公开(公告)号：US20220395611A1

公开(公告)日：2022-12-15

申请号：US17774875

申请日：2020-12-18

申请人： Spiderwort Inc. ,  University of Ottawa

发明人： Maxime LEBLANC LATOUR ,  Ryan HICKEY ,  Charles M. CUERRIER ,  Andrew E. PELLING ,  Maryam TARAR ,  Isabelle CATELAS

IPC分类号： A61L27/36 ,  A61L27/52 ,  A61L27/24 ,  A61L27/20 ,  A61L27/38 ,  A61L27/12 ,  A61L27/04 ,  A61L27/10

摘要： Provided herein are scaffold biomaterials including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure; wherein the decellularized plant or fungal tissue may optionally be at least partially coated or mineralized, wherein the scaffold biomaterial may optionally further include a protein-based hydrogel and/or a polysaccharide-based hydrogel, or both. Also provided herein are methods and uses of such scaffold biomaterials, including methods of manufacture as well as methods and uses for bone tissue engineering, for example.

公开(公告)号：US20210395787A1

公开(公告)日：2021-12-23

申请号：US17285654

申请日：2019-10-15

申请人： University of Ottawa

发明人： Kristin Baetz ,  Eugene Fletcher

IPC分类号： C12P7/24 ,  C12N1/18

摘要： Embodiments provide a modified microbe capable of growing in or fermenting a solution, or lignocellulosic hydrolysate, comprising ferulic acid and/or coniferyl aldehyde. The microbe has one or more modifications to provide: (a) a decrease in copy number or expression of a BNA7 gene; (b) an increase in copy number or expression of one or more pentose phosphate pathway genes; and/or (c) localization of one or more products of the pentose phosphate pathway genes to the mitochondria or endoplasmic reticulum. Also provided is a microbe having modified expression or copy number of BNA7 and/or one or more of the pentose phosphate pathway genes. The pentose phosphate pathway genes may in certain embodiments be selected from at least one of ZWF1, TKL1, RPE1 and GND1. Also provided is a method for fermenting a substrate comprising ferulic acid and/or coniferyl aldehyde to produce a fermentation product.

公开(公告)号：US20210239995A1

公开(公告)日：2021-08-05

申请号：US17165810

申请日：2021-02-02

申请人： UNIVERSITY OF OTTAWA

发明人： Jeffrey Stephen Lundeen ,  Robert William Boyd ,  Orad Reshef ,  Michael Patrick Delmastro ,  Ali Hussain H. Alhulaymi ,  Lambert Giner ,  Katherine Karla Misaye Bearne ,  Jordan Theodore Roger PAGÉ

IPC分类号： G02B27/10 ,  G02B7/28 ,  G02B27/16

摘要： Described are various embodiments of space-compressing methods, materials, devices, and systems, and imaging or optical devices and systems using same. In one embodiment, an optical system comprises an optical convergence element having a defined optical path convergence distance and disposed so to produce converging optical rays along an optical convergence path to converge at said distance; an optical space-compression medium disposed along the optical convergence path to intersect the converging optical rays to compress a resulting optical convergence distance by imparting an inward transverse translation of the converging optical rays while substantially maintaining respective incident convergence angles upon output.

公开(公告)号：US10894777B2

公开(公告)日：2021-01-19

申请号：US16093751

申请日：2017-04-13

申请人： UNIVERSITY OF OTTAWA ,  UNIVERSITY OF MARYLAND, BALTIMORE ,  UNIVERSITY OF ROCHESTER

发明人： Jeffrey W. Keillor ,  Abdullah Akbar ,  Richard L. Eckert ,  Matthew Fisher ,  Gail V. W. Johnson

IPC分类号： A61K31/4965 ,  C07D295/10 ,  C07D241/04 ,  C07C317/36 ,  C07D405/06

摘要： There are provided Tissue Transglutaminase (TG2) inhibitor compounds, and compositions and methods of use thereof for the prevention or treatment of a cancer. Compounds of Formula I, and pharmaceutically acceptable salts thereof, are provided:

公开(公告)号：US20200325593A1

公开(公告)日：2020-10-15

申请号：US16907897

申请日：2020-06-22

申请人： THE UNIVERSITY OF OTTAWA

发明人： Vincent TABARD-COSSA ,  Michel GODIN ,  Radin TAHVILDARI ,  Eric BEAMISH

IPC分类号： C25F7/00 ,  C25F3/14 ,  G01N33/487 ,  B81B3/00 ,  G01N27/40 ,  G01N27/447

摘要： Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethylsiloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.

公开(公告)号：US10759683B2

公开(公告)日：2020-09-01

申请号：US16031660

申请日：2018-07-10

申请人： University of Ottawa

发明人： Alexandre Poulain ,  Daniel Grégoire

IPC分类号： C02F1/62 ,  C02F1/70 ,  C02F3/34 ,  C02F101/20

摘要： Provided herein are methods for removing mercury contaminant from an aqueous solution, the methods including: providing an aqueous solution, the aqueous solution being contaminated with at least trace amounts of an oxidized mercury species; culturing a photoheterotrophic or fermentative heterotrophic bacteria in the aqueous solution under anaerobic conditions in which the bacteria reduce the oxidized mercury species to elemental mercury (Hg0), wherein the bacteria comprises one or more bacteria of the order Clostridiales; and removing the elemental mercury from the aqueous solution. Also provided are bioreactors for removing mercury contaminant from an aqueous solution, as well as uses of photoheterotrophic or fermentative heterotrophic bacteria, wherein the bacteria comprises one or more bacteria of the order Clostridiales, for removing mercury contaminant from an aqueous solution.

公开(公告)号：US10721954B2

公开(公告)日：2020-07-28

申请号：US15971406

申请日：2018-05-04

申请人： University of Ottawa

发明人： Chantal Matar ,  Luc J. Martin

IPC分类号： A23L33/105 ,  A21D8/04 ,  A61K8/99 ,  A61K35/74 ,  A61K36/45 ,  A61K36/87 ,  A61Q19/00 ,  C12G1/022 ,  C12P1/04 ,  C12R1/425 ,  A23L33/135 ,  A61K31/192 ,  C12P7/40 ,  C12R1/01 ,  A61K9/00 ,  C12P7/22

摘要： Bacterial strains are provided that can be isolated from the microflora of lowbush blueberry (Vaccinium angustifolium), and that are capable of increasing the antioxidant content of their growth medium. The bacteria can be used, for example, to increase the antioxidant content of various foodstuffs, as probiotics or as additives to animal feed. Antioxidant-enriched compositions produced by fermentation processes utilizing the bacteria are also provided. The antioxidant-enriched compositions can be used in the preparation of cosmetics and nutritional supplements. The antioxidant-enriched compositions also have therapeutic applications.

公开(公告)号：US20200216918A1

公开(公告)日：2020-07-09

申请号：US16650895

申请日：2018-04-27

申请人： University of Ottawa

发明人： Marc-Andre LANGLOIS ,  Vera TANG ,  Tyler Milston RENNER

IPC分类号： C12Q1/6897 ,  G01N15/10 ,  G01N15/14 ,  C12Q1/70 ,  C12N15/86

摘要： Described herein are uses of fluorescent enveloped virus particles as standards in nanoscale flow cytometry applications. The virus particles comprise a fluorescent dye or a fluorescent protein. A standard ladder comprising a plurality of fluorescent enveloped virus particles of different sizes is also provided. The standards may also comprise marker(s) of interest, and may be used as controls for detection of other viruses or extracellular vesicle, e.g. in diagnostic applications. Methods of producing controls for such applications are provided, including those having desired profiles. The controls may be used for enumeration of markers on microparticles (e.g. extracellular vesicles or viruses). Also described is a modified gammaretrovirus comprising a mutation that abolishes expression of the viral glyco-Gag protein, and having a fluorescent protein inserted in-frame into the proline-rich region (PRR) of the viral env protein. The gammaretrovirus may be M-MLV bearing a mutation that abolishes expression of the glyco-Gal protein, gPr80.

公开(公告)号：US20190350298A1

公开(公告)日：2019-11-21

申请号：US16429374

申请日：2019-06-03

申请人： UNIVERSITY OF OTTAWA

发明人： Thomas Blaine Hoshizaki ,  Andrew Michael Post ,  Philippe Rousseau

IPC分类号： A42B3/12 ,  A42B3/06

摘要： Safety head wear for use for example in high risk activities such as sports and industrial purposes where protection from head injuries is required. Components are provided inserted between the liner and outer shell and consists of two parts; a chamber or bladder and a fluid or gel like material. The fluid or gel material is contained in the chamber or bladder and is positioned in such a way to create low friction between the surface of the shell and liner or liner and head. It can also be used on the outer surface of the shell or placed within two layers of the liner. The device provides a method of independently managing both compression and shear force characteristics of the helmet around the head designed to decrease brain trauma resulting from high linear and angular acceleration during impacts to the helmet.

公开(公告)号：US20190150494A1

公开(公告)日：2019-05-23

申请号：US16267503

申请日：2019-02-05

申请人： University of Ottawa

发明人： Chantal Matar ,  Luc J. Martin

IPC分类号： A23L33/105 ,  C12P7/22 ,  A21D8/04 ,  A61K9/00 ,  A61K8/99 ,  A23L33/135 ,  C12R1/01 ,  C12P7/40 ,  A61K31/192 ,  C12R1/425 ,  C12P1/04 ,  C12G1/02 ,  A61Q19/00 ,  A61K36/87 ,  A61K36/45 ,  A61K35/74

摘要： Bacterial strains are provided that can be isolated from the microflora of lowbush blueberry (Vaccinium angustifolium), and that are capable of increasing the antioxidant content of their growth medium. The bacteria can be used, for example, to increase the antioxidant content of various foodstuffs, as probiotics or as additives to animal feed. Antioxidant-enriched compositions produced by fermentation processes utilising the bacteria are also provided. The antioxidant-enriched compositions can be used in the preparation of cosmetics and nutritional supplements. The antioxidant-enriched compositions also have therapeutic applications.