公开(公告)号：US08499757B2

公开(公告)日：2013-08-06

申请号：US12484125

申请日：2009-06-12

Applicant: Chad C. Smutney ,  P. Spencer Kinsey ,  Carl R. Sahi ,  Benoit Adamo ,  John M. Polidoro ,  Scott McLean ,  Dennis Overfield ,  Anthony Bryant

Inventor： Chad C. Smutney ,  P. Spencer Kinsey ,  Carl R. Sahi ,  Benoit Adamo ,  John M. Polidoro ,  Scott McLean ,  Dennis Overfield ,  Anthony Bryant

IPC: A61M16/00

CPC classification number: A61M15/0045 ,  A61K9/0075 ,  A61K38/00 ,  A61K38/1709 ,  A61K38/22 ,  A61K38/26 ,  A61K38/28 ,  A61K47/22 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0028 ,  A61M15/0043 ,  A61M15/0048 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2205/6081 ,  A61M2206/20

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

公开(公告)号：USD664640S1

公开(公告)日：2012-07-31

申请号：US29356555

申请日：2010-02-26

Applicant: Chad C. Smutney ,  John M. Polidoro ,  Benoit Adamo ,  P. Spencer Kinsey

Designer： Chad C. Smutney ,  John M. Polidoro ,  Benoit Adamo ,  P. Spencer Kinsey

公开(公告)号：USD636869S1

公开(公告)日：2011-04-26

申请号：US29363775

申请日：2010-06-14

Applicant: Brendan Laurenzi ,  P. Spencer Kinsey ,  Benoit Adamo ,  John M. Polidoro ,  Chad C. Smutney

Designer： Brendan Laurenzi ,  P. Spencer Kinsey ,  Benoit Adamo ,  John M. Polidoro ,  Chad C. Smutney

公开(公告)号：USD629506S1

公开(公告)日：2010-12-21

申请号：US29328733

申请日：2008-12-01

Applicant: Benoit Adamo ,  Chad C. Smutney ,  P. Spencer Kinsey ,  Daniel McMichael Stipe ,  David Schoch Chapin

Designer： Benoit Adamo ,  Chad C. Smutney ,  P. Spencer Kinsey ,  Daniel McMichael Stipe ,  David Schoch Chapin

公开(公告)号：US20100238457A1

公开(公告)日：2010-09-23

申请号：US12727179

申请日：2010-03-18

Applicant: Benoit Adamo ,  Saiyam Shah ,  Chad C. Smutney

Inventor： Benoit Adamo ,  Saiyam Shah ,  Chad C. Smutney

IPC: G01B9/02 ,  G01N21/01

CPC classification number: G01N15/0205 ,  A61M11/001 ,  A61M15/00 ,  A61M15/0065 ,  A61M2202/064 ,  A61M2209/02 ,  G01N15/0211 ,  G01N15/06 ,  G01N2015/025

Abstract: The present disclosure relates to an improved device and methods for adapting to a laser diffraction apparatus used for measuring particle size distribution and density of the plume of a powder composition emitted from a dry powder inhaler.

Abstract translation: 本公开涉及一种用于适应于用于测量从干粉吸入器发射的粉末组合物的羽流的粒度分布和密度的激光衍射装置的改进的装置和方法。

公开(公告)号：USD597657S1

公开(公告)日：2009-08-04

申请号：US29319777

申请日：2008-06-13

Applicant: P. Spencer Kinsey ,  Benoit Adamo ,  Chad C. Smutney ,  John M. Polidoro

Designer： P. Spencer Kinsey ,  Benoit Adamo ,  Chad C. Smutney ,  John M. Polidoro

公开(公告)号：US20130104887A1

公开(公告)日：2013-05-02

申请号：US13702024

申请日：2011-06-21

Applicant: Chad C. Smutney ,  Benoit Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl Sahi ,  Christine Billings ,  Mark T. Marino

Inventor： Chad C. Smutney ,  Benoit Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl Sahi ,  Christine Billings ,  Mark T. Marino

IPC: A61M15/00

CPC classification number: A61M15/0091 ,  A61M11/06 ,  A61M15/0021 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/6045 ,  A61M2205/6081

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.

Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以设置有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括小有机分子，肽和蛋白质，包括用于治疗疾病和病症的胰岛素和胰高血糖素样肽1 ，例如内分泌疾病如糖尿病和/或肥胖症。

公开(公告)号：USD636867S1

公开(公告)日：2011-04-26

申请号：US29363768

申请日：2010-06-14

Applicant: John M. Polidoro ,  Benoit Adamo ,  Brendan Laurenzi ,  P. Spencer Kinsey ,  Chad C. Smutney

Designer： John M. Polidoro ,  Benoit Adamo ,  Brendan Laurenzi ,  P. Spencer Kinsey ,  Chad C. Smutney

公开(公告)号：US20100235116A1

公开(公告)日：2010-09-16

申请号：US12722464

申请日：2010-03-11

Applicant: Benoit Adamo ,  Scott McLean ,  Chad C. Smutney ,  John M. Polidoro ,  Carl R. Sahi

Inventor： Benoit Adamo ,  Scott McLean ,  Chad C. Smutney ,  John M. Polidoro ,  Carl R. Sahi

IPC: G01F1/34 ,  G06F19/00

CPC classification number: G01N7/00 ,  A61M15/00 ,  A61M15/0065 ,  A61M16/0003 ,  A61M16/0057 ,  A61M16/10 ,  A61M16/201 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2202/064 ,  A61M2205/3334 ,  A61M2209/02 ,  G01F1/00 ,  G01L13/00

Abstract: An apparatus, a closed-loop system and method for measuring the resistance of inhalation systems and/or devices are disclosed.

Abstract translation: 公开了一种用于测量吸入系统和/或装置的阻力的装置，闭环系统和方法。

公开(公告)号：US20100197565A1

公开(公告)日：2010-08-05

申请号：US12717884

申请日：2010-03-04

Applicant: Chad C. Smutney ,  Benoit Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl R. Sahi ,  Christine Billings ,  Mark T. Marino

Inventor： Chad C. Smutney ,  Benoit Adamo ,  John M. Polidoro ,  P. Spencer Kinsey ,  Dennis Overfield ,  Carl R. Sahi ,  Christine Billings ,  Mark T. Marino

IPC: A61K38/28 ,  A61K38/00 ,  A61P3/10 ,  A61P3/04

CPC classification number: A61M15/0091 ,  A61K9/0075 ,  A61K38/28 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/6081

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.

Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以配备药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质如胰岛素和胰高血糖素样肽1，用于治疗内分泌疾病，例如糖尿病和 /或肥胖。