公开(公告)号：US06757060B2

公开(公告)日：2004-06-29

申请号：US10350499

申请日：2003-01-24

Applicant: Kevin Davis ,  Joseph B. Slater

Inventor： Kevin Davis ,  Joseph B. Slater

IPC: G01J344

CPC classification number: G01N21/65 ,  G01N21/645

Abstract: Disclosed is a method of positioning a focused image within a sampled medium in an optical measurement probe of the type wherein a focused sampling image is transmitted through a window having a surface facing a sampled medium. A test medium is measured, preferably through the window, and the magnitude of an optical signal associated with the test medium is then compared to the magnitude of an optical signal associated with the window, and the result of the comparison is used to position the focused image. Typically, the magnitudes of optical signals are representative or Raman scattering or another wavelength-selective radiative sampling process such as fluorescence detection. The method is not limited in terms of window composition, and is compatible with sapphire windows commonly used in industry. Nor is the invention limited in terms of test medium though, in the preferred embodiment a fluid hydrocarbon such as isopropyl alcohol is used.

Abstract translation: 公开了一种将聚焦图像定位在采样介质中的光学测量探针中的方法，其中聚焦采样图像通过具有面向采样介质的表面的窗口传输。 最好通过窗口测量测试介质，然后将与测试介质相关联的光学信号的大小与与窗口相关联的光学信号的幅度进行比较，并且比较结果用于定位聚焦 图片。 通常，光信号的大小是代表性的或拉曼散射或另一种波长选择性辐射采样过程，例如荧光检测。 该方法不限于窗口组成，并且与工业中通常使用的蓝宝石窗口兼容。 本发明也不限于测试介质，尽管在优选实施方案中使用流化烃如异丙醇。

公开(公告)号：US06744500B2

公开(公告)日：2004-06-01

申请号：US10002680

申请日：2001-10-23

Applicant: James E. Bradbury ,  Donald R. Smith ,  Edward R. Grant ,  Philipp Kukura

Inventor： James E. Bradbury ,  Donald R. Smith ,  Edward R. Grant ,  Philipp Kukura

IPC: G01J344

CPC classification number: G01N33/34 ,  G01N21/65 ,  G01N2021/656

Abstract: Pulp and/or paper samples are scanned with a Laser Raman Spectroscopic probe, utilizing Raman spectroscopic technology, to generate Raman spectroscopic images of all or selected ones of the constituents and/or contaminants contained in the sample, to compare the same with a library of Raman spectroscopic fingerprints of known constituents and/or contaminants, and to identify and communicate data on all or selected ones of the constituents and/or contaminants for purposes of controlling the paper making process and/or determination of the quality of the paper produced.

Abstract translation: 使用拉曼光谱技术用激光拉曼光谱探针扫描纸浆和/或纸样品，以产生样品中包含的所有或选定的成分和/或污染物的拉曼光谱图像，以将其与 为了控制造纸过程和/或确定所生产的纸张的质量，已知成分和/或污染物的拉曼光谱指纹，以及识别和传送所有成分和/或污染物上的所有或选定的成分和/或污染物的数据。

公开(公告)号：US06734963B2

公开(公告)日：2004-05-11

申请号：US10051305

申请日：2002-01-22

Applicant: Heather A. Gamble ,  John C. Robbins ,  Gervase I. Mackay ,  Harold I. Schiff

Inventor： Heather A. Gamble ,  John C. Robbins ,  Gervase I. Mackay ,  Harold I. Schiff

IPC: G01J344

CPC classification number: G01J3/44 ,  G01N21/05 ,  G01N21/65 ,  G01N21/85

Abstract: The present invention relates to a method and apparatus for detecting transitions between different gas or liquid products in a flow path and, more particularly, it relates to an apparatus and method utilizing Raman spectroscopy for detecting transitions between petroleum products. A Raman spectrometer is preferably to produce a monochromatic excitation beam at a wavelength of approximately 670 nm. The spectrometer consists of an entrance slit, a combined diffraction grating/focussing element, and an exit slit. The Raman signal, which exits the spectrometer exit slit is detected by a highly sensitive photomultiplier tube, and sent to a computer device for data acquisition and analysis. The proposed invention detects liquid or gas products in a flow path by detecting the changes in the composition of various petroleum products flowing through a gasoline pipeline, by means of exposing samples of various petroleum products to the Raman spectrometer system.

Abstract translation: 本发明涉及一种用于检测流路中不同气体或液体产物之间的转变的方法和装置，更具体地说，涉及利用拉曼光谱法检测石油产品之间的转变的装置和方法。 拉曼光谱仪优选地产生波长约670nm的单色激发光束。 光谱仪由入射狭缝，组合衍射光栅/聚焦元件和出口狭缝组成。 通过高灵敏度的光电倍增管检测离开光谱仪出口狭缝的拉曼信号，并发送到计算机设备进行数据采集和分析。 本发明通过将各种石油产品的样品暴露于拉曼光谱仪系统，通过检测流经汽油管道的各种石油产品的组成变化来检测流路中的液体或气体产物。

公开(公告)号：US06734962B2

公开(公告)日：2004-05-11

申请号：US09976391

申请日：2001-10-12

Applicant: Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

Inventor： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

IPC: G01J344

CPC classification number: G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

Abstract: A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

公开(公告)号：US06646738B2

公开(公告)日：2003-11-11

申请号：US09985649

申请日：2001-11-05

Applicant: Jeffrey N. Roe

Inventor： Jeffrey N. Roe

IPC: G01J344

CPC classification number: G01N21/658 ,  G01N21/35 ,  G01N33/49 ,  G01N33/54366

Abstract: Surface-enhanced spectroscopy for quantitative analysis of analytes in biological liquid samples. A device for testing a biological liquid sample for the presence or concentration of an analyte includes: (a) a substrate defining a surface which has electrically conductive particles disposed thereon, wherein the surface is adapted to accommodate the liquid sample; (b) means for generating radiation and directing the radiation to be incident on said surface of the substrate so that radiation is emitted from the electrically conductive particles; and (c) means for detecting the emitted radiation. In another embodiment a matrix having electrically conductive particles that are incorporated in the matrix or that are disposed on a surface thereof, wherein the matrix is permeable to the liquid biological sample is used in place of the substrate. The device is particularly suited for determining glucose in human whole blood.

公开(公告)号：US06608678B1

公开(公告)日：2003-08-19

申请号：US09692549

申请日：2000-10-19

Applicant: Radislav Alexandrovich Potyrailo ,  Ronald Eugene Shaffer ,  Patrick Joseph McCloskey

Inventor： Radislav Alexandrovich Potyrailo ,  Ronald Eugene Shaffer ,  Patrick Joseph McCloskey

IPC: G01J344

CPC classification number: G01N21/65

Abstract: The present invention provides a method for monitoring a reaction mixture using Raman spectroscopy. In a preferred embodiment, the invention provides a method for monitoring bulk and thin film melt polycarbonate polymerization reactions. In this method, the relative and absolute concentrations of the starting materials diphenylcarbonate (DPC) and bisphenol-A (BPA) are determined. Monitoring and maintenance of optimum stoichiometry in such a reaction is critical to ensuring desired polycarbonate product quality.

Abstract translation: 本发明提供使用拉曼光谱法监测反应混合物的方法。 在优选的实施方案中，本发明提供了一种用于监测体积和薄膜熔融聚碳酸酯聚合反应的方法。 在该方法中，测定原料二苯基碳酸酯（DPC）和双酚A（BPA）的相对和绝对浓度。 在这种反应中监测和维持最佳化学计量对于确保所需的聚碳酸酯产品质量至关重要。

公开(公告)号：US06608670B2

公开(公告)日：2003-08-19

申请号：US09908453

申请日：2001-07-18

Applicant: Francis A. Nottke ,  James A. Kirchoff ,  Jonathan N. Lucke ,  John Pollard

Inventor： Francis A. Nottke ,  James A. Kirchoff ,  Jonathan N. Lucke ,  John Pollard

IPC: G01J344

CPC classification number: G01J3/44 ,  G01N21/65 ,  G07D7/1205

Abstract: The LVARS is a fully instrumental, non-destructive spectroscopic device for the analysis and verification and authentication of the optical and electromagnetic properties (OEMP) of the inks, dyes, thin films, plastics, toners, paper, fixatives, paints, and printing agents used in documents and financial instruments. The instrument is quantitative in nature so as to correlate compositional data (elemental, isotopic, structure) with Raman optical spectra. The LVARS design consists of a computer-controlled spectrometer with a microscope-guided grid head containing the laser excitation source and detector and optics.

公开(公告)号：US06603545B2

公开(公告)日：2003-08-05

申请号：US09871045

申请日：2001-05-31

Applicant: Joseph B. Slater

Inventor： Joseph B. Slater

IPC: G01J344

CPC classification number: G01N21/8507

Abstract: Various optical probe configurations are particularly suited to the monitoring of a process flow through the wall of a containment vessel. A probe body extends through, and is sealed to, the wall of the containment vessel. The probe body has an inner wall terminating in a distal end with a window, enabling light from the process flow to pass therethrough and into the probe body. In one embodiment, one or more lenses are disposed within the probe body to focus the light into a focal point, and a restriction of the inner wall of the probe body is used to create a narrow aperture at the focal point. In an alternative embodiment, a plug transparent to the light of interest is sealed to the inner wall of the probe body. As a further alternative, the elements include a second window creating a cavity with the distal window, and a port into the cavity accessible from outside the window for sampling purposes. Although these embodiments are referred to as ‘alternative,’ they may be used in combination as well as separately. Indeed, all three embodiments may be used simultaneously for increased integrity. In addition, although the probe body is presumed to carry light in both directions for excitation and collection, invention is not limited in this regard or the way in which light is carried to, or from, the body itself. That is, a probe according to the invention may be used only for excitation or collection, and optical fibers may, or may not, be used between the body and a source or radiation and/or analysis means.

Abstract translation: 各种光学探针配置特别适用于监控通过安全壳的壁的工艺流程。 探针主体延伸穿过并密封到安全壳的壁上。 探针主体具有终止于具有窗口的远端的内壁，使得来自过程流的光能够通过其并进入探针体。 在一个实施例中，一个或多个透镜设置在探针体内以将光聚焦到焦点中，并且使用探针体的内壁的限制在焦点处产生窄孔。 在替代实施例中，对感兴趣的光线透明的塞子被密封到探针主体的内壁。 作为另一替代方案，元件包括产生具有远端窗口的空腔的第二窗口和从外部窗口可进入取样目的的入口。 虽然这些实施例被称为“替代”，但是它们可以组合使用，也可以单独使用，实际上，所有三个实施例可以同时使用以提高完整性。另外，虽然探针体被推定为在两个方向上携带光 对于激发和收集，本发明不限于此，也不限于将光传送到身体或从身体本身的方式。也就是说，根据本发明的探针可以仅用于激发或收集，并且光纤 可以或可以不在身体和源或辐射和/或分析手段之间使用。

公开(公告)号：US06542232B2

公开(公告)日：2003-04-01

申请号：US09887826

申请日：2001-06-22

Applicant: Joseph A. Abys ,  Michael L. Ammerman ,  Alan Blair ,  Edward J. Kudrak ,  Chen Xu

Inventor： Joseph A. Abys ,  Michael L. Ammerman ,  Alan Blair ,  Edward J. Kudrak ,  Chen Xu

IPC: G01J344

CPC classification number: G01N21/65 ,  G01J3/44

Abstract: In accordance with the invention, the quality of hard gold is determined by Raman vibrational spectroscopy. A sample of the hard gold is provided, a monochromatic light beam is directed onto the sample, and the frequency and intensity of the light scattered by the sample is analyzed for the vibrational frequencies of polymer molecules. Scattering frequencies offset from the initial beam frequency by about 2132 cm−1 and about 2182 cm−1, for example, are indicative of high quality nickel-hardened gold.

公开(公告)号：USH2002H1

公开(公告)日：2001-11-06

申请号：US08800366

申请日：1997-02-14

Applicant: Richard D. McLachlan ,  Mary Anne Leugers

Inventor： Richard D. McLachlan ,  Mary Anne Leugers

IPC: G01J344

Abstract: A fiber optic probe apparatus useful for conducting Raman spectroscopy remotely over optical fibers with minimal interference from Raman scattering within said fibers which includes three elements. The first element is at least one transmitting optical fiber having a first end and a second end. The second element is at least one collecting optical fiber for collecting light from a sample positioned near the first end of the transmitting optical fiber, the collecting optical fiber having a first end and a second end, the first end of the collecting optical fiber being in closely spaced relationship with the first end of the transmitting optical fiber wherein the longitudinal axis of the first end of the collecting optical fiber converges with the longitudinal axis of the first end of the transmitting optical fiber at an angle of less than forty five degrees. The third element is at the heart of the invention. The third element is a rejection optical filter in optical communication with the second end of the collecting optical fiber.