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351 条记录 (耗时 0.051 秒)

    Biodegradable poly(beta-amino esters) and uses thereof
    51.
    发明授权
    Biodegradable poly(beta-amino esters) and uses thereof 有权
    可生物降解的聚（β-氨基酯）及其用途

    公开(公告)号：US08287849B2

    公开(公告)日：2012-10-16

    申请号：US12507999

    申请日：2009-07-23

    申请人： Robert S. Langer ,  David M. Lynn ,  David Putnam ,  Mansoor M. Amiji ,  Daniel G. Anderson

    发明人： Robert S. Langer ,  David M. Lynn ,  David Putnam ,  Mansoor M. Amiji ,  Daniel G. Anderson

    IPC分类号： A61K31/765 ,  A61K9/00 ,  C08F26/00

    CPC分类号： A61K47/34 ,  A61K9/5146 ,  A61K31/711 ,  A61K31/713 ,  A61K47/59 ,  A61K47/593 ,  A61K47/6929 ,  B82Y5/00 ,  C08G63/685 ,  C08G73/02 ,  C08G73/0273 ,  C08G73/06 ,  C08G73/0611 ,  C08G73/0616 ,  C12N15/88

    摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

    摘要翻译： 描述了从双（仲胺）或伯胺向双（丙烯酸酯）共轭加成制备的聚（＆（bgr。 - 氨基酯））。 还提供了从市售的原料制备这些聚合物的方法。 这些含叔胺的聚合物优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。 鉴于这些聚合物的聚（胺）性质，它们特别适用于递送多核苷酸。 已经制备了含有聚合物/多核苷酸复合物的纳米颗粒。 本发明的聚合物也可以用于包封待递送的其它试剂。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

    Disposable medical supplies from hydrolytically biodegradable plastics
    52.
    发明授权
    Disposable medical supplies from hydrolytically biodegradable plastics 有权
    水解生物降解塑料的一次性医疗用品

    公开(公告)号：US08143368B2

    公开(公告)日：2012-03-27

    申请号：US11722655

    申请日：2005-12-22

    申请人： Abraham J. Domb ,  Robert S. Langer

    发明人： Abraham J. Domb ,  Robert S. Langer

    IPC分类号： C08G63/54

    CPC分类号： A61L29/148 ,  Y10T428/1352 ,  Y10T428/2913 ,  Y10T428/2915 ,  Y10T428/31786

    摘要： Hydrolytically degradable polymers in the form of biodegradable disposable medical devices for use in medicine and laboratories such as syringes, test tubes, catheters, tubing, trays, medical fabrics, and gloves are described. The devices are formed in whole or in part of a hydrolytically degradable polymer. In the preferred embodiment, the devices or structural components thereof degrade in a period of weeks to months, preferably within a year and more preferably within six months of exposure to aqueous solutions. Conventional hydrolytically degradable polymers may be utilized or these may be modified to increase mechanical or processing characteristics, for example, using a polyfunctional branching agent and/or a chain extending agent. In one embodiment, the hydrolytically degradable polymer is a member of a new class of polyesters comprising an aliphatic dicarboxylic acid, an aliphatic diol and optionally, one or more bifunctional fatty acids such as ricinoleic acid and/or castor oil. The devices are prepared using standard techniques, such as by injection molding, extrusion or melt spinning. The devices can be formed entirely of the degradable polymer, or they can be coated with a polymer coating in order to increase the compatibility of and reduce the possibility for interaction between the surface of the device and liquids that may come in contact with the device, or they may include core or other internal structural member formed of either the biodegradable or non-biodegradable material.

    摘要翻译： 描述了用于药物和实验室（例如注射器，试管，导管，管道，托盘，医用织物和手套）的可生物降解的一次性医疗装置形式的水解可降解聚合物。 该装置全部或部分形成水解可降解聚合物。 在优选的实施方案中，装置或其结构组分在暴露于水溶液中的几周至数月内，优选在一年内，更优选在六个月内降解。 可以使用常规的可水解降解聚合物，或者这些聚合物可以被改性以增加机械或加工特性，例如使用多官能支化剂和/或扩链剂。 在一个实施方案中，水解可降解聚合物是包含脂族二羧酸，脂族二醇和任选的一种或多种双官能脂肪酸如蓖麻油酸和/或蓖麻油的新类聚酯的成员。 这些装置使用标准技术制备，例如通过注塑，挤出或熔融纺丝。 这些装置可以完全由可降解的聚合物形成，或者它们可以用聚合物涂层涂覆，以增加装置的表面与可能与装置接触的液体之间的相互作用的相容性并降低其相互作用的可能性， 或者它们可以包括由可生物降解或不可生物降解的材料形成的芯或其它内部结构构件。

    Composition and methods for enhancing receptor-mediated cellular internalization
    58.
    再颁专利
    Composition and methods for enhancing receptor-mediated cellular internalization 有权
    用于增强受体介导的细胞内化的组合物和方法

    公开(公告)号：USRE41996E1

    公开(公告)日：2010-12-14

    申请号：US11821513

    申请日：2007-06-21

    申请人： Daniel R. Deaver ,  David A. Edwards ,  Robert S. Langer

    发明人： Daniel R. Deaver ,  David A. Edwards ,  Robert S. Langer

    IPC分类号： A61F2/02 ,  A61F13/02 ,  A61K9/48 ,  A61K9/20 ,  A61K9/14

    CPC分类号： A61K9/0046 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/06 ,  A61K31/56 ,  A61K31/573 ,  A61K31/715 ,  A61K47/38 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0083 ,  Y10S977/906

    摘要： Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.

    摘要翻译： 公开了用于改善一种或多种化合物的细胞内化的组合物和方法。 组合物包括待递送的化合物和生物相容的粘性材料，例如水凝胶，脂凝胶或高粘度溶胶。 该组合物还包括或者与增效剂一起施用，其量可以有效地最大程度地使受体的表达或结合，并增强化合物进入细胞的RME。 这导致要跨细胞膜递送的化合物的高传输速率，有助于更有效地递送药物和诊断剂。 组合物经口，鼻，阴道，直肠和眼部局部应用。 增强剂与组合物一起施用或分开施用，全部或优选局部施用。 待递送的化合物也可以是增强剂。