公开(公告)号：US08016774B2

公开(公告)日：2011-09-13

申请号：US11317912

申请日：2005-12-22

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

IPC: A61B5/00

CPC classification number: A61M5/46 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M5/158 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905 ,  G01N33/557 ,  G06F19/00

Abstract: An agent injection device is provided that is capable of injecting an agent to a known predetermined tissue depth. An injection member has an elongate injection shaft with an outlet port configured to dispense an agent at a controllable time. A controllable driver is coupled to the elongate injection shaft and is configured to drive the injection member into target tissue. A velocity control system is in communication with the controllable driver and is configured to control the velocity of the elongate injection shaft.

Abstract translation: 提供了能够将药剂注射到已知的预定组织深度的药剂注射装置。 注射构件具有细长注射轴，其具有配置成在可控制时间分配药剂的出口端口。 可控制的驱动器联接到细长注射轴并被构造成将注射构件驱动到靶组织中。 速度控制系统与可控驱动器连通，并被配置成控制细长注射轴的速度。

公开(公告)号：US07988644B2

公开(公告)日：2011-08-02

申请号：US11688927

申请日：2007-03-21

Applicant: Dominique Freeman ,  Don Alden ,  Dirk Boecker ,  Michael Cane ,  Matt Schumann ,  Michael Beadman

Inventor： Dominique Freeman ,  Don Alden ,  Dirk Boecker ,  Michael Cane ,  Matt Schumann ,  Michael Beadman

IPC: A61B5/00

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61M37/0015

Abstract: A device for use with a gripper is provided. A cartridge is provided that defines a plurality of cavities. A plurality of penetrating members are at least partially contained in the cavities of the cartridge. The penetrating members are slidably movable to extend outward from the cartridge to penetrate tissue. Each cavity has a longitudinal opening that provides access to an elongate portion of the penetrating member. A sterility barrier is coupled to the cartridge. The sterility barrier covers a plurality of the longitudinal openings. The sterility barrier is configured to be moved so that the elongate portion is accessed by the gripper without touching the barrier.

公开(公告)号：US07959582B2

公开(公告)日：2011-06-14

申请号：US11689375

申请日：2007-03-21

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a single drive force generator. A plurality of penetrating members are operatively coupled to the force generator. The force generator moves each of the members along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A flexible support member couples the penetrating members to define a linear array. The support member is movable and configured to move each of the penetrating members to a launch position associated with the force generator. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.

公开(公告)号：US07833171B2

公开(公告)日：2010-11-16

申请号：US11674191

申请日：2007-02-13

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A cartridge houses the penetrating member. The cartridge has first and second seals coupled to the penetrating member to maintain a sterile environment around a portion of the penetration member prior to penetrating member actuation. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.

Abstract translation: 本发明的这些和其它目的是在包括电动驱动力发生器的组织部位上使用的体液取样系统中实现的。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 墨盒容纳穿透构件。 筒具有联接到穿透构件的第一和第二密封件，以在穿透构件致动之前保持穿透构件的一部分周围的无菌环境。 用户界面被配置为中继穿透构件性能或穿透构件设置中的至少一种。

公开(公告)号：US07717863B2

公开(公告)日：2010-05-18

申请号：US10335240

申请日：2002-12-31

Applicant: Dominique M. Freeman ,  Don Alden ,  Dirk Boecker

Inventor： Dominique M. Freeman ,  Don Alden ,  Dirk Boecker

IPC: A61B5/00

CPC classification number: G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

Abstract: A tissue penetration device includes a penetrating member driver and a cartridge. A plurality of penetrating members are integrated with the cartridge. Each penetrating member is coupled to the penetrating member driver when advanced along a path into a tissue target. A penetrating member sensor is coupled to the plurality of penetrating members. The penetrating member sensor is configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.

Abstract translation: 组织穿透装置包括穿透构件驱动器和盒。 多个穿透构件与盒一体化。 当沿着进入组织靶的路径前进时，每个穿透构件联接到穿透构件驱动器。 穿透构件传感器联接到多个穿透构件。 穿透构件传感器被配置为提供关于穿透构件穿过皮肤表面的穿透深度的信息。

公开(公告)号：US20090259146A1

公开(公告)日：2009-10-15

申请号：US12421776

申请日：2009-04-10

Applicant: Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/151

CPC classification number: A61B5/1411 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150259 ,  A61B5/150419 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150702 ,  A61B5/150946 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15176 ,  A61B5/15182 ,  A61B5/157 ,  A61B2562/0295

Abstract: An integrated analyte measurement system includes a housing and a disposable configured to be positioned in the housing. A plurality of penetrating members are positioned in the disposable. A penetrating member driver is configured to be coupled to each of a penetrating member. A plurality of analyte sensors are positioned in the disposable. The disposable houses both used and unused penetrating members and analyte sensors.

Abstract translation: 集成分析物测量系统包括壳体和一次性配置以定位在壳体中。 多个穿透构件被定位在一次性物品中。 穿透构件驱动器被配置为联接到每个穿透构件。 多个分析物传感器被定位在一次性物品中。 所使用的一次性房屋和未使用的穿透构件和分析物传感器。

公开(公告)号：US07524462B2

公开(公告)日：2009-04-28

申请号：US10113112

申请日：2002-03-29

Applicant: Leslie Leonard ,  Klaus Stefan Drese ,  Dirk Boecker

Inventor： Leslie Leonard ,  Klaus Stefan Drese ,  Dirk Boecker

IPC: G01N30/00 ,  G01N30/28

CPC classification number: B01L3/5027 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/0694 ,  B01L2400/084 ,  B01L2400/086 ,  B01L2400/088 ,  G01N2035/00257 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Apparatus and methods consistent with certain principles related to the present invention include a first channel, where a fluid flows through the first channel, where the first channel comprises an upstream region, a tagging region downstream of the upstream region, where at least one analyte is tagged when the fluid flows through the tagging region, a capture region downstream of the tagging region, where at least one tagged analyte is captured when the fluid flows through the capture region. A second channel communicating the upstream region of the first channel with the first channel intermediate the tagging region and capture regions, where a portion of the fluid flows through the second channel and subsequently flows into the capture region of the first channel, and where the fluid flowing through the tagging region flows into the capture region before the portion of the fluid flowing through the second channel flows into the capture region of the first channel.

Abstract translation: 与本发明相关的某些原理一致的设备和方法包括第一通道，其中流体流过第一通道，其中第一通道包括上游区域，上游区域下游的标记区域，其中至少一个分析物是 当流体流过标记区域时，标记标签，标签区域下游的捕获区域，其中当流体流过捕获区域时捕获至少一个带标签的分析物。 第二通道将第一通道的上游区域与标记区域和捕获区域之间的第一通道相通，其中一部分流体流过第二通道并随后流入第一通道的捕获区域，并且其中流体 在通过第二通道流动的流体的部分流入第一通道的捕获区域之前流过标记区域流入捕获区域。

公开(公告)号：US20090054811A1

公开(公告)日：2009-02-26

申请号：US11813014

申请日：2005-12-30

Applicant: Dirk Boecker

Inventor： Dirk Boecker

IPC: A61B5/151

CPC classification number: A61B5/157 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15182

Abstract: A method is provided for the analyte measurement by a user using an analyte measurement device. A penetrating member and unused analyte detecting member of the analyte measurement device are presented into an active position. The penetrating member is fired to prick the skin and bring a fluid sample to the analyte detecting member. The analyte level is measured. These three steps occur in less than 10 seconds.

Abstract translation: 提供了一种用户使用分析物测量装置进行分析物测量的方法。 分析物测量装置的穿透构件和未使用的分析物检测构件被呈现到活动位置。 烧穿穿透构件以刺激皮肤并将流体样品带到分析物检测构件。 测量分析物水平。 这三个步骤发生在不到10秒钟。

公开(公告)号：US07481776B2

公开(公告)日：2009-01-27

申请号：US10335259

申请日：2002-12-31

Applicant: Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

Inventor： Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

IPC: A61B5/00 ,  A61B17/14 ,  A61B17/32 ,  B65D81/00

CPC classification number: A61B5/15178 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905 ,  G01N33/557

Abstract: A skin penetrating system is provided with a drive force generator and a disposable housing member. A plurality of penetrating members are positioned in the disposable housing member. Each penetrating member is coupled to the drive force generator. A plurality of analyte detecting members are each associated with a penetrating member and are positioned in the disposable housing member. Each analyte detecting member is positioned in a sample chamber. The sample chambers have openings for transport of a body fluid into the sample chamber. Each analyte detecting member is configured to determine a concentration of an analyte in a body fluid. A user interface is configured to relay at least one of, skin penetrating performance or a skin penetrating setting.

Abstract translation: 皮肤穿透系统设置有驱动力发生器和一次性外壳构件。 多个穿透构件定位在一次性外壳构件中。 每个穿透构件联接到驱动力发生器。 多个分析物检测构件各自与穿透构件相关联并且被定位在一次性外壳构件中。 每个分析物检测构件定位在样品室中。 样品室具有用于将体液输送到样品室中的开口。 每个分析物检测构件被配置成确定体液中分析物的浓度。 用户界面被配置为中继皮肤穿透性能或皮肤穿透设置中的至少一种。

公开(公告)号：US20080294068A1

公开(公告)日：2008-11-27

申请号：US12143373

申请日：2008-06-20

Applicant: Barry Briggs ,  Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Barry Briggs ,  Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/151

CPC classification number: A61B5/15146 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15087 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15174 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157

Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet and a processor coupled to the drive force generator capable of changing the direction and magnitude of force exerted on the lancet during the lancing cycle. The driver further includes a human interface on the housing providing at least one output for communicating with the patient.

Abstract translation: 提供了一种刺血针驱动器，其中驾驶员在穿刺周期期间在柳叶刀上施加驱动力并且在组织部位上使用。 驱动器包括用于使柳叶刀前进的驱动力发生器和与驱动力发生器耦合的处理器，其能够改变在穿刺周期期间施加在刺血针上的力的方向和大小。 驱动器还包括在壳体上的人机接口，提供至少一个用于与患者通信的输出。