公开(公告)号：USRE39977E1

公开(公告)日：2008-01-01

申请号：US11103423

申请日：2005-04-11

申请人： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

发明人： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

IPC分类号： G01G5/03

CPC分类号： G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, or emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation images of the collimated beam. The spectrometer comprises a liquid crystal tunable filter. The filtered selected images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

摘要翻译： 提供使用近红外辐射显微镜的化学成像系统。 该系统包括使用近红外辐射波长的光和可见波长的光来照射样品的区域的照明源。 发送的反射的<？delete-start id =“DEL-S-00001”date =“20080101”？>，<？delete-end id =“DEL-S-00001”？> <？ insert-start id =“INS-S-00001”date =“20080101”？>或<？insert-end id =“INS-S-00001”？>发出<？delete-start id =“DEL-S-00002 收集来自被照射区域的近红外波长的辐射光的“日期=”20080101“→>或分散的<？delete-end id =”DEL-S-00002“？>从其产生准直光束。 提供近红外成像光谱仪用于选择<？delete-start id =“DEL-S-00003”date =“20080101”？> a <？delete-end id =“DEL-S-00003”？>近红外辐射 准直光束的<？insert-start id =“INS-S-00002”date =“20080101”？> s <？insert-end id =“INS-S-00002”？> <？insert-start id =“INS-S-00003”date =“20080101”？>光谱仪包括液晶可调滤波器。 <？insert-end id =“INS-S-00003”？> <？delete-start id =“DEL-S-00004”date =“20080101”？> filters <？delete-end id =“DEL-S -00004“？> <？insert-start id =”INS-S-00004“date =”20080101“？>选择<？insert-end id =”INS-S-00004“？> 进一步处理。 同时检测来自样品的照射区域的可见波长的光，提供样品的同时可见和近红外化学成像分析。 提供了三维近红外化学成像显微镜的两种有效手段。

公开(公告)号：US20080297885A1

公开(公告)日：2008-12-04

申请号：US12006798

申请日：2008-01-04

申请人： Eugene Pochapsky ,  Scott Keitzer

发明人： Eugene Pochapsky ,  Scott Keitzer

IPC分类号： G02B23/12

CPC分类号： F41G1/38 ,  F41G1/32 ,  G02B23/12

摘要： A night vision device provides both an amplified visible light image and an infrared image, overlayed upon each other so that they appear to be a single image. A user may select to utilize either an intensified visual image only, an infrared image only, or ratios of both images simultaneously. Dichroic surfaces within the night vision device are utilized first to separate light into visible and infrared portions, and then to recombine the visible and infrared images to a single image.

公开(公告)号：US20060157652A1

公开(公告)日：2006-07-20

申请号：US11366887

申请日：2006-03-02

申请人： Patrick Treado ,  Matthew Nelson ,  Scott Keitzer

发明人： Patrick Treado ,  Matthew Nelson ,  Scott Keitzer

IPC分类号： G01N21/35

CPC分类号： G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

公开(公告)号：US20120044386A1

公开(公告)日：2012-02-23

申请号：US13213836

申请日：2011-08-19

申请人： Scott Keitzer ,  Eugene J. Pochapsky ,  Michael R. Matzko

发明人： Scott Keitzer ,  Eugene J. Pochapsky ,  Michael R. Matzko

IPC分类号： H04N5/262

CPC分类号： H04N5/332 ,  H04N5/2254 ,  H04N5/23209 ,  H04N5/23293 ,  H04N5/243

摘要： An apparatus and method improve sight. The apparatus includes a first sight configured to view a scene. A second sight is configured to alter content representative of the scene in a first manner to form first altered content. A third sight is configured to alter content representative of the scene in a second manner to form second altered content. An image combiner is configured to combine the second altered content with the first altered content to form combined altered scene content.

摘要翻译： 一种改善视力的装置和方法。 该装置包括被配置为观看场景的第一视线。 第二视角被配置为以第一方式改变代表场景的内容以形成第一改变的内容。 第三视觉被配置为以第二方式改变表示场景的内容以形成第二改变的内容。 图像组合器被配置为将第二改变的内容与第一改变的内容组合以形成组合的改变的场景内容。

公开(公告)号：US07436500B2

公开(公告)日：2008-10-14

申请号：US11257222

申请日：2005-10-24

申请人： Patrick J Treado ,  Matthew Nelson ,  Scott Keitzer

发明人： Patrick J Treado ,  Matthew Nelson ,  Scott Keitzer

IPC分类号： G01N21/00

CPC分类号： G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

公开(公告)号：US07123360B2

公开(公告)日：2006-10-17

申请号：US11257219

申请日：2005-10-24

申请人： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

发明人： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

IPC分类号： G01J3/44 ,  G01J3/20

CPC分类号： G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

公开(公告)号：US07068357B2

公开(公告)日：2006-06-27

申请号：US11257139

申请日：2005-10-24

申请人： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

发明人： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

IPC分类号： G01N21/00

CPC分类号： G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

公开(公告)号：US07317516B2

公开(公告)日：2008-01-08

申请号：US11366129

申请日：2006-03-02

申请人： Patrick J Treado ,  Matthew Nelson ,  Scott Keitzer

发明人： Patrick J Treado ,  Matthew Nelson ,  Scott Keitzer

IPC分类号： G01N21/00 ,  G01J3/40

CPC分类号： G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

摘要翻译： 提供使用近红外辐射显微镜的化学成像系统。 该系统包括使用近红外辐射波长的光和可见波长的光来照射样品的区域的照明源。 收集来自样品的照射区域的透射，反射，发射或散射的近红外波长辐射光的多个空间解析光谱，并从其中产生准直光束。 提供近红外成像光谱仪用于选择准直光束的近红外辐射图像。 滤波后的图像由检测器收集以进一步处理。 同时检测来自样品的照射区域的可见波长的光，提供样品的同时可见和近红外化学成像分析。 提供了三维近红外化学成像显微镜的两种有效手段。

公开(公告)号：US20070263290A1

公开(公告)日：2007-11-15

申请号：US11744797

申请日：2007-05-04

申请人： Patrick Treado ,  Matthew Nelson ,  Scott Keitzer ,  Ryan Smith

发明人： Patrick Treado ,  Matthew Nelson ,  Scott Keitzer ,  Ryan Smith

IPC分类号： G02B5/04 ,  G02B3/00 ,  G02B5/22

CPC分类号： G02B6/06 ,  A61B1/00165 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0227 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/0262 ,  G01J3/0286 ,  G01J3/44 ,  G01J2003/1213

摘要： A fiberscope device is disclosed which is suitable for video imaging, laser Raman spectroscopy and laser Raman spectroscopic (i.e. chemical) imaging. The fiberscope design minimizes fiber background interference arising from the laser delivery fiber optic and the coherent fiber optic light gathering bundle while maintaining high light throughput efficiency through the use of integrated spectral filters. In the fiberscope design, the laser delivery fiber optic is offset from the coherent fiber optic light gathering bundle. The laser delivery field is captured entirely by the light gathering field of view of the coherent fiber bundle. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The fiberscope is suited to the analysis of a wide range of condensed phase materials (solids and liquids), including the analysis of biological materials such as breast tissue lesions and arterial plaques, in such a manner to delineate abnormal from normal tissues.

摘要翻译： 公开了适用于视频成像，激光拉曼光谱和激光拉曼光谱（即化学）成像的纤维内窥镜装置。 纤维镜设计可以最大限度地减少激光传输光纤和相干光纤采集光束产生的光纤背景干扰，同时通过使用集成光谱滤波器保持高光通量效率。 在纤维镜设计中，激光传输光纤与相干光纤聚光束偏移。 激光输送场完全由相干光纤束的聚光场捕获。 纤维镜包含光谱滤光器光学元件，其提供环境不敏感性，特别是对温度和湿度。 纤维内窥镜适用于分析各种凝聚相材料（固体和液体），包括分析生物材料如乳房组织损伤和动脉斑块，以便从正常组织中描绘异常。

公开(公告)号：US07268862B2

公开(公告)日：2007-09-11

申请号：US11366887

申请日：2006-03-02

申请人： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

发明人： Patrick J. Treado ,  Matthew Nelson ,  Scott Keitzer

IPC分类号： G01N21/00 ,  G01J3/40

CPC分类号： G01N21/359 ,  G01J3/2823 ,  G02B21/0016 ,  G02B21/06

摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.