公开(公告)号：US20150272922A1

公开(公告)日：2015-10-01

申请号：US14441620

申请日：2013-11-08

申请人： BIONICHE LIFE SCIENCES INC. ,  UNIVERSITY OF OTTAWA

发明人： Tony Durst ,  Zulfiquar Merali ,  Christian Cayer ,  John Thor Arnason ,  John Douglas Baker

IPC分类号： A61K31/235 ,  A61K31/19 ,  A61K31/045 ,  A61K31/215

CPC分类号： A61K31/235 ,  A61K31/045 ,  A61K31/19 ,  A61K31/215 ,  A61K31/573

摘要： A method for reducing glucocorticoids in an animal in need thereof comprising the use of compounds of the formula (I), wherein the definitions for R′, R1-R11 and n are as disclosed in the description. The compounds of formula (I) are for the treatment or prevention of a glucocorticoid-related disorder for maintaining bone density, maintaining and improving the immune system, treating Cushing's syndrome, treating obesity, improving reproduction efficiency, treating metabolic disorder, treating hypertension, treating hyperglycemia, treating insulin resistance, treating type 2 diabetes, and/or aiding in cancer and immune therapies

摘要翻译： 一种在需要的动物中减少糖皮质激素的方法，包括使用式（I）化合物，其中R'，R 1 -R 11和n的定义如说明书中所公开的。 式（I）化合物用于治疗或预防用于维持骨密​​度，维持和改善免疫系统，治疗库兴综合征，治疗肥胖症，改善生殖效率，治疗代谢紊乱，治疗高血压，治疗的糖皮质激素相关病症 治疗胰岛素抵抗，治疗2型糖尿病和/或辅助癌症和免疫疗法

公开(公告)号：US20150117333A1

公开(公告)日：2015-04-30

申请号：US14335580

申请日：2014-07-18

申请人： UNIVERSITY OF OTTAWA

发明人： Zhipeng WANG ,  Tianyu DU ,  Dimitrios MAKRAKIS ,  Hussein T. MOUFTAH

IPC分类号： H04W72/08 ,  H04W16/14

CPC分类号： H04W16/14 ,  H04L1/18

摘要： In some examples, a method may include determining whether a data packet is correctly received. In response to the data packet being correctly received, the method may include reading a received signal strength indication (RSSI) value, and based on the RSSI value, determining whether to transmit an acknowledgement (ACK) packet.

摘要翻译： 在一些示例中，方法可以包括确定数据分组是否被正确接收。 响应于正确接收到的数据分组，该方法可以包括读取接收的信号强度指示（RSSI）值，并且基于RSSI值，确定是否发送确认（ACK）分组。

公开(公告)号：US20150109008A1

公开(公告)日：2015-04-23

申请号：US14399091

申请日：2013-05-07

申请人： THE UNIVERSITY OF OTTAWA

发明人： Michel Godin ,  Eric Beamish ,  Vincent Tabard-Cossa ,  Wing Hei Kwok

IPC分类号： G01B7/00 ,  G01N33/00 ,  G01N27/04

CPC分类号： C25F3/14 ,  B01D65/02 ,  B01D67/009 ,  B01D2321/22 ,  B01D2323/42 ,  B01D2325/02 ,  B81B2203/0353 ,  B81C1/00087 ,  B82Y15/00 ,  C25F7/00 ,  G01B7/00 ,  G01N27/04 ,  G01N33/00 ,  G01N33/48721 ,  G01N2033/0095

摘要： A method is provided for precisely enlarging a nanopore formed in a membrane. The method includes: applying an electric potential across the nanopore, where the electric potential has a pulsed waveform oscillating between a high value and a low value; measuring current flowing though the nanopore while the electric potential is being applied to the nanopore at a low value; determining size of the nanopore based in part on the measured current; and removing the electric potential applied to the membrane when the size of the nanopore corresponds to a desired size.

摘要翻译： 提供了一种精确地扩大形成在膜中的纳米孔的方法。 该方法包括：在纳米孔上施加电位，其中电位具有在高值和低值之间振荡的脉冲波形; 测量流过纳米孔的电流，同时电位以低值施加到纳米孔; 部分地基于测量的电流确定纳米孔的尺寸; 并且当纳米孔的尺寸对应于期望的尺寸时去除施加到膜的电势。

公开(公告)号：US20150005267A1

公开(公告)日：2015-01-01

申请号：US14489834

申请日：2014-09-18

申请人： UNIVERSITY OF OTTAWA

发明人： Tony Durst ,  Zulifiquar Merali ,  John T. Arnason ,  E. Pablo Sanchez-Vindas ,  Luis J. Poveda-Alvarez

IPC分类号： C07J53/00 ,  A61K36/185 ,  A61K31/565

CPC分类号： C07J53/002 ,  A61K31/16 ,  A61K31/19 ,  A61K31/215 ,  A61K31/40 ,  A61K31/56 ,  A61K31/565 ,  A61K31/58 ,  A61K36/185 ,  A61K36/45 ,  A61K2300/00

摘要： Pharmaceutical compositions for preventing or treating anxiety, comprising betulinic acid or derivatives thereof are provided. Methods for preventing or treating anxiety with betulinic acid or derivatives thereof are also provided. The invention further provides betulinic-acid containing preparations of plants of the family Marcgraviaceae having anxiolytic activity and methods for making such extracts and using them to prevent or treat anxiety in a subject.

摘要翻译： 提供了用于预防或治疗焦虑症的药物组合物，其包含桦木酸或其衍生物。 还提供了用桦木酸或其衍生物预防或治疗焦虑症的方法。 本发明还提供具有抗焦虑活性的具有抗焦虑活性的马克鞭科科植物的含桦木酸的制剂，以及制备这些提取物的方法，并且使用它们来预防或治疗受试者的焦虑。

公开(公告)号：US12072508B2

公开(公告)日：2024-08-27

申请号：US17165810

申请日：2021-02-02

申请人： UNIVERSITY OF OTTAWA

发明人： Jeffrey Stephen Lundeen ,  Robert William Boyd ,  Orad Reshef ,  Michael Patrick Delmastro ,  Ali Hussain H Alhulaymi ,  Lambert Giner ,  Katherine Karla Misaye Bearne ,  Jordan Theodore Roger Pagé

IPC分类号： G02B1/00 ,  G02B5/30 ,  G02B7/28 ,  G02B27/09 ,  G02B27/10 ,  G02B27/16

CPC分类号： G02B27/1006 ,  G02B7/28 ,  G02B27/0938 ,  G02B27/16 ,  G02B1/002 ,  G02B5/3083

摘要： Described are various embodiments of space-compressing methods, materials, devices, and systems, and imaging or optical devices and systems using same. In one embodiment, an optical system comprises an optical convergence element having a defined optical path convergence distance and disposed so to produce converging optical rays along an optical convergence path to converge at said distance; an optical space-compression medium disposed along the optical convergence path to intersect the converging optical rays to compress a resulting optical convergence distance by imparting an inward transverse translation of the converging optical rays while substantially maintaining respective incident convergence angles upon output.

公开(公告)号：US11696960B2

公开(公告)日：2023-07-11

申请号：US16482492

申请日：2018-02-05

申请人： UNIVERSITY OF OTTAWA

发明人： Adam Shuhendler ,  Mojmir Suchy ,  Trina Dang

IPC分类号： A61K49/10 ,  A61K51/04 ,  C07C251/76 ,  C07C309/46

CPC分类号： A61K49/10 ,  A61K51/04 ,  C07C251/76 ,  C07C309/46

摘要： Methods of detecting an aldehyde-containing compound in a subject or in a sample from a subject are described herein, comprising administering an aldehyde-binding compound of Formula I to the subject, or combining such a compound with the sample; and detecting the product of the compound of Formula I and the aldehyde-containing compound. Detection of the product may involve imaging, such as MRI, CEST-MRI or positron emission tomography (PET) imaging; or may involve fluorescence or an electrochemical detection method. Biologically relevant aldehydes detected according to the described method can be used to monitor conditions such as brain injury, neurodegenerative disorders such as Alzheimer's disease, diabetes, heart disease, and cancer.

公开(公告)号：US20230115964A1

公开(公告)日：2023-04-13

申请号：US17899230

申请日：2022-08-30

申请人： University of Ottawa

发明人： Arnaud Weck ,  Xitong Xie ,  Jaspreet Walia

IPC分类号： B21D37/20 ,  B23K26/364 ,  G01B11/02

摘要： Systems and methods described for embossing micro-scale features are provided. On various substrates. Micro-scaled features can contain nanometer to micrometer structural features. Various embodiments may relate to methods and systems that may allow substrates, non-limiting examples of which may include metals such as silver, copper, tin, gold, or the like, to be embossed to diffract light into various colors that can be refracted at various perspective angles. High-quality grooves can be machined down to the sub-micron or nanometer regime to generate embossment moulds for fast, single-step, repeated (e.g. in the order of tens to thousands) replication of gratings on bulk metallic substrates using a same embossing die without significant loss of embossing quality.

公开(公告)号：US20220016317A1

公开(公告)日：2022-01-20

申请号：US17488454

申请日：2021-09-29

申请人： University of Ottawa

发明人： Andrew Edward PELLING ,  Charles Michel CUERRIER ,  Daniel J. MODULEVSKY ,  Ryan Joseph HICKEY

IPC分类号： A61L27/36 ,  A61L27/38 ,  A61L27/60 ,  A61L27/50 ,  A61L27/52 ,  C12N5/00 ,  A61L27/54

摘要： Provided herein are scaffold biomaterials comprising a decellularised fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularised fungal tissue comprising a cellulose- or chitin-based 3-dimensional porous structure. Methods for preparing such scaffold biomaterials, as well as uses thereof as an implantable scaffold for supporting animal cell growth, for promoting tissue regeneration, for promoting angiogenesis, for a tissue replacement procedure, and/or as a structural implant for cosmetic surgery are also provided. Therapeutic treatment and/or cosmetic methods employing such scaffolds are additionally described.

公开(公告)号：US20210288202A1

公开(公告)日：2021-09-16

申请号：US17337875

申请日：2021-06-03

申请人： THE UNIVERSITY OF OTTAWA

发明人： Christopher E. VALDIVIA ,  Karin HINZER

IPC分类号： H01L31/05 ,  H01L31/043 ,  H01L31/0735 ,  H01L31/18

摘要： A photovoltaic device comprises at least two sub-cells, at least one connecting element electrically connecting adjacent sub-cells to one another, each sub-cell comprising: at least one segment; and at least one connecting element electrically connecting adjacent segments to one another in the event that a sub-cell has more than one segment; each one of the sub-cells having a unique bandgap and being arranged such that bandgaps of the sub-cells are in descending order with respect to a light incident surface of the photovoltaic device, each sub-cell being designed such that all segments of the photovoltaic device produce approximately the same current.

公开(公告)号：US20210163550A1

公开(公告)日：2021-06-03

申请号：US16954149

申请日：2018-12-14

申请人： University of Ottawa

发明人： Derrick GIBBINGS

IPC分类号： C07K14/47 ,  C07K16/18 ,  C07K14/705 ,  A61K45/06 ,  A61K38/17 ,  A61K39/395

摘要： Provided herein are fusion constructs including a biologically active agent such as an antibody or derivative thereof which is functionally linked with a functional moiety such as an LC3 protein or portion thereof. Also provided are compositions and exosomes including such constructs, as well as methods for preparing exosomes containing such constructs, and methods for delivering such constructs to cells. Methods and uses of such constructs and exosomes for treating diseases or disorders are also provided, in which the constructs trigger autophagy of disease-related cellular or cytoplasmic targets such as misfolded/aggregated proteins in neurodegenerative diseases, for example.