公开(公告)号：US06774368B2

公开(公告)日：2004-08-10

申请号：US10093584

申请日：2002-03-08

Applicant: Kenneth W. Busch ,  Dennis H. Rabbe

Inventor： Kenneth W. Busch ,  Dennis H. Rabbe

IPC: G01J344

CPC classification number: G01N21/274 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/28 ,  G01J2003/2866 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359

Abstract: The present invention is a dispersive, diffraction grating, NIR spectrometer that automatically calibrates the wavelength scale of the instrument without the need for external wavelength calibration materials. The invention results from the novel combination of: 1) a low power He—Ne laser at right angles to the source beam of the spectrometer; 2) a folding mirror to redirect the collimated laser beam so that it is parallel to the source beam; 3) the tendency of diffraction gratings to produce overlapping spectra of higher orders; 4) a “polka dot” beam splitter to redirect the majority of the laser beam toward the reference detector; 5) PbS detectors and 6) a software routine written in Lab VIEW that automatically corrects the wavelength scale of the instrument from the positions of the 632.8 nm laser line in the spectrum.

Abstract translation: 本发明是一种分散衍射光栅，NIR光谱仪，可自动校准仪器的波长标度，无需外部波长校准材料。 本发明的结果是：1）与光谱仪的源光束成直角的低功率He-Ne激光器; 2）折叠镜，以使准直激光束重定向成平行于源光束; 3）衍射光栅产生高阶重叠光谱的趋势; 4）一个“波尔卡点”分束器，将大部分激光束重定向到参考探测器; 5）PbS检测器和6）Lab VIEW中编写的软件程序，可自动从波长632.8 nm激光线的位置校正仪器的波长范围。

公开(公告)号：US06707549B2

公开(公告)日：2004-03-16

申请号：US10095938

申请日：2002-03-13

Applicant: Junji Tominaga ,  Masashi Kuwahara ,  Christophe Mihalcea ,  Dorothea Buechel ,  Takashi Kikukawa ,  Hiroshi Fuji

Inventor： Junji Tominaga ,  Masashi Kuwahara ,  Christophe Mihalcea ,  Dorothea Buechel ,  Takashi Kikukawa ,  Hiroshi Fuji

IPC: G01J344

CPC classification number: G01N21/658

Abstract: A molecular sensor comprising a sensor film containing a metal compound wherein Raman spectroscopic analysis is carried out utilizing the amplification of Raman light by the localized plasmons that fine particles resulting from reduction of the metal compound generate has a small size and a very high sensitivity. A high sensitivity Raman spectroscopic process is provided.

Abstract translation: 一种分子传感器，包括含有金属化合物的传感器膜，其中通过局部等离子体激元利用拉曼光的扩增进行拉曼光谱分析，产生的金属化合物的还原产生的细小颗粒具有小尺寸和非常高的灵敏度。 提供了高灵敏度拉曼光谱法。

公开(公告)号：US06624886B2

公开(公告)日：2003-09-23

申请号：US10144611

申请日：2002-05-13

Applicant: Michael J. Natan ,  Michael D. Musick ,  Christine Keating ,  Kenneth R. Brown

Inventor： Michael J. Natan ,  Michael D. Musick ,  Christine Keating ,  Kenneth R. Brown

IPC: G01J344

CPC classification number: B82Y30/00 ,  B01J13/0043 ,  G01N21/658

Abstract: Methods for preparing colloidal metal nanoparticles, in which seed colloids are added to a solution of reductant mixed with a solution containing a source of metal ions, include a method in which the seeds are colloidal gold nanoparticles, the source of gold ions is HAuCl4, and the reductant is NH2OH. SERS substrates are prepared by combining a colloidal gold monolayer with a solution containing a source of metal ions and a reductant such as NH2OH.

公开(公告)号：US06621574B1

公开(公告)日：2003-09-16

申请号：US09578975

申请日：2000-05-25

Applicant: Robert W. Forney ,  Nancy T. Kawai

Inventor： Robert W. Forney ,  Nancy T. Kawai

IPC: G01J344

CPC classification number: G01N21/276 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0297 ,  G01J3/44 ,  G01J2003/2866 ,  G01N21/65

Abstract: This invention relates to an accessory for incorporation into Raman and other spectroscopic instruments for combining shuttering and spectroscopic calibration functions. The accessory is comprised of an assembly with at least two positions that may be inserted into the light path, one position allowing light to be directed to and from the sample, and another position containing a reference standard that blocks the beam and provides a shuttering function. When the light strikes the reference standard, a reference spectrum is produced that may be used to calibrate the spectrograph. The device is especially useful in combination with compact sampling accessories for Raman spectroscopy.

Abstract translation: 本发明涉及一种用于并入拉曼的附件和用于组合快门和光谱校准功能的其它光谱仪器。 附件由具有至少两个位置的组件组成，该组件可插入到光路中，一个位置允许光被引导到样本，另一个位置包含阻挡光束并提供光栅功能的参考标准 。 当光照参考标准时，产生可用于校准光谱仪的参考光谱。 该器件特别适用于拉曼光谱的紧凑采样附件。

公开(公告)号：US06453264B1

公开(公告)日：2002-09-17

申请号：US09350329

申请日：1999-07-09

Applicant: John Francis Maguire ,  John David Busbee ,  Steven R. LeClair

Inventor： John Francis Maguire ,  John David Busbee ,  Steven R. LeClair

IPC: G01J344

CPC classification number: C23C14/28 ,  C23C14/547 ,  C23C14/548 ,  G01N21/65 ,  G01N21/88 ,  G01N2021/8427 ,  H01L21/67253

Abstract: A Raman-based spatial analysis method of detecting surface flaws. Special filters and optics are used to acquire filtered Raman response data from a portion of the surface. The filtered Raman response data represents the Raman response of the surface at a selected frequency. A camera records the response, thereby providing a two dimensional image of the portion of the surface. The image may be analyzed to determine whether that portion has desired thickness and chemical characteristics.

Abstract translation: 一种用于检测表面缺陷的基于拉曼的空间分析方法。 特殊滤光片和光学元件用于从表面的一部分获取滤波的拉曼响应数据。 滤波的拉曼响应数据表示所选频率处的表面的拉曼响应。 相机记录响应，从而提供表面部分的二维图像。 可以分析图像以确定该部分是否具有期望的厚度和化学特性。

公开(公告)号：US06307625B1

公开(公告)日：2001-10-23

申请号：US09343148

申请日：1999-06-29

Applicant: Clay Marcus Sharts ,  Vladimir Semenovich Gorelik

Inventor： Clay Marcus Sharts ,  Vladimir Semenovich Gorelik

IPC: G01J344

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N21/658 ,  G01N2021/651

Abstract: A method and apparatus for determination of fluoroorganic compounds in liquid, gaseous, or crystalline or amorphous solids is based on the detection of carbon-halogen bonds by laser Raman spectroscopy. The method and apparatus provide a general method for detecting and determination of halooorganic compounds. The method and apparatus are applicable in the pharmaceutical industry, in fluorinated drug research and manufacturing; in the medical and clinical studies of the effects of fluoroorganic compounds; in the environmental and agricultural studies and screening, in the analysis of water, soils and air contaminated with fluoroorganic compounds.

Abstract translation: 用于测定液体，气态或结晶或无定形固体中的氟代有机化合物的方法和装置是基于通过激光拉曼光谱法检测碳 - 卤键。 该方法和装置提供了一种用于检测和测定卤味无机化合物的通用方法。 该方法和装置适用于制药工业，氟化药品研究和制造; 在氟代有机化合物的作用的医学和临床研究中; 在环境和农业研究和筛选中，分析了氟，氟化合物污染的水，土壤和空气。

公开(公告)号：US06226082B1

公开(公告)日：2001-05-01

申请号：US09104749

申请日：1998-06-25

Applicant: Jeffrey N. Roe

Inventor： Jeffrey N. Roe

IPC: G01J344

CPC classification number: G01N21/658 ,  G01N21/35 ,  G01N33/49 ,  G01N33/54366

Abstract: Surface-enhanced spectroscopy for quantitative analysis of analytes in biological liquid samples. A device for testing a biological liquid sample for the presence or concentration of an analyte includes: (a) a substrate defining a surface which has electrically conductive particles disposed thereon, wherein the surface is adapted to accommodate the liquid sample; (b) means for generating radiation and directing the radiation to be incident on said surface of the substrate so that radiation is emitted from the electrically conductive particles; and (c) means for detecting the emitted radiation. In another embodiment a matrix having electrically conductive particles that are incorporated in the matrix or that are disposed on a surface thereof, wherein the matrix is permeable to the liquid biological sample is used in place of the substrate. The device is particularly suited for determining glucose in human whole blood.

公开(公告)号：US06809812B2

公开(公告)日：2004-10-26

申请号：US09877773

申请日：2001-06-08

Applicant: Huiqu Yin

Inventor： Huiqu Yin

IPC: G01J344

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0227

Abstract: For identifying black plastics effectively and rapidly with a laser-powered identification probe, it is desirable to maintain full laser power while reducing the power density. This is achieved by providing the probe with a moving lens that disperses the 0.5 mm laser spot over a larger area typically of about 5 mm in diameter. The entire signal from the larger (5 mm) diameter is collected at the same spot in the fiber bundle within the probe that leads to a Raman or other spectral analyzer. There are no other modifications required for the rest of the system as the moving lens does not affect the collection efficiency of the characteristic signal from the sample.

Abstract translation: 为了用激光供电的识别探针有效快速地识别黑色塑料，希望在降低功率密度的同时保持全激光功率。 这通过为探针提供将0.5mm激光光斑分散在通常为大约5mm直径的较大区域的移动透镜来实现。 来自较大（5mm）直径的整个信号被收集在探针内的纤维束中的相同点处，其通向拉曼或其它光谱分析仪。 由于移动镜头不影响来自样品的特征信号的收集效率，因此系统的其余部分不需要其他修改。

公开(公告)号：US06747735B2

公开(公告)日：2004-06-08

申请号：US10450403

申请日：2003-06-13

Applicant: Peter Chen ,  Candace C. Joyner ,  Sheena T. Patrick ,  Dean R. Guyer

Inventor： Peter Chen ,  Candace C. Joyner ,  Sheena T. Patrick ,  Dean R. Guyer

IPC: G01J344

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2021/651 ,  G01N2021/653 ,  G01N2021/655

Abstract: A multiplex coherent Raman spectrometer (10) and spectroscopy method rapidly detects and identifies individual components of a chemical mixture separated by a separation technique, such as gas chromatography. The spectrometer (10) and method accurately identify a variety of compounds because they produce the entire gas phase vibrational Raman spectrum of the unknown gas. This is accomplished by tilting a Raman cell (20) to produce a high-intensity, backward-stimulated, coherent Raman beam of 683 nm, which drives a degenerate optical parametric oscillator (28) to produce a broadband beam of 1100-1700 nm covering a range of more than 3000 wavenumber. This broadband beam is combined with a narrowband beam of 532 nm having a bandwidth of 0.003 wavenumbers and focused into a heated windowless cell (38) that receives gases separated by a gas chromatograph (40). The Raman radiation scattered from these gases is filtered and sent to a monochromator (50) with multichannel detection.

Abstract translation: 多重相干拉曼光谱仪（10）和光谱法快速检测并识别通过分离技术（如气相色谱）分离的化学混合物的各个组分。 光谱仪（10）和方法准确识别各种化合物，因为它们产生未知气体的整个气相振动拉曼光谱。 这是通过使拉曼单元（20）倾斜以产生683nm的高强度，反向激发的相干拉曼光束来实现的，其驱动退化光参量振荡器（28）以产生1100-1700nm的宽带束覆盖 范围超过3000波数。 该宽带波束与带宽为0.003波数的532nm的窄带波束组合，并聚焦到接收由气相色谱仪（40）分离的气体的加热的无窗孔室（38）中。 从这些气体散射的拉曼辐射被过滤并发送到具有多通道检测的单色仪（50）。

公开(公告)号：US06707548B2

公开(公告)日：2004-03-16

申请号：US09939887

申请日：2001-08-27

Applicant: David I. Kreimer ,  Oleg A. Yevin ,  Robert Weber

Inventor： David I. Kreimer ,  Oleg A. Yevin ,  Robert Weber

IPC: G01J344

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/32 ,  G01J3/36 ,  G01J3/44 ,  G01J2003/1213 ,  G01N21/31 ,  G01N21/6428 ,  G01N21/658 ,  G01N2021/3137 ,  G01N2021/3177 ,  G01N2021/6484 ,  G01N2021/656

Abstract: Systems and methods for filter based spectrographic analysis are provided that permit rapid analysis of bioanalytes. Systems include devices for illuminating a sample with electromagnetic radiation and capturing radiation emitted from the sample. Emitted radiation can be collected by a plurality of waveguides each associated with a filter for a particular wavelength of radiation. Focusing devices are associated with filters and waveguides in certain embodiments. Radiation captured by waveguides can then be transmitted to a remote detector, which can determine the intensity of radiation for each waveguide. The use of a plurality of filters having different, band pass characteristics can permits the simultaneous detection of a plurality of different wavelengths of radiation emitted by a sample, thereby providing spectrographic information about the sample under study. Systems can include computers for storing acquired spectrographic information, addressable arrays of samples, and information security measures. Spectrographic information of samples can be diagnostic tools for identifying and quantifying a variety of different materials, including bioanalytes.

Abstract translation: 提供了基于过滤器的光谱分析的系统和方法，可以快速分析生物分析物。 系统包括用于用电磁辐射照射样品并捕获从样品发射的辐射的装置。 发射的辐射可以被多个波导收集，每个波导与用于特定波长的辐射的滤波器相关联。 在某些实施例中，聚焦装置与滤波器和波导相关联。 然后可以将波导捕获的辐射传输到远程检测器，这可以确定每个波导的辐射强度。 使用具有不同带通特性的多个滤光器可以允许同时检测由样品发射的多个不同波长的辐射，从而提供关于正在研究的样品的光谱信息。 系统可以包括用于存储获取的光谱信息的计算机，可寻址的样本阵列和信息安全措施。 样品的光谱信息可以是用于识别和量化各种不同材料（包括生物分析物）的诊断工具。