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公开(公告)号:US06187792B1
公开(公告)日:2001-02-13
申请号:US09029633
申请日:1998-03-05
申请人: Daniel Delorme , Edward Roberts , Zhongyong Wei
发明人: Daniel Delorme , Edward Roberts , Zhongyong Wei
IPC分类号: A61K31445
CPC分类号: C07D401/06 , C07D211/46 , C07D211/70 , C07D405/06
摘要: Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: 通式(I)的化合物在本申请中公开和要求保护,以及它们的药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是用于治疗疼痛。
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公开(公告)号:US6153626A
公开(公告)日:2000-11-28
申请号:US29468
申请日:1998-03-03
申请人: Benjamin Pelcman , Edward Roberts
发明人: Benjamin Pelcman , Edward Roberts
IPC分类号: A61K31/00 , A61K31/40 , A61K31/445 , A61K31/4462 , A61K31/4468 , A61K31/63 , A61K51/04 , A61P1/00 , A61P25/00 , A61P29/00 , C07D207/14 , C07D211/56 , C07D211/58
CPC分类号: C07D211/58 , A61K51/0446 , A61K51/0455 , C07D207/14 , C07D211/56 , A61K2123/00
摘要: Compounds of general formula (I) ##STR1## wherein m is 0 or 1, and n is 1 or 2; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.
摘要翻译: PCT No.PCT / SE97 / 02051 Sec。 371日期1998年3月3日 102(e)1998年3月3日PCT 1997年12月9日PCT公布。 公开号WO98 / 28270 日期1998年7月2日通式(I)的化合物,其中m为0或1,n为1或2; 在本申请中公开和要求保护,以及它们的药学上可接受的盐,包含新化合物的药物组合物及其在治疗中的用途,特别是在疼痛的治疗中的用途。
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公开(公告)号:US5856354A
公开(公告)日:1999-01-05
申请号:US953037
申请日:1997-10-17
申请人: David Christopher Horwell , William Howson , Martyn Clive Pritchard , Edward Roberts , David Charles Rees
发明人: David Christopher Horwell , William Howson , Martyn Clive Pritchard , Edward Roberts , David Charles Rees
IPC分类号: C07D333/68 , A61K31/27 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K49/00 , A61P1/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P25/00 , A61P25/04 , A61P27/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07C271/18 , C07C271/22 , C07D209/20 , C07D209/30 , C07D231/56 , C07D333/60 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , A61K31/165 , C07C229/36 , C07C271/20
CPC分类号: C07D209/30 , C07C271/22 , C07D209/20 , C07D231/56 , C07D333/60 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要: The invention concerns tachykinin antagonists. The compounds are neopeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included. The compounds are expected to be especially useful in asthma and rheumatoid arthritis.
摘要翻译: 本发明涉及速激肽拮抗剂。 这些化合物是可用于治疗由速激肽介导的疾病的新肽。 这些疾病是呼吸道,炎性,胃肠道,眼睛,过敏,疼痛,血管,中枢神经系统疾病和偏头痛。 还包括制备化合物和新型中间体的方法。 化合物预期在哮喘和类风湿性关节炎中特别有用。
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公开(公告)号:US5462286A
公开(公告)日:1995-10-31
申请号:US377470
申请日:1995-01-24
申请人: Edward Roberts
发明人: Edward Roberts
CPC分类号: G07F17/3297 , A63F9/00 , A63F2250/136
摘要: An amusement device contains a playing area housed inside a cabinet which is visible from outside the cabinet. The device contains a coin feeder which allows only coins of a particular size to pass and to drop down into the playing area. The playing area contains at least one horizontal platform positioned in the playing area so that the coins dropping down from the coin feeder land on the platform. The coins landing on the platform accumulate in a random pile and occasionally spill over the platform and a portion of them are discharged to the player.
摘要翻译: 娱乐设备包含一个放置在机柜内部的游戏区域,可从机柜外面看到。 该装置包含硬币进给器,其仅允许特定大小的硬币通过并落入玩耍区域。 游戏区域包括至少一个位于游戏区域中的水平平台,使得从硬币馈送器落下的硬币落在平台上。 落在平台上的硬币堆积在随机堆中,偶尔会溢出平台,其中一部分被排放到玩家身上。
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公开(公告)号:US4963403A
公开(公告)日:1990-10-16
申请号:US114500
申请日:1987-10-30
CPC分类号: B29C47/025 , B29C47/003 , B60J10/265 , B60R13/04 , Y10T428/24198 , Y10T428/24942 , Y10T428/2495 , Y10T428/24983 , Y10T428/31551 , Y10T428/3158 , Y10T428/31609 , Y10T428/31681 , Y10T428/31696 , Y10T428/31786 , Y10T428/31797 , Y10T428/3192 , Y10T428/31928 , Y10T428/31935
摘要: Extrusion method and apparatus and part produced by the method and apparatus, such as a molding strip which includes a decorative Mylar plastic strip located between a pair of interbonded plastic layers. The top plastic layer or top coat is clear so that the decorative strip can be seen therethrough. A single die is utilized to produce the molding strip. The plastic layers are both preferably flexible PVC plastic which are interbonded by interfusion between adjacent surfaces while in a molten state within a bonding chamber of the die so that the plastic layers do not separate during use of the molding strip. The top coat is interbonded with the other plastic layer or body without requiring the clear plastic to totally encapsulate the resulting molding strip. Also, preferably, a reenforcement wire is embedded in the plastic body within the bonding chamber to give the molding strip additional strength.
摘要翻译: 挤出方法和装置以及通过方法和装置制造的部件,例如包括位于一对键合间塑料层之间的装饰性聚酯薄膜塑料条的成型条。 顶部塑料层或顶涂层是透明的,从而可以看到装饰条。 使用单个模具来生产模制条。 塑料层优选是柔性PVC塑料,它们在模具的粘合室内处于熔融状态时通过相邻表面之间的界面相互结合,使得在使用成型条期间塑料层不分离。 顶涂层与另一个塑料层或主体相互结合,而不需要透明塑料来完全包封所得的模制条。 此外,优选地,将再增强电线嵌入到粘合室内的塑料体中,以使模制带附加强度。
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