公开(公告)号：US20220025051A1

公开(公告)日：2022-01-27

申请号：US17311148

申请日：2019-12-06

Applicant: ONO PHARMACEUTICAL CO., LTD. ,  TOKUSHIMA UNIVERSITY

Inventor： Taku OKAZAKI ,  Daisuke SUGIURA ,  Takeo MAEDA ,  Shiro SHIBAYAMA

IPC: C07K16/28 ,  A61P37/06

Abstract: An immunosuppressive agent containing a substance that is selected from anti-CD80 antibodies and anti-PD-L1 antibodies and that promotes binding between PD-L1 and PD-1.

公开(公告)号：US20210338809A1

公开(公告)日：2021-11-04

申请号：US17270561

申请日：2019-08-20

Applicant: Tokushima University

Inventor： Hiroshi Kido ,  Etsuhisa Takahashi ,  Takashi Kimoto ,  Satoko Sakai

IPC: A61K39/35 ,  A61K39/39 ,  A61P37/08

Abstract: An object of the present invention is to provide an allergen vaccine for treatment or prevention of an allergic disease, while reducing the risk of developing an immediate type allergy including anaphylaxis. The present inventors have found that (1) oral inoculation of a composition comprising a particular antigen (allergen) and SF10 into subjects having allergic diseases can suppress the development of an immediate type allergy caused by sensitization with the antigen, and (2) oral inoculation of a composition comprising a particular antigen (allergen) and SF10 into subjects not having allergic diseases can inhibit establishment of sensitization to the antigen, and have completed the present invention.

公开(公告)号：US11124881B2

公开(公告)日：2021-09-21

申请号：US17272765

申请日：2020-06-04

Applicant: CHEMICAL DENSHI CO., LTD. ,  Tokushima University

Inventor： Shoichi Yamada ,  Toshio Hyuga ,  Hisao Nemoto

IPC: C23F11/12 ,  C07D319/06 ,  C23F11/16 ,  C07C327/22 ,  C07D317/20

Abstract: The objective of the present invention is to provide a hydrophilic metal surface treatment agent by which a water-repellent property can be given to a metal surface with suppressing a corrosion and a discolorment of the metal, a method for treating a surface of a metal by using the hydrophilic metal surface treatment agent, a synthetic intermediate compound of a branched glycerol derivative as an active ingredient of the hydrophilic metal surface treatment agent, and a method for efficiently producing the synthetic intermediate compound. The hydrophilic metal surface treatment agent of the present invention is characterized in comprising the branched glycerol derivative represented by the following formula (I) as an active ingredient. wherein R1 is a hydrocarbon group having a carbon number of 10 or more and 30 or less, X is S or a carbonyl group, Y is an n+1 valent linker group, n is an integer of 1 or more and 5 or less.

公开(公告)号：US11091517B2

公开(公告)日：2021-08-17

申请号：US16631141

申请日：2018-07-18

Applicant: TOKUSHIMA UNIVERSITY ,  ONCOTHERAPY SCIENCE, INC.

Inventor： Toyomasa Katagiri ,  Tetsuro Yoshimaru ,  Takashi Miyamoto ,  Yasuhide Okamoto

IPC: C07K7/08 ,  A61K47/65 ,  A61P35/00 ,  A61K38/00

Abstract: The present invention provides peptides having a structure in which portions of a dominant-negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 are replaced by at least two stapling structures. The peptides of the present invention have excellent cell growth inhibiting activity. The cell growth inhibiting activity lasts longer, compared to a single-stapled peptide. Therefore, the peptides of the present invention have a feature suitable for clinical applications in cancer therapy.

公开(公告)号：US20210030823A1

公开(公告)日：2021-02-04

申请号：US16964142

申请日：2019-01-25

Applicant: TOKUSHIMA UNIVERSITY ,  JICHI MEDICAL UNIVERSITY ,  GENE THERAPY RESEARCH INSTITUTION CO., LTD.

Inventor： Kohji ITOH ,  Daisuke TSUJI ,  Shinichi MURAMATSU ,  Katsuhito ASAI

IPC: A61K35/76 ,  C12N7/00 ,  A61P25/28

Abstract: According to a conventional method for treatment of Sandhoff disease and Tay-Sachs disease comprising administering a modified β-subunit to a patient in the form of a protein, it is necessary that administration be performed frequently. This invention relates to a recombinant adeno-associated virus virion comprising: capsomere comprising a protein capable of forming a virus virion; and a polynucleotide packaged in the capsomere comprising a promoter sequence and nucleotide sequences operably linked to the promoter sequence encoding a first amino acid sequence derived from the amino acid sequence of the β-subunit of wild-type human β-hexosaminidase composed of amino acids 55 to 556 in the sequence as shown in SEQ ID NO: 28 by substitution of amino acids 312 to 318 with glycine, serine, glutamic acid, proline, serine, glycine, and threonine in that order and a second amino acid sequence, which is an amino acid sequence of a signal peptide linked to the N terminus of the first amino acid.

公开(公告)号：US10371630B2

公开(公告)日：2019-08-06

申请号：US14909424

申请日：2014-07-18

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Nobukazu Ikeda ,  Michio Yamaji

IPC: G01N21/31 ,  G01N21/33 ,  G01N21/59 ,  G01N21/84 ,  G01N21/85

Abstract: An inline concentration meter includes a light source unit emitting mixed light containing at least two wavelengths with a phase difference, a detecting unit including a light incident part for entering the mixed light emitted from the light source unit into a fluid passage of a detector body and at least two light detection parts receiving the mixed light passed through the fluid passage, a computing processor unit conducting frequency analyzes of detection signals of the mixed light output from the respective light detection parts and computing variations of intensities of the detection signals corresponding to absorbances in at least two frequency ranges to compute a concentration of fluid in the fluid passage based on the variations of the intensities of the detection signals, and a recording/displaying unit recording and displaying a value of the fluid concentration computed at the computing processor unit.

公开(公告)号：US20190049368A1

公开(公告)日：2019-02-14

申请号：US16068087

申请日：2016-12-20

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Yoshihiro Deguchi

IPC: G01N21/27 ,  G01N21/39

CPC classification number: G01N21/27 ,  G01N21/031 ,  G01N21/3504 ,  G01N21/39

Abstract: A gas analysis device includes a laser light source configured to output a laser beam, an irradiation unit configured to irradiate a measurement region including measurement target gas with the laser beams in plural directions, plural photoreceivers each configured to receive a laser beam having passed through the measurement region and output an electric signal according to intensity of the received laser beam, and an analyzer configured to analyze the physical state of the measurement target gas based on the electric signal output from each photoreceiver. The analyzer sets a function (e.g. two-dimensional polynomial f(X,Y)) representing the physical state (e.g. concentration, temperature) of the target gas at least in the measurement region, and measures the physical state of the target gas by determining a coefficient of each of terms included in the function based on a measured value obtained from the electric signal output from the photoreceiver.

公开(公告)号：US20190023739A1

公开(公告)日：2019-01-24

申请号：US16070896

申请日：2017-01-16

Applicant: TOKUSHIMA UNIVERSITY ,  ONCOTHERAPY SCIENCE, INC.

Inventor： TOYOMASA KATAGIRI ,  TAKASHI MIYAMOTO ,  RIE HAYASHI

IPC: C07K7/04 ,  A61P35/00

Abstract: The present invention provides peptides containing a structure in which a portion of the dominant negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 is substituted with stapling structure(s). Peptides of the present invention have excellent cell growth inhibitory actions. Furthermore, their cell growth inhibitory actions continue for a longer time than the actions of peptides without stapling structures. Therefore, these peptides have features suitable for clinical applications in cancer therapy.

公开(公告)号：US20180311313A1

公开(公告)日：2018-11-01

申请号：US15938839

申请日：2018-03-28

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Akihito YAMAMOTO ,  Minoru UEDA ,  Kohki MATSUBARA ,  Akio SUZUMURA ,  Koichi FURUKAWA ,  Yoshihiro MATSUSHITA ,  Hirotaka WAKAYAMA ,  Nobunori TAKAHASHI ,  Shin TSUNEKAWA ,  Takako IZUMOTO

IPC: A61K38/19 ,  C12N5/0786 ,  A61K45/06 ,  A61K38/17 ,  A61K31/737

CPC classification number: A61K38/195 ,  A61K31/737 ,  A61K38/178 ,  A61K45/06 ,  C12N5/0645 ,  C12N2501/21 ,  C12N2501/59 ,  C12N2501/90 ,  A61K2300/00

Abstract: A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.

公开(公告)号：US09651467B2

公开(公告)日：2017-05-16

申请号：US14888841

申请日：2014-04-30

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Ryousuke Dohi ,  Nobukazu Ikeda ,  Kouji Nishino ,  Michio Yamaji ,  Tadayuki Yakushijin

IPC: G01N9/00 ,  G01N21/05 ,  G01N21/59 ,  G01N9/24 ,  G01N21/33 ,  G01N21/85

CPC classification number: G01N9/00 ,  G01N9/24 ,  G01N21/05 ,  G01N21/33 ,  G01N21/59 ,  G01N21/85 ,  G01N2201/08

Abstract: This invention is related to an optical-analysis-type raw material fluid density detector including a detector main body and a light oscillation unit and a light detection unit that are provided on the upper surface or the under surface of the detector main body, in which the detector main body has at least one recess formed in the upper surface and the under surface, a fluid flow path connecting a fluid inlet of the detector main body to the recess, a fluid flow path connecting the recesses to each other, and a fluid flow path connecting the recess to a fluid outlet of the detector main body; the light oscillation unit is disposed in the recess that is closest to the inlet; and light detection units are disposed in the remaining recesses.