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公开(公告)号：US09358352B2
公开(公告)日：2016-06-07
申请号：US13702024
申请日：2011-06-21
Applicant: Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl Sahi , Christine Billings , Mark T. Marino
Inventor： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl Sahi , Christine Billings , Mark T. Marino
CPC classification number: A61M15/0091 , A61M11/06 , A61M15/0021 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6045 , A61M2205/6081
Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity.
Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以设置有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括小有机分子，肽和蛋白质，包括用于治疗疾病和病症的胰岛素和胰高血糖素样肽1 ，例如内分泌疾病如糖尿病和/或肥胖症。
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公开(公告)号：US08485180B2
公开(公告)日：2013-07-16
申请号：US12717884
申请日：2010-03-04
Applicant: Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl R. Sahi , Christine Billings , Mark T. Marino
Inventor： Chad C. Smutney , Benoit Adamo , John M. Polidoro , P. Spencer Kinsey , Dennis Overfield , Carl R. Sahi , Christine Billings , Mark T. Marino
CPC classification number: A61M15/0091 , A61K9/0075 , A61K38/28 , A61M15/0021 , A61M15/0028 , A61M15/0043 , A61M2202/064 , A61M2205/6081
Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
Abstract translation: 公开了一种肺部药物递送系统，包括呼吸动力的干粉吸入器和用于递送干粉制剂的药筒。 吸入器和药筒可以配备药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质如胰岛素和胰高血糖素样肽1，用于治疗内分泌疾病，例如糖尿病和 /或肥胖。
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公开(公告)号：US20120247235A1
公开(公告)日：2012-10-04
申请号：US13505729
申请日：2010-11-03
Applicant: Benoit Adamo , John M. Polidoro , Dennis Overfield , Carl R. Sahi , Brendan Laurenzi , Chad C. Smutney , Spencer P. Kinsey
Inventor： Benoit Adamo , John M. Polidoro , Dennis Overfield , Carl R. Sahi , Brendan Laurenzi , Chad C. Smutney , Spencer P. Kinsey
IPC: G01N19/00
CPC classification number: A61B5/08 , A61B5/4839 , A61B7/003 , A61K9/0075 , A61K31/496 , A61M15/0028 , A61M15/008 , A61M16/161 , A61M2016/0018 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2202/064 , A61M2205/3327 , A61M2205/3368 , A61M2205/3375 , A61M2205/3546 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/8206 , G09B19/003 , G09B23/28
Abstract: An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.
Abstract translation: 提供吸入模拟系统，用于吸入器，特别是呼吸动力的干粉吸入器。 仿真系统可以重建患者的吸入曲线，该吸入曲线适用于具有感测和监测装置的吸入器，用于检测从使用中的吸入器产生的特征信号，该信号被传送到计算机，该算法被配置为分析信号 并通过发射器产生新的信号，以启动吸入模拟系统组件，使得对象的吸入曲线同时或实时复制，或存储以供以后使用。 还提供了测量吸入器性能的方法。
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公开(公告)号：US20110319814A1
公开(公告)日：2011-12-29
申请号：US13170149
申请日：2011-06-27
Applicant: Vincent J. Sullivan , Ge Jiang , Matthew S. Ferriter , Kenneth G. Powell , P. Spencer Kinsey , Carl R. Sahi , John M. Polidoro
Inventor： Vincent J. Sullivan , Ge Jiang , Matthew S. Ferriter , Kenneth G. Powell , P. Spencer Kinsey , Carl R. Sahi , John M. Polidoro
IPC: A61M5/31
CPC classification number: A61M5/145 , A61M5/1407 , A61M5/1409 , A61M5/14248 , A61M5/14566 , A61M5/14586 , A61M2005/14256
Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.
Abstract translation: 一种用于贴片状，独立的多组分物质输注装置的系统和方法，其提供一个或多个基本上隐藏的患者针头，所述患者针头可与流体储存器组件流体连通，所述流体储存器组件包括与 不扩张的膀胱膜，例如金属化膜。 该装置可以通过粘合剂接触附接到皮肤表面，并且加压系统向流体储存器组件的内容物提供压力。 还公开了用于重构用于装置中优选使用的干燥粉末制剂的改进。
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公开(公告)号：US20110270223A1
公开(公告)日：2011-11-03
申请号：US13185492
申请日：2011-07-18
Applicant: Vincent J. Sullivan , Ge Jiang , Matthew S. Ferriter , Kenneth G. Powell , P. Spencer Kinsey , Carl R. Sahi , John M. Polidoro
Inventor： Vincent J. Sullivan , Ge Jiang , Matthew S. Ferriter , Kenneth G. Powell , P. Spencer Kinsey , Carl R. Sahi , John M. Polidoro
CPC classification number: A61M5/145 , A61M5/1407 , A61M5/1409 , A61M5/14248 , A61M5/14566 , A61M5/14586 , A61M2005/14256
Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20090308390A1
公开(公告)日：2009-12-17
申请号：US12484125
申请日：2009-06-12
Applicant: Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
Inventor： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
IPC: A61M15/00
CPC classification number: A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
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7.发明授权Interactive apparatus and method for real-time profiling of inhalation efforts 有权用于实时分析吸入努力的交互式设备和方法公开(公告)号：US09364619B2
公开(公告)日：2016-06-14
申请号：US12488469
申请日：2009-06-19
Applicant: Dennis Overfield , Carl R. Sahi , Benoit Adamo , P. Spencer Kinsey , Scott McLean , John M. Polidoro , Chad C. Smutney
Inventor： Dennis Overfield , Carl R. Sahi , Benoit Adamo , P. Spencer Kinsey , Scott McLean , John M. Polidoro , Chad C. Smutney
CPC classification number: A61M15/0065 , A61B5/087 , A61M15/0021 , A61M15/0025 , A61M15/008 , A61M2016/0027 , A61M2016/003 , A61M2202/064 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2206/10 , A61M2209/086 , A61M2230/40 , G06F19/00 , G09B23/28
Abstract: Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system, to evaluate the performance of the inhalation system and/or to detect the characteristics profile of a dry powder formulation emitted from the inhalation system in use.
Abstract translation: 这里描述了用于感测和测量受试者使用干粉吸入系统的实时特征模式的交互式装置和方法。 这些装置可以在有线或无线通信模式下用于与显示器通信，以评估受试者对吸入系统的使用情况，评估吸入系统的性能和/或检测从 吸入系统正在使用。
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公开(公告)号：US08636001B2
公开(公告)日：2014-01-28
申请号：US12484129
申请日：2009-06-12
Applicant: Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfileld , Anthony Bryant , Tom He , Alfred Mann
Inventor： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfileld , Anthony Bryant , Tom He , Alfred Mann
IPC: A61M15/00
CPC classification number: A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
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公开(公告)号：US08538707B2
公开(公告)日：2013-09-17
申请号：US12722464
申请日：2010-03-11
Applicant: Benoit Adamo , Scott McLean , Chad C. Smutney , John M. Polidoro , Carl R. Sahi
Inventor： Benoit Adamo , Scott McLean , Chad C. Smutney , John M. Polidoro , Carl R. Sahi
CPC classification number: G01N7/00 , A61M15/00 , A61M15/0065 , A61M16/0003 , A61M16/0057 , A61M16/10 , A61M16/201 , A61M2016/0027 , A61M2016/0039 , A61M2202/064 , A61M2205/3334 , A61M2209/02 , G01F1/00 , G01L13/00
Abstract: An apparatus, a closed-loop system and method for measuring the resistance of inhalation systems and/or devices are disclosed.
Abstract translation: 公开了一种用于测量吸入系统和/或装置的阻力的装置，闭环系统和方法。
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公开(公告)号：US07678079B2
公开(公告)日：2010-03-16
申请号：US11739784
申请日：2007-04-25
Applicant: Charles D. Shermer , Kenneth G. Powell , Alexander G. Lastovich , P. Spencer Kinsey , Chad C. Smutney , John M. Polidoro , Ed Browka , Carl R. Sahi , James K. Fentress , David S. Chapin , Daniel Stipe , Jeff M. Moss , Melody Kuroda
Inventor： Charles D. Shermer , Kenneth G. Powell , Alexander G. Lastovich , P. Spencer Kinsey , Chad C. Smutney , John M. Polidoro , Ed Browka , Carl R. Sahi , James K. Fentress , David S. Chapin , Daniel Stipe , Jeff M. Moss , Melody Kuroda
CPC classification number: A61M5/148 , A61M5/142 , A61M5/14248 , A61M5/145 , A61M2005/14252 , A61M2005/1426 , A61M2005/14268 , A61M2005/14506
Abstract: A system and method for a patch-like, self-contained substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir subassembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. Simple removal of an interlock allows a disk, or Belleville spring assembly to apply an essentially even and constant pressure to the contents of the fluid reservoir assembly, and allows the device to then be attached to a skin surface via an adhesive contact surface. A push button activation assembly is provided which can then be used to release and seat one or more spring-loaded patient needles into the skin surface, and establish a fluid communication path between the patient needles and the pressurized fluid reservoir contents thereby delivering an infusion into the skin.
Abstract translation: 一种用于贴片状独立物质输注装置的系统和方法，其提供一个或多个基本上隐藏的患者针头，所述患者针头可与流体储存器子组件流体连通，所述流体储存器子组件包括与非结合使用的刚性囊部分， 可扩张的膀胱膜，例如金属化膜。 互锁的简单去除允许盘或贝氏弹簧组件对流体储存器组件的内容物施加基本均匀且恒定的压力，并且允许该装置经由粘合剂接触表面附接到皮肤表面。 提供按钮激活组件，其可以用于将一个或多个弹簧加载的患者针头释放并安置到皮肤表面中，并且在患者针和加压流体储存器内容物之间建立流体连通路径，从而将输注输送到 皮。
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