-
1.发明授权公开(公告)号：US08173602B2
公开(公告)日：2012-05-08
申请号：US12633643
申请日：2009-12-08
申请人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
发明人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
IPC分类号： A01N61/00 , A61K31/00 , A61K38/00 , A61P35/00 , C12Q1/00 , C12Q1/68 , C12Q19/30 , G01N1/00 , G01N21/75 , G01N33/00 , G01N33/48 , G01N33/567
CPC分类号： G01N33/5011 , C12Q1/48 , G01N33/57415 , G01N33/82
摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.
摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。
-
2.发明授权公开(公告)号：US07648826B1
公开(公告)日：2010-01-19
申请号：US09285292
申请日：1999-04-02
申请人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ystra
发明人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ystra
IPC分类号： C12Q1/00 , C12Q1/68 , C12Q19/30 , G01N33/567 , G01N33/00 , G01N33/48 , G01N21/75 , G01N1/00 , A61K38/00
CPC分类号： G01N33/5011 , C12Q1/48 , G01N33/57415 , G01N33/82
摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.
摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。
-
3.发明授权公开(公告)号：US08685929B2
公开(公告)日：2014-04-01
申请号：US13443639
申请日：2012-04-10
申请人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
发明人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
IPC分类号： A01K61/00 , A61K31/00 , A61K38/00 , A61P35/00 , C12Q1/00 , C12Q1/68 , G01N1/00 , G01N21/75 , G01N33/00 , G01N33/48 , G01N33/567
CPC分类号： G01N33/5011 , C12Q1/48 , G01N33/57415 , G01N33/82
摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.
摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。
-
4.发明申请公开(公告)号：US20100285023A1
公开(公告)日：2010-11-11
申请号：US12633643
申请日：2009-12-08
申请人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
发明人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
IPC分类号： A61K39/395 , A61K48/00 , A61P35/00
CPC分类号： G01N33/5011 , C12Q1/48 , G01N33/57415 , G01N33/82
摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.
摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。
-
5.发明申请DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES BY COMPARATIVE GENOMIC HYBRIDIZATION 审中-公开通过比较基因组杂交检测核酸序列差异公开(公告)号：US20100279876A1
公开(公告)日：2010-11-04
申请号：US12405867
申请日：2009-03-17
申请人： Donna G. Albertson , Daniel Pinkel , Jane Fridyland , Bing Huey , Antoine Snijders , Joe W. Gray , Anne Kallioniemi , Olli-Pekka Kallioniemi , Frederic Waldman
发明人： Donna G. Albertson , Daniel Pinkel , Jane Fridyland , Bing Huey , Antoine Snijders , Joe W. Gray , Anne Kallioniemi , Olli-Pekka Kallioniemi , Frederic Waldman
IPC分类号： C40B30/00
CPC分类号： C12Q1/6809
摘要： The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).
摘要翻译： 本发明提供了检测两个核酸样品之间的核苷酸序列差异的方法。 该方法采用比较基因组杂交（CGH）技术分析样品间的序列差异。 该方法允许在高复杂度的核酸样品（例如，整个基因组）中鉴定小序列差异（例如，1％或更少的序列发散）。
-
公开(公告)号：US07267947B2
公开(公告)日：2007-09-11
申请号：US10198805
申请日：2002-07-19
申请人： Daniel Pinkel , Donna G. Albertson , Joe W. Gray
发明人： Daniel Pinkel , Donna G. Albertson , Joe W. Gray
IPC分类号： C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6841 , C12Q1/6886 , C12Q2600/156 , Y10S435/81 , Y10S435/975 , Y10S436/813
摘要： The present invention relates to DNA sequences from regions of copy number change on chromosome 20. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases.
摘要翻译： 本发明涉及来自20号染色体上拷贝数变化的区域的DNA序列。该序列可用于鉴定与各种疾病相关的染色体异常的杂交方法。
-
7.发明申请公开(公告)号：US20120322674A1
公开(公告)日：2012-12-20
申请号：US13443639
申请日：2012-04-10
申请人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
发明人： Donna G. Albertson , Daniel Pinkel , Colin Collins , Joe W. Gray , Bauke Ylstra
CPC分类号： G01N33/5011 , C12Q1/48 , G01N33/57415 , G01N33/82
摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.
摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。
-
8.发明授权Detection of nucleic acid sequence differences by comparative genomic hybridization 有权通过比较基因组杂交检测核酸序列差异公开(公告)号：US07534567B2
公开(公告)日：2009-05-19
申请号：US11060644
申请日：2005-02-16
申请人： Donna G. Albertson , Daniel Pinkel , Jane Fridyland , Bing Huey , Antoine Snijders , Joe W. Gray , Anne Kallioniemi , Olli-Pekka Kallioniemi , Frederic Waldman
发明人： Donna G. Albertson , Daniel Pinkel , Jane Fridyland , Bing Huey , Antoine Snijders , Joe W. Gray , Anne Kallioniemi , Olli-Pekka Kallioniemi , Frederic Waldman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , C12Q2600/156 , C12Q2565/601
摘要： The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).
摘要翻译： 本发明提供了检测两个核酸样品之间的核苷酸序列差异的方法。 该方法采用比较基因组杂交（CGH）技术分析样品间的序列差异。 该方法允许在高复杂度的核酸样品（例如，整个基因组）中鉴定小序列差异（例如，1％或更少的序列发散）。
-
公开(公告)号：US07312068B2
公开(公告)日：2007-12-25
申请号：US10456943
申请日：2003-06-06
申请人： Daniel Pinkel , Donna G. Albertson , Joe W. Gray , Greg Hamilton , Nils W. Brown , Steven M. Clark , John Hanson
发明人： Daniel Pinkel , Donna G. Albertson , Joe W. Gray , Greg Hamilton , Nils W. Brown , Steven M. Clark , John Hanson
CPC分类号： B41J2/25 , B41J2/005 , C12Q1/6837 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575 , C12Q2565/507
摘要： This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.
摘要翻译： 本发明提供了用于微阵列打印装置的改进的组件（例如，阵列“针”，打印头，基板压板，打印头压板等）以及并入这些组件的微阵列打印装置。 在一个实施方案中，本发明提供了一种微阵列打印头，其包括设置在支撑体中的多个玻璃或石英斑点毛细管，其在斑点毛细管之间保持固定的间隔，并且允许斑点毛细管沿平行于长轴的方向移动 毛细血管
-
公开(公告)号：US06855538B2
公开(公告)日：2005-02-15
申请号：US09894863
申请日：2001-06-27
申请人： Daniel Pinkel , Donna G. Albertson , Joe W. Gray , Greg Hamilton , Nils W. Brown , Steven M. Clark
发明人： Daniel Pinkel , Donna G. Albertson , Joe W. Gray , Greg Hamilton , Nils W. Brown , Steven M. Clark
CPC分类号： B41J2/25 , B41J2/005 , C12Q1/6837 , Y10T436/119163 , Y10T436/143333 , Y10T436/2575 , C12Q2565/507
摘要： This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.
摘要翻译： 本发明提供了用于微阵列打印装置的改进的组件（例如，阵列“针”，打印头，基板压板，打印头压板等）以及并入这些组件的微阵列打印装置。 在一个实施方案中，本发明提供了一种微阵列打印头，其包括设置在支撑体中的多个玻璃或石英斑点毛细管，其在斑点毛细管之间保持固定的间隔，并且允许斑点毛细管沿平行于长轴的方向移动 毛细血管
-
-
-
-
-
-
-
-
-
搜索结果
100 条记录 (耗时 0.026 秒)