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    MINIATURE LINEAR VIBROTACTILE ACTUATOR
    51.
    发明申请
    MINIATURE LINEAR VIBROTACTILE ACTUATOR 审中-公开
    微型线性振动致动器

    公开(公告)号：US20140346901A1

    公开(公告)日：2014-11-27

    申请号：US14366572

    申请日：2012-12-19

    申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

    发明人： Vincent Hayward ,  Amir Berrezag ,  George Dietz

    IPC分类号： H02K33/00 ,  H02K15/14 ,  H02K15/06

    摘要： The invention relates to a miniature linear vibrotactile actuator comprising: a first element 14, 104 of generally cylindrical shape, comprising permanent magnets 15, 105 aligned so that two adjacent sides of two adjacent magnets 15, 105 have identical polarities; a second element 11, 101 defining a cylindrical cavity 12, 102 into which the first element 14, 104 is inserted with play so as to be able to slide therein in a sliding direction X2, the second element 11, 101 comprising coils 13, 103 of conductive wire having strands that extend perpendicularly to the sliding direction X2, in order to form magnetic force generators, and that are placed so as to be able to influence the first element 14, 104 electromagnetically; and means 25, 41, 125 for returning and guiding the first element 14, 104 toward an equilibrium position in the second element 11, 101, in which position a median plane P2 between two adjacent magnets substantially coincides with a median plane P1 of a facing force generator 111.

    摘要翻译： 本发明涉及一种微型线性振动触觉致动器，其包括：大致圆柱形形状的第一元件14,104，包括永磁体15,105，其被排列成使得两个相邻磁体15,105的两个相邻侧具有相同的极性; 限定圆柱形腔12,102的第二元件11,101，第一元件14,104以滑动方向X2插入其中以便能够在其中滑动到其中，第二元件11,101包括线圈13,103 的导线，其具有垂直于滑动方向X2延伸的线束，以形成磁力发生器，并被放置成能够以电磁方式影响第一元件14,104; 以及用于将第一元件14,104朝向第二元件11,101中的平衡位置返回和引导的装置25,41,125，其中两个相邻磁体之间的中间平面P2基本上与面对面的中间平面P1重合 力发生器111。

    PRODUCTS USEFUL FOR THE TREATMENT OF MALIGNANT NEOPLASMS OF THE HUMAN NERVOUS SYSTEM
    52.
    发明申请
    PRODUCTS USEFUL FOR THE TREATMENT OF MALIGNANT NEOPLASMS OF THE HUMAN NERVOUS SYSTEM 有权
    用于治疗人神经系统恶性肿瘤的产品

    公开(公告)号：US20140302123A1

    公开(公告)日：2014-10-09

    申请号：US14350005

    申请日：2012-10-11

    申请人： Institut Pasteur ,  Universite Pierre Et Marie Curie (Paris 6) ,  Centre National de la Recherche Scientifique

    发明人： Nicolas Wolfe ,  Monique Lafon ,  Nicolas Babault

    IPC分类号： C07K7/08 ,  A61K9/127 ,  A61K45/06 ,  A61K38/10

    CPC分类号： C07K7/08 ,  A61K9/127 ,  A61K38/10 ,  A61K45/06 ,  C07K14/005 ,  C07K14/705 ,  C12N2760/20122 ,  C12N2760/20133

    摘要： The application provides products, which may trigger pro-apoptotic or pro-death effects on neoplastic cells and/or tissues of the human nervous system, more particularly on neoplastic cells and/or tissues of the human CNS. The products of the application can be used as anti-proliferative or tumoricid agents in the treatment and/or palliation and/or prevention of neoplasms of the human nervous system, more particularly of glioblastoma or brain stem glioma. Therefore, the application also relates to compositions, such as pharmaceutical compositions or drugs, which comprise at least one of said products, as well as to the biotechnological and medical applications of said products and compositions.

    摘要翻译： 该应用提供的产品可以触发对人类神经系统的肿瘤细胞和/或组织的促凋亡或死亡作用，更特别地涉及人CNS的肿瘤细胞和/或组织。 该应用的产品可用作抗增殖剂或肿瘤剂，用于治疗和/或缓解和/或预防人类神经系统肿瘤，尤其是胶质母细胞瘤或脑干胶质瘤。 因此，本申请还涉及包含至少一种所述产品的组合物，例如药物组合物或药物，以及所述产品和组合物的生物技术和医学应用。

    USE OF COUMARIN DERIVATIVES FOR THE PREPARATION OF DRUGS FOR TREATING SKIN DISEASES
    53.
    发明申请
    USE OF COUMARIN DERIVATIVES FOR THE PREPARATION OF DRUGS FOR TREATING SKIN DISEASES 有权
    用于制备用于治疗皮肤疾病的药物的欧马林衍生物的使用

    公开(公告)号：US20140148480A1

    公开(公告)日：2014-05-29

    申请号：US14155633

    申请日：2014-01-15

    申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

    发明人： Michele REBOUD-RAVAUX ,  Chahrazade YERROUM-EL AMRI ,  Xiao TAN ,  Lixian QIN ,  Maurice PAGANO ,  Alain HOVNANIAN ,  Laetitia FURIO ,  Bernard PIROTTE

    IPC分类号： C07D311/12 ,  C07D405/12 ,  C07D311/14

    CPC分类号： A61K31/37 ,  A61K31/4433 ,  A61K31/4725 ,  C07D311/12 ,  C07D311/14 ,  C07D405/12

    摘要： A compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting of hydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a —O—R12 group, wherein R12 is a C1-C7 alkyl, a group —CH2—O—CO—R5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group —O—R13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a —CH2— amine, R′1 represents a group chosen among hydrogen and —O—R14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for the treatment of pathologies involving excess activity of at least one member of the kallikrein family.

    摘要翻译： 式（I-1）的化合物，其中n等于0或1，Z表示O或S，R1表示选自氢，C1-C7烷基，被取代或未被卤素取代的一个基团，羟基 或-O-R 12基团，其中R 12是C 1 -C 7烷基，基团-CH 2 -O-CO-R 5，其中R 5选自氢原子和C 1 -C 7烷基，被至少一个卤素 ，基团-O-R13，其中R13选自氢和C1-C7烷基，胺或-CH2-胺，R'1表示选自氢和-O-R14中的基团，其中R14选自 氢和C 1 -C 7烷基，R 2选自C 1 -C 7烷基，C 3 -C 6环烷基，芳基和杂芳基，用于治疗涉及至少一种成员的过量活性的病态 的激肽释放酶家族。