Abstract:
An EKG structure comprising geosynthetic material associated with at least one conducting element wherein the structure comprises at least one core element substantially enclosed by at least one sheath, one or both comprising the geosynthetic material; the use thereof as an electrode, a method for treating substrate with the EKG structure, the treated substance obtained thereby.
Abstract:
The present invention provides a compound of formula (I) in which R1 is generally hydrogen or CF3, R2 is generally hydrogen, W is a cyclic amine, a heterocycle or a group L-Y—X where L-Y is a linking portion and X is generally an aromatic or non-aromatic heterocycle, alkyl or alkylcarbonyl and Z is generally a heterocycle such as 5-methylisoxazol-3-yl, and pharmaceutically acceptable salts thereof for enhancing cognition in conditions such as Alzheimer's Disease, pharmaceutical compositions comprising them, their use for manufacturing medicaments and methods of treatment using them
Abstract:
A flashing warning light apparatus wherein there is provided one or more light-emitting diodes, the light-emitting diode being driven in a pulsed manner to achieve light output at a selected flash rate, with control means adapted to detect any light induced signal from the same light-emitting diode or diodes during periods when the light-emitting diode is not emitting light, said signal being dependent on the level of ambient light. The same diode or diodes can be at a focus center of a reflector. A magnitude of any signal can then be used to determine whether the ambient light is such that the warning light should operate.
Abstract:
The present invention provides a pharmaceutical composition providing a compound of formula I or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable excipient: (I), in which: X and Y independently represent CH or N, with the proviso that if X is CH then Y is also CH; R1 represents hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, nitro, —ORa, —SRa, —SORa, —SO2Ra, —SO2NRaRb, —NRaRb, —NRaCORb, —NRaCO2Rb, —CORa, —CO2Ra, —CONRaRb or CRa═NORb; Ra and Rb independently represent hydrogen, hydrocarbon or a heterocyclic group; V and W are independently selected from H, halogen, C11-6alkyl, OH and C-1-6alkoxy; Z represents H, halogen, CN, NO2, CF3, OCF3, CF2H, SCF3, R2, OR3, SR3, (CH2)pN(R3)2, O(CH2)pN(R3)2, SO2R2, SO2N(R3)2, COR4, CO2R3, CON(R3)2, NHCOR4, NR1(CH2)nheteroaryl or O(CH2)nheteroaryl the heteroaryl is optionally substituted by one, two or three groups chosen from C1-6alkyl, benzyl, (CH2)pN(R3)2, halogen and CF3, R1 is C1-6alkyl, where n is 1 or 2 and p is 0, 1 or 2; with the proviso that at least one of V, W and Z is other than H; R2 represents C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-4alkyl, C2-6alkenyl, C2-6alkynyl or heteroaryl, any of which may bear a substituent selected from halogen, CN, NO2, CF3, OCF3, CF2H, SCF3, OH, C1-4alkoxy, C1-4alkoxycarbonyl, amino, C1-4alkylamino, or di(C1-4alkyl)amino; R3 represents H or R2; or two R3 groups bonded to the same nitrogen atom may complete a 5-7 membered nonaromatic heterocyclic ring; and R4 represents R3 or heteroaryl; the compounds are ligands for GABA-A receptors containing the alpha 5 subtype and thus are useful for enhancing cognition in individuals suffering from conditions such as Alzheimer's Disease.
Abstract:
The invention relates to compositions and methods for treating inflammatory disorders. More specifically, the invention relates to antibody compositions and their use in the treatment of inflammatory disorders.
Abstract:
A class of substituted or 6,7-ring fused [1, 2, 3]triazolo[1,5-&agr;]-pyrimidine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and an amino moiety at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
Abstract:
An inductive sensor head for detecting ferrous or non-ferrous electrically conducting objects, in particular rebars in a surrounding medium like concrete or a brick wall, comprising at least one field coil with a small axial length compared to its diameter and at least one twin pair of sense coils with a small diameter compared to the diameter of the field coil. The number of turns of wire on the field coil is small relative to the number of turns of wire on the sense coils. The common axis of the sense coils is arranged perpendicular to the axis of the field coil so that there will be no component or a minimum component of maximum flux that is coaxial with the sense coils. A twin pair of coaxially arranged identical field coils is provided that are sequentially excited for giving not only positional but also depths information. In a center plane between the field coils an orthogonal arrangement of two twin pairs of sense coils is provided enabling for a three-dimensional hidden object positioning. The sensor head according to the invention can be automatically calibrated, controlled and read out under control of a microcontroller.
Abstract:
In an optical ranging apparatus, especially designed for measuring the range to a source of infrared radiation, a narrow band time-shift servoloop processor is used to resolve the offset (separation distance) of images of the infrared source that are projected onto first and second, juxtaposed photooptical detector arrays. The range (distance) to the infrared source is functionally related to the measured offset of the infrared images. To enable the servoloop processor to measure this offset, the outputs of the first and second detector arrays are automatically scanned by electronic scanning circuitry to develop first and second time-variable signals that represent the relative positions of the infrared images on the respective arrays. These time-variable signals are substantially overlapping, and the slight phase or time separation between these signals is related to the offset of the images on the detector arrays. The servoloop processor receives the substantially overlapping time-variable signals from the scanning circuitry and resolves the time difference therebetween as a continuously variable time shift .DELTA.t signal. The measured offset is then fed to a ranging processor to produce a signal representing the range (R) to the distant infrared source.