公开(公告)号：US11515722B2

公开(公告)日：2022-11-29

申请号：US16319223

申请日：2017-07-19

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Charles V. Cammarata ,  Thomas J. Bao

IPC: H02J9/06 ,  H02J1/10 ,  H02J3/00 ,  G01N35/04 ,  H02P6/00

Abstract: A modular in vitro diagnostics (IVD) vessel mover system providing redundant power management includes a plurality of modules which are configured to provide storage to one or more IVD samples. Each module comprising a power failover switch which is configured to receive internal power from an internal primary power source and transmit backup power to one or more of the plurality of modules.

公开(公告)号：US20220373500A1

公开(公告)日：2022-11-24

申请号：US17755390

申请日：2020-10-30

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Kyoung Ha Cha ,  Zhu Teng ,  Si Yang

IPC: G01N27/333 ,  C08G59/06 ,  C08G59/50 ,  C08J7/12 ,  C08K5/07

Abstract: Improved formulation(s), device(s), and method(s) for producing ion-selective electrodes (ISEs) that comprise at least one photo-curable, epoxy-based, ion-selective chloride membrane(s) compounds that can be pre-mixed together to form a singularly-dispensed mixture for the formation of an ion-exchange resin membrane(s) for incorporation and use in a chloride ISE.

公开(公告)号：US11498217B2

公开(公告)日：2022-11-15

申请号：US16316938

申请日：2017-06-27

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Benjamin S. Pollack ,  Steven Pollack

IPC: B25J9/16 ,  B25J13/08 ,  G05B19/401 ,  G01B5/012 ,  G01N35/00 ,  G01N35/10 ,  G01N35/04

Abstract: Methods of calibrating a position of a component include providing a robot with a gripper and crush and crash sensors, a calibration tool coupled to the gripper, and the component, which has a recess and a crush zone. The methods also include moving the gripper in a first direction to sense contact between the calibration tool and the crush zone, recording the contact position, and moving the gripper to insert the tool into the recess. The gripper is then moved in second directions to sense contact between the tool and the recess and moved in third directions to also sense contact between the tool and the recess. The methods further include recording and processing the contact positions to determine a surface location in the first direction and a physical center of the recess. Robot calibration apparatus for performing the method is also disclosed, as are other aspects.

公开(公告)号：US20220333058A1

公开(公告)日：2022-10-20

申请号：US17640483

申请日：2020-08-18

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Alex Hofai Lee ,  Daniel Chu

IPC: C12M1/00 ,  B01L3/00 ,  C12N15/10

Abstract: An apparatus, multi-well plate and method for automated cell lysis and nucleic acid purification and processing. The plate includes a lysis well, at least one wash well, and an elution well. The apparatus includes a vertically aligned rotor mixer comprising a magnetic tip and actuators for moving the rotor mixer in a vertical and horizontal directions, to transfer magnetic beads from well to well. The rotor mixer is used to vortex lysis mixtures, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and mixer tip and disperse the beads in solution, to collect nucleic acids such as DNA.

公开(公告)号：US20220325272A1

公开(公告)日：2022-10-13

申请号：US17640686

申请日：2020-08-18

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Daniel Chu ,  Alex Hofai Lee

IPC: C12N15/10

Abstract: An apparatus, multi-well plate and method for automated cell lysis and nucleic acid purification and amplification. The plate includes a lysis well, at least one wash well, an elution well, and a PCR chip. The apparatus includes a vertically aligned rotor mixer comprising a magnetic tip and actuators for moving the rotor mixer in a vertical and horizontal directions, to transfer magnetic beads from well to well. The rotor mixer is used to vortex lysis mixtures, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and mixer tip and disperse the beads in solution, to collect nucleic acids such as DNA in an elution solution that is transferred to the PCR chip for amplification of target sequences.

公开(公告)号：US11460476B2

公开(公告)日：2022-10-04

申请号：US17435433

申请日：2020-02-26

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Aaron Kauffmann ,  David Ledden ,  Chris Zimmerle ,  Jon Stradinger

IPC: G01N33/72 ,  G01N33/49 ,  G01N33/58 ,  B01L3/00

Abstract: Devices, kits, and methods are disclosed for use in detecting a concentration of an analyte of interest in a patient's liquid test sample. The devices, kits, and methods employ the use of one or more solid reagent zones that includes at least one analytical reagent for detection of an analyte of interest. The solid reagent zone(s) also includes at least one dye for determining whether results obtained from the diagnostic assay for the at least one analyte of interest are biased or inaccurate due to a loss of volume of a liquid reagent during the dispensing of the liquid reagent.

公开(公告)号：US11446652B2

公开(公告)日：2022-09-20

申请号：US17595802

申请日：2020-05-08

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Jason Bryant ,  Eric Yeaton ,  Dan Harris ,  Josiah Hackendorf ,  Steven Allen ,  Mark Talmer

IPC: B01L3/00 ,  C12N1/06

Abstract: Magnetic beads having cell components of interest are translated between a sequence of processing wells in a tray without need for pipetting. The circular tray contains one or more sequences of wells each interconnected by a respective channel. The tray is rotated about a central axis and a magnet, an agitator, and a heater provided external to the tray enable magnetic bead translation, mixing, and incubation, respectively. The magnet proximate a well forms a cluster of beads. Manipulation of the tray in rotation and elevation results in translation of the cluster from one well, through a channel, and into an adjacent well. The well containing a cluster may be rotationally positioned in front of the agitator, the agitator extended into contact with the well, followed by mechanical agitation. The heater, disposed beneath the tray, may accept a well lowered thereto for selective heating.

公开(公告)号：US20220236209A1

公开(公告)日：2022-07-28

申请号：US17617866

申请日：2020-06-05

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Jennifer Samproni

IPC: G01N27/333 ,  G01N27/416 ,  G01N33/49 ,  G01N27/30

Abstract: The inventive concepts disclosed herein are generally directed to the need to measure a microsample and obtain one or more measurement for one or more analyte in the microsample by configuring a sensor array having one or more first reference signal source interlaced with one or more analyte sensor positioned along the longitudinal axis the sensor body and a second reference signal source positioned downstream of the sensor body along a sample flow path.

公开(公告)号：US20220229049A1

公开(公告)日：2022-07-21

申请号：US17595478

申请日：2019-10-25

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Tie Wei

IPC: G01N33/53 ,  G01N33/543

Abstract: Reagents for use in sandwich immunoassays for haptens are disclosed, along with kits containing same. Also disclosed are diagnostic immunoassay methods that utilize these immunoassay reagents in a particle enhanced agglutination detection assay for detecting haptens/drugs in samples.

公开(公告)号：US11386291B2

公开(公告)日：2022-07-12

申请号：US16961222

申请日：2019-01-08

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Stefan Kluckner ,  Yao-Jen Chang ,  Kai Ma ,  Vivek Singh ,  Terrence Chen ,  Benjamin S. Pollack

IPC: G06K9/62 ,  G06K9/20 ,  G06K9/46 ,  G06N3/04 ,  G06N3/08 ,  G06T7/00 ,  G06V10/22 ,  G06V10/143 ,  G06V10/50 ,  G06V10/58

Abstract: A method of training a neural network (Convolutional Neural Network-CNN) including reduced graphical annotation input is provided. The training method can be used to train a Testing CNN that can be used for determining Hemolysis (H), Icterus (I), and/or Lipemia (L), or Normal (N) of a serum or plasma portion of a test specimen. The training method includes capturing training images of multiple specimen containers including training specimens, generating region proposals of the serum or plasma portions of the training specimens; and selecting the best matches for the location, size and shape of the region proposals for the multiple training specimens. The obtained features (network and weights) from the training CNN can be used in a testing CNN. Quality check modules and testing apparatus adapted to carry out the training method, and characterization methods using abounding box regressor are described, as are other aspects.