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公开(公告)号：US08961589B2
公开(公告)日：2015-02-24
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
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52.发明授权公开(公告)号：US08870847B2
公开(公告)日：2014-10-28
申请号：US13079239
申请日：2011-04-04
申请人： Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
发明人： Dariush Davalian , Stephen Pacetti , Florian Niklas Ludwig , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Kimchi Tran
CPC分类号： A61K9/0019 , A61F2/95 , A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/62 , A61M25/0084 , A61M25/104 , A61M2025/105
摘要： This invention is directed to a method of treating a vascular disease involving administration to a patient by means of an angioplasty balloon a composition comprising a permeability-enhancing substance and a therapeutic agent.
摘要翻译： 本发明涉及一种治疗血管疾病的方法，所述血管疾病涉及通过血管成形术球囊向患者施用包含渗透性增强物质和治疗剂的组合物。
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公开(公告)号：US08834556B2
公开(公告)日：2014-09-16
申请号：US13584678
申请日：2012-08-13
申请人： John E. Papp , Syed Faiyaz Ahmed Hossainy , Michael Ngo , Chad Abunassar , Boris Anukhin , Mikael Trollsas , Lewis B. Schwartz
发明人： John E. Papp , Syed Faiyaz Ahmed Hossainy , Michael Ngo , Chad Abunassar , Boris Anukhin , Mikael Trollsas , Lewis B. Schwartz
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/958 , A61F2002/826 , A61F2002/9155 , A61F2002/91591 , A61F2210/00 , A61F2230/0013 , A61F2230/0054 , A61F2240/001 , B29C35/0805 , B29C65/64 , B29C66/1248 , B29C66/71 , B29C2035/0838 , B29K2067/046 , B29K2995/006 , B29L2031/7534
摘要： Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.
摘要翻译： 公开了由具有重叠端环的断开的支架段组成的分段支架。 还公开了具有至少一个不连续链节的支架。
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公开(公告)号：US08828069B2
公开(公告)日：2014-09-09
申请号：US12546534
申请日：2009-08-24
申请人： Lothar W. Kleiner , Jessica Reneé´ DesNoyer , Thierry Glauser , Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy
发明人： Lothar W. Kleiner , Jessica Reneé´ DesNoyer , Thierry Glauser , Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/422 , A61L2300/606 , Y10T428/265 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , C08L29/04
摘要： A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.
摘要翻译： 提供了一种在医疗装置上的基底涂层上形成包含羟基聚合物的表面层的方法。
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公开(公告)号：US08500680B2
公开(公告)日：2013-08-06
申请号：US12013286
申请日：2008-01-11
IPC分类号： A61M37/00
CPC分类号： A61K9/0024 , A61K9/06
摘要： A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.
摘要翻译： 一种方法，包括在哺乳动物宿主内的处理部位引入处理剂; 并在处理部位引入可生物浸渍的凝胶材料。 一种包括第一环形构件的装置，所述第一环形构件具有围绕所述第一环形构件的长度设置的第一腔和在所述第一环形构件的近端处的第一入口，以及联接到所述第一环形构件的第二环形构件，所述第二环形构件具有第二内腔 设置在所述第二环形构件的大约一定长度处和在所述第二环形构件的近端处的第二入口，其中所述第一环形构件和所述第二环形构件被定位成允许通过每个环形构件引入的处理剂在 治疗部位。
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公开(公告)号：US20130085564A1
公开(公告)日：2013-04-04
申请号：US13252121
申请日：2011-10-03
IPC分类号： A61F2/82
CPC分类号： A61F2/89 , A61F2/915 , A61F2002/825 , A61F2002/828 , A61F2002/91558 , A61F2002/91575 , A61F2220/005 , A61F2230/0013 , A61F2230/0054
摘要： Stent scaffolds that include a polymeric structure or structures bonded to the scaffold and extending along their length are disclosed. The polymeric structure extends across some or all of the gaps in struts along the length of the scaffold. Segmented scaffolds are also disclosed that include two or more axial segments arranged end to end not connected by link struts.
摘要翻译： 公开了包括结合到支架上并沿其长度延伸的聚合物结构或结构的支架。 聚合物结构沿着支架的长度延伸穿过支柱中的一些或全部间隙。 还公开了分段脚手架，其包括两个或更多个轴向段，其端对端设置，不通过连杆支柱连接。
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57.发明授权Poly(ester amide)-based drug delivery systems with controlled release rate and morphology 有权具有控制释放速率和形态的基于聚（酯酰胺）的药物递送系统公开(公告)号：US08377107B2
公开(公告)日：2013-02-19
申请号：US13037169
申请日：2011-02-28
申请人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
发明人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61F2/06
CPC分类号： A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02
摘要： A method of forming a coating on a medical device having a controlled morphology is described. A medical device having a controlled morphology is described.
摘要翻译： 描述了在具有受控形态的医疗装置上形成涂层的方法。 描述具有受控形态的医疗装置。
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公开(公告)号：US08367093B2
公开(公告)日：2013-02-05
申请号：US13186207
申请日：2011-07-19
IPC分类号： A61F2/00
CPC分类号： A61L31/10 , A61L31/14 , C08F8/00 , C08F8/04 , C08F8/40 , C08F8/48 , Y10T428/1393 , C08L101/04 , C08F214/22
摘要： Provided herein are methods for functionalizing an polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer.
摘要翻译： 本文提供了用于官能化用于形成涂层的聚合物和由其形成的涂层和装置或用于官能化包括聚合物的涂层或装置表面的方法。
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公开(公告)号：US20120296312A1
公开(公告)日：2012-11-22
申请号：US13559423
申请日：2012-07-26
CPC分类号： A61K9/0024 , A61K9/06
摘要： A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.
摘要翻译： 一种方法，包括在哺乳动物宿主内的处理部位引入处理剂; 并在处理部位引入可生物浸渍的凝胶材料。 一种包括第一环形构件的装置，所述第一环形构件具有围绕所述第一环形构件的长度设置的第一腔和在所述第一环形构件的近端处的第一入口，以及联接到所述第一环形构件的第二环形构件，所述第二环形构件具有第二内腔 设置在所述第二环形构件的大约一定长度处和在所述第二环形构件的近端处的第二入口，其中所述第一环形构件和所述第二环形构件被定位成允许通过每个环形构件引入的处理剂在 治疗部位。
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60.发明授权Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics 有权具有聚合物涂层的植入式医疗装置，其表面积与体积比提供了表面侵蚀特性公开(公告)号：US08021678B2
公开(公告)日：2011-09-20
申请号：US11351598
申请日：2006-02-10
IPC分类号： A61F2/02
CPC分类号： A61L27/34 , A61K31/395 , A61K31/4745 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： The present invention relates to an implantable medical device comprising therapeutic agents coated on the device using polyesters for the drug reservoir layer that exhibit surface-eroding characteristics.
摘要翻译： 本发明涉及可植入医疗装置，其包括使用展示表面侵蚀特征的药物储存层的聚酯涂覆在该装置上的治疗剂。
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