公开(公告)号：US20140206614A1

公开(公告)日：2014-07-24

申请号：US14221193

申请日：2014-03-20

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Wouter E. Roorda ,  Stephen D. Pacetti

IPC: A61K9/14 ,  A61K38/18 ,  A61K31/727 ,  A61K31/573

CPC classification number: A61K9/14 ,  A61K9/1617 ,  A61K9/1647 ,  A61K9/1658 ,  A61K9/1694 ,  A61K31/573 ,  A61K31/727 ,  A61K38/1825 ,  A61K47/26 ,  A61K47/36 ,  A61K48/00

Abstract: Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.

Abstract translation: 提供使用组合物的组合物和方法，用于在解剖腔的一个区域内形成一个临时期的栓塞，以达到治疗效果。

公开(公告)号：US20140161862A1

公开(公告)日：2014-06-12

申请号：US14182211

申请日：2014-02-17

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Lothar W. Kleiner ,  Syed F.A. Hossainy ,  Mikael Trollsas ,  Stephen D. Pacetti

IPC: A61L31/10

CPC classification number: A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.

Abstract translation: 本发明提供了一种用于可植入装置的可吸收涂层及其制造和使用方法。

公开(公告)号：US20140154400A1

公开(公告)日：2014-06-05

申请号：US14155217

申请日：2014-01-14

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yung-Ming Chen ,  Jason Van Sciver ,  Syed F.A. Hossainy ,  Stephen D. Pacetti

IPC: A61F2/91 ,  B05D1/38 ,  B05D3/04

CPC classification number: B29C65/76 ,  A61F2/82 ,  A61F2/86 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/00389 ,  A61L31/14 ,  A61L31/148 ,  A61L2420/02 ,  B05D1/38 ,  B05D3/0254 ,  B05D3/0473 ,  B29C65/10 ,  B29K2067/046 ,  B29K2105/258 ,  B29L2031/7534

Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.

Abstract translation: 本文描述了用于涂覆支架的方法的各种实施例。 公开了将包含聚合物组分和溶剂的组合物施用到支架基底，然后将聚合物组分暴露于等于或大于聚合物组分的Tg的温度。 重复施加和暴露一次或多次以形成涂层，结果是在最终曝光步骤之后涂层的溶剂含量处于适合成品支架的水平​​。

公开(公告)号：US20140147686A1

公开(公告)日：2014-05-29

申请号：US14168806

申请日：2014-01-30

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L31/06 ,  Y10T428/31725 ,  C08L77/12

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, and the coatings comprise biologically absorbable poly(ester amides).

公开(公告)号：US20140033504A1

公开(公告)日：2014-02-06

申请号：US14053019

申请日：2013-10-14

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Cameron K. Kerrigan

IPC: A61F2/91

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2250/0068 ,  B33Y80/00 ,  Y10T29/49826

Abstract: A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.

Abstract translation: 用于管腔内药物递送的假体可以包括形成管状支架结构的多个互连的支柱。 支柱包括具有被构造成保持生物可吸收储库的内表面的通孔。 生物可吸收贮库包括在植入时水解降解的药物 - 聚合物组合物。 通孔的内表面可以是一个完全平滑和连续的凹或凸的区域，没有几何不连续。 通孔的内表面可以包括任何数量的收缩和扩张区域，以形成仔细选择以与生物可吸收储库的相应几何特征接合的尺寸和形状的凹槽。

公开(公告)号：US20130330393A1

公开(公告)日：2013-12-12

申请号：US13968263

申请日：2013-08-15

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61L31/04 ,  A61L31/16

CPC classification number: A61L31/048 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08F214/18 ,  C08F295/00 ,  C09D127/16 ,  C08L27/12 ,  A61K31/10

Abstract: It is provided a method of treating a disorder, the method comprising implanting in a patient an implantable device including a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer.

Abstract translation: 提供了一种治疗病症的方法，该方法包括在患者体内植入包括由氟化单体和烃单体形成的聚合物和另一生物相容性聚合物的可植入装置。

公开(公告)号：US20130330392A1

公开(公告)日：2013-12-12

申请号：US13967262

申请日：2013-08-14

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61L31/04 ,  A61L31/16 ,  A61K31/436

CPC classification number: A61L31/048 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08F214/18 ,  C08F295/00 ,  C09D127/16 ,  C08L27/12 ,  A61K31/10

Abstract: It is provided an implantable device including a polymer blend that contains a polymer formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer.

Abstract translation: 提供了一种可植入装置，其包括聚合物共混物，其包含由氟化单体和烃单体形成的聚合物和另一种生物相容性聚合物。

公开(公告)号：US20130190725A1

公开(公告)日：2013-07-25

申请号：US13741099

申请日：2013-01-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Stephen D. Pacetti ,  Binh Nguyen

IPC: A61M25/10

CPC classification number: A61M25/104 ,  A61B17/320725 ,  A61M25/10 ,  A61M2025/1004 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/109

Abstract: Medical device includes a tubular member having a proximal end and distal end defining a longitudinal axis therebetween, an expandable member proximate the distal end of the tubular member having at least one axial fold in a deflated condition, a tissue engaging member comprising at least one straight wire extending along at least part of the longitudinal axis of the expandable member, and a therapeutic agent disposed on at least the expandable member or the tissue engaging member. The at least one straight wire of the tissue engaging member is located inside the at least one fold of the expanded member when in the deflated condition. The tissue engaging member is configured for deployment at a select location upon inflation of the expandable member. A method of delivering a therapeutic agent is also provided.

Abstract translation: 医疗装置包括：管状构件，其具有限定其间的纵向轴线的近端和远端;靠近所述管状构件的远端的可扩张构件，其具有处于放气状态的至少一个轴向折叠;组织接合构件，包括至少一个直的 沿着可扩张构件的纵向轴线的至少一部分延伸的线，以及设置在至少可扩张构件或组织接合构件上的治疗剂。 当处于放气状态时，组织接合构件的至少一条直线位于膨胀构件的至少一个折叠内侧。 组织接合构件构造成在可膨胀构件膨胀时在选择位置展开。 还提供了递送治疗剂的方法。

公开(公告)号：US10155599B2

公开(公告)日：2018-12-18

申请号：US14557057

申请日：2014-12-01

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: B65B3/00 ,  A61K31/573 ,  A61K31/436 ,  B05D1/00 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61F2/91

Abstract: A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and wherein at a temperature of 30° C. and at one atmosphere, the composition may be in a solid state or semi-solid state.

公开(公告)号：US20180093020A1

公开(公告)日：2018-04-05

申请号：US15832450

申请日：2017-12-05

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Lothar W. Kleiner ,  Syed F.A. Hossainy ,  Mikael Trollsas ,  Stephen D. Pacetti

IPC: A61L31/14 ,  A61L31/10 ,  A61L31/16 ,  C08L67/04

CPC classification number: A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.