公开(公告)号：US20240082400A1

公开(公告)日：2024-03-14

申请号：US18272168

申请日：2022-01-18

Applicant: THE GENERAL HOSPITAL CORPORATION ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Soldano FERRONE ,  Giuseppe SCONOCCHIA ,  Sara CARATELLI

IPC: A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K14/735 ,  C12N5/0783

CPC classification number: A61K39/4631 ,  A61K39/3955 ,  A61K39/4611 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70535 ,  C12N5/0636 ,  C07K2317/24 ,  C07K2319/03 ,  C07K2319/30 ,  C12N2510/00

Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes a chimeric receptor which comprises an CD64 binding domain, a transmembrane domain, and a CD3zeta signaling domain.

公开(公告)号：US20230414175A1

公开(公告)日：2023-12-28

申请号：US18253368

申请日：2021-11-15

Applicant: CAMLIN ITALY S.r.l. ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Giuseppe TARABELLA ,  Luca ASCARI ,  Stefano LAI ,  Konstantin KOSHMAK ,  Davide VURRO ,  Pasquale D’ANGELO ,  Salvatore IANNOTTA

IPC: A61B5/00 ,  A61B5/268 ,  A61B5/257 ,  C09D11/04 ,  C09D11/52 ,  C07K14/435

CPC classification number: A61B5/6833 ,  A61B5/268 ,  A61B5/257 ,  C09D11/04 ,  C09D11/52 ,  C07K14/43586 ,  A61B2562/125 ,  A61B2560/0412

Abstract: A process (100) for manufacturing a patch (10) to be applied on a human or animal organ, comprising the steps of:



preparing a bio-polymeric ink (200);
providing a substrate at least partially made by said bio-polymeric ink (300);
printing a circuit on said substrate (400).

公开(公告)号：US20230181763A1

公开(公告)日：2023-06-15

申请号：US17922300

申请日：2021-04-30

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Sevice ,  Consiglio Nazionale Delle Ricerche

Inventor： John A. Chiorini ,  Giovanni Di Pasquale ,  Fabio Mammano ,  Veronica Zorzi

IPC: A61K48/00 ,  A61P27/16 ,  A61K45/06

CPC classification number: A61K48/0041 ,  A61P27/16 ,  A61K45/06 ,  A61K48/0066

Abstract: Provided are methods of transducing hair cells of the inner ear in a subject comprising administering to the subject an adeno-associated viral (AAV) vector comprising a nucleic acid sequence encoding a capsid comprising the amino acid sequence of SEQ ID NO: 1, wherein the AAV vector further comprises a heterologous nucleic acid sequence. Additionally, methods of treating, preventing, or inhibiting a cochlear disorder or balance disorder in a subject comprising administering the AAV vector to the subject are provided.

公开(公告)号：US20230161056A1

公开(公告)日：2023-05-25

申请号：US17919241

申请日：2021-03-24

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Alessandro SOLURI ,  Roberto MASSARI

IPC: G01T1/202 ,  G01T1/20 ,  G01T1/161 ,  A61B6/00

CPC classification number: G01T1/202 ,  G01T1/20184 ,  G01T1/1612 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/4411 ,  A61B6/12

Abstract: Described is a directional gamma detector including a detection probe and a handgrip, wherein the detection probe includes: a supporting rod and a detection head coupled or integrated with a first end of the supporting rod. The detection head includes a plurality of detection elements distinct from each other for simultaneously detecting gamma rays directed in different directions and including at least one scintillation crystal and a corresponding first electronic conversion circuitry. Each detection element is associated with a respective collimator. The handgrip is equipped internally with a second electronic circuitry for converting the signals. The detection probe, and in particular a second end of the supporting rod, is reversibly connectable to the handgrip by a mechanical connector equipped with electrical contacts for transferring the signals from the first electronic conversion circuitry to the second electronic conversion circuitry.

公开(公告)号：US20230051031A1

公开(公告)日：2023-02-16

申请号：US17757564

申请日：2020-12-15

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Maria Rosaria Plutino ,  Simone Cappello

IPC: B01J20/12 ,  B01J20/28 ,  C02F1/28 ,  C02F3/34

Abstract: A multifunctional hybrid material based on sepiolite for environmental recovery and bio-remediation is described. In particular, the invention describes the design and development of suitably functionalized hybrid nanomaterials starting from sepiolite and the subsequent study of the absorbent and degrading properties in relation to aromatic hydrocarbons, by activating hydrocarbon-clastic bacteria. These nanomaterials have been prepared in order to remove hydrocarbon pollutants (e.g. oil) in natural matrices (marine environment), with potential applications in the field of environmental remediation.

公开(公告)号：US20230034883A1

公开(公告)日：2023-02-02

申请号：US17757567

申请日：2020-12-15

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE (60%) ,  UNIVERSITA' DEGLI STUDI DI MESSINA (40%)

Inventor： Maria Rosaria Plutino ,  Simone Cappello ,  Giuseppe Sabatino ,  Giulia Rando

IPC: B01J20/12 ,  B01J20/26 ,  B01J20/28 ,  C09K3/32

Abstract: A multi-functional hybrid material based on natural clays for environmental bio-remediation and recover), is disclosed. In particular, the invention discloses the design and development of appropriately functionalized nanohybrid materials starting from nanostructured clays and the subsequent study of the absorbent properties in relation to hydrocarbons, heavy metals, chemical pollutants, oils, particulate, and microplastics. These nanomaterials were prepared in order to remove the hydrocarbon pollutants (for example oil) and metal pollutants in natural matrices (marine environment), with potential applications in the field of environmental remediation.

公开(公告)号：US11547721B2

公开(公告)日：2023-01-10

申请号：US17051329

申请日：2019-05-03

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI ,  FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA ,  UNIVERSIDADE DE SANTIAGO DE COMPOSTELA ,  UNIVERSITA DEGLI STUDI DI GENOVA

Inventor： Markus Barthel ,  Marco Cassani ,  Mariangela Figini ,  Juan Granja ,  Teresa Pellegrino ,  Alessandra Quarta

IPC: A61K33/243 ,  A61K47/60 ,  A61K47/68 ,  A61K47/52 ,  A61K9/16 ,  A61P35/00

Abstract: The present invention relates to magnetic nanoparticles based on iron oxide having cubic shape, suitably functionalized for the release of targeting chemotherapeutic agents, i.e. selectively in the tumors being treated The invention also relates to the pharmaceutical compositions having such nanoparticles and to their use in combined oncological therapies of hyperthermia and chemotherapy, useful in particular in the treatment of ovarian tumors.

公开(公告)号：US20220411799A1

公开(公告)日：2022-12-29

申请号：US17772769

申请日：2020-10-28

Applicant: National University of Singapore ,  Beth Israel Deaconess Medical Center, Inc. ,  Consiglio Nazionale Delle Ricerche

Inventor： Daniel Geoffrey Tenen ,  Carla Lucia Esposito ,  Annalisa Di Ruscio ,  Vittorio De Franciscis ,  Alexander K. Ebralidze

IPC: C12N15/115 ,  C12Q1/6811 ,  C12N15/10

Abstract: An aptamer, capable of inhibiting DNA methyltransferase 1 (DNMT1) for use in therapy of diseases characterised by aberrant DNA methylation, e.g. cancer. Method for identifying inhibitors of DNA methyltransferase. An aptamer, capable of inhibiting DNA methyltransferase 1 (DNMT1) for use in therapy of diseases characterised by aberrant DNA methylation, e.g. cancer. SELEX method for identifying aptamers of DNA methyltransferase optionally using 2-fluoro-pyrimindine nucleotide derivatives.

公开(公告)号：US20220356475A1

公开(公告)日：2022-11-10

申请号：US17640647

申请日：2020-08-31

Applicant: UNIVERSITA' DEGLI STUDI DI TORINO ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Daniela TAVERNA ,  Lorena QUIRICO ,  Francesca ORSO ,  Vittorio DE FRANCISCIS ,  Carla Lucia ESPOSITO ,  Silvia CATUOGNO

IPC: C12N15/115 ,  A61K9/00 ,  A61P35/00

Abstract: A chimeric complex comprising a microRNA in combination with an aptamer for AXL receptor tyrosine kinase is provided. Use of the chimeric complex for targeted treatment of a tumor disease, in particular in a therapy affecting onset and/or progression of tumor metastasis is also provided.

公开(公告)号：US11448549B2

公开(公告)日：2022-09-20

申请号：US16593781

申请日：2019-10-04

Applicant: University of Rochester ,  Consiglio Nazionale delle Ricerche—CNR

Inventor： Andrew N. Jordan ,  Francesco Giazotto ,  Sreenath K. Manikandan

IPC: G01J1/42 ,  H01L39/22 ,  G06N10/00 ,  G01J1/02 ,  H01L39/10

Abstract: A heat transfer device and method are disclosed. The device includes a working region (i.e., working substance) made from a first superconducting material having a superconducting state and a normal state when magnetized. The first superconducting material has a first energy gap while in the superconducting state. A substrate (i.e., cold reservoir) is connected to the working region at a first tunnel junction. The substrate may be a metallic substrate. A heat sink (i.e., hot reservoir) is connected to the working region at a second tunnel junction. The heat sink is made from a second superconducting material having a second energy gap that is larger than the first energy gap. In a particular example, the heat transfer device includes a metallic substrate is made from Copper, a working region made from Tantalum, a heat sink made from Niobium, and the first and second tunnel junctions are made from Tantalum Oxide.