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75 条记录 (耗时 0.056 秒)

    Amplicon in the 20q13 region of human chromosome 20 and uses thereof
    51.
    发明授权
    Amplicon in the 20q13 region of human chromosome 20 and uses thereof 有权
    人20号染色体20q13区域的扩增子及其用途

    公开(公告)号：US06664057B2

    公开(公告)日：2003-12-16

    申请号：US09896070

    申请日：2001-06-28

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Conrad Collins ,  Joe W. Gray

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Conrad Collins ,  Joe W. Gray

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6841 ,  C12Q1/6886 ,  C12Q2600/156

    摘要： This invention pertains to the field of cancer genetics and cytogenetics. In particular, this invention pertains to the identification of a novel amplicon on human chromosome 20 which is associated with cancer. More particularly this invention pertains to the identification of a novel “amplicon” or genomic nucleic acid in a region of amplification at about 20q13.2 which has been associated with a variety of cancers, particularly breast cancer. The novel amplicon of the invention can be used as a probe specific for this region of 20q13.2 as well as for the diagnosis and prognosis of various cancers. Also provided are kits for screening for the presence and copy number of the novel amplicon of the invention in a sample containing human nucleic acid.

    摘要翻译： 本发明涉及癌症遗传学和细胞遗传学领域。 特别地，本发明涉及与癌症相关的人20号染色体上的新型扩增子的鉴定。 更具体地，本发明涉及在约20q13.2的扩增区域中鉴定与多种癌症特别是乳腺癌相关的新型“扩增子”或基因组核酸。 本发明的新型扩增子可用作20q13.2的该区域特异性的探针以及各种癌症的诊断和预后。 还提供了用于在含有人核酸的样品中筛选本发明的新型扩增子的存在和拷贝数的试剂盒。

    Detection of premalignant melanocytes
    53.
    发明授权
    Detection of premalignant melanocytes 有权
    癌前期黑素细胞的检测

    公开(公告)号：US06465180B1

    公开(公告)日：2002-10-15

    申请号：US09271619

    申请日：1999-03-17

    申请人： Boris Bastian ,  Daniel Pinkel

    发明人： Boris Bastian ,  Daniel Pinkel

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6886 ,  C12Q2549/125 ,  C12Q2600/156

    摘要： The present invention provides methods of screening for the presence of premalignant melanocytes in a sample from a patient. The methods comprise contacting a nucleic acid sample from a biological sample from the patient with a probe which binds selectively to a target polynucleotide sequence on a chromosomal region which is amplified in melanoma cells.

    摘要翻译： 本发明提供筛选来自患者的样品中癌前期黑素细胞的存在的方法。 所述方法包括使来自患者的生物样品的核酸样品与选择性结合在黑素瘤细胞中扩增的染色体区上的靶多核苷酸序列的探针接触。

    Method of detecting genetic translocations identified with chromosomal abnormalities
    54.
    发明授权
    Method of detecting genetic translocations identified with chromosomal abnormalities 失效
    检测染色体异常鉴定遗传易位的方法

    公开(公告)号：US06280929B1

    公开(公告)日：2001-08-28

    申请号：US08487974

    申请日：1995-06-07

    申请人： Joe W. Gray ,  Daniel Pinkel ,  Douglas Tkachuk

    发明人： Joe W. Gray ,  Daniel Pinkel ,  Douglas Tkachuk

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6886 ,  C12Q1/6811 ,  C12Q1/6827 ,  C12Q1/6841 ,  C12Q1/6853 ,  C12Q1/6879 ,  C12Q2600/156 ,  C12Q2563/131 ,  C12Q2563/107 ,  C12Q2525/151

    摘要： Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

    摘要翻译： 提供了基于使用核酸探针的核酸序列进行染色的方法和组合物。 所述方法产生可针对特定细胞遗传学分析进行定制的染色模式。 所述探针适用于原位杂交并染色具有可靠信号的相间和中期染色体材料。 核酸探针通常具有大于50kb的复杂度，其复杂性取决于细胞遗传学应用。 提供方法和试剂用于检测遗传重排。 探针和测试试剂盒用于检测遗传重排，特别是用于肿瘤细胞遗传学，检测疾病相关的基因座，特别是癌症，如慢性骨髓性白血病（CML）和生物剂量学。 描述了细胞遗传学研究的方法和试剂，用于细胞遗传学上相似但遗传上不同的疾病的分化，以及许多预后和诊断应用。

    Detecting CYP24 expression level as a marker for predisposition to cancer
    60.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US08685929B2

    公开(公告)日：2014-04-01

    申请号：US13443639

    申请日：2012-04-10

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： A01K61/00 ,  A61K31/00 ,  A61K38/00 ,  A61P35/00 ,  C12Q1/00 ,  C12Q1/68 ,  G01N1/00 ,  G01N21/75 ,  G01N33/00 ,  G01N33/48 ,  G01N33/567

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。