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公开(公告)号：US10005774B2
公开(公告)日：2018-06-26
申请号：US15150038
申请日：2016-05-09
Applicant: Gilead Sciences, Inc.
Inventor： Peter A. Blomgren , Jayaraman Chandrasekhar , Kevin S. Currie , Zhimin Du , Julie Farand , Juan A. Guerrero , Ashley A. Katana , Darryl Kato , Jeffrey E. Kropf , Scott E. Lazerwith , Seung H. Lee , Jiayao Li , John O. Link , Jennifer R. Lo , Nicholas Mai , Scott A. Mitchell , Gregory Notte , Hyung-jung Pyun , Michael Sangi , Aaron C. Schmitt , Adam J. Schrier , Kirk L. Stevens , Chandrasekar Venkataramani , William J. Watkins , Jin-Ming Xiong , Jianjun Xu , Zheng-Yu Yang , Jeff Zablocki , Zhongdong Zhao , Sheila Zipfel
IPC: C07D471/04 , C07D401/14 , C07D403/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D407/14 , C07D417/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D491/08 , C07D498/04 , C07D519/00
CPC classification number: C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/08 , C07D498/04 , C07D519/00
Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.
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公开(公告)号：US20180161307A1
公开(公告)日：2018-06-14
申请号：US15686499
申请日：2017-08-25
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC: A61K31/403 , A61K31/16 , A61K31/03 , A61K31/38 , A61K31/4192 , A61P31/20
CPC classification number: A61K31/403 , A61K31/03 , A61K31/16 , A61K31/38 , A61K31/4192 , A61P31/20 , C07D487/04 , C07D519/00
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US20180153887A1
公开(公告)日：2018-06-07
申请号：US15618464
申请日：2017-06-09
Applicant: Gilead Sciences, Inc.
Inventor： Mingzhe Ji , Scott E. Lazerwith , Hyung-Jung Pyun
IPC: A61K31/4985 , A61K31/537 , A61K45/06
CPC classification number: A61K31/4985 , A61K31/537 , A61K31/553 , A61K45/06 , C07D471/14 , C07D471/18 , C07D498/14 , C07D498/18
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US09795602B2
公开(公告)日：2017-10-24
申请号：US15349353
申请日：2016-11-11
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Zhenhong R. Cai , Jeromy J. Cottell , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Philip Anthony Morganelli , Hyung-Jung Pyun
IPC: A61K31/4985 , C07D491/147 , A61K45/06
CPC classification number: A61K31/4985 , A61K45/06 , C07D471/04 , C07D491/147 , C07D491/20
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US20170119764A1
公开(公告)日：2017-05-04
申请号：US15349353
申请日：2016-11-11
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Zhenhong R. Cai , Jeromy J. Cottell , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Philip Anthony Morganelli , Hyung-Jung Pyun
IPC: A61K31/4985 , A61K45/06 , C07D491/147
CPC classification number: A61K31/4985 , A61K45/06 , C07D471/04 , C07D491/147 , C07D491/20
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20170057976A1
公开(公告)日：2017-03-02
申请号：US15349934
申请日：2016-11-11
Applicant: Gilead Sciences, Inc.
Inventor： Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun , Manoj C. Desai , Teresa Alejandra Trejo , Elizabeth Bacon , Jeromy J. Cottell , Zhenhong R. Cai , Philip Anthony Morganelli , Mingzhe Ji , James G. Taylor , Xiaowu Chen , Michael R. Mish
IPC: C07D498/14 , A61K31/537 , A61K31/553 , A61K45/06
CPC classification number: C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Abstract translation: 包括立体异构体及其药学上可接受的盐，其中R1，X，W，Y1，Y2，Z1和Z4如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US20150018298A1
公开(公告)日：2015-01-15
申请号：US14329694
申请日：2014-07-11
Applicant: GILEAD SCIENCES, INC.
Inventor： Mingzhe Ji , Scott E. Lazerwith , Hyung-Jung Pyun
IPC: A61K31/553 , A61K45/06 , C07D471/18 , A61K31/4985 , C07D498/18 , A61K31/537
CPC classification number: A61K31/4985 , A61K31/537 , A61K31/553 , A61K45/06 , C07D471/14 , C07D471/18 , C07D498/14 , C07D498/18
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。 所述化合物具有下式（I）：其包括立体异构体及其药学上可接受的盐，其中R 1，X，Y 1，Y 2或L如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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公开(公告)号：US20250154116A1
公开(公告)日：2025-05-15
申请号：US18918629
申请日：2024-10-17
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Tae H. Hwang , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , John E. Knox , Scott E. Lazerwith , Xiaofen Li , David W. Lin , Jonathan W. Medley , Michael L. Mitchell , Devan Naduthambi , Zachary Newby , Neil H. Squires , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang
IPC: C07D267/20 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
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公开(公告)号：US20250042922A1
公开(公告)日：2025-02-06
申请号：US18756455
申请日：2024-06-27
Applicant: Gilead Sciences, Inc.
Inventor： Chaodi Dai , Julie Farand , Juan A. Guerrero , Tezcan Guney , Hongyan Guo , Jason R. Hudlicky , Darryl Kato , Irene N. Kiburu , Scott E. Lazerwith , Paulo A. Machicao Tello , James B.C. Mack , Erik P. McAuley , Jessica L. McKinley , Jonathan William Medley , Hyung-Jung Pyun , Thomas P. Stratton , Maoqun Tian , Jeremy R. Tuck , William J. Watkins , Jie Xu , Jennifer R. Zhang
IPC: C07D519/00 , A61K31/55 , C07D471/22
Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
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公开(公告)号：US12162844B2
公开(公告)日：2024-12-10
申请号：US18181336
申请日：2023-03-09
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Tae H. Hwang , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , John E. Knox , Scott E. Lazerwith , Xiaofen Li , David W. Lin , Jonathan W. Medley , Michael L. Mitchell , Devan Naduthambi , Zachary Newby , Neil H. Squires , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang
IPC: C07D513/08 , A61K31/553 , C07D267/20 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/10 , C07D513/20 , C07D513/22 , A61K45/06
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
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