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公开(公告)号：US06649399B2
公开(公告)日：2003-11-18
申请号：US09963791
申请日：2000-12-08
申请人： Gregory Donoho , C. Alexander Turner, Jr. , Glenn Friedrich , John Scoville , Brian Zambrowicz , Arthur T. Sands
发明人： Gregory Donoho , C. Alexander Turner, Jr. , Glenn Friedrich , John Scoville , Brian Zambrowicz , Arthur T. Sands
IPC分类号： C12N964
CPC分类号： C12N9/6489
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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公开(公告)号：US20080213878A1
公开(公告)日：2008-09-04
申请号：US11365756
申请日：2006-03-01
申请人： Gregory Donoho , Carl Johan Friddle , Glenn Friedrich , Brenda Gerhardt , Erin Hilbun , Yi Hu , Brian Mathur , Maricar Miranda , Michael C. Nehls , Boris Nepomnichy , Arthur T. Sands , John Scoville , Hong Sun , C. Alexander Turner , D. Wade Walke , Xiaoming Wang , Nathaniel L. Wilganowski , Xuanchuan Yu , Brian Zambrowicz
发明人： Gregory Donoho , Carl Johan Friddle , Glenn Friedrich , Brenda Gerhardt , Erin Hilbun , Yi Hu , Brian Mathur , Maricar Miranda , Michael C. Nehls , Boris Nepomnichy , Arthur T. Sands , John Scoville , Hong Sun , C. Alexander Turner , D. Wade Walke , Xiaoming Wang , Nathaniel L. Wilganowski , Xuanchuan Yu , Brian Zambrowicz
CPC分类号： C07K14/47
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译： 公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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公开(公告)号：US06852521B2
公开(公告)日：2005-02-08
申请号：US10419276
申请日：2003-04-17
申请人： Gregory Donoho , C. Alexander Turner, Jr. , Glenn Friedrich , John Scoville , Brian Zambrowicz , Arthur T. Sands
发明人： Gregory Donoho , C. Alexander Turner, Jr. , Glenn Friedrich , John Scoville , Brian Zambrowicz , Arthur T. Sands
CPC分类号： C12N9/6489
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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54.发明授权公开(公告)号：US06720412B2
公开(公告)日：2004-04-13
申请号：US09784358
申请日：2001-02-15
申请人： Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Brian Zambrowicz , Arthur T. Sands
发明人： Gregory Donoho , John Scoville , C. Alexander Turner, Jr. , Glenn Friedrich , Brian Zambrowicz , Arthur T. Sands
IPC分类号： C07H2104
CPC分类号： C07K14/78
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译： 公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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55.发明申请Genetically engineered and phenotyped mice and stem cell clones for producing the same 审中-公开基因工程和表型小鼠和干细胞克隆用于生产相同的公开(公告)号：US20080189799A1
公开(公告)日：2008-08-07
申请号：US11978234
申请日：2007-10-26
申请人： Liangfen Fan , Glenn Friedrich , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel , Brian Zambrowicz
发明人： Liangfen Fan , Glenn Friedrich , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel , Brian Zambrowicz
IPC分类号： C12N15/11 , A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2267/03 , C07K14/705 , C07K14/70503 , C07K14/7151 , C07K14/775 , C07K14/8114 , C07K14/8121 , C12N9/1051 , C12N9/12 , C12N9/1205 , C12N2799/027 , C12N2800/60
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。
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公开(公告)号：US07144730B2
公开(公告)日：2006-12-05
申请号：US10422264
申请日：2003-04-23
申请人： C. Alexander Turner, Jr. , Brian Zambrowicz , Michael Nehls , Glenn Friedrich , Arthur T. Sands
发明人： C. Alexander Turner, Jr. , Brian Zambrowicz , Michael Nehls , Glenn Friedrich , Arthur T. Sands
CPC分类号： C12N9/0069 , A01K2217/05
摘要： The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human gene trap clones and human cDNA libraries.
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公开(公告)号：US06586582B2
公开(公告)日：2003-07-01
申请号：US09765069
申请日：2001-01-18
IPC分类号： C07K100
CPC分类号： C07K14/70571 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/705
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译： 公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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58.发明授权公开(公告)号：US06433153B1
公开(公告)日：2002-08-13
申请号：US09653839
申请日：2000-09-01
申请人： Gregory Donoho , C. Alexander Turner, Jr. , Michael C. Nehls , Glenn Friedrich , Brian Zambrowicz , Arthur T. Sands
发明人： Gregory Donoho , C. Alexander Turner, Jr. , Michael C. Nehls , Glenn Friedrich , Brian Zambrowicz , Arthur T. Sands
IPC分类号： C07H2104
CPC分类号： C12N9/6472
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
摘要翻译： 公开了可用于治疗，诊断和药物基因组应用的新型人多核苷酸和多肽序列。
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公开(公告)号：US6080576A
公开(公告)日：2000-06-27
申请号：US57328
申请日：1998-04-08
CPC分类号： C40B40/02 , C12N15/1037 , C12N15/86 , C12N2740/10043 , C12N2800/60 , C12N2840/203 , C12N2840/44
摘要： A novel 3' gene trap cassette is described that does not encode a marker conferring antibiotic resistance and can be used to efficiently trap and identify cellular genes. Vectors incorporating the presently 3' gene trap cassette find particular application in gene discovery, the production of transgenic cells and animals, and gene activation.
摘要翻译： 描述了一种新颖的3'基因捕获盒，其不编码赋予抗生素抗性的标记，并且可用于有效捕获和鉴定细胞基因。 结合目前3'基因捕获盒的载体在基因发现，转基因细胞和动物的产生以及基因激活方面具有特别的应用。
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公开(公告)号：US06777221B2
公开(公告)日：2004-08-17
申请号：US10200910
申请日：2002-07-22
申请人： Gregory Donoho , Erin Hilbun , C. Alexander Turner, Jr. , Michael C. Nehls , Glenn Friedrich , Brian Zambrowicz , Arthur T. Sands
发明人： Gregory Donoho , Erin Hilbun , C. Alexander Turner, Jr. , Michael C. Nehls , Glenn Friedrich , Brian Zambrowicz , Arthur T. Sands
IPC分类号： C12N120
摘要： Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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