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公开(公告)号:US20130184333A1
公开(公告)日:2013-07-18
申请号:US13757221
申请日:2013-02-01
Applicant: University Of Bristol
Inventor: David O. Bates , Steven J. Harper
IPC: C07K14/475
CPC classification number: C07K14/475 , A61K38/1866 , A61K48/00 , C07K14/52 , C12N15/1136 , C12N2310/14 , G01N2333/475 , G01N2333/515 , G01N2333/71
Abstract: An isolated VEGF polypeptide having anti-angiogenic activity, said polypeptide including the amino acid sequence of SEQ. ID NO. 1, or variants thereof.
Abstract translation: 具有抗血管生成活性的分离的VEGF多肽,所述多肽包括SEQ ID NO:1的氨基酸序列。 证件号码。 1,或其变体。
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公开(公告)号:US20040051542A1
公开(公告)日:2004-03-18
申请号:US10612133
申请日:2003-07-02
Applicant: University of Bristol of Senate House
Inventor: Mervyn John Miles , Andrew David Laver Humphris , Jamie Kayne Hobbs
IPC: G01B005/28 , G01R031/02
CPC classification number: G01Q60/34
Abstract: A scanning probe microscope detects or induces changes in a probe-sample interaction. In imaging mode, the probe 54 is brought into a contact distance of the sample 12 and the strength of the interaction measured as the probe 54 and sample surface are scanned relative to each other. Image collection is rapidly performed by carrying out a relative translation of the sample 12 and probe 54 whilst one or other is oscillated at or near its resonant frequency. In a preferred embodiment the interaction is monitored by means of capacitance developed at an interface between a metallic probe and the sample. In lithographic mode, an atomic force microscope is adapted to write information to a sample surface.
Abstract translation: 扫描探针显微镜检测或诱导探针 - 样品相互作用的变化。 在成像模式下,将探针54置于样品12的接触距离中,并且当探针54和样品表面相对于彼此扫描时测量的相互作用的强度。 通过执行样品12和探针54的相对平移,同时一个或另一个在其谐振频率处或其附近振荡,来快速执行图像采集。 在优选实施例中,通过在金属探针和样品之间的界面处产生的电容来监测相互作用。 在光刻模式中,原子力显微镜适于将信息写入样品表面。
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公开(公告)号:US20250064975A1
公开(公告)日:2025-02-27
申请号:US18886555
申请日:2024-09-16
Applicant: The University of Bristol
Inventor: Moin Ahson Saleem-Uddin , Gavin Iain Welsh , Wen Yi Ding
Abstract: The application provides gene therapies for treating monogenic forms of nephrotic syndrome.
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公开(公告)号:US12172747B2
公开(公告)日:2024-12-24
申请号:US18250195
申请日:2021-09-29
Applicant: AIRBUS OPERATIONS LIMITED , THE UNIVERSITY OF BRISTOL
Inventor: Enzo Cosentino , Catherine Llewellyn-Jones , Gaetano Arena , Rainer Groh , Alberto Pirrera
Abstract: A flow control device on a structure such that strain in the structure is at least partially transferred to the flow control device is disclosed having at least two states, or shapes, separated by an elastic instability region. The flow control device is arranged to rapidly transition, or snap through, from the first state to the second state when strain in the structure exceeds an activation threshold of the flow control device. A spoiler on an aerofoil has a rest position where it is substantially flush with the low pressure surface and an activated position where it protrudes from the low pressure surface and modifies the airflow over that surface. The spoiler bends to move from the rest position to the activated position when the strain in the aerofoil crosses a threshold. The deployed spoiler reduces the lift on the aerofoil, acting to reduce the lift induced strain of the aerofoil to which the spoiler is attached.
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公开(公告)号:US12066661B2
公开(公告)日:2024-08-20
申请号:US18370785
申请日:2023-09-20
Applicant: PsiQuantum, Corp. , The University of Bristol
Inventor: Damien Bonneau , Mark Thompson
CPC classification number: G02B6/2861 , G02B6/262 , H01P9/00
Abstract: An optical device includes a first multi-mode waveguide, a first optical coupler coupled to the first multi-mode waveguide, the first coupler being tapered and curved, and a first single-mode waveguide having a first end coupled to the first optical coupler. The optical device may be used in an optical delay device. A method of propagating light in a first multi-mode waveguide toward a first optical coupler, propagating the light in the first optical coupler toward a first single-mode waveguide, the first optical coupler being tapered and curved, and propagating the light along the first single-mode waveguide is also disclosed.
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公开(公告)号:US20240113586A1
公开(公告)日:2024-04-04
申请号:US18264812
申请日:2022-02-07
Applicant: UNIVERSITY OF BRISTOL
Inventor: Nick SIMPSON
Abstract: An electrical winding element for an electrical machine can have a first end portion with a first single elongate conductive member; a second end portion with a second single elongate conductive member; and an intermediate portion with a plurality of intermediate conductive members arranged in an electrically parallel arrangement to conductively connect between the first end portion and the second end portion. A stator and an electrical machine are also disclosed.
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公开(公告)号:US11905594B2
公开(公告)日:2024-02-20
申请号:US17639490
申请日:2020-09-02
Applicant: The University of Bristol
Inventor: Neil Fox , Hugo Dominguez Andrade , Thomas B Scott , Edward JD Mahoney , Alexander Croot
CPC classification number: C23C16/274 , C23C16/272 , C23C16/277 , C23C16/52
Abstract: A chemical vapor deposition (CVD) process for producing diamond includes providing a CVD Growth Chamber containing a growth substrate, charging the CVD growth chamber with a source gas mixture that includes a carbon source gas, activating the gas mixture to facilitate growth of diamond on the growth substrate, and providing for a period of diamond growth in a static mode during which the gas mixture is sealed within the CVD growth chamber.
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公开(公告)号:US11905287B2
公开(公告)日:2024-02-20
申请号:US18178176
申请日:2023-03-03
Applicant: The University of Bristol
Inventor: Timothy Charles Gallagher , Hugo Rego Campello
IPC: C07D471/18 , B01J31/18 , B01J31/24
CPC classification number: C07D471/18 , B01J31/1815 , B01J31/1825 , B01J31/2409
Abstract: Disclosed are novel analogs of cytisine, a process for their preparation, pharmaceutical compositions containing them, and their use in the prevention of or treatment of CNS disorders including addictive disorders.
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公开(公告)号:US20240053464A1
公开(公告)日:2024-02-15
申请号:US18268206
申请日:2021-12-18
Applicant: The University of Bristol
Inventor: Naim Dahnoun , Han Cui
CPC classification number: G01S13/72 , G01S7/417 , G01S13/878 , G01S13/48 , G01S7/2955 , G01S7/415
Abstract: A system (100) for subject (50) detection is disclosed. The system (100) comprises a plurality of radar systems (21, 31). Each radar system (21, 31) comprises an antenna configured to transmit an electromagnetic signal and to detect reflections of the electromagnetic signal and determine a plurality of data points corresponding with the position of reflectors. The system also comprises a processor (10) configured to receive the plurality of data points from each radar system (21. 31), and to process the data points to detect and/or track a subject (50) therefrom. Each of the radar systems (21, 31) has a boresight (22, 32), corresponding with an axis of maximum antenna gain for the electromagnetic signal. The plurality of radar systems (21, 31) comprises a first radar system (21) with a first boresight (22) and a second radar system (31) with a second boresight (32). The first boresight (22) is at an angle of at least 25 degrees to the second boresight (32).
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公开(公告)号:US20230375534A1
公开(公告)日:2023-11-23
申请号:US18247865
申请日:2021-10-05
Inventor: Jeroen Raes , Sebastian Proost , Gwen Falony , Sara Manuel Araujo Vieira Da Silva , Nicholas John Timpson , David Allen Hughes
IPC: G01N33/53
CPC classification number: G01N33/5308 , G01N2800/06
Abstract: The disclosure relates to the field of the human gut microbiome, more particularly, to its effect on health and disease. Provided herein are means and methods to diagnose and treat or reduce the severity of gut flora dysbiosis as well as of gastro-intestinal inflammation and inflammation-associated disorders or conditions in a subject in need thereof.
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