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    Detecting CYP24 expression level as a marker for predisposition to cancer
    1.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US08173602B2

    公开(公告)日：2012-05-08

    申请号：US12633643

    申请日：2009-12-08

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： A01N61/00 ,  A61K31/00 ,  A61K38/00 ,  A61P35/00 ,  C12Q1/00 ,  C12Q1/68 ,  C12Q19/30 ,  G01N1/00 ,  G01N21/75 ,  G01N33/00 ,  G01N33/48 ,  G01N33/567

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    Detecting CYP24 expression level as a marker for predisposition to cancer
    2.
    发明授权
    Detecting CYP24 expression level as a marker for predisposition to cancer 有权
    检测CYP24表达水平作为癌症倾向的标志物

    公开(公告)号：US07648826B1

    公开(公告)日：2010-01-19

    申请号：US09285292

    申请日：1999-04-02

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ystra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ystra

    IPC分类号： C12Q1/00 ,  C12Q1/68 ,  C12Q19/30 ,  G01N33/567 ,  G01N33/00 ,  G01N33/48 ,  G01N21/75 ,  G01N1/00 ,  A61K38/00

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER
    3.
    发明申请
    DETECTING CYP24 EXPRESSION LEVEL AS A MARKER FOR PREDISPOSITION TO CANCER 有权
    检测CYP24表达水平作为癌症预测标记

    公开(公告)号：US20120322674A1

    公开(公告)日：2012-12-20

    申请号：US13443639

    申请日：2012-04-10

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Collins ,  Joe W. Gray ,  Bauke Ylstra

    IPC分类号： C40B30/04 ,  C12N5/09 ,  C12Q1/26 ,  C40B30/06 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/5011 ,  C12Q1/48 ,  G01N33/57415 ,  G01N33/82

    摘要： This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.

    摘要翻译： 本发明涉及以下发现：CYP24基因的扩增或CYP24活性的增加是癌症（例如乳腺癌）的存在，进展或倾向的标志物。 使用该信息，本发明提供了检测动物中癌症倾向的方法。 所述方法包括（i）从动物（例如人类患者）提供生物样品; （ii）检测生物样品中CYP24的水平; 和（iii）将CYP24的水平与来自正常的无癌组织的对照样品中的CYP24水平进行比较，其中生物样品中的CYP24水平与对照样品中的CYP24水平相比增加表明存在 的所述癌症。

    Amplicon in the 20q13 region of human chromosome 20 and uses thereof
    10.
    发明授权
    Amplicon in the 20q13 region of human chromosome 20 and uses thereof 有权
    人20号染色体20q13区域的扩增子及其用途

    公开(公告)号：US06664057B2

    公开(公告)日：2003-12-16

    申请号：US09896070

    申请日：2001-06-28

    申请人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Conrad Collins ,  Joe W. Gray

    发明人： Donna G. Albertson ,  Daniel Pinkel ,  Colin Conrad Collins ,  Joe W. Gray

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6841 ,  C12Q1/6886 ,  C12Q2600/156

    摘要： This invention pertains to the field of cancer genetics and cytogenetics. In particular, this invention pertains to the identification of a novel amplicon on human chromosome 20 which is associated with cancer. More particularly this invention pertains to the identification of a novel “amplicon” or genomic nucleic acid in a region of amplification at about 20q13.2 which has been associated with a variety of cancers, particularly breast cancer. The novel amplicon of the invention can be used as a probe specific for this region of 20q13.2 as well as for the diagnosis and prognosis of various cancers. Also provided are kits for screening for the presence and copy number of the novel amplicon of the invention in a sample containing human nucleic acid.

    摘要翻译： 本发明涉及癌症遗传学和细胞遗传学领域。 特别地，本发明涉及与癌症相关的人20号染色体上的新型扩增子的鉴定。 更具体地，本发明涉及在约20q13.2的扩增区域中鉴定与多种癌症特别是乳腺癌相关的新型“扩增子”或基因组核酸。 本发明的新型扩增子可用作20q13.2的该区域特异性的探针以及各种癌症的诊断和预后。 还提供了用于在含有人核酸的样品中筛选本发明的新型扩增子的存在和拷贝数的试剂盒。