STABLE PHARMACEUTICAL COMPOSITIONS OF METFORMIN WITH CONTROL ON NITROSO IMPURITIES

    公开(公告)号:US20230133326A1

    公开(公告)日:2023-05-04

    申请号:US17975595

    申请日:2022-10-27

    摘要: In an embodiment, the present disclosure pertains to a stable formulation of a primary, secondary, and/or tertiary amino group containing composition that prevents or reduces formation of a nitroso impurity until the end of stated expiration or longer. In some embodiments, the composition includes metformin and at least one pharmaceutical excipient. In some embodiments, the at least one pharmaceutical excipient includes a magnesium salt and at least one of a calcium salt, dicalcium phosphate, polyethylene glycol, or polyethylene oxide. In some embodiments, the magnesium salt can include, without limitation, magnesium aluminum silicate, magnesium aluminometasilicate, magnesium carbonate, magnesium oxide, magnesium silicate, magnesium stearate, magnesium sulfate, magnesium trisilicate, and combinations thereof. In some embodiments, a weight ratio of the drug to the at least one pharmaceutical excipient ranges from 1 to 99 to 99 to 1% w/w. In some embodiments, the at least one pharmaceutical excipient is a protective pharmaceutical ingredient.

    Light weight, modular, powered, transfemoral prosthesis

    公开(公告)号:US11596530B2

    公开(公告)日:2023-03-07

    申请号:US16769013

    申请日:2018-12-12

    摘要: In an embodiment, a prosthetic leg including a modular knee element coupled to a modular ankle element. The modular knee element includes a knee motor rotatable about an axis of a shaft in the knee motor. The modular ankle element includes a drive portion coupled to a surface-contacting portion via a pylon having a top and bottom end. The top end is coupled to the drive portion and the bottom end is coupled to the surface-contacting portion. The drive portion includes an ankle motor coupled to a rotary series elastic actuator (RSEA) and a first pulley coupled to the RSEA. The surface-contacting portion includes a hinge and a second pulley with a belt engaging at least a portion of at least one of the first and second pulley, and a modular foot element coupled to the bottom of the hinge.

    System for measuring anomalous diffusion using fluorescence recovery after photobleaching and associated method

    公开(公告)号:US11585755B2

    公开(公告)日:2023-02-21

    申请号:US17083365

    申请日:2020-10-29

    发明人: Minchul Kang

    IPC分类号: G01N21/64 G02B21/00

    摘要: A system and associated method measures anomalous diffusion of biomolecules in cell membranes of intact cells and includes a laser that illuminates a cell membrane within an intact cell to express fluorescently tagged biomolecules. The laser photobleaches a region of interest and illuminates the region of interest over time. A detector detects the fluorescence recovery over time within the region of interest to yield fluorescence recovery after photobleaching (FRAP) data. A controller computes the mean square displacement (MSD) of diffusing biomolecules and a time-dependent diffusion coefficient D(t) from a plurality of time points of the FRAP data and determines the anomalous diffusion in the cell membrane.

    An Ultra-Wide Bandwidth Ultra-Isolation DC-100 Gigahertz Front-End Module with Integrated Duplexer, Low Noise Amplifier, and Power Amplifier for Wireless Communication Applications

    公开(公告)号:US20230036705A1

    公开(公告)日:2023-02-02

    申请号:US17787958

    申请日:2021-01-29

    IPC分类号: H04B1/525 H04B1/12 H04L5/14

    摘要: Architectures of millimeter wave fully-integrated frequency-division duplex (FDD) transmitting-receiving (T/R) front-end (FE) modules include a duplexer (DUX), power amplifier (PA), and low noise amplifier (LNA) on a single semiconductor substrate to facilitate the development of system on a chip (SoC) for millimeter wave 5G wireless and next-generation communications applications. The entire balanced DUX module implements TX signals in differential mode, and RX signals in single-ended mode. LNA input is located at the center of a symmetrical plane of the entire FE module, resulting in an inherent ultra-high isolation between the differential PA output ports and the LNA input port across a ultra-wide bandwidth. The DUX can stand alone as a single unit in a system and is used together with external PA and LNA provided in the system, or it can include its own internal PA and LNA to form a DUX FE module.