公开(公告)号：US09586982B2

公开(公告)日：2017-03-07

申请号：US14901394

申请日：2014-06-26

Applicant: IFP ENERGIES NOUVELLES ,  UNIVERSITEIT VAN AMSTERDAM

Inventor： Pierre-Alain Breuil ,  Pierre Boulens ,  Joost Reek ,  Helene Olivier-Bourbigou

IPC: C07F9/09 ,  C07F15/04 ,  C08F4/80 ,  C07C2/36 ,  B01J31/18 ,  C07C2/32

CPC classification number: C07F15/045 ,  B01J31/00 ,  B01J31/188 ,  B01J2231/20 ,  B01J2531/847 ,  C07C2/32 ,  C07C2/36 ,  C07C2531/14 ,  C07C2531/22 ,  C07C2531/24 ,  C08F4/80 ,  C08F110/02 ,  C08F2500/02 ,  C08F110/06 ,  C07C11/107 ,  C07C11/08

Abstract: The invention describes a novel dissymmetric nickel-based complex and the method of preparation thereof from at least one diphosphinamine ligand B1 of formula (R1)(R′1)P—N(R3)—P(R2)(R′2), or an iminobisphosphine ligand B2 of formula (R3)N═P(R1)(R′1)—P(R2)(R′2). The invention also concerns the use of said complex in a method for oligomerisation of olefins.

Abstract translation: 本发明描述了一种新的不对称镍基络合物及其由式（R1）（R'1）P-N（R3）-P（R2）（R'2）的至少一种二磷酸胞嘧啶配体B1制备的方法， 或式（R3）N = P（R1）（R'1）-P（R2）（R'2）的亚氨基双膦配体B2。 本发明还涉及在烯烃低聚方法中使用所述络合物。

公开(公告)号：US20160367978A1

公开(公告)日：2016-12-22

申请号：US14901495

申请日：2014-06-26

Applicant: IFP ENERGIES NOUVELLES ,  UNIVERSITEIT VAN AMSTERDAM

Inventor： Pierre-Alain BREUIL ,  Pierre BOULENS ,  Joost REEK ,  Helene OLIVIER-BOURBIGOU

IPC: B01J31/24 ,  B01J31/14 ,  C07C2/36

Abstract: The invention describes a novel catalytic composition comprising at least one nickel precursor A with at least one diphosphinamine ligand B1 of formula (R1)(R′1)P—N(R3)—P(R2)(R′2) or an iminobisphosphine ligand B2 of formula (R3)N═P(R1)(R′1)—P(R2)(R′2) or an iminobisphosphine ligand B′2 of formula (R3)N═P(R2)(R′2)—P(R1)(R′1). The invention also describes the use of said catalytic composition in a method for the oligomerisation of olefins.

Abstract translation: 本发明描述了一种新的催化组合物，其包含至少一种镍前体A与至少一种式（R1）（R'1）P-N（R3）-P（R2）（R'2）的二核心胺配体B1或亚氨基二膦 式（R 3）N = P（R 1）（R'1）-P（R 2）（R'2）或式（R 3）的亚氨基二膦配体B'2 N = P（R 2）（R' ）-P（R1）（R'1）。 本发明还描述了所述催化组合物在烯烃低聚方法中的用途。

公开(公告)号：US09428531B2

公开(公告)日：2016-08-30

申请号：US14698500

申请日：2015-04-28

Applicant: IFP Energies nouvelles ,  Universiteit Van Amsterdam

Inventor： Pierre Boulens ,  Pierre-Alain Breuil ,  Joost Reek ,  Helene Olivier-Bourbigou

IPC: C07F15/00 ,  C07F15/04 ,  C07C2/32 ,  B01J31/18 ,  C07F9/28 ,  C07C211/65 ,  B01J31/22 ,  B01J31/24

CPC classification number: C07F15/045 ,  B01J31/1845 ,  B01J31/188 ,  B01J31/2247 ,  B01J31/2256 ,  B01J31/24 ,  B01J2231/20 ,  B01J2531/0213 ,  B01J2531/847 ,  C07C2/32 ,  C07C211/65 ,  C07C2531/22 ,  C07F9/28

Abstract: The invention describes a novel type of nickel-based complex and its preparation method. The invention also concerns the use of said complex in a process for the transformation of olefins.

Abstract translation: 本发明描述了一种新型的镍基络合物及其制备方法。 本发明还涉及所述络合物在烯烃转化方法中的用途。

公开(公告)号：US20150073389A1

公开(公告)日：2015-03-12

申请号：US14541164

申请日：2014-11-14

Applicant: AVCADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM

Inventor： Robert Antoine Francois Marie CHAMULEAU ,  Ruurdtje HOEKSTRA ,  Gerardus Adrianus Antonius NIBOURG

IPC: A61M1/36 ,  C12M1/12 ,  C12M1/00 ,  C12N5/071 ,  C12M3/00

CPC classification number: A61M1/3621 ,  C12M21/08 ,  C12M25/14 ,  C12M29/00 ,  C12N5/0671 ,  C12N2500/32 ,  C12N2500/46

Abstract: Human hepatocyte cell cultures and their use in bioreactors and bioartificial liver (BAL) systems are provided. The cells have constitutive liver-specific metabolic activity resembling that of freshly isolated human hepatocytes. The hepatocyte cells and BAL systems can be used to treat patients suffering from acute liver failure, end-stage liver disease, or acute-on-chronic liver disease.

Abstract translation: 提供人肝细胞培养物及其在生物反应器和生物人造肝（BAL）系统中的应用。 细胞具有类似于新鲜分离的人肝细胞的组成型肝特异性代谢活性。 肝细胞和BAL系统可用于治疗患有急性肝衰竭，终末期肝病或急性慢性肝病的患者。

公开(公告)号：US20140341338A1

公开(公告)日：2014-11-20

申请号：US14447088

申请日：2014-07-30

Applicant: Academisch Medisch Centrum bij de Universiteit van Amsterdam

Inventor： Cornelis Antonius Grimbergen ,  Gerard Johan Den Heeten

IPC: A61B6/00 ,  A61B6/04

CPC classification number: A61B90/17 ,  A61B6/0414 ,  A61B6/502 ,  A61B90/03 ,  A61B2090/033 ,  A61B2090/034 ,  A61B2090/036 ,  A61B2560/0406 ,  A61B2562/164 ,  A61B2576/02 ,  H05G1/02

Abstract: Mammography-apparatus for detecting malignant cells in a breast, comprising an x-ray source and an x-ray detector that cooperates with the x-ray source for providing an x-ray image of said breast, and further comprising a paddle for flattening the breast by pressing it against said x-ray detector, and comprising a contact area measuring device for measuring a contact area between the breast and the paddle, wherein the contact area measuring device is embodied with at least a first laminate of an electrically insulating material and an electrically low resistance material, which first laminate is provided on a side of the paddle facing the breast, and wherein the electrically low resistance material is sandwiched between the paddle and the insulating material.

Abstract translation: 用于检测乳房中的恶性细胞的乳房摄影装置，包括与X射线源配合的x射线源和X射线检测器，用于提供所述乳房的X射线图像，并且还包括用于使 通过将其按压在所述X射线检测器上，并且包括用于测量乳房和桨叶之间的接触面积的接触面积测量装置，其中接触面积测量装置具有至少一个电绝缘材料和 电阻低的材料，其中第一层压体设置在面向乳房的桨的一侧，并且其中电阻低的材料夹在桨和绝缘材料之间。