利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

24 条记录 (耗时 0.058 秒)

    Novel Metalloproteinases
    1.
    发明申请
    Novel Metalloproteinases 审中-公开
    新型金属蛋白酶

    公开(公告)号：US20070238130A1

    公开(公告)日：2007-10-11

    申请号：US11627246

    申请日：2007-01-25

    申请人： Jian Ni ,  Steven Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    发明人： Jian Ni ,  Steven Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    IPC分类号： C12P1/04 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  G01N33/53 ,  C12N15/00 ,  C12N5/06

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

    摘要： The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

    摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

    Metalloproteinases
    3.
    发明授权
    Metalloproteinases 失效
    金属蛋白酶

    公开(公告)号：US06878812B2

    公开(公告)日：2005-04-12

    申请号：US09950688

    申请日：2001-09-13

    申请人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    发明人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/735 ,  C12N1/21 ,  C12N9/00 ,  C12N9/64 ,  C12N15/57 ,  C07K16/00

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

    摘要： The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

    摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

    Metalloproteinases
    4.
    发明授权
    Metalloproteinases 失效
    金属蛋白酶

    公开(公告)号：US06312937B1

    公开(公告)日：2001-11-06

    申请号：US09372154

    申请日：1999-08-11

    申请人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    发明人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    IPC分类号： C12N950

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

    摘要： The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

    摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。

    Metalloproteinases
    5.
    发明授权
    Metalloproteinases 失效
    金属蛋白酶

    公开(公告)号：US6046031A

    公开(公告)日：2000-04-04

    申请号：US9156

    申请日：1998-01-20

    申请人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    发明人： Jian Ni ,  Steve Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/735 ,  C12N1/21 ,  C12N9/00 ,  C12N9/64 ,  C12N15/57 ,  C12P21/06

    CPC分类号： C12N9/6489 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  A61K38/00 ,  C12N2799/026

    摘要： The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

    摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。