公开(公告)号：US20230251277A1

公开(公告)日：2023-08-10

申请号：US18125708

申请日：2023-03-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Silvia Baecher ,  Andrea Geistanger ,  Dominik Gruber ,  Hans-Peter Josel

IPC: G01N33/82

CPC classification number: G01N33/82

Abstract: The present invention relates to a method and the use thereof for for determining the level of Vitamin D and metabolites thereof. Further, it is an object of the present invention to provide a kit and the use thereof for determining the level of Vitamin D and metabolites thereof.

公开(公告)号：US11719710B2

公开(公告)日：2023-08-08

申请号：US16695713

申请日：2019-11-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andrea Horsch ,  Dietmar Zdunek ,  Georg Hess

IPC: G01N33/74 ,  G01N33/68 ,  A61P13/12 ,  C07K14/47

CPC classification number: G01N33/74 ,  C07K14/4716 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2333/4712 ,  G01N2333/495 ,  G01N2333/52 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present disclosure relates to the field of laboratory diagnostics. Specifically, means and methods are disclosed for determining a patient's risk of suffering from acute kidney injury after a surgical procedure based on the detection of GDF-15, troponin T and/or a natriuretic peptide.

公开(公告)号：US20230203460A1

公开(公告)日：2023-06-29

申请号：US18068739

申请日：2022-12-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christian Helmut Bell ,  Harald Sobek ,  Heiko Walch ,  Kiyoshi Yasukawa ,  Misato Baba

IPC: C12N9/12 ,  C12Q1/68 ,  C12P19/34

CPC classification number: C12N9/1276 ,  C12Q1/68 ,  C12Y207/07049 ,  C12P19/34

Abstract: The present invention relates to a mutant reverse transcriptase (RT) with increased thermal stability relative to the wildtype, a nucleic acid encoding the mutant RT, a cell comprising the mutant RT or the nucleic acid, a kit comprising the mutant RT, the use of the mutant RT for cDNA synthesis, method for reverse transcription of RNA comprising synthesizing cDNA with the use of the mutant RT and a method for detecting an RNA marker in a sample with the use of the mutant RT.

公开(公告)号：US20230184796A1

公开(公告)日：2023-06-15

申请号：US18061717

申请日：2022-12-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Avinash Addihalli Narayana ,  Michael Rein

IPC: G01N35/02

CPC classification number: G01N35/025

Abstract: A laboratory sample container carrier handling apparatus is provided comprising a revolving device, a guiding surface, and a force-applying device, wherein the force-applying device is adapted to apply a force to a laboratory sample container carrier supplied to the revolving device to such an extent that the laboratory sample container carrier is forced against the guiding surface to such an extent that the laboratory sample container carrier rolls off at the guiding surface pushed by the revolving device. A laboratory automation system is also provided comprising such a laboratory sample container carrier handling apparatus and to a use of such a laboratory sample container carrier handling apparatus for handling a laboratory sample container carrier in, in particular such, a laboratory automation system.

公开(公告)号：US11644472B2

公开(公告)日：2023-05-09

申请号：US16217612

申请日：2018-12-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Herbert Andres ,  Dirk Block ,  Johann Karl ,  Peter Kastner ,  Ursula-Henrike Wienhues-Thelen ,  Roberto Latini ,  Serge Masson ,  Andre Ziegler ,  Edelgard Kaiser ,  Stefan Palme ,  Markus Thomas ,  Simona Barlera

IPC: G01N33/53 ,  G01N33/68

CPC classification number: G01N33/6887 ,  G01N33/6893 ,  G01N2800/326

Abstract: A method for predicting the risk of recurrence of Atrial Fibrillation in a subject based on measuring the amount of the biomarker Angiopoietin-2 (Ang-2) and optionally of at least one further biomarker in a sample from the subject is described. Also described is a method of diagnosing Atrial Fibrillation in a subject suspected to suffer from Atrial Fibrillation based on measuring the amount of the biomarker Angiopoietin-2 (Ang-2) and optionally of at least one further biomarker in a sample from the subject. Also described are devices adapted to carry out the method of the present disclosure.

公开(公告)号：US11635438B2

公开(公告)日：2023-04-25

申请号：US15196718

申请日：2016-06-29

Applicant: Roche Diagnostics Operations, Inc. ,  Medizinische Universität Graz

Inventor： Susanne Grueb ,  Nicole Neuboeck ,  Freyja-Maria Smolle-Juettner ,  Annelie-Martina Weinberg

IPC: G01N33/53 ,  G01N33/68

Abstract: Methods, systems and kits for the early diagnosis or prediction of systemic inflammatory response syndrome (SIRS) including sepsis in asymptomatic patients, such as patients undergoing a surgical intervention, are provided. Some embodiments include a method and system for the detection or diagnosis of SIRS, or detection or diagnosis of a risk to suffer from or develop SIRS, in an asymptomatic patient comprising the steps of determining the level of IL-6 (or a variant thereof) in a sample from the patient; comparing the level of IL-6 (or a variant thereof) to a reference level; detecting or diagnosing SIRS or diagnosing a risk to suffer from or develop SIRS, wherein the sample is isolated at least 2 times at short intervals and the determining and comparing steps are both repeated for each sample. Also provided are methods, systems and kits for therapy monitoring and mortality prediction.

公开(公告)号：US20230097824A1

公开(公告)日：2023-03-30

申请号：US17981244

申请日：2022-11-04

Applicant: Ventana Medical Systems, Inc. ,  Roche Diagnostics Operations, Inc.

Inventor： Edward E. Durrant ,  Dieter Heindl ,  Florian Mauritius Erasumu Huber ,  Eric Klein ,  Jerome W. Kosmeder, II ,  Edgar Voss

IPC: G01N1/31

Abstract: A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.

公开(公告)号：US11592454B2

公开(公告)日：2023-02-28

申请号：US16910579

申请日：2020-06-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Werner Smit ,  Florian Weber ,  Bauke Sjoerd Hollander ,  Riccardo Triunfo ,  Chye Yin Priscillia Tan

IPC: G01N35/00

Abstract: A method of handling laboratory sample containers by a laboratory sample container handling system is presented. The method comprises providing a laboratory sample container comprising an assigned ID information to the laboratory sample container handling system, reading the assigned ID information, checking, if the read ID information is unique or not unique within the laboratory sample container handling system, and if the read ID information (2) is not unique within the laboratory sample container handling system, assigning a new ID information to the laboratory sample container. The new ID information is unique within the laboratory sample container handling system.

公开(公告)号：US20230030564A1

公开(公告)日：2023-02-02

申请号：US17772959

申请日：2020-10-27

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Andrea Horsch ,  Eberhard Spanuth

IPC: G01N33/68 ,  G16H50/20 ,  G16H50/30

Abstract: The present invention concerns methods for aiding in the risk assessment of a patient with suspected sepsis. For example, the risk of poor outcome (such as of a complicated clinical course and/or of mortality) can be assessed. The methods of the present invention may comprise the steps of (a) determining the amount of the biomarker Presepsin in a sample from a patient with suspected sepsis who has a known qSOFA (quick Sequential Organ Failure-Assessment) score of 0, 1, 2 or 3, (b) determining the amount of the biomarker Pro-calcitonin (PCT) in a sample from the patient, comparing the amounts determined in steps (b) and (c) to reference amounts, and (d) aiding in the risk assessment of a patient with suspected sepsis. The methods of the present invention may be computer-implemented.

公开(公告)号：US20230028525A1

公开(公告)日：2023-01-26

申请号：US17813194

申请日：2022-07-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Nils Bruenggel ,  Patrick Conway ,  Pascal Vallotton

IPC: G16H30/40 ,  G06T5/50

Abstract: A computer-implemented method of generating training data to be used to train a machine learning model for generating a segmentation mask of an image containing overlapping particles. Training data is generated from sparse particle images which contain no overlaps. Generating masks for non-overlapping particles is generally not a problem if the particles can be identified clearly; in many cases simple methods such as thresholding already yield usable masks. The sparse images can then be combined to images which contain artificial overlaps. The same can be done for the masks as well which yields a large amount of training data, because of the many combinations which can be created from just a small set of images. The method is simple yet effective and can be adapted to many domains for example by adding style-transfer to the generated images or by including additional augmentation steps.