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公开(公告)号：US5624674A
公开(公告)日：1997-04-29
申请号：US487964
申请日：1995-06-07
摘要： The present invention is directed to apparatus and methods for forming open-cell porous mold forms to mold porous devices having substantially continuously interconnected pores. The mold form is made from selected material comprising particles having predetermined sizes and shapes which is capable of forming a stable mold form under selected conditions. The particles are treated such that the particles are manipulable into a mass of continuously interconnected particles defining continuously interconnected pores and connecting interstices within the mass. The formed mass is made into a predetermined shape and solidified to form a mold form.
摘要翻译： 本发明涉及用于形成开孔多孔模具形状以用于模制具有基本连续相互连通的孔的多孔装置的装置和方法。 模具形式由包括具有预定尺寸和形状的颗粒的选定材料制成，其能够在选定的条件下形成稳定的模具形状。 处理颗粒使得颗粒可操纵成大量连续互连的颗粒，其限定连续互连的孔和连接质量块内的间隙。 将形成的物料制成预定形状并固化以形成模具形式。
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42.发明授权
公开(公告)号：US5458647A
公开(公告)日：1995-10-17
申请号：US204238
申请日：1994-04-26
申请人： Michel Brochier , Jacques Gaidry , Claude Moreau , Franccois Moutet , Rene Ranc
发明人： Michel Brochier , Jacques Gaidry , Claude Moreau , Franccois Moutet , Rene Ranc
CPC分类号： A61F2/4241 , A61L27/08 , A61F2/30771 , A61F2002/30024 , A61F2002/30626 , A61F2002/3063 , A61F2002/4243 , A61F2002/4251 , A61F2250/0021 , A61F2310/00023 , A61F2310/00161 , Y10T403/32918
摘要： A finger joint prosthesis for metacarpalphalangeal and interphalangeal joints is provided including two diaphyseal parts which are implantable in the phalangeal and/or metacarpal bones and are fixed to a pivotable joint. The joint includes a female cap, a male cap, a shaft force fitted into two openings in the female cap and extending through an opening in the male cap, and a collar surrounding the shaft in the male cap. The joint also includes two side flanges which hold disks for holding the collar in place. The female and male caps and the side flanges are made of titanium alloy while the collar, the shaft, and the disks are made of pyrocarbon so that friction during rotation of the joint occurs only between components that are made of pyrocarbon.
摘要翻译： PCT No.PCT / FR92 / 00845 Sec。 371日期1994年04月26日 102（e）日期1994年4月26日PCT 1991年9月6日PCT PCT。 第WO93 / 04644号公报 日期：1993年3月18日。提供了掌指和指间关节的手指关节假体，包括可植入趾骨和/或掌骨中的两个骨干部分，并固定到可枢转关节。 该接头包括一个阴盖，一个公帽，一个轴压力装配在雌帽中的两个开口中并延伸穿过阳盖中的一个开口，以及一个围绕男帽的轴的衣领。 接头还包括两个侧凸缘，其保持用于将套环保持在适当位置的盘。 阴和阳盖和侧凸缘由钛合金制成，而套环，轴和盘由热解碳制成，使得接头旋转期间的摩擦仅发生在由热解碳制成的部件之间。
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公开(公告)号：US5236448A
公开(公告)日：1993-08-17
申请号：US690936
申请日：1991-07-10
申请人： Gianni Angelini , Claudio Pistolesi
发明人： Gianni Angelini , Claudio Pistolesi
CPC分类号： A61F2/2403 , A61L27/08 , A61F2310/00161
摘要： The prosthesis comprises a unitary annular valve body having a pair of leaflets (2, 3) mounted on pivot posts adjacent their outer edges, so as to pivot between a closed position (in which the free edges of the leaflets (2, 3) are contiguous so as to inhibit flow of blood through the valve body) and a fully open position (in which the free edges are parallel to one another so as to permit flow of blood through the valve body). The valve body and the leaflets (2, 3) are each precision moulded, homogenous monolithic vitreous carbon artifacts having an as moulded surface of optical quality.
摘要翻译： PCT No.PCT / GB90 / 00121 Sec。 371日期：1991年7月10日 102（e）日期1991年7月10日PCT 1990年1月26日PCT PCT。 第WO90 / 08518号公报 日期1990年8月9日。假体包括一体的环形阀体，其具有安装在靠近其外边缘的枢轴柱上的一对传单（2,3），以便在闭合位置（其中 小叶（2,3）是连续的，以防止血液通过阀体流动）和完全打开位置（其中自由边缘彼此平行以允许血液通过阀体流动）。 阀体和小叶（2,3）均为具有光学质量的模制表面的精密模制均匀的整体玻璃碳伪像。
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公开(公告)号：US4986831A
公开(公告)日：1991-01-22
申请号：US186002
申请日：1988-04-25
CPC分类号： A61L31/04 , A61F2/062 , A61L27/08 , A61L27/14 , A61L27/16 , A61L27/18 , A61L27/50 , A61F2310/00161
摘要： This invention is described and illustrated in connection with the generation of a homograft composed of collagenous tissue generated on a prosthetic device. A tubular substrate having generally cylindrical outside and inside surfaces is suspended in the lumen of a blood vessel of a living body. The tubular substrate is open at each end to permit blood to flow over both the inside and outside surfaces. One of the surfaces of the substrate is a thrombogenic surface or supports a thrombogenic mesh material to promote growth of a tube of collagenous tissue suitable for use as a surgical graft. The substrate is suspended in the blood flow of a blood vessel by an anchor which permits the substrate to freely move within the lumen of the vessel but is anchored by the tether to prevent the substrate from moving along the vessel in the direction of blood flow. The collagenous tissue growth about the substrate is generally tubular and suitable for use as a surgical graft.The method of generating a homograft includes preparing a prosthesis composed of a tubular substrate. The substrate is open at each end to permit blood to flow along the length of the substrate inside wall. The substrate is selected to have at least one thrombogenic surface or a thrombogenic mesh material supported by the substrate. The prosthesis is inserted in the lumen of a blood vessel, either a vein or artery, of a living body and anchored in the lumen of the vessel to prevent the substrate from moving along the vessel with the blood flow. The body generates collagenous growth on the thrombogenic surface of the substrate while the substrate is freely suspended in the blood flow of the vessel. The substrate is then removed from the vessel after which a tubular homograft of collagenous tissue is removed from the substrate.
摘要翻译： 结合在假肢装置上产生的由胶原组织组成的同种移植物的产生来描述和说明本发明。 具有大致圆柱形的外表面和内表面的管状基底悬挂在生物体的血管的内腔中。 管状基底在每一端开放以允许血液流过内表面和外表面。 底物的一个表面是血栓形成表面或支持血栓形成网状物质，以促进适合用作手术移植物的胶原组织管的生长。 基底通过锚固体悬挂在血管的血流中，该锚固体允许基底在血管的内腔内自由移动，但是被系绳锚定，以防止基底沿血管沿血管方向移动。 围绕基底的胶原组织生长通常是管状的并且适合用作手术移植物。 产生同种移植物的方法包括制备由管状基质组成的假体。 基底在每一端开口以允许血液沿着基底内壁的长度流动。 衬底被选择为具有由衬底支撑的至少一个血栓形成表面或血栓形成网状物质。 将假体插入生物体的静脉或动脉的血管的内腔中并锚定在血管的内腔中，以防止基底沿着血管沿血管移动。 身体在衬底的血栓形成表面上产生胶原生长，同时衬底自由地悬挂在血管的血流中。 然后从容器中取出底物，然后从基质中除去胶原组织的管状同种移植物。
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公开(公告)号：US4822355A
公开(公告)日：1989-04-18
申请号：US210165
申请日：1988-06-21
申请人： G. S. Bhuvaneshwar
发明人： G. S. Bhuvaneshwar
CPC分类号： A61F2/2406 , A61F2/2409 , A61L27/08 , A61L27/14 , A61L27/303 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00047 , A61F2310/00161 , A61F2310/0058 , A61F2310/00862 , A61F2310/0088 , Y10S623/90
摘要： Improved heart valve assembly 1(FIG. 4) includes: Sewing ring 2 made preferably of woven/knitted fabric of carbon/carbon coated polyester/polytetra-fluoroethylene;Metallic valve housing 3, with external groove accommodating sewing ring, with flat lugs 3a on one side and lug 3b having hook 3c on the other side, said housing being preferably made of "Stellite", titanium or alloys of titanium with aluminum, vanadium or palladium or of stainless steel or cobalt based alloys optionally with coating of boron nitride, titanium nitride or diamond and;Valve occluder disc 4 made of Agate, polyacetal homopolymer, synthetic sapphire, synthetic ruby, corundum or ceramics like alumina, tungsten carbide, titanium carbide or their mixture or of metals like aluminum, titanium, steel or cobalt-chromium-tungsten alloy having coating of one or more of said ceramics, and tapered surface 4a with depression/groove 4c therein held by hook 3c on its less pronounced depression 4d as seen in FIG. 5 more clearly.
摘要翻译： 改进的心脏瓣膜组件1（图4）包括：优选由碳/碳涂覆的聚酯/聚四氟乙烯的编织物/针织物制成的缝合环2; 金属阀壳体3具有外槽容纳缝合环，一侧具有扁平凸耳3a，另一侧具有钩3c，所述壳体优选由“钨铬铁合金”制成，钛或钛与铝合金，钒或 钯或不锈钢或钴基合金，任选具有氮化硼，氮化钛或金刚石的涂层; 由玛瑙，聚缩醛均聚物，合成蓝宝石，合成红宝石，刚玉或陶瓷如氧化铝，碳化钨，碳化钛或它们的混合物制成的闭塞堵塞盘4或诸如铝，钛，钢或钴 - 铬 - 钨合金的金属，具有涂层 一个或多个所述陶瓷和锥形表面4a，其中凹陷/凹槽4c在其中由钩3c保持在其不太明显的凹陷4d上，如图3所示。 5更清楚
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公开(公告)号：US4624822A
公开(公告)日：1986-11-25
申请号：US634085
申请日：1984-07-25
申请人： Pietro Arru , Gioacchino Bona , Maria Curcio , Franco Vallana
发明人： Pietro Arru , Gioacchino Bona , Maria Curcio , Franco Vallana
CPC分类号： A61L27/507 , A61F2/2415 , A61L27/08 , A61L27/3683 , A61F2220/0075 , A61F2310/00161 , Y10S623/901
摘要： Sheets of incompletely fixed biological tissue comprising portions for defining valve flaps of a cardiac valve prosthesis are mounted on forming means which can separate in a substantially fluid-tight manner the opposite faces of such portions. These opposite faces are subjected to a fluid pressure difference which produces deformation of the portions towards a conformation substantially identical with the conformation of the valve flaps when mounted in the prosthesis. The biological tissue is finally fixed while the portions defining the valve flaps of the prosthesis are maintained in the said conformation. The sheets of biological tissue are then separated from the forming means to be subsequently mounted in the frame of the prosthesis.
摘要翻译： 包括用于限定心脏瓣膜假体的瓣膜的部分的不完全固定的生物组织的片材被安装在形成装置上，该装置可以以基本上流体密封的方式分离这些部分的相对面。 这些相对的面受到流体压力差，当安装在假体中时，该压力差导致部分朝向与瓣瓣的构象基本相同的构象的变形。 生物组织最后被固定，而限定假体瓣瓣的部分保持在所述构型中。 然后将生物组织片与成形装置分离，随后安装在假体的框架中。
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47.发明授权
公开(公告)号：US4544599A
公开(公告)日：1985-10-01
申请号：US615137
申请日：1984-05-30
申请人： Bernard Buttazzoni
发明人： Bernard Buttazzoni
IPC分类号： D06N7/00 , A61F2/00 , A61F2/06 , A61F2/24 , A61L27/08 , C04B35/83 , D01F9/12 , D01F9/133 , D01F11/12 , B32B7/00
CPC分类号： C04B35/83 , A61F2/06 , A61F2/2469 , A61L27/08 , D01F11/125 , A61F2310/00161 , Y10T428/30 , Y10T442/2984
摘要： The present invention relates to a method for producing elastically deformable articles constituted of a textile substrate of carbon fibers which are elastically deformable with respect to an at rest shape, wherein a flexible structure of carbon fibers is used, a predetermined form being set for this textile by means of shaping tools, and said textile being retained in said at rest shape by forming around the said fibers a thin coating of rough laminar pyrolytic carbon deposited by chemical vapor infiltration at high temperature without bonding of the fibers one to another. The textile can be given a flat form by using holding plates. It is possible to start from a braided sleeve which is either compressed or stretched axially around a mandrel. It is also possible to use a woven tape which is wound in a conical pseudo-spiral for use as a cardiac valve.
摘要翻译： 本发明涉及一种制造弹性变形制品的方法，所述弹性变形制品由碳纤维织物基材构成，所述纤维基材可相对于静止形状可弹性变形，其中使用碳纤维的柔性结构，为该纺织品设定预定形式 通过成形工具，并且所述织物通过在所述纤维周围形成而在高温下通过化学气相渗透沉积的粗层状热解碳的薄涂层而保持在所述静止形状，而不会将纤维彼此粘合。 纺织品可以通过使用保持板给予平坦的形式。 可以从编织套筒开始，该套筒被压缩或者围绕心轴轴向拉伸。 也可以使用缠绕在锥形假螺旋中作为心脏瓣膜的编织带。
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公开(公告)号：US11981571B2
公开(公告)日：2024-05-14
申请号：US17531651
申请日：2021-11-19
发明人： Andre E. Nel , Tian Xia , Ruibin Li , Mark C. Hersam , Nikhita D. Mansukhani , Linda Guiney
IPC分类号： C01B32/198 , A01N43/90 , A01N59/00 , A61L27/08
CPC分类号： C01B32/198 , A01N43/90 , A01N59/00 , A61L27/08
摘要： In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (·C) density.
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公开(公告)号：US11980548B2
公开(公告)日：2024-05-14
申请号：US16640735
申请日：2018-08-17
发明人： Zhoujian Tan , Jiqiao Liao , Xiang Zhang , Xu Yi
CPC分类号： A61F2/28 , A61L27/08 , A61L27/306 , D03D1/00 , A61F2002/30113 , A61F2002/30154 , A61F2002/30187 , A61F2002/30433 , A61F2002/30563 , A61F2310/00161 , A61F2310/00574 , A61L2430/02 , D10B2101/12 , D10B2509/00
摘要： The invention discloses a carbon fiber composite artificial bone and a preparation method thereof. The artificial bone includes a carbon fiber composite spring-like frame or includes a carbon fiber composite spring-like frame and a carbon fiber composite plate dowel, and the carbon fiber composite plate dowel is inserted into one end or both ends of a cavity of the spring-like frame or penetrates through the cavity of the carbon fiber composite spring-like frame. The preparation method includes: preparing a spring-like carbon fiber preform through a weaving technology by using carbon fibers as a raw material, performing densification and high-temperature purification treatment and preparing a wear-resistant coating to obtain the carbon fiber composite spring-like frame; and combining the carbon fiber composite spring-like frame with the carbon fiber composite plate bowel to obtain the artificial bone.
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公开(公告)号：US11957799B2
公开(公告)日：2024-04-16
申请号：US16675388
申请日：2019-11-06
发明人： Jackson Hobble , Brian Peterson
摘要： A device for providing treatment is disclosed. The device provides proper skin electrical conductivity while still being minimally invasive by adhering to the patient's skin that also implements safety measures that off-the-shelf electrode options do not have. This device includes a graphite powder-based skin counter electrode that has a graphite powder suspended in an electrolyte gel that allows for electrochemical conduction between the graphite particles in the graphite powder. The gel is spread over a first side of a hydrogel layer. A device housing is mounted on the hydrogel layer over the first side. The device housing contains the electrolyte gel and graphite powder, defines an opening or lead opening as well as an empty expansion chamber for gaseous anodic byproduct. A metallic wire or rod extends from the electrolyte gel and through the housing opening and connects to a potentiostat. The second side of the hydrogel layer is adhered to the skin of the patient. The graphite powder-based skin counter electrode device takes into account safety.
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