公开(公告)号：US20080082782A1

公开(公告)日：2008-04-03

申请号：US11613355

申请日：2006-12-20

申请人： Henricus Johannes Maria Meijer ,  Raymond E. Ozzie ,  Thomas F. Bergstraesser ,  Michael Connolly ,  Daniel S. Glasser ,  Matthew B. MacLaurin ,  Kartik N. Raghavan

发明人： Henricus Johannes Maria Meijer ,  Raymond E. Ozzie ,  Thomas F. Bergstraesser ,  Michael Connolly ,  Daniel S. Glasser ,  Matthew B. MacLaurin ,  Kartik N. Raghavan

IPC分类号： G06F12/00

CPC分类号： G06F17/30864

摘要： The innovation enables generation of an index of cloud-based resources (e.g., data, services, applications). The index can be used to retrieve a subset of the cloud-based resources by analyzing a user-generated or standing query. ‘Identity’ and contextual factors can be incorporated to enable rich indexing as well as subsequent retrieval of meaningful resources. The cloud-based resources can be indexed and/or searched in accordance with diverse criteria including, but not limited to, type, size, data created, date modified, author core identity, object size, etc. As well, the innovation can provide for dynamically indexing and/or searching resources in accordance with current contextual factors including, but not limited to, author current acting capacity (e.g., current identity), current engaged activity of a user, location, time, date, etc. All of these criteria can facilitate indexing and categorizing of the resources for later retrieval and rendering via a rich index view.

摘要翻译： 该创新使得能够生成基于云的资源（例如，数据，服务，应用）的索引。 该索引可用于通过分析用户生成的或站立的查询来检索基于云的资源的子集。 可以并入“身份”和背景因素，以实现丰富的索引以及随后检索有意义的资源。 可以根据不同的标准来索引和/或搜索基于云的资源，包括但不限于类型，大小，创建的数据，日期修改，作者核心标识，对象大小等。此外，创新可以提供 用于根据当前的上下文因素来动态索引和/或搜索资源，包括但不限于作者当前的动作能力（例如，当前身份），用户当前的参与活动，位置，时间，日期等等。所有这些 标准可以促进资源的索引和分类，以便通过丰富的索引视图进行后续检索和呈现。

公开(公告)号：US20070232913A1

公开(公告)日：2007-10-04

申请号：US11735279

申请日：2007-04-13

申请人： Michael Lau ,  Nelson Teng ,  Shahram Vaezy ,  Alexander Lebedev ,  Michael Lau ,  Michael Connolly

发明人： Michael Lau ,  Nelson Teng ,  Shahram Vaezy ,  Alexander Lebedev ,  Michael Lau ,  Michael Connolly

IPC分类号： A61H1/00 ,  A61B8/00

CPC分类号： A61N7/022 ,  A61B1/303 ,  A61B8/12 ,  A61B2017/22008 ,  A61B2017/4216 ,  A61B2090/378

摘要： A probe having a high intensity focused ultrasound (HIFU) transducer is positioned in a female patient. The HIFU transducer is deployed within the vagina of the patient outside of the cervix and uterine cavity and is configured to direct HIFU energy to a treatment site within the uterus of the patient. An imaging component positioned relative to the patient images a portion of the patient's uterus that includes the treatment site to help guide the delivery of the HIFU energy to the treatment site. A liquid medium may be infused into the uterine cavity of the patient where it is maintained during imaging and delivery of the HIFU therapy. The HIFU transducer produces a thermal heating of tissue at a focus within the treatment site to initiate necrosis of the tissue. The location of the focus is controlled in accordance with an image obtained by the imaging component.

摘要翻译： 具有高强度聚焦超声（HIFU）换能器的探针定位在女性患者体内。 HIFU传感器部署在患者子宫颈和子宫腔外的阴道内，并配置为将HIFU能量引导到患者子宫内的治疗部位。 相对于患者定位的成像组件对包括治疗部位的患者子宫的一部分进行成像，以帮助指导将HIFU能量递送到治疗部位。 液体培养基可以输注到患者的子宫腔中，在HIFU治疗的成像和传送过程中维持它。 HIFU换能器在处理部位的焦点处产生组织的热加热，以引起组织的坏死。 根据由成像部件获得的图像来控制焦点的位置。

公开(公告)号：US20050020630A1

公开(公告)日：2005-01-27

申请号：US10860524

申请日：2004-06-03

申请人： Michael Connolly ,  Rocco Gogliotti ,  Helen Lee ,  Mark Plummer ,  Karen Sexton ,  Melean Visnick

发明人： Michael Connolly ,  Rocco Gogliotti ,  Helen Lee ,  Mark Plummer ,  Karen Sexton ,  Melean Visnick

IPC分类号： A61K31/41 ,  A61K31/454 ,  A61P11/00 ,  C07D409/12 ,  C07D409/14 ,  C07

CPC分类号： C07D409/12 ,  C07D409/14

摘要： The present invention provides benzo[b]thiophenes of Formula I: wherein R1, R2, R3, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

摘要翻译： 本发明提供式I的苯并[b]噻吩：其中R 1，R 2，R 3和L具有本说明书中定义的任何值及其药学上可接受的盐，其为 可用作治疗疾病和病症（包括炎性疾病，心血管疾病和癌症）的药剂。 还提供了包含一种或多种式I化合物的药物组合物。

公开(公告)号：US20080082490A1

公开(公告)日：2008-04-03

申请号：US11536440

申请日：2006-09-28

申请人： Matthew B. MacLaurin ,  Raymond E. Ozzie ,  Thomas F. Bergstraesser ,  Michael Connolly ,  Daniel S. Glasser ,  Henricus Johannes Maria Meijer ,  Kartik N. Raghavan

发明人： Matthew B. MacLaurin ,  Raymond E. Ozzie ,  Thomas F. Bergstraesser ,  Michael Connolly ,  Daniel S. Glasser ,  Henricus Johannes Maria Meijer ,  Kartik N. Raghavan

IPC分类号： G06F17/30

CPC分类号： G06F16/951

摘要： The innovation enables generation of an index of cloud-based resources (e.g., data, services, applications). The index can be used to retrieve a subset of the cloud-based resources by analyzing a user-generated or standing query. ‘Identity’ and contextual factors can be incorporated to enable rich indexing as well as subsequent retrieval of meaningful resources. The cloud-based resources can be indexed and/or searched in accordance with diverse criteria including, but not limited to, type, size, data created, date modified, author core identity, object size, etc. As well, the innovation can provide for dynamically indexing and/or searching resources in accordance with current contextual factors including, but not limited to, author current acting capacity (e.g., current identity), current engaged activity of a user, location, time, date, etc. All of these criteria can facilitate indexing and categorizing of the resources for later retrieval and rendering via a rich index view.

摘要翻译： 该创新使得能够生成基于云的资源（例如，数据，服务，应用）的索引。 该索引可用于通过分析用户生成的或站立的查询来检索基于云的资源的子集。 可以并入“身份”和背景因素，以实现丰富的索引以及随后检索有意义的资源。 可以根据不同的标准来索引和/或搜索基于云的资源，包括但不限于类型，大小，创建的数据，日期修改，作者核心标识，对象大小等。此外，创新可以提供 用于根据当前的上下文因素来动态索引和/或搜索资源，包括但不限于作者当前的动作能力（例如，当前身份），用户当前的参与活动，位置，时间，日期等等。所有这些 标准可以促进资源的索引和分类，以便通过丰富的索引视图进行后续检索和呈现。

公开(公告)号：US20070087972A1

公开(公告)日：2007-04-19

申请号：US11518091

申请日：2006-09-08

申请人： David Peretz ,  Michael Connolly ,  Ronald Zuckermann ,  Man Gao ,  Gulliver Timoteo ,  Robert Shimizu

发明人： David Peretz ,  Michael Connolly ,  Ronald Zuckermann ,  Man Gao ,  Gulliver Timoteo ,  Robert Shimizu

IPC分类号： A61K38/08 ,  C07K7/06

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/47 ,  Y02P20/55

摘要： The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.

摘要翻译： 本发明涉及与构象疾病蛋白质的非致病形式相比优先与构象疾病蛋白质的致病形式相互作用的拟肽试剂，其中拟肽试剂包含氨基末端区域，羧基末端区域和至少一个 氨基末端区域和羧基末端区域之间的拟肽区域，其中拟肽区域包含3至约30个N-取代的甘氨酸，以及任选的一个或多个氨基酸。 本发明还涉及使用拟肽来检测和分离朊病毒以及治疗和预防朊病毒相关疾病的方法。

公开(公告)号：US20070044267A1

公开(公告)日：2007-03-01

申请号：US11209601

申请日：2005-08-23

申请人： Michael Connolly

发明人： Michael Connolly

IPC分类号： B66B7/12

CPC分类号： B66B7/1284

摘要： An adjustable wire rope cleaning device comprising a first base plate and a second base plate, each having opposite ends and two longitudinal sides. Side bars are at the longitudinal sides of at least one of the first base plate and the second base plate and are aligned along an axis of the first base plate, such that a guide channel is defined and partially enclosed by the side bars. The second base plate is slidably attached to the first base plate and within the guide channel. A lateral bar at one end of the first base plate and between the two side bars, and the lateral bar is transverse to the side bars. An adjustment device positioned between the lateral bar and the second base plate, the adjustment device is operable to move the second base plate relative to the first base plate along the axis defined by the guide channel. A brush is coupled to the second base plate, and the brush is adjusted by movement of the second base plate within the guide channel.

摘要翻译： 一种可调节的钢丝绳清洁装置，包括第一基板和第二基板，每个具有相对端和两个纵向侧。 侧杆在第一基板和第二基板中的至少一个的纵向侧面上并且沿着第一基板的轴线对齐，使得引导通道被侧杆限定和部分地包围。 第二基板可滑动地附接到第一基板并且在引导通道内。 在第一基板的一端和两个侧杆之间的横向杆和侧杆横向于侧杆。 位于侧杆和第二基板之间的调节装置，调节装置可操作以沿着由引导通道限定的轴线相对于第一基板移动第二基板。 刷子耦合到第二基板，并且通过第二基板在引导通道内的运动来调节刷子。

公开(公告)号：US20060138286A1

公开(公告)日：2006-06-29

申请号：US11023484

申请日：2004-12-29

申请人： Michael Connolly

发明人： Michael Connolly

IPC分类号： F16L3/00

CPC分类号： F16L3/11 ,  F16B2200/406 ,  F16L3/133 ,  F16L3/18 ,  Y10T403/1683 ,  Y10T403/581

摘要： The pipe hanger assembly is a pipe hanger and a holding assembly for retaining the pipe hanger against a pipe support. The pipe hanger has an inverted, generally U-shaped yoke having a slot defined in the bight of the yoke, a U-shaped saddle for supporting the pipe, and a bolt connecting the yoke and the saddle to each other. The holding assembly is at least a bracket having a pair of flanges defining a guide channel, the bracket being attached to a stud, threaded rod, or other pipe support suspended from a ceiling. The pipe hanger is assembled to the pipe, the bracket is attached to the rod, and the yoke is slid onto the rod between the bracket and a keeper, the yoke being aligned with the guide channel. The keeper is tightened to secure the pipe hanger to the pipe support. A pair of embossments protrude from an inner surface of the saddle.

摘要翻译： 管衣架组件是管衣架和用于将管衣架保持在管支架上的保持组件。 管挂架具有倒置的大致U形的轭，其具有限定在轭的弯曲部中的槽，用于支撑管的U形鞍座和将轭和鞍座彼此连接的螺栓。 保持组件至少是具有限定引导通道的一对凸缘的支架，该支架附接到从天花板悬挂的螺柱，螺杆或其它管道支撑件。 管衣架组装在管子上，支架与杆连接，轭架滑动到支架与保持器之间的杆上，轭架与引导通道对齐。 管子被拧紧以将管衣架固定在管道支架上。 一对压花从鞍座的内表面突出。

公开(公告)号：US20050096350A1

公开(公告)日：2005-05-05

申请号：US10935356

申请日：2004-09-07

申请人： Michael Connolly ,  Rocco Gogliotti ,  Clarence Hurt ,  Gregory Reichard ,  Melean Visnick

发明人： Michael Connolly ,  Rocco Gogliotti ,  Clarence Hurt ,  Gregory Reichard ,  Melean Visnick

IPC分类号： A61K31/41 ,  A61K31/454 ,  C07D409/12 ,  C07D409/14 ,  C07D49/14

CPC分类号： C07D409/14 ,  C07D409/12

摘要： The present invention provides benzo[b]thiophenes of Formula I: wherein R3, R4, R5, R6, R7, Y, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

摘要翻译： 本发明提供式I的苯并[b]噻吩：其中R 3，R 4，R 5，R 6， Y和L具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症（包括炎症）的试剂 疾病，心血管疾病和癌症。 还提供了包含一种或多种式I化合物的药物组合物。

公开(公告)号：US20050009063A1

公开(公告)日：2005-01-13

申请号：US10844602

申请日：2004-05-13

申请人： Jiu-Lin Xia ,  Mindy Goldsborough ,  Michael Connolly ,  Gulilat Gebeyehu

发明人： Jiu-Lin Xia ,  Mindy Goldsborough ,  Michael Connolly ,  Gulilat Gebeyehu

IPC分类号： C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/10 ,  C12Q1/68 ,  C12Q1/6806 ,  C07H21/04

CPC分类号： C12N15/1017 ,  C12N15/1006 ,  C12Q1/6806 ,  C12Q2527/125

摘要： The present invention relates to compositions and methods for releasing nucleic acid molecules from solid matrices. The invention further relates to compositions and methods for purifying and isolating nucleic acid molecules from biological materials such as animal tissues and plant matter. The methods of the invention can be readily adapted for rapid processing of multiple samples. Thus, the invention further provides automated methods for the purification of nucleic acid molecules from numerous samples. The invention also relates to kits for removing nucleic acid molecules from solid matrices.

摘要翻译： 本发明涉及从固体基质中释放核酸分子的组合物和方法。 本发明还涉及从生物材料如动物组织和植物物质中纯化和分离核酸分子的组合物和方法。 本发明的方法可以容易地适用于多个样品的快速处理。 因此，本发明还提供了用于从许多样品纯化核酸分子的自动化方法。 本发明还涉及从固体基质中除去核酸分子的试剂盒。

公开(公告)号：US4237654A

公开(公告)日：1980-12-09

申请号：US927503

申请日：1978-07-24

申请人： Roy Landem ,  Michael Connolly

发明人： Roy Landem ,  Michael Connolly

IPC分类号： A62B3/00 ,  A62C2/24 ,  E05B65/10

CPC分类号： A62B3/00 ,  A62C2/247 ,  E05B65/1033

摘要： A fire escape window system has a fixed outer, peripheral frame set permanently into a window opening of a wall. An inner frame carrying sash units, screens, storm glass, and the like is mounted in the outer frame on a hinge axis. The inner frame pivots from a position weather-sealed across the outer frame to an open position where the opening in the outer frame is unobstructed for emergency personal egress. A latch retains the inner frame in a closed, sealed position but is quickly releasable for swinging of the inner frame to the open position. A spring may be used to bias the inner frame to move automatically to the open position upon release of the latch. A safety alarm signals upon opening of the inner frame. The latch may be electrically operated and, if so, it may be connected for opening the inner frame selectively in conjunction with a smoke or other fire detector which is activated by an emergency condition.

摘要翻译： 防火窗系统具有固定的外部周边框架，永久地设置在墙壁的窗户开口中。 在铰链轴上的外框架中安装有框架单元，筛网，风暴玻璃等的内框架。 内框架从通过外框架暴露密封的位置枢转到打开位置，其中外框架中的开口不通过紧急个人出口。 闩锁将内框架保持在封闭的密封位置，但是可快速地释放以使内框架摆动到打开位置。 可以使用弹簧来偏压内部框架，以在释放闩锁时自动地移动到打开位置。 内框架开启时，安全报警信号。 闩锁可以是电动的，并且如果是这样，它可以被连接用于与由紧急情况激活的烟或其他火灾探测器选择性地打开内部框架。