公开(公告)号：US06885192B2

公开(公告)日：2005-04-26

申请号：US10360823

申请日：2003-02-06

申请人： John Clarke ,  Robert McDermott ,  Alexander Pines ,  Andreas Heinz Trabesinger

发明人： John Clarke ,  Robert McDermott ,  Alexander Pines ,  Andreas Heinz Trabesinger

IPC分类号： G01R33/36 ,  G01V3/00

CPC分类号： G01R33/326 ,  G01R33/0356 ,  G01R33/445

摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned de superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.

摘要翻译： 核磁共振（NMR）信号在微量场中检测。 随后用毫米级超导量子干涉仪（SQUID）磁力计检测millitesla场的预极化。 由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。 超低磁场中的MRI是基于超低场的NMR。 应用梯度磁场，并根据检测到的NMR信号构建图像。

公开(公告)号：US6154026A

公开(公告)日：2000-11-28

申请号：US69707

申请日：1998-04-29

申请人： Eugene Dantsker ,  John Clarke

发明人： Eugene Dantsker ,  John Clarke

IPC分类号： G01R33/022 ,  G01R33/035

CPC分类号： G01R33/022 ,  G01R33/0358 ,  Y10S505/846

摘要： An asymmetric planar gradiometer for use in making biomagnetic measurements. The gradiometer is formed from a magnetometer which is inductively-coupled to the smaller of two connected loops patterned in a superconducting film which form a flux transformer. The magnetometer is based on a SQUID formed from a high T.sub.c superconducting material. The flux transformer and magnetometer may be formed on separate substrates, allowing the baseline to be increased relative to presently available devices.

摘要翻译： 用于制作生物磁性测量的非对称平面梯度计。 梯度计由磁强计形成，该磁力计感应耦合到形成磁通变换器的超导膜中图案化的两个连接环中较小的一个。 磁强计基于由高Tc超导材料形成的SQUID。 通量变压器和磁力计可以形成在单独的基板上，从而允许相对于目前可用的装置增加基线。

公开(公告)号：US5256636A

公开(公告)日：1993-10-26

申请号：US586435

申请日：1990-09-21

申请人： Frederick C. Wellstood ,  John J. Kingston ,  John Clarke

发明人： Frederick C. Wellstood ,  John J. Kingston ,  John Clarke

IPC分类号： H01L39/24 ,  H01L39/22 ,  B05D5/12 ,  H01B12/00

CPC分类号： H01L39/2422 ,  H01L39/2461 ,  H01L39/2464 ,  Y10S505/701 ,  Y10S505/702

摘要： A microelectronic component comprising a crossover is provided comprising a substrate, a first high T.sub.c superconductor thin film, a second insulating thin film comprising SrTiO.sub.3 ; and a third high T.sub.c superconducting film which has strips which crossover one or more areas of the first superconductor film. An insitu method for depositing all three films on a substrate is provided which does not require annealing steps. The photolithographic process is used to separately pattern the high T.sub.c superconductor thin films.

摘要翻译： 提供了包括交叉的微电子部件，其包括基板，第一高Tc超导体薄膜，包含SrTiO 3的第二绝缘薄膜; 以及第三高Tc超导膜，其具有穿过第一超导体膜的一个或多个区域的条带。 提供了一种用于在基板上沉积所有三个膜的基本方法，其不需要退火步骤。 光刻工艺用于分别对高Tc超导体薄膜进行图案化。

公开(公告)号：US20220396239A1

公开(公告)日：2022-12-15

申请号：US17827935

申请日：2022-05-30

申请人： John Clarke

发明人： John Clarke

IPC分类号： B60R25/09

摘要： A wheel immobilizer has a plurality of C-shaped members extendable about the wheel, including a telescopic member that is lockable in place. A unit connector and a wheel fastener cover are shaped to extend about fasteners of the wheel. The unit connector includes a threaded member and is shaped to enable macro and micro adjustments of the extent to which the wheel fastener cover extends from the C-shaped members. Slots of the unit connector enable the wheel immobilizer to couple together within a plane in a storage position. Projections of the wheel immobilizer inhibit rotation of the wheel and are tuned to make a noise when rotation of the wheel is attempted. An elongate round member is positioned within the telescopic member and configured to inhibit cutting therethrough. C-shaped members are rotatably coupled together via detent mechanisms the tension of which is adjusted via set screws which are externally accessible.

公开(公告)号：US20120095396A1

公开(公告)日：2012-04-19

申请号：US13210790

申请日：2011-08-16

申请人： Rajesh Radhakrishnan ,  Steve Larsen ,  Scott Schewe ,  James Feng ,  Robert Warner ,  Martyn Folan ,  Aiden Flanagan ,  John Clarke ,  Tim O'Connor ,  Anthony Malone

发明人： Rajesh Radhakrishnan ,  Steve Larsen ,  Scott Schewe ,  James Feng ,  Robert Warner ,  Martyn Folan ,  Aiden Flanagan ,  John Clarke ,  Tim O'Connor ,  Anthony Malone

IPC分类号： A61L29/16 ,  B05D1/28 ,  B05D1/02 ,  B05D5/00 ,  B05D7/00

CPC分类号： A61M25/1027 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/40 ,  A61L2420/08 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1086

摘要： A medical balloon having an inner surface and an outer surface comprising a first coating composition comprising at least one therapeutic agent, the first coating composition disposed on the balloon outer surface and forming an interface between the balloon outer surface and the first coating composition and a second coating composition comprising a bioadhesive, the second coating composition disposed on the first coating composition so as to not affect the interface between the balloon outer surface and the first coating composition, the bioadhesive selected so as to adhere to body tissue, and methods of making the same.

摘要翻译： 一种具有内表面和外表面的医用气囊，包括包含至少一种治疗剂的第一涂层组合物，所述第一涂层组合物设置在球囊外表面上并形成球囊外表面和第一涂层组合物之间的界面， 涂料组合物，其包含生物粘合剂，所述第二涂料组合物设置在所述第一涂料组合物上，以便不影响所述球囊外表面和所述第一涂料组合物之间的界面，所述生物粘合剂被选择以粘附到身体组织，以及制备 相同。

公开(公告)号：US20080021534A1

公开(公告)日：2008-01-24

申请号：US11781670

申请日：2007-07-23

申请人： Peter Stratford ,  Alistair Taylor ,  Vincent O'Byrne ,  John Clarke ,  Denis Healy

发明人： Peter Stratford ,  Alistair Taylor ,  Vincent O'Byrne ,  John Clarke ,  Denis Healy

IPC分类号： A61F2/82

CPC分类号： A61L29/085 ,  A61L31/10

摘要： The present invention relates to a balloon expandable stent mounted on a balloon catheter, the entire assembly being overcoated with a coherent polymer coating, which is preferably substantially continuous over the circumference and, more preferably, axial length of the stem on the balloon. The polymer coating improves retention of the stent on the balloon during delivery and does not adversely effect the deployment characteristics, nor the balloon failure characteristics. The product is made by mounting the stent on the balloon and coating the assembly with a liquid coating composition containing a suitable polymer followed by curing of the coating. The polymer is biocompatible and preferably crosslinkable in the coating composition, and crosslinked in the final product. A suitable polymer is formed from monomers including a zwitterionic, preferably a phosphoryl choline, group, and monomers including a trialkoxysilyl group. Preferably the coated product is contacted with ethylene oxide to provide simultaneous sterilization and additional curing.

摘要翻译： 本发明涉及一种安装在球囊导管上的球囊可扩张支架，整个组件用一层粘合聚合物涂层进行涂覆，该涂层优选在圆周上基本上连续，并且更优选地在气囊上的杆的轴向长度。 聚合物涂层改善了支架在输送过程中在气囊上的保持性，并且不会对展开特征以及球囊破坏特性产生不利影响。 该产品通过将支架安装在气球上并用包含合适聚合物的液体涂料组合物涂覆组合物，然后固化涂层而制成。 聚合物是生物相容的并且优选在涂料组合物中可交联，并在最终产物中交联。 合适的聚合物由包括两性离子，优选磷酰胆碱的单体和包含三烷氧基甲硅烷基的单体形成。 优选地，涂覆的产品与环氧乙烷接触以提供同时的灭菌和额外的固化。

公开(公告)号：US07187169B2

公开(公告)日：2007-03-06

申请号：US10980984

申请日：2004-11-03

申请人： John Clarke ,  Nathan Kelso ,  SeungKyun Lee ,  Michael Moessle ,  Whittier Myers ,  Robert McDermott ,  Bernard ten Haken ,  Alexander Pines ,  Andreas Trabesinger

发明人： John Clarke ,  Nathan Kelso ,  SeungKyun Lee ,  Michael Moessle ,  Whittier Myers ,  Robert McDermott ,  Bernard ten Haken ,  Alexander Pines ,  Andreas Trabesinger

IPC分类号： G01V3/00

CPC分类号： G01R33/326

摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. Additional signal to noise benefits are obtained by use of a low noise polarization coil, comprising litz wire or superconducting materials. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.

摘要翻译： 核磁共振（NMR）信号在微量场中检测。 随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。 由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。 通过使用包含绞合线或超导材料的低噪声极化线圈可以获得额外的噪声有益效果。 超低磁场中的MRI是基于超低场的NMR。 应用梯度磁场，并根据检测到的NMR信号构建图像。

公开(公告)号：US20060176054A1

公开(公告)日：2006-08-10

申请号：US11277550

申请日：2006-03-27

申请人： John Clarke ,  Robert McDermott ,  Alexander Pines ,  Andreas Trabesinger

发明人： John Clarke ,  Robert McDermott ,  Alexander Pines ,  Andreas Trabesinger

IPC分类号： G01V3/00

CPC分类号： G01R33/326 ,  G01R33/0356 ,  G01R33/445

摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.

摘要翻译： 核磁共振（NMR）信号在微量场中检测。 随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。 由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。 超低磁场中的MRI是基于超低场的NMR。 应用梯度磁场，并根据检测到的NMR信号构建图像。

公开(公告)号：US20060131305A1

公开(公告)日：2006-06-22

申请号：US11300428

申请日：2005-12-15

申请人： John Clarke

发明人： John Clarke

IPC分类号： B65D6/12 ,  B65D6/16

CPC分类号： B65D19/385 ,  B65D19/12

摘要： A collapsible crate assembly is provided that has a base and a first support member secured to the base. The first support member has first and second ends. A first socket member is connected to the first end and a second socket member is connected to the second end of the first support member. A first post is removably received by the first socket member. A second post is removably received by the second socket member. A first cross support member is removably connected to the first and second posts. The first and second posts are received by the first and second socket members and the first cross support member is received by the first and second posts when the crate assembly is in an assembled condition. The first and second posts are removed from the first and second socket members and the first cross support member is received by the first and second socket members when the crate assembly is in a collapsed condition.

摘要翻译： 提供了一种可折叠的箱子组件，其具有底座和固定到底座的第一支撑构件。 第一支撑构件具有第一和第二端。 第一插座构件连接到第一端，并且第二插座构件连接到第一支撑构件的第二端。 第一插座构件可拆卸地接收第一柱。 第二柱由第二插座构件可拆卸地接收。 第一交叉支撑构件可拆卸地连接到第一和第二柱。 第一和第二柱由第一和第二插座构件容纳，当第一和第二支柱构件处于组装状态时，第一和第二柱被第一和第二柱接纳。 第一和第二柱从第一和第二插座构件移除，并且当包装组件处于折叠状态时，第一横向支撑构件被第一和第二插座构件容纳。

公开(公告)号：US20050264002A1

公开(公告)日：2005-12-01

申请号：US10854441

申请日：2004-05-26

申请人： John Clarke ,  Jerry Arivett

发明人： John Clarke ,  Jerry Arivett

IPC分类号： A63B69/00 ,  F16L33/00 ,  F16L33/207

CPC分类号： F16L33/2071 ,  F16L33/025 ,  F16L2201/10 ,  Y10T24/1457

摘要： A clamp locator for hose assemblies is provided. The clamp locator includes releasable connections for holding hose clamps during assembly of a hose to a hose fitting. The releasable connections comprise generally elastic fingers that hold the clamps to the locator. As the hose clamps are crimped and closed over the hose the clamps are pulled from the fingers and released from the locator. The locator includes a reference locating tab protruding from the body of the locator. The tab corresponds to a reference locating groove in a fitting to which the hose is to be attached. The locator, with clamps attached, is first slid over an end of the hose and the fitting is inserted into the hose end. A ramp on the fitting leads the tab to the groove in the fitting as the fitting is inserted into the hose end. The tab will snap into the groove, indicating that the hose, fitting and clamps are properly aligned. The clamps are then crimped over the hose and the locator released for proper disposal.

摘要翻译： 提供了软管组件的夹具定位器。 夹具定位器包括在将软管组装到软管接头处时用于保持软管夹的可释放连接。 可释放的连接包括将夹具保持在定位器上的大致弹性的指状物。 当软管夹被压接并在软管上封闭时，夹具从手指中拉出并从定位器释放。 定位器包括从定位器的主体突出的参考定位凸片。 翼片对应于软管所附接的配件中的基准定位槽。 定位器，连接有夹具，首先在软管的一端滑动，并将接头插入软管端。 当配件插入软管端时，配件上的斜坡将接头的接头引导到配件中的凹槽。 卡舌将卡入槽中，表示软管，配件和夹具正确对齐。 然后将夹具压接在软管上，并释放定位器以便妥善处理。