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    Plasticized bioerodible controlled delivery system
    52.
    发明授权
    Plasticized bioerodible controlled delivery system 失效
    塑化生物可蚀性控制输送系统

    公开(公告)号：US06372245B1

    公开(公告)日：2002-04-16

    申请号：US08233211

    申请日：1994-04-22

    Applicant: Lyle M. Bowman ,  Santosh Kumar Chandrasekaran ,  Rajesh Patel ,  Hoa Vinh Vo

    Inventor： Lyle M. Bowman ,  Santosh Kumar Chandrasekaran ,  Rajesh Patel ,  Hoa Vinh Vo

    IPC: A61K910

    CPC classification number: A61K9/0048 ,  A61K47/34 ,  Y10S514/912

    Abstract: A controlled release medicament delivery system comprises a plasticized bioerodible polymer, such as a polyorthoester. Medicament desirably is entrapped in the plasticized polymer. The resulting delivery system is able to release the medicament in a controlled and sustained manner. The formulation is particularly advantageous for use as a once-a-day eyedrop. During preparation, the polymer may be heated to an elevated temperature for a sufficient time to substantially reduce its molecular weight.

    Abstract translation: 控释药物递送系统包括增塑的生物可腐蚀聚合物，例如聚原酸酯。 药物期望地被包埋在增塑聚合物中。 所得到的递送系统能够以受控和持续的方式释放药物。 该制剂特别有利于用作一日一次的眼药水。 在制备过程中，可将聚合物加热至高温足够的时间以显着降低其分子量。

    Quantitative determination of nucleic acid amplification products
    53.
    发明授权
    Quantitative determination of nucleic acid amplification products 失效

    公开(公告)号：US06365346B1

    公开(公告)日：2002-04-02

    申请号：US09025639

    申请日：1998-02-18

    Applicant: Rajesh Patel ,  Nurith Kurn

    Inventor： Rajesh Patel ,  Nurith Kurn

    IPC: C12Q168

    CPC classification number: C12Q1/6851 ,  C12Q1/6818 ,  C12Q2565/519 ,  C12Q2527/101

    Abstract: The present invention relates to a method for detecting the amount of a target polynucleotide in a sample. A combination is provided in a medium. The combination comprises (i) a sample suspected of containing the target polynucleotide, the target polynucleotide being in single stranded form, (ii) a reference polynucleotide comprising a sequence that is common with a sequence of the target polynucleotide, and (iii) a predetermined amount of an oligonucleotide probe that has a sequence that hybridizes with the sequence that is common. The combination is subjected to conditions for amplifying the target polynucleotide and the reference polynucleotide. The conditions permit formation of substantially non-dissociative complexes of the target polynucleotide and the reference polynucleotide, respectively, with the oligonucleotide probe. Furthermore, the predetermined amount of the oligonucleotide probe is less than the expected amount of the amplified target polynucleotide. The ratio of the amount of the complex of the target polynucleotide with the oligonucleotide probe to the amount of the complex of the reference polynucleotide with the oligonucleotide probe is determined. Determination of the ratio is facilitated by employing second and third oligonucleotide probes. The second oligonucleotide probe has a sequence that hybridizes only with the second sequence of the target polynucleotide. The third oligonucleotide probe has a sequence that hybridizes only with a respective second sequence of the reference polynucleotide. The ratio is related to the known amount of the reference polynucleotide to determine the amount of the target polynucleotide in the sample. One or more reference polynucleotides may be employed with a corresponding third oligonucleotide probe for each reference probe. Kits for carrying out the above methods are also disclosed. The method is particularly applicable to the amplification and detection of RNA.

    Dynamically modifying queued transactions in a cache memory system
    54.
    发明授权
    Dynamically modifying queued transactions in a cache memory system 失效
    动态修改缓存内存系统中的排队事务

    公开(公告)号：US06321303B1

    公开(公告)日：2001-11-20

    申请号：US09271492

    申请日：1999-03-18

    Applicant: Thomas Alan Hoy ,  Belliappa Manavattira Kuttanna ,  Rajesh Patel ,  Michael Dean Snyder

    Inventor： Thomas Alan Hoy ,  Belliappa Manavattira Kuttanna ,  Rajesh Patel ,  Michael Dean Snyder

    IPC: G06F1208

    CPC classification number: G06F12/0831

    Abstract: A computer and its corresponding cache system includes a cache memory, a buffer unit, and a bus transaction queue. The buffer unit includes a plurality of entries suitable for temporarily storing data, address, and attribute information of operations generated by the CPU. A first operation initiated by the load store unit buffers an operation in a first entry of the buffer unit, which initiates a first transaction to be queued in a first entry of the bus transaction queue where the first transaction in the bus transaction queue points to the first entry in the buffer unit. Preferably, the buffer unit is configured to modify the first transaction from a first transaction type to a second transaction type prior to execution in response to an event that alters the data requirements of the queued transaction. Additional utility is achieved by merging multiple store operation that miss to a common cache line into a single entry. Further benefits is achieved by allowing multiple load misses to the same cache line to be completed from a buffer that reduces cache pipeline stalls.

    Abstract translation: 计算机及其对应的缓存系统包括高速缓冲存储器，缓冲器单元和总线事务队列。 缓冲单元包括适于临时存储由CPU生成的操作的数据，地址和属性信息的多个条目。 由加载存储单元启动的第一操作缓冲在缓冲单元的第一条目中的操作，该操作启动要在总线事务队列的第一条目中排队的第一事务，其中总线事务队列中的第一事务指向 缓冲单元中的第一个条目。 优选地，缓冲单元被配置为响应于改变排队交易的数据需求的事件，在执行之前将第一事务从第一事务类型修改为第二事务类型。 通过将多个存储操作错过公用高速缓存行合并到单个条目中来实现附加效用。 通过允许从减少高速缓存管道停顿的缓冲器中完成相同高速缓存行的多个加载错误来实现进一步的益处。

    In-shower lotion compositions comprising up to 10% free fatty acids wherein ratio of unsaturated to saturated fatty acids is at least 1:1
    57.
    发明授权
    In-shower lotion compositions comprising up to 10% free fatty acids wherein ratio of unsaturated to saturated fatty acids is at least 1:1 失效
    包含高达10％游离脂肪酸的淋浴洗剂组合物，其中不饱和脂肪酸与饱和脂肪酸的比例至少为1:1

    公开(公告)号：US08691197B2

    公开(公告)日：2014-04-08

    申请号：US11850144

    申请日：2007-09-05

    Applicant: Rajesh Patel ,  Rosa Mercedes Paredes

    Inventor： Rajesh Patel ,  Rosa Mercedes Paredes

    IPC: A61K8/00 ,  A01N37/00 ,  A61K31/20

    CPC classification number: A61K8/922 ,  A61K8/31 ,  A61K8/342 ,  A61K8/345 ,  A61K8/375 ,  A61K8/8152 ,  A61Q19/00 ,  A61Q19/10

    Abstract: This invention relates to rinse-off skin conditioning compositions comprising relatively low amounts of oil/emollient and relatively low amounts of aqueous phase stabilizer/structurant. Use of unsaturated fatty acid (or at least minimum amount of unsaturated fatty acid as percentage of total fatty acid) has been found to result in unexpectedly high hydration. In a second embodiment, use of branched fatty acid (at minimum amount branched as percentage of total) also results in superior hydration. Also mixtures of unsaturated and branched fatty acids can be used.In a second embodiment, the invention relates to method of enhancing hydration using compositions as noted.

    Abstract translation: 本发明涉及包含相对低量的油/润肤剂和相对低量的水相稳定剂/结构剂的漂洗皮肤调理组合物。 已经发现使用不饱和脂肪酸（或至少最少量的不饱和脂肪酸占总脂肪酸的百分比）导致意想不到的高水合作用。 在第二个实施方案中，使用支链脂肪酸（最小量分支占总量的百分比）也导致优异的水合作用。 还可以使用不饱和和支链脂肪酸的混合物。 在第二个实施方案中，本发明涉及使用如上所述的组合物来增强水合的方法。

    METHODS FOR CHARACTERIZATION OF THE MECHANICAL PROPERTIES OF THIN FILMS AND TEST STRUCTURES FOR PERFORMING THE SAME
    60.
    发明申请
    METHODS FOR CHARACTERIZATION OF THE MECHANICAL PROPERTIES OF THIN FILMS AND TEST STRUCTURES FOR PERFORMING THE SAME 审中-公开
    用于表征薄膜的机械性能的方法和用于实施其的测试结构

    公开(公告)号：US20110273701A1

    公开(公告)日：2011-11-10

    申请号：US12680512

    申请日：2007-09-28

    Applicant: Manish Kothari ,  Sauri Gudlavalleti ,  Satyadev Rajesh Patel

    Inventor： Manish Kothari ,  Sauri Gudlavalleti ,  Satyadev Rajesh Patel

    IPC: G01L1/24 ,  G02B26/00

    CPC classification number: G01N3/32 ,  G01N2203/005 ,  G01N2203/0286 ,  G01N2203/0682 ,  G02B26/001

    Abstract: A test structure allows one or more deposited thin film layers to be moved such that mechanical properties of the thin film layer or layers may be determined. Methods for characterizing the mechanical properties of the deposited thin film layer include the determination of a transition voltage of the movable thin film layer in the test structure, or the mechanical stiffness of the movable layer, and/or a determination of residual stress within the movable layer. Methods may also include the determination of creep rate or fatigue, as well as the variance in mechanical properties of the movable layer at various temperatures. Test structures used with the testing methods may include structures which interferometrically modulate incident light, enabling electrical or optical determination of the state of the test structures.

    Abstract translation: 测试结构允许移动一个或多个沉积的薄膜层，使得可以确定薄膜层的机械性能。 表征沉积的薄膜层的机械性能的方法包括确定测试结构中可移动薄膜层的转变电压或可移动层的机械刚度，和/或确定可移动层内的残余应力 层。 方法还可以包括确定蠕变速率或疲劳，以及可移动层在各种温度下的机械性能的变化。 与测试方法一起使用的测试结构可以包括对入射光进行干涉测量的结构，使得能够电或光学地确定测试结构的状态。

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