公开(公告)号：US20230126400A1

公开(公告)日：2023-04-27

申请号：US17821006

申请日：2022-08-19

Applicant: Alector LLC

Inventor： Philip KONG ,  Herve RHINN ,  Tina SCHWABE ,  Angie YEE ,  Ilaria TASSI ,  Muhammad Abbas ALHAWAGRI ,  Arnon ROSENTHAL

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc.. that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220348656A1

公开(公告)日：2022-11-03

申请号：US17836707

申请日：2022-06-09

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Michael KURNELLAS ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20220251190A1

公开(公告)日：2022-08-11

申请号：US17459835

申请日：2021-08-27

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Francesca AVOGADRI-CONNORS ,  Seung-Joo LEE ,  William MONTEITH ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210261685A1

公开(公告)日：2021-08-26

申请号：US17118921

申请日：2020-12-11

Applicant: Alector LLC

Inventor： Seung-Joo LEE ,  Spencer LIANG ,  Angie YEE ,  Marina ROELL ,  Arnon ROSENTHAL

IPC: C07K16/40 ,  C07K16/28 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK or human MerTK, and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20200339680A1

公开(公告)日：2020-10-29

申请号：US16959081

申请日：2018-12-21

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Eric BROWN ,  Tina SCHWABE ,  Angie YEE ,  Herve RHINN

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20200277374A1

公开(公告)日：2020-09-03

申请号：US16792040

申请日：2020-02-14

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Francesca AVOGADRI-CONNORS ,  William MONTEITH

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190233496A1

公开(公告)日：2019-08-01

申请号：US16121297

申请日：2018-09-04

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL

IPC: C07K14/725 ,  C07K14/715 ,  C12N5/00 ,  A61P25/28 ,  C07K14/47 ,  C07K16/18 ,  C07K14/705 ,  A61K39/00

CPC classification number: C07K14/7051 ,  A01K2227/105 ,  A01K2267/0312 ,  A61K35/15 ,  A61K38/00 ,  A61K39/0007 ,  A61K48/00 ,  A61K48/005 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61P25/28 ,  C07K14/4711 ,  C07K14/70517 ,  C07K14/7153 ,  C07K16/18 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33 ,  C12N5/00 ,  C12N2740/16043

Abstract: The present disclosure is related to compositions that include polynucleotides encoding chimeric receptors, methods of delivering polynucleotides encoding chimeric receptors to immune cells, and methods of using immune cells encoding chimeric receptors to treat or prevent a neurological disease, disorder, or injury.

公开(公告)号：US20190127475A1

公开(公告)日：2019-05-02

申请号：US15999627

申请日：2018-08-20

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS

IPC: C07K16/28 ,  A61K31/7088

CPC classification number: C07K16/2863 ,  A61K31/7088 ,  C07K16/286 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/32

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190085076A1

公开(公告)日：2019-03-21

申请号：US15735946

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Kate MONROE ,  Francesca AVOGADRI-CONNORS

IPC: C07K16/28 ,  C12N15/62 ,  C12N15/85 ,  A61K47/68 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20180265586A1

公开(公告)日：2018-09-20

申请号：US15867609

申请日：2018-01-10

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K31/7088 ,  C07K16/286 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/32

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.