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    SYSTEM AND METHOD FOR ANALYSIS OF BIOLOGICAL DATA
    52.
    发明申请
    SYSTEM AND METHOD FOR ANALYSIS OF BIOLOGICAL DATA 审中-公开

    公开(公告)号：US20190180846A1

    公开(公告)日：2019-06-13

    申请号：US16324562

    申请日：2017-08-10

    申请人： MeMed Diagnostics Ltd.

    发明人： Kfir OVED ,  Eran EDEN ,  Roy NAVON ,  Assaf COHEN-DOTAN ,  Gali KRONENFELD ,  Olga BOICO

    IPC分类号： G16B40/20 ,  G01N33/569

    摘要： A method of analyzing biological data is disclosed. The method comprises obtaining biological data containing at least an expression level of MX dynamin-like GTPase 1 (MX1) and an expression level of C-reactive protein (CRP) in the blood of a subject, calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction, and correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection.

    Signatures and determinants for diagnosing infections and methods of use thereof
    54.
    发明授权
    Signatures and determinants for diagnosing infections and methods of use thereof 有权

    公开(公告)号：US10209260B2

    公开(公告)日：2019-02-19

    申请号：US15641400

    申请日：2017-07-05

    申请人： MeMed Diagnostics Ltd.

    发明人： Kfir Oved ,  Eran Eden ,  Ilan Ifergan

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/02 ,  C07H21/04 ,  C12N15/115 ,  G01N33/68 ,  C07K16/24 ,  C07K16/18

    摘要： Antibiotics (Abx) are the worlds most misused drugs. Antibiotics misuse occurs when the drug is administered in case of a non-bacterial infection (such as a viral infection) for which it is ineffective. Overall, it is estimated that 40-70% of the worldwide Abx courses are mis-prescribed. The financial and health consequences of Abx over-prescription include the direct cost of the drugs, as well as the indirect costs of their side effects, which are estimated at >$15 billion annually. Furthermore, over-prescription directly causes the emergence of Abx-resistant strains of bacteria, which are recognized as one of the major threats to public health today. This generates an immediate need for reliable diagnostics to assist physicians in correct Abx prescription, especially at the point-of-care (POC) where most Abx are prescribed. Accordingly, some aspects of the present invention provide methods using biomarkers for rapidly detecting the source of infection and administrating the appropriate treatment.

    SIGNATURES AND DETERMINANTS FOR DISTINGUISHING BETWEEN A BACTERIAL AND VIRAL INFECTION AND METHODS OF USE THEREOF
    57.
    发明申请
    SIGNATURES AND DETERMINANTS FOR DISTINGUISHING BETWEEN A BACTERIAL AND VIRAL INFECTION AND METHODS OF USE THEREOF 有权
    用于细菌和病毒感染之间鉴别的标记和决定因素及其使用方法

    公开(公告)号：US20160153993A1

    公开(公告)日：2016-06-02

    申请号：US15015309

    申请日：2016-02-04

    申请人： MeMed Diagnostics Ltd.

    发明人： Eran EDEN ,  Kfir OVED

    IPC分类号： G01N33/569 ,  A61K45/06

    CPC分类号： G01N33/56983 ,  A61K45/06 ,  G01N33/569 ,  G01N33/56911 ,  G01N2333/4737 ,  G01N2333/914

    摘要： The present invention provides methods of detecting infection using biomarkers. The methods disclosed herein include measuring the expression level of one or more polypeptide determinants in which the alteration of the expression level indicates infection of the patient. The methods provided herein are for distinguishing between bacterial infection, mixed infection, and/or viral infection. The methods disclosed herein may also further comprise measuring one or more non-polypeptide determinants. The present disclosure also provides methods for selection of a treatment regimen for the subject based on whether the subject is identified as having a bacterial or mixed infection, or a viral infection.

    摘要翻译： 本发明提供使用生物标志物检测感染的方法。 本文公开的方法包括测量一种或多种多肽决定簇的表达水平，其中表达水平的改变指示患者的感染。 本文提供的方法用于区分细菌感染，混合感染和/或病毒感染。 本文公开的方法还可以进一步包括测量一种或多种非多肽决定簇。 本公开还提供了基于受试者是否被鉴定为具有细菌或混合感染或病毒感染来选择受试者的治疗方案的方法。