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公开(公告)号：US09638653B2
公开(公告)日：2017-05-02
申请号：US14710299
申请日：2015-05-12
Applicant: General Electric Company
Inventor： Radislav Alexandrovich Potyrailo , Cheryl Margaret Surman , Andrew Arthur Paul Burns , Nandini Nagraj
IPC: G01N27/02 , G01N33/487 , G01N33/483
CPC classification number: G01N27/026 , G01N27/02 , G01N33/483 , G01N33/48792
Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g. 10×, 1,000,000×) compared to other components in the mixture.
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公开(公告)号：US09389296B2
公开(公告)日：2016-07-12
申请号：US13838884
申请日：2013-03-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Radislav Alexandrovich Potyrailo , Ian James Forster
CPC classification number: G01R35/005 , A61B5/0031 , A61B2560/0219 , G01N22/00 , G01N22/04 , G01N27/023 , G01N27/026 , G01N33/0006 , G01N33/0073
Abstract: In one embodiment a method for sensor reader calibration comprising: performing a calibration of a sensor reader wherein the calibration comprises open circuit calibration, a short circuit calibration, and a load circuit calibration, or any combination thereof in any succession; enabling connection of a pickup coil to the sensor reader to measure a sensor response; and applying a baseline correction to the sensor response, wherein the baseline correction is obtained utilizing measurements from the calibration step. In a further embodiment, a method for sensor response calibration incorporating environmental correction comprising: measuring a first resonance impedance spectrum of the sensor with a first applied power to the pickup coil; measuring a second resonance impedance spectrum of the sensor with a second applied power to the pickup coil; and applying a correction to the sensor response corresponding to the respective measured first and second resonance impedance spectrum to mitigate for environmental parameters.
Abstract translation: 在一个实施例中，一种用于传感器读取器校准的方法，包括：执行传感器读取器的校准，其中所述校准包括开路校准，短路校准和负载电路校准，或任何连续的任何组合; 使得拾取线圈连接到传感器读取器以测量传感器响应; 以及对传感器响应应用基线校正，其中使用来自校准步骤的测量获得基线校正。 在另一个实施例中，一种包括环境校正的传感器响应校准方法，包括：以对所述拾取线圈施加的第一施加功率来测量所述传感器的第一共振阻抗谱; 测量具有第二施加功率的传感器的第二共振阻抗谱到拾取线圈; 以及对与所测量的第一和第二共振阻抗谱对应的传感器响应应用校正，以减轻环境参数。
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公开(公告)号：US20150115983A1
公开(公告)日：2015-04-30
申请号：US14585690
申请日：2014-12-30
Applicant: General Electric Company
Inventor： Radislav Alexandrovich Potyrailo , Igor Tokarev
CPC classification number: G01N33/2888 , G01N27/026
Abstract: A system that includes a sensor for measuring a resonant impedance spectral response of an inductor-capacitor-resistor (LCR) resonator and correlating the measured response of one or more spectral parameters to one or more characteristics of the fluid. Such characteristics may be the age or health of the fluid and/or the identification of and concentration of components in the fluid.
Abstract translation: 一种系统，其包括用于测量电感器 - 电容器 - 电阻器（LCR）谐振器的谐振阻抗谱响应的传感器，并将一个或多个频谱参数的测量响应与流体的一个或多个特性相关联。 这些特征可以是流体的年龄或健康状况和/或流体中组分的识别和浓度。
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54.发明申请公开(公告)号：US20150093839A1
公开(公告)日：2015-04-02
申请号：US14043895
申请日：2013-10-02
Applicant: General Electric Company
Inventor： Radislav Alexandrovich Potyrailo , Andrew David Pris , Nandini Nagraj , Anthony John Murray
IPC: G01N33/53
CPC classification number: G01N33/5306 , G01N33/5308 , G01N33/54306 , G01N33/54386
Abstract: A method of recovering a target from a sample is provided. The method of recovering the target follows different steps. The steps include providing a binding element, wherein the binding elements are immobilized on a solid support, adding the sample comprising the target to the binding element to form a binding element-target complex; washing the binding element-target complex; and eluting the target from the binding element-target complex. The system for reversible detection of target in a range from 2 to 1,000,000 bind/release cycles is also provided.
Abstract translation: 提供了从样品中回收靶的方法。 恢复目标的方法遵循不同的步骤。 所述步骤包括提供结合元件，其中所述结合元件固定在固体支持物上，将包含所述靶的样品添加到所述结合元件以形成结合元件 - 目标复合物; 洗涤结合元素 - 目标复合物; 并从结合元件 - 目标复合物洗脱目标物。 还提供了在2至1,000,000个结合/释放循环范围内可目标检测靶的系统。
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公开(公告)号：US08990025B2
公开(公告)日：2015-03-24
申请号：US14031965
申请日：2013-09-19
Applicant: General Electric Company
IPC: G01N27/02 , G01N33/487
CPC classification number: G01N27/02 , G01N27/025 , G01N33/48792 , Y10T29/49007
Abstract: Methods and sensors for selective fluid sensing are provided. A sensor includes a resonant inductor-capacitor-resistor (LCR) circuit and a sensing material disposed over a sensing region. The sensing region comprises at least a portion of the LCR circuit. Temperature-dependent response coefficients of inductance L, capacitance C, and resistance R properties of the LCR circuit and the sensing material are at least approximately 5 percent different from one another. The difference in the temperature-dependent response coefficients of the properties of the LCR circuit and the sensing material enables the sensor to selectively detect analyte fluids from an analyzed fluid mixture substantially independent of temperature.
Abstract translation: 提供了选择性流体感测的方法和传感器。 传感器包括谐振电感器 - 电容器电阻（LCR）电路和设置在感测区域上的感测材料。 感测区域包括LCR电路的至少一部分。 LCR电路和传感材料的电感L，电容C和电阻R性质的温度依赖性响应系数至少大约相差5％。 LCR电路和感测材料的性质的温度依赖性响应系数的差异使得传感器能够基本上独立于温度从分析的流体混合物中选择性地检测分析物流体。
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Patent Agency Ranking
公开(公告)号：US20150080226A1
公开(公告)日：2015-03-19
申请号：US14030386
申请日：2013-09-18
Applicant: General Electric Company
Inventor： Nandini Nagraj , Radislav Alexandrovich Potyrailo , Andrew David Pris , John Richard Nelson
CPC classification number: C12N15/1034 , C12N15/1048 , C12Q1/6811 , C40B30/04 , G01N33/53 , G01N33/5308 , H04N1/32309 , H04N1/3232 , H04N1/32352 , H04N1/40 , H04N1/60 , H04N2201/0094 , H04N2201/3233 , H04N2201/327 , H04N2201/3271 , H04N2209/00 , C12Q2525/205 , C12Q2531/125 , C12Q2537/162 , C12Q2565/107
Abstract: Methods for selecting a binding-element are provided. The method comprised of different steps. A first mixture is formed using at least one target molecule and a plurality of oligomers, followed by incubating the first mixture to form a second mixture comprising at least one target-bound oligomer and at least one target-unbound oligomer. Then a first accelerator is added to cleave the target-unbound oligomer and the target-bound oligomer is separated from the target molecule. This is followed by addition of a second accelerator for ligation, and a third accelerator for amplification followed by sequencing and post sequence analysis to select the binding-element.
Abstract translation: 提供了选择结合元件的方法。 该方法由不同的步骤组成。 使用至少一种靶分子和多个低聚物形成第一混合物，随后温育第一混合物以形成包含至少一种靶结合的低聚物和至少一种靶未结合的低聚物的第二混合物。 然后加入第一促进剂以切割目标未结合的寡聚物，并且靶向寡聚体与目标分子分离。 然后加入第二种用于连接的促进剂，和第三种用于扩增的加速剂，然后进行测序和后序列分析以选择结合元件。
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公开(公告)号：US20140095102A1
公开(公告)日：2014-04-03
申请号：US13630939
申请日：2012-09-28
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Radislav Alexandrovich Potyrailo , Jeffrey Michael Ashe , Sm Shajed Hasan , Naresh Kesavan Rao , Krishnakumar Sundaresan
CPC classification number: G01R27/28 , G01R31/2824
Abstract: An impedance analyzer is provided. The analyzer includes a signal excitation generator comprising a digital to analog converter, where a transfer function of the digital to analog converter from digital to analog is programmable. The impedance analyzer further includes a receiver comprising a low noise amplifier (LNA) and an analog to digital converter (ADC), where the LNA is a current to voltage converter; where the programmable digital to analog transfer function is implemented by a direct digital synthesizer (DDS) and a voltage mode digital to analog converter, or a digital phase locked loop (PLL), or both. Further, a multivariable sensor node having an impedance analyzer is provided. Furthermore, a multivariable sensor network having a plurality of multivariable sensor nodes is provided.
Abstract translation: 提供阻抗分析仪。 该分析器包括一个包括数模转换器的信号激励发生器，其中从数字到模拟的数模转换器的传递函数是可编程的。 该阻抗分析器还包括一个包括低噪声放大器（LNA）和模数转换器（ADC）的接收器，其中LNA是电流到电压转换器; 其中可编程数字到模拟传递功能由直接数字合成器（DDS）和电压模式数模转换器或数字锁相环（PLL）或两者实现。 此外，提供了具有阻抗分析器的多变量传感器节点。 此外，提供了具有多个多变量传感器节点的多变量传感器网络。
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公开(公告)号：US20140091811A1
公开(公告)日：2014-04-03
申请号：US13630954
申请日：2012-09-28
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Radislav Alexandrovich Potyrailo , Jeffrey Michael Ashe , Sm Shajed Hasan , Naresh Kesavan Rao , Krishnakumar Sundaresan
IPC: G01R27/02
CPC classification number: G06K19/0717 , G06K19/0723 , G06K19/07749
Abstract: A method for multivariable measurements using a single-chip impedance analyzer includes providing a sensor, exposing the sensor to an environmental parameter, determining a complex impedance of the sensor over a measured spectral frequency range of the sensor, and monitoring at least three spectral parameters of the sensor.
Abstract translation: 使用单芯片阻抗分析仪进行多变量测量的方法包括提供传感器，将传感器暴露于环境参数，在传感器的测量光谱频率范围内确定传感器的复阻抗，以及监测至少三个光谱参数 传感器。
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公开(公告)号：US20140025313A1
公开(公告)日：2014-01-23
申请号：US14031951
申请日：2013-09-19
Applicant: General Electric Company
Inventor： Radislav Alexandrovich Potyrailo , Cheryl Margaret Surman , Andrew Arthur Paul Burns , Nandini Nagraj
IPC: G01N27/02
CPC classification number: G01N27/026 , G01N27/02 , G01N33/483 , G01N33/48792
Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g. 10×, 1,000,000×) compared to other components in the mixture.
Abstract translation: 提供了选择性流体感测的方法和传感器。 每个传感器包括一个涂有传感材料的谐振电感 - 电容电阻（LCR）传感器。 为了收集数据，在相对窄的频率范围（例如LCR电路的谐振频率范围）上获取阻抗谱。 可以从所获得的光谱计算多变量特征，以辨别某些流体和/或流体混合物的存在。 通过观察电路的谐振电子特性的变化来测量所用材料的介电性质，尺寸，电阻，电荷转移和其它变化的变化来检测流体的存在。 通过使用诸如主成分分析（PCA）等的数学方法，可以在彼此存在的情况下检测多种流体和混合物，即使在高湿度环境或其中一种或多种流体具有显着更高浓度的环境中 （例如10×1,000,000×）与混合物中的其他成分相比。
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公开(公告)号：US20240011934A1
公开(公告)日：2024-01-11
申请号：US17859921
申请日：2022-07-07
Applicant: General Electric Company
Inventor： Radislav Alexandrovich Potyrailo , Baokai Cheng , Janell Marie Crowder
IPC: G01N27/404 , G01N27/413
CPC classification number: G01N27/404 , G01N27/413
Abstract: An electrochemical gas sensor for multi-gas analysis of a fluid sample includes an electrochemical gas sensing element and a data collection component. The data collection component is configured to cycle the electrochemical gas sensing element between first excitation and signal detection values and second excitation and signal detection values at a predetermined time constant, and to measure responses of the electrochemical gas sensor to the fluid sample at the first excitation and signal detection values and the second excitation and signal detection values wherein the responses of the electrochemical gas sensor to the fluid sample at the first excitation and signal detection values and the second excitation and signal detection values are indicative of identities, respective concentrations, or a combination thereof, of at least two analyte gases of the fluid sample.
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