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209 条记录 (耗时 0.04 秒)

    Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
    53.
    发明授权
    Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz 有权
    包含1-N-芳基吡唑衍生物和氨基拉唑的局部制剂

    公开(公告)号：US08242161B2

    公开(公告)日：2012-08-14

    申请号：US12420325

    申请日：2009-04-08

    申请人： Albert Boeckh ,  Luiz Gustavo Cramer ,  Mark D. Soll

    发明人： Albert Boeckh ,  Luiz Gustavo Cramer ,  Mark D. Soll

    IPC分类号： A01N43/56

    CPC分类号： A01N43/56 ,  A01N47/02 ,  A01N2300/00 ,  A01N37/52

    摘要： The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs.

    摘要翻译： 本发明特别提供了包含至少一种1-N-阿吡唑衍生物和氨喋啶的新型局部制剂，以及用于治疗，控制或预防哺乳动物或鸟类寄生虫侵袭的方法。本发明的制剂包括点状， 可以包括另外的外寄生物杀虫剂，例如IGR化合物，除虫菌素或米尔倍霉素衍生物，拟除虫菊酯杀虫剂，以及驱肠虫药如苯并咪唑和咪唑并噻唑。 本发明的配方以更快的控制速率提供更大的寄生虫控制持续时间。 本发明的公式从第一次申请至多三个月仍然有效。 此外，本发明的制剂防止蜱附着于动物，从而提供防止蜱携带疾病的保护。 本发明可以控制，治疗或预防的外寄生虫包括蜱，跳蚤，螨虫，虱子，虱子，蚊子，苍蝇和牛。。。

    Adjustable animal watering system
    54.
    发明授权
    Adjustable animal watering system 有权
    可调节动物浇水系统

    公开(公告)号：US08196549B2

    公开(公告)日：2012-06-12

    申请号：US12113483

    申请日：2008-05-01

    申请人： John Seagraves

    发明人： John Seagraves

    IPC分类号： A01K39/00

    CPC分类号： A01K39/0213 ,  A01K1/0356

    摘要： The assemblies of the invention are suitable for mounting to, or being an integral part of, an animal enclosure such that the height of a valve-controlled liquid outlet may be adjusted according to the changing needs of growing animals. The adjustable liquid delivery assemblies comprise an elongated rail, a liquid delivery unit having at least one liquid delivery head slideably engaged with the elongated rail, a flexible liquid delivery tube for connecting a liquid delivery head to a liquid source, and a means for securing the liquid delivery unit at a selected position on the elongated rail.

    摘要翻译： 本发明的组件适合于安装到动物外壳上或作为其动物外壳的组成部分，使得阀控液体出口的高度可根据生长动物的不断变化的需要进行调节。 可调节的液体输送组件包括细长导轨，液体输送单元，其具有可滑动地与细长轨道接合的至少一个液体输送头，用于将液体输送头连接到液体源的柔性液体输送管，以及用于将 液体输送单元位于细长导轨上的选定位置。

    Attenuated Gram Negative Bacteria
    56.
    发明申请
    Attenuated Gram Negative Bacteria 有权
    减毒革兰氏阴性细菌

    公开(公告)号：US20120009218A1

    公开(公告)日：2012-01-12

    申请号：US13091046

    申请日：2011-04-20

    申请人： Helen Rachel Crooke ,  Jacqueline Elizabeth Shea ,  Robert Graham Feldman ,  Sylvain Gabriel Goutebroze ,  Francois-Xavier Le Gros

    发明人： Helen Rachel Crooke ,  Jacqueline Elizabeth Shea ,  Robert Graham Feldman ,  Sylvain Gabriel Goutebroze ,  Francois-Xavier Le Gros

    IPC分类号： A61K39/02 ,  A61P31/04 ,  C12N1/21

    CPC分类号： C07K14/285 ,  A61K39/00 ,  Y02A50/407

    摘要： Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.

    摘要翻译： 披露并要求保护的是革兰氏阴性细菌的突变体，其中所述细菌在核苷酸序列中具有至少一个突变，所述核苷酸序列编码具有等于或大于70％，75％，80％，85％ 90％，95％，96％，97％，98％或99％，其中氨基酸序列由选自SEQ ID NO：2,6,9,12,16的核苷酸序列的核苷酸序列编码 ，19，22，25，28，31，34，37，40，43，46，49，52，55，58，61，64，67，70，75，78，81，84，87，90，93 ; 所述突变导致细菌的毒力减弱。 还公开并要求保护含有这种突变体的免疫原性组合物和疫苗。

    Methods of identifying modulators of L-glutamate-gated chloride channel proteins from Rhipicephalus sanguineus
    60.
    发明授权
    Methods of identifying modulators of L-glutamate-gated chloride channel proteins from Rhipicephalus sanguineus 有权
    鉴定来自R us属的L-谷氨酸盐化氯化物通道蛋白的调节剂的方法

    公开(公告)号：US07674586B2

    公开(公告)日：2010-03-09

    申请号：US11620390

    申请日：2007-01-05

    申请人： Jeffrey W. Warmke ,  Youfeng Yang ,  Doris F. Cully ,  Michel J. Hamelin

    发明人： Jeffrey W. Warmke ,  Youfeng Yang ,  Doris F. Cully ,  Michel J. Hamelin

    IPC分类号： C12Q1/68 ,  C12Q1/00

    CPC分类号： C07K14/43527 ,  C07K14/705 ,  G01N33/6872 ,  G01N2333/43556

    摘要： The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding R. sanguineus glutamate gated chloride channels, substantially purified forms of associated R. sanguineus glutamate gated chloride channels and recombinant membrane fractions comprising these proteins, associated mutant proteins, and methods associated with identifying compounds which modulate associated Rhipicephalus sanguineus glutamate gated chloride channels, which will be useful as insecticides.

    摘要翻译： 本发明部分涉及编码Rigicephalus sanguineus glutamate门控氯化物通道的分离的核酸分子（多核苷酸）。 本发明还涉及重组载体和重组宿主，其含有编码雷神酵母谷氨酸盐门控氯化物通道的DNA片段，基本上纯化形式的相关的谷氨酸谷氨酸盐化氯化物通道和包含这些蛋白质的重组膜级分，相关突变蛋白质，和 与鉴定调节相关联的Rhipicephalus sanguineus glutamate门控氯化物通道的化合物相关的方法，其将用作杀虫剂。