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51.发明申请Device,system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject 有权用于向哺乳动物受试者靶向递送抗炎药物的装置，系统和方法公开(公告)号：US20110118652A1
公开(公告)日：2011-05-19
申请号：US12590860
申请日：2009-11-13
申请人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61K31/192 , A61B5/1116 , A61B5/112 , A61B5/1126 , A61B5/4528 , A61K31/195 , A61M37/0015 , A61M2005/3022 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061
摘要： A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.
摘要翻译： 描述了用于治疗哺乳动物受试者中关节骨的一个或多个关节的疾病或病症的装置，系统或方法。 该装置向哺乳动物受试者的一个或多个关节提供一种或多种药物。 描述了一种装置，其包括被配置为接触靠近哺乳动物受试者的关节骨的一个或多个关节的一个或多个身体轮廓的一个或多个基底; 一个或多个传感器被配置为检测所述一个或多个关节的一个或多个生理状况; 以及一个或多个由一个或多个基底支撑并且经配置以通过将一种或多种药物注射到哺乳动物受试者的一个或多个关节组织来响应于一个或多个传感器的微喷射施加器。
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52.发明申请Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject 有权用于向哺乳动物受试者靶向递送抗炎药物的装置，系统和方法公开(公告)号：US20110118698A1
公开(公告)日：2011-05-19
申请号：US12661079
申请日：2010-03-09
申请人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M37/00
CPC分类号： A61K31/192 , A61B5/1116 , A61B5/112 , A61B5/1126 , A61B5/4528 , A61K31/195 , A61M37/0015 , A61M2005/3022 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061
摘要： A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more sheaths configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more applicators supported by the one or more sheaths and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.
摘要翻译： 描述了用于治疗哺乳动物受试者中关节骨的一个或多个关节的疾病或病症的装置，系统或方法。 该装置向哺乳动物受试者的一个或多个关节提供一种或多种药物。 描述了一种装置，其包括构造成接触哺乳动物受试者的关节骨的一个或多个关节附近的一个或多个身体轮廓的一个或多个护套; 一个或多个传感器被配置为检测所述一个或多个关节的一个或多个生理状况; 以及由所述一个或多个护套支撑并且被配置为通过将一种或多种药物注射到哺乳动物受试者的一个或多个关节组织来响应所述一个或多个传感器的一个或多个施用器。
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53.发明申请Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject 有权用于向哺乳动物受试者靶向递送抗炎药物的装置，系统和方法公开(公告)号：US20110118560A1
公开(公告)日：2011-05-19
申请号：US12590857
申请日：2009-11-13
申请人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61B5/1126 , A61B5/01 , A61B5/1116 , A61B5/1118 , A61B5/112 , A61B5/441 , A61B5/4528 , A61B5/4866 , A61B5/6843 , A61B6/505 , A61B8/0875 , A61B8/4472 , A61M5/14248 , A61M37/0015 , A61M2005/3022 , A61M2037/0023 , A61M2037/0061
摘要： A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes an enclosure including one or more sensors, a controller, and one or more applicators configured to surround one or more joints of articulating bone of a mammalian subject, wherein the one or more sensors are configured to detect one or more physiological conditions of the one or more joints of the mammalian subject, and the controller, configured to communicate with the one or more sensors, is configured to activate the one or more applicators, and wherein the one or more applicators are configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.
摘要翻译： 描述了用于治疗哺乳动物受试者中关节骨的一个或多个关节的疾病或病症的装置，系统或方法。 该装置向哺乳动物受试者的一个或多个关节提供一种或多种药物。 描述了一种装置，其包括包括一个或多个传感器的壳体，控制器和被配置为围绕哺乳动物对象的关节骨的一个或多个关节的一个或多个施用器，其中所述一个或多个传感器被配置为检测一个或多个 哺乳动物受试者的一个或多个关节的生理条件以及被配置为与所述一个或多个传感器通信的所述控制器被配置为激活所述一个或多个施用器，并且其中所述一个或多个施用器被配置为注入一个或多个 更多的药物到哺乳动物受试者的一个或多个关节组织。
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54.发明申请Device,system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject 有权用于向哺乳动物受试者靶向递送抗炎药物的装置，系统和方法公开(公告)号：US20110117151A1
公开(公告)日：2011-05-19
申请号：US12590859
申请日：2009-11-13
申请人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61K31/192 , A61K9/00 , A61K31/195 , A61P29/00
CPC分类号： A61K31/192 , A61K31/195
摘要： A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to monitor movement of the one or more body contours; and one or more applicators supported by the one or more substrates and configured to respond to the movement of the one or more body contours by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.
摘要翻译： 描述了用于治疗哺乳动物受试者中关节骨的一个或多个关节的疾病或病症的装置，系统或方法。 该装置向哺乳动物受试者的一个或多个关节提供一种或多种药物。 描述了一种装置，其包括被配置为接触靠近哺乳动物受试者的关节骨的一个或多个关节的一个或多个身体轮廓的一个或多个基底; 一个或多个传感器被配置为监测所述一个或多个身体轮廓的运动; 以及一个或多个施用器，由一个或多个基底支撑并且构造成通过将一种或多种药物注射到哺乳动物受试者的一个或多个关节组织来响应一个或多个身体轮廓的移动。
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55.发明申请Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject 有权用于向哺乳动物受试者靶向递送抗炎药物的装置，系统和方法公开(公告)号：US20110118695A1
公开(公告)日：2011-05-19
申请号：US12660112
申请日：2010-02-19
申请人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61K31/192 , A61K31/195
摘要： A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to monitor movement of the one or more body contours; and one or more applicators supported by the one or more substrates and configured to respond to the movement of the one or more body contours by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.
摘要翻译： 描述了用于治疗哺乳动物受试者中关节骨的一个或多个关节的疾病或病症的装置，系统或方法。 该装置向哺乳动物受试者的一个或多个关节提供一种或多种药物。 描述了一种装置，其包括被配置为接触靠近哺乳动物受试者的关节骨的一个或多个关节的一个或多个身体轮廓的一个或多个基底; 一个或多个传感器被配置为监测所述一个或多个身体轮廓的运动; 以及一个或多个施用器，由一个或多个基底支撑并且构造成通过将一种或多种药物注射到哺乳动物受试者的一个或多个关节组织来响应一个或多个身体轮廓的移动。
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56.发明申请公开(公告)号：US20110118656A1
公开(公告)日：2011-05-19
申请号：US12590856
申请日：2009-11-13
申请人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M37/00
CPC分类号： A61K31/192 , A61B5/1116 , A61B5/112 , A61B5/1126 , A61B5/4528 , A61K31/195 , A61M37/0015 , A61M2005/3022 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061
摘要： A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more sheaths configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more applicators supported by the one or more sheaths and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.
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公开(公告)号：US20100069606A1
公开(公告)日：2010-03-18
申请号：US12283908
申请日：2008-09-15
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C07K2/00 , C07K16/00 , C07H1/00 , C07H21/04 , C07D323/00 , C07C69/00 , C07C229/00 , C07C49/00 , C07C47/00 , C07C43/00 , C07K14/42
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构的装置，组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域，侧壁有两个亲水性表面区域的疏水性表面区域，所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔，以及至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞，感染细胞或患病细胞。 管状纳米结构可以在细胞器（例如线粒体）的脂质双层膜中形成孔，其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。
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公开(公告)号：US20100068808A1
公开(公告)日：2010-03-18
申请号：US12322367
申请日：2009-01-30
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构或复合管状纳米结构的装置，组合物和方法。 管状纳米结构包括侧面有两个亲水表面区域的疏水表面区域。 管状纳米结构被配置为与脂质双层膜相互作用并在脂质双层膜中形成孔。 管状纳米结构可以通过包括至少一种被配置成结合靶细胞的脂质双层膜上的一个或多个同源物的配体来靶向。
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公开(公告)号：US20100233781A1
公开(公告)日：2010-09-16
申请号：US12322366
申请日：2009-01-30
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C07C49/00 , C07C69/00 , C07C43/00 , C07C229/00 , C07C47/00 , C07C211/00 , C07C35/00 , C07K16/00 , C07K14/00 , C12N9/10 , C07K2/00 , C07D323/00 , C07H21/04 , C07K14/765 , C07H1/00 , C07D207/40 , C07K14/415 , D01F9/12 , C08G63/91
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
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公开(公告)号：US20110177154A1
公开(公告)日：2011-07-21
申请号：US12283907
申请日：2008-09-15
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61K9/127 , C07K7/64 , C07D321/00 , C07H21/00 , C07K14/00 , C07H7/00 , C07C229/00 , C08G63/48 , C07K16/00 , C12N9/14 , A61K9/14 , A61K38/02 , A61K38/16 , A61K31/335 , A61K31/7088 , A61K38/14 , A61K39/395 , A61K38/12 , A61P43/00 , B82Y5/00
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构或复合管状纳米结构的装置，组合物和方法。 管状纳米结构包括侧面有两个亲水表面区域的疏水表面区域。 管状纳米结构被配置为与脂质双层膜相互作用并在脂质双层膜中形成孔。 管状纳米结构可以通过包括至少一种被配置成结合靶细胞的脂质双层膜上的一个或多个同源物的配体来靶向。
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