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    G-protein parathyroid hormone receptor HLTDG74
    51.
    发明申请
    G-protein parathyroid hormone receptor HLTDG74 失效
    G蛋白甲状旁腺激素受体HLTDG74

    公开(公告)号：US20050009107A1

    公开(公告)日：2005-01-13

    申请号：US10921218

    申请日：2004-08-19

    申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    IPC分类号： A61K48/00 ,  C07K14/72 ,  C12N15/12 ,  G01N33/53 ,  C12N5/06 ,  C12P21/04

    CPC分类号： C07K14/723 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein parathyroid hormone (PTH) receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the PTH receptor receptor polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the PTH receptor receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host. Disclosed embodiments of the invention also include antibodies that bind Human G-Protein parathyroid hormone (PTH) receptor polypeptides and methods for making and using such antibodies.

    摘要翻译： 公开了人类G蛋白甲状旁腺激素（PTH）受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及在治疗上使用激动剂和拮抗剂治疗与PTH受体受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测PTH受体受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式水平的诊断方法。 本发明的公开的实施方案还包括结合人类G蛋白甲状旁腺激素（PTH）受体多肽的抗体以及制备和使用这些抗体的方法。

    Human Prostate Specific G-Protein Receptor HPRAJ70
    52.
    发明申请
    Human Prostate Specific G-Protein Receptor HPRAJ70 审中-公开
    人前列腺特异性G蛋白受体HPRAJ70

    公开(公告)号：US20070154474A1

    公开(公告)日：2007-07-05

    申请号：US11456261

    申请日：2006-07-10

    申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  C12P21/06 ,  C07K14/72 ,  C07H21/04

    CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K2317/622

    摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

    摘要翻译： 本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。 更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。 本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。 还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。 本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

    Human G-protein coupled receptor (HETGQ23)
    53.
    发明申请
    Human G-protein coupled receptor (HETGQ23) 审中-公开
    人G蛋白偶联受体（HETGQ23）

    公开(公告)号：US20060140942A1

    公开(公告)日：2006-06-29

    申请号：US11357204

    申请日：2006-02-21

    申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

    Human prostate specific G-protein receptor HPRAJ70
    54.
    发明申请
    Human prostate specific G-protein receptor HPRAJ70 审中-公开
    人前列腺特异性G蛋白受体HPRAJ70

    公开(公告)号：US20050064499A1

    公开(公告)日：2005-03-24

    申请号：US10968294

    申请日：2004-10-20

    申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  C12Q1/68 ,  A61K38/17 ,  C07H21/04 ,  C07K14/72 ,  G01N33/574

    CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K2317/622

    摘要： The present invention relates to PSGR, a novel prostate specific gene with homology to a G-protein coupled receptor overexpressed in prostate cancer. More specifically, the invention relates to PSGR polynucleotides and the polypeptides encoded by these polynucleotides, and the use of PSGR polynucleotides and polypeptides for detecting disorders of the reproductive system, including disorders of the prostate, particularly the presence of cancer. This invention relates to PSGR polynucleotides and polypeptides as well as vectors, host cells, antibodies directed to PSGR polynucleotides and polypeptides and recombinant and synthetic methods for producing the same. Also provided are methods for diagnosing, treating, preventing, and/or prognosing disorders related to the prostate, including cancer. The invention further relates to screening methods for identifying agonists and antagonists of PSGR polynucleotides and polypeptides of the invention and methods and/or compositions for inhibiting or enhancing the production and/or function of the PSGR polypeptides of the present invention.

    摘要翻译： 本发明涉及PSGR，一种与在前列腺癌中过表达的G蛋白偶联受体具有同源性的新型前列腺特异性基因。 更具体地，本发明涉及PSGR多核苷酸和由这些多核苷酸编码的多肽，以及使用PSGR多核苷酸和多肽来检测生殖系统疾病，包括前列腺疾病，特别是癌症的存在。 本发明涉及PSGR多核苷酸和多肽以及载体，宿主细胞，针对PSGR多核苷酸和多肽的抗体以及用于制备它的重组和合成方法。 还提供了用于诊断，治疗，预防和/或预后与前列腺相关的疾病（包括癌症）的方法。 本发明还涉及用于鉴定本发明的PSGR多核苷酸和多肽的激动剂和拮抗剂的筛选方法以及用于抑制或增强本发明的PSGR多肽的产生和/或功能的方法和/或组合物。

    Peptidoglycan recognition proteins
    55.
    发明申请
    Peptidoglycan recognition proteins 失效
    肽聚糖识别蛋白

    公开(公告)号：US20060003378A1

    公开(公告)日：2006-01-05

    申请号：US11214796

    申请日：2005-08-31

    申请人： Paul Young ,  Steven Ruben ,  Craig Rosen ,  Henrik Olsen

    发明人： Paul Young ,  Steven Ruben ,  Craig Rosen ,  Henrik Olsen

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention related to three novel recognition protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

    摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型识别蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-C多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

    Novel Metalloproteinases
    56.
    发明申请
    Novel Metalloproteinases 审中-公开
    新型金属蛋白酶

    公开(公告)号：US20070238130A1

    公开(公告)日：2007-10-11

    申请号：US11627246

    申请日：2007-01-25

    申请人： Jian Ni ,  Steven Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    发明人： Jian Ni ,  Steven Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    IPC分类号： C12P1/04 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  G01N33/53 ,  C12N15/00 ,  C12N5/06

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

    摘要： The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

    摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

    Antibodies to Chemokine Alpha-5
    60.
    发明申请
    Antibodies to Chemokine Alpha-5 失效
    趋化因子α-5抗体

    公开(公告)号：US20060008882A1

    公开(公告)日：2006-01-12

    申请号：US11224076

    申请日：2005-09-13

    申请人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig Rosen ,  Steven Ruben

    发明人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig Rosen ,  Steven Ruben

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/52 ,  C07K16/24

    CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K2319/00 ,  C12N2799/026 ,  Y02A50/423 ,  Y10T436/143333

    摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。 特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。 还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备这种抗体的组合物和方法。 本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。