears, held in the side plates, have pins on which the magazine is supported when raised or lowered. Driving worm gears are rotated by the shafts and mesh with the feeding gears and the lifting gears. The unit also includes a slide feeding device having a robot arm displaceable perpendicularly to the direction of advance of the magazine for removing a slide from the magazine.

摘要翻译： 用于显微镜的滑动进给单元包括具有基板的滑动架; 齿条固定在料斗侧壁上; 并且使引导元件垂直于打开的刀库侧滑动。 该单元还包括具有包括相对侧板的盒收容槽的盒移动机构。 由槽支撑的两个旋转轴沿着槽侧板延伸。 杂志推进进给齿轮由侧板支撑，并可与齿形刀架架啮合。 保持在侧板上的提升齿轮具有在升高或降低时支撑仓的销。 驱动蜗轮由轴旋转并与进给齿轮和提升齿轮啮合。 该单元还包括滑动进给装置，其具有可垂直于料仓前进方向移位的机器人臂，用于从料盒移除滑动件。

公开(公告)号：US20060127276A1

公开(公告)日：2006-06-15

申请号：US10537826

申请日：2002-12-17

申请人： Oystein Ljungmann ,  Torstein Ljungmann

发明人： Oystein Ljungmann ,  Torstein Ljungmann

IPC分类号： G01N35/00

CPC分类号： G01N1/312 ,  G01N2035/00039 ,  Y10T436/113332 ,  Y10T436/114165

摘要： A Staining machine for treatment of tissue specimens on slides placed in baskets (9) includes a number of baths (7, 12) placed successively in a row (6 resp. 11), and a device for successive transport of the baskets in a transport path from one bath to the next one, the baskets (9) being transported from an input station (5) to an output station (14) in accordance with a predetermined treatment program. The machine includes at least two bath rows (6 resp. 11) placed juxtaposed and parallel with each other, the first bath row (6) extending from the input station (5) to an opposite end of this row, and second path row (11) extending from the output station (14) to an opposite end of this row. Further, the machine includes a first device (8, 21, 22) for transport of baskets (9) in a first transport path from the input station (5) to the opposite end of the first row (6), a second device (13, 15-19) for transport of baskets (9) in a second transport path towards the output station (14) from the opposite end of the second row (11), and a device for transfer of baskets between the transport paths of opposite ends of the rows belonging together.

摘要翻译： 用于处理放置在篮子（9）中的载玻片上的组织标本的染色机包括连续放置在一排（6或11）中的多个浴室（7,12））和用于在运输工具中连续运送篮子的装置 从一个浴槽到下一个洗涤槽的路径，根据预定的处理程序将篮子（9）从输入站（5）运送到输出站（14）。 该机器包括彼此并置并且平行放置的至少两个浴排（6或11），从输入站（5）延伸到该行的相对端的第一浴槽排（6）和第二路径排 11）从输出站（14）延伸到该行的相对端。 此外，机器包括用于在从输入站（5）到第一排（6）的相对端的第一传送路径中传送筐（9）的第一设备（8,21,22），第二设备 用于在第二传送路径中从第二排（11）的相对端向输出站（14）输送筐（9）的装置，以及用于在相对的传送路径之间传送筐的装置 属于一行的行尾。

公开(公告)号：US20060099108A1

公开(公告)日：2006-05-11

申请号：US10539425

申请日：2003-12-22

申请人： Hans List ,  Jochen Schulat ,  Paul Jansen ,  Volkar Zimmer ,  Michael Schabbach ,  Manfred Augstein ,  Werner Ruhl ,  Hans-Peter Haar ,  Joachim Hoenes ,  Karl Miltner

发明人： Hans List ,  Jochen Schulat ,  Paul Jansen ,  Volkar Zimmer ,  Michael Schabbach ,  Manfred Augstein ,  Werner Ruhl ,  Hans-Peter Haar ,  Joachim Hoenes ,  Karl Miltner

IPC分类号： G01N21/73

CPC分类号： G01N33/48757 ,  A61B5/150022 ,  G01N35/04 ,  G01N2035/00019 ,  G01N2035/00039 ,  G01N2035/00108

摘要： According to the invention the analytical system includes a transport unit which is driven by piezoactive elements. The transport unit enables a direct or indirect transport of the test elements thus enabling a complete or partial automation of analytical methods. Furthermore the invention encompasses a transport unit for transporting a test element which according to the invention is controlled by an optical detector which detects the test element in the system.

摘要翻译： 根据本发明，分析系统包括由压电元件驱动的运输单元。 运输单元可以直接或间接运送测试元件，从而实现分析方法的全面或部分自动化。 此外，本发明包括用于传送测试元件的传送单元，其根据本发明由检测系统中的测试元件的光学检测器控制。

公开(公告)号：US20060062693A1

公开(公告)日：2006-03-23

申请号：US11229561

申请日：2005-09-20

申请人： Katsuaki Muraishi

发明人： Katsuaki Muraishi

IPC分类号： G01N21/00

CPC分类号： G01N35/00029 ,  G01N21/553 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00376 ,  G01N2035/0425

摘要： A surface plasmon resonance (SPR) assay apparatus has at least one sensor unit. A sensing surface of the sensor unit is adapted to causing interaction between ligand and analyte. An optical assay unit applies illuminating light through the dielectric medium to the light entrance surface in such a form as to satisfy a condition of total reflection, and detects the illuminating light reflected by the light entrance surface during the interaction of the ligand and the analyte. There is an immobilizing stage for introducing the ligand to the sensor unit to be immobilized on the sensing surface. An assay stage causes the analyte to contact the sensing surface, and assays the interaction by detecting attenuation of the illuminating light. A stacking stage storing the sensor unit after introduction of the ligand before assay in the assay stage.

摘要翻译： 表面等离子体共振（SPR）测定装置具有至少一个传感器单元。 传感器单元的感测表面适于引起配体和分析物之间的相互作用。 光学测定单元将光照射光通过介电介质施加到光入射表面，以满足全反射的条件，并且在配体和分析物的相互作用期间检测由光入射表面反射的照明光。 存在用于将配体引入传感器单元以固定在感测表面上的固定阶段。 分析阶段使分析物与感测表面接触，并通过检测照明光的衰减来测定相互作用。 在测定阶段中在测定前引入配体之后的堆叠阶段存储传感器单元。

公开(公告)号：US20060046298A1

公开(公告)日：2006-03-02

申请号：US10539561

申请日：2003-12-19

申请人： Marc Key ,  Gordon Feingold ,  Rosanne Welcher

发明人： Marc Key ,  Gordon Feingold ,  Rosanne Welcher

IPC分类号： G01N35/00

CPC分类号： G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

摘要： A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

摘要翻译： 公开了可以是自动化的样本处理系统101和方法，其中样本198布置在载体元件197上，并且过程操作控制系统171可以根据事件规定的所需聚合自动地处理样本 通过输入173。 可以在系统正在处理初始聚合并且可变参数机器人控制模拟功能606时完成初始聚合事件拓扑的改变，以确定用于处理的增强的序列。 可以显示建议的操作者动作，其可以进一步增强改变的聚合事件拓扑的调度以及可以通知操作者需要特定动作以实现所需任务的自动操作者需求提示608。 提出的改变的可逆性可以提供，以便操作者可以避免在导致不可接受的处理结果时激活所提出的改变。

公开(公告)号：US20060045806A1

公开(公告)日：2006-03-02

申请号：US10539308

申请日：2003-12-19

申请人： Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

发明人： Lars Winther ,  Marc Key ,  Kristopher Buchanan ,  John Favuzzi ,  Benno Guggenheimer

IPC分类号： G01N35/00

CPC分类号： G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

公开(公告)号：US20050238541A1

公开(公告)日：2005-10-27

申请号：US11002599

申请日：2004-12-02

申请人： Stanislaw Barski ,  Joseph Chiapperi ,  Mark Deacon ,  Mark Dumont ,  Mark Pierson ,  Timothy Keegan ,  Mark Loeser ,  Gerald Meiler ,  Ross Goldman ,  Carl Rich ,  Richard Versluys

发明人： Stanislaw Barski ,  Joseph Chiapperi ,  Mark Deacon ,  Mark Dumont ,  Mark Pierson ,  Timothy Keegan ,  Mark Loeser ,  Gerald Meiler ,  Ross Goldman ,  Carl Rich ,  Richard Versluys

IPC分类号： B01L9/00 ,  G01N33/543 ,  G01N35/00 ,  B01L3/00

CPC分类号： B01L9/52 ,  B01L2200/025 ,  B01L2300/0822 ,  G01N33/54386 ,  G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00138

摘要： A retaining clip for retaining reagent test slides in a stacked arrangement includes a first assembly having a first cover plate and at least two parallel, co-planar rails extending transversely from an inner surface of the first cover plate. A second assembly includes a second cover plate, and a rail receiving platform extending transversely from an inner surface of the second cover plate. The first cover plate and the second cover plate define between them a space for receiving the plurality of reagent test slides. The rails of the first assembly include ratchet teeth, and the rail receiving platform of the second assembly includes pawls. The pawls engage the ratchet teeth to prevent the separation of the first assembly and the second assembly and to securely but removably hold the plurality of reagent test slides in a stacked arrangement between the first and second cover plates.

摘要翻译： 用于保持试剂测试滑块的保持夹具堆叠布置包括具有第一盖板的第一组件和从第一盖板的内表面横向延伸的至少两个平行的共平面轨道。 第二组件包括第二盖板和从第二盖板的内表面横向延伸的导轨接收平台。 第一盖板和第二盖板在它们之间限定用于容纳多个试剂试验片的空间。 第一组件的轨道包括棘齿，并且第二组件的轨道接收平台包括棘爪。 棘爪接合棘齿以防止第一组件和第二组件的分离，并且牢固但可移除地将多个试剂测试滑块保持在第一和第二盖板之间的堆叠布置中。