公开(公告)号：US20220027979A1

公开(公告)日：2022-01-27

申请号：US17498721

申请日：2021-10-11

申请人： John Bruno

发明人： John Bruno

IPC分类号： G06Q30/06

摘要： A geographical merchant consortium commerce system provides contextual offers to subscribed customers to encourage shopping locally. The system includes a plurality of merchants that operate a business within a geographical region, such as within a mall or town. A customer subscribes to the system and provides contextual data such as demographic data, a shopping list and specific personal dates, such as wedding anniversary, or birthday. The system also conducts analysis of internet activity to determine smart needs of the customer. The system then provides contextual offers to the subscribed customer for products based on the contextual data. These offers may be a combined contextual offer, having two or more products from two or more of the plurality of merchants. In addition, a contextual offer may be a proximity contextual offer that is provided to the subscribed customer when they move close to the geographical region of the plurality of merchants.

公开(公告)号：US09424002B2

公开(公告)日：2016-08-23

申请号：US12960327

申请日：2010-12-03

申请人： John Bruno ,  Viswanath Vadlamani ,  Steve C. Tullis

发明人： John Bruno ,  Viswanath Vadlamani ,  Steve C. Tullis

IPC分类号： G06F17/30 ,  G06F9/44

CPC分类号： G06F8/30 ,  G06F17/30395

摘要： The present disclosure describes a meta-application framework that enables data to be associated with a class of applications called a meta-application. A meta-application entity may store attributes in common across multiple platforms. A platform entity may store attributes in common across multiple devices and/or operating systems. A device entity may be comprised by a particular set of hardware features and an operating system entity may be comprised of a particular set of software feature. Data associated with the meta-application framework may be accessed directly via data manipulation operations or alternatively by application operations via an application programming interface or via the aforementioned data manipulation operations. Applications may then identify application specific behavior at the appropriate level of detail.

摘要翻译： 本公开描述了一种元应用框架，其使数据能够与称为元应用的一类应用相关联。 元应用程序实体可以跨多个平台共同存储属性。 平台实体可以在多个设备和/或操作系统之间共同存储属性。 设备实体可以由特定的一组硬件特征组成，并且操作系统实体可以由特定的一组软件特征组成。 与元应用程序框架相关联的数据可以通过数据操作操作直接访问，或者通过应用程序操作经由应用编程接口或经由上述数据操作操作来访问。 然后，应用程序可以在适当的细节级别识别应用程序特定的行为。

公开(公告)号：US08975390B2

公开(公告)日：2015-03-10

申请号：US14177962

申请日：2014-02-11

申请人： John Bruno

发明人： John Bruno

IPC分类号： C07H21/04 ,  C12N15/115

CPC分类号： C12N15/115 ,  C07H21/04 ,  C12N2310/16

摘要： Specific DNA ligand sequences for binding various arthropod-borne pathogens including arboviruses, rickettsia and parasites are described. Each of these sequences or their linear, two- and three-dimensional linked sequences can function in varying assay and sensor formats with varying degrees of success. Linkage of the whole or partial DNA sequences (putative binding sites) can be used to enhance specificity and affinity towards complex targets, thereby improving assay selectivity and sensitivity in many instances. In addition, the DNA sequences may bind and neutralize or prevent infection from arthropod-borne viruses, rickettsia and Leishmania or other parasites.

摘要翻译： 描述了用于结合各种节肢动物传播的病原体的具体DNA配体序列，包括罗非鱼病毒，立克次体和寄生虫。 这些序列中的每一个或其线性，二维和三维连接的序列可以以不同的测定和传感器形式发挥不同程度的成功。 可以使用全部或部分DNA序列（推定的结合位点）的连接来增强对复杂靶标的特异性和亲和力，从而在许多情况下提高测定选择性和灵敏度。 此外，DNA序列可以结合并中和或防止节肢动物传播的病毒，立克次体和利什曼原虫或其他寄生虫的感染。

公开(公告)号：US20140349873A1

公开(公告)日：2014-11-27

申请号：US14294847

申请日：2014-06-03

申请人： John Bruno ,  Joseph Chanpong

发明人： John Bruno ,  Joseph Chanpong

IPC分类号： G01N33/53 ,  G01N33/58 ,  G01N33/569

CPC分类号： G01N33/5308 ,  C12Q1/6818 ,  C12Q1/6825 ,  G01N33/542 ,  Y02A50/55 ,  C12Q2525/205 ,  C12Q2565/1015

摘要： Methods are described for the production and use of fluorescence resonance energy transfer (FRET)-based competitive displacement aptamer assay formats. The assay schemes involve FRET in which the analyte (target) is quencher (Q)-labeled and previously bound by a fluorophore (F)-labeled aptamer such that when unlabeled analyte is added to the system and excited by specific wavelengths of light, the fluorescence intensity of the system changes in proportion to the amount of unlabeled analyte added. Alternatively, the aptamer can be Q-labeled and previously bound to an F-labeled analyte so that when unlabeled analyte enters the system, the fluorescence intensity also changes in proportion to the amount of unlabeled analyte. The F or Q is covalently linked to nucleotide triphosphates (NTPs), which are incorporated into the aptamer by various nucleic acid polymerases, such as Taq or Deep Vent Exo− during PCR or asymmetric PCR, and then selected by affinity chromatography, size-exclusion, and fluorescence techniques.

摘要翻译： 描述了用于生产和使用基于荧光共振能量转移（FRET）的竞争性置换适配体测定形式的方法。 测定方案涉及FRET，其中分析物（靶）被猝灭剂（Q）标记并预先通过荧光团（F）标记的适体结合，使得当将未标记的分析物加入到体系中并被特定波长的光激发时， 系统的荧光强度与未标记的分析物的添加量成比例地变化。 或者，适体可以被Q标记并且​​预先与F标记的分析物结合，使得当未标记的分析物进入系统时，荧光强度也与未标记的分析物的量成比例地变化。 F或Q与核苷酸三磷酸（NTPs）共价连接，其通过各种核酸聚合酶如PCR或不对称PCR中的Taq或Deep Vent Exo-引入适体中，然后通过亲和层析，大小排阻 ，和荧光技术。

公开(公告)号：US08660003B2

公开(公告)日：2014-02-25

申请号：US12733996

申请日：2008-10-01

申请人： Stephen P. Cooke ,  John Bruno

发明人： Stephen P. Cooke ,  John Bruno

IPC分类号： G01R31/08 ,  H04J4/00 ,  H04L12/43

CPC分类号： H04L47/122 ,  H04L12/66 ,  H04L47/10 ,  H04L47/11 ,  H04L47/13 ,  H04L47/263 ,  H04L47/33 ,  Y02D50/10

摘要： Dynamic, asymmetric rings and related communication equipment and methods are disclosed. Various features may be implemented to provide any or all of several degrees of freedom for managing resources in a communication network. Communication rates may be optimized on a node-to-node basis or overall on a network level. Different rates may be configured and possibly dynamically adjusted between different nodes, and/or for different directions of traffic transfer. Bandwidth can be dynamically allocated along a string of the communication nodes in a ring or linear topology in some embodiments. Direction of traffic transfer represents an additional possible degree of freedom in a ring topology, in that traffic can be transferred in either direction in a ring, such as the direction of least delay.

摘要翻译： 公开了动态非对称环和相关通信设备和方法。 可以实现各种特征以提供用于管理通信网络中的资源的几个自由度中的任何一个或全部。 通信速率可以在节点到节点的基础上或整体上在网络级上进行优化。 可以配置不同的速率，并且可以在不同节点之间和/或针对不同的业务传输方向进行动态调整。 在一些实施例中，可以沿环形或线性拓扑中的通信节点的串来动态分配带宽。 流量传输的方向在环形拓扑中表示额外的可能的自由度，因为业务可以在环路中的任一方向上传送，例如最小延迟的方向。

公开(公告)号：US08593470B2

公开(公告)日：2013-11-26

申请号：US10906559

申请日：2005-02-24

申请人： John Bruno ,  Erwin Pang

发明人： John Bruno ,  Erwin Pang

IPC分类号： G06F13/372

CPC分类号： G06F13/1689 ,  G06F1/3203 ,  G06F1/324 ,  G06F1/3275 ,  G09G5/363 ,  G09G5/39 ,  G09G2300/0473 ,  Y02D10/126 ,  Y02D10/14

摘要： A power adjustment circuit includes memory controller logic that is couplable to system memory or other memory if desired. The memory control logic is operative to provide a variable memory clock signal to the system memory and to place the system memory in a self refresh mode wherein the self refresh mode does not require a memory clock signal. Thereafter, the memory clock control logic adjusts the frequency of the memory clock signal to a lower (or higher) frequency clock signal, and in response to the frequency of the memory clock signal becoming stable, the memory clock control logic restores the memory to a normal mode using the lower adjusted frequency memory clock signal. As such, a dynamic memory clock switching mechanism is employed for quickly varying the frequency of memory modules for discrete graphics processors, graphics processors integrated on a chip, or any other processors such that the memory clock can be reduced to a lower frequency in real time to save power.

摘要翻译： 功率调节电路包括如果需要可连接到系统存储器或其它存储器的存储器控​​制器逻辑。 存储器控制逻辑可操作以向系统存储器提供可变存储器时钟信号，并将系统存储器置于自刷新模式，其中自刷新模式不需要存储器时钟信号。 此后，存储器时钟控制逻辑将存储器时钟信号的频率调整到较低（或更高）的频率时钟信号，并且响应于存储器时钟信号的频率变得稳定，存储器时钟控制逻辑将存储器恢复到 正常模式使用较低的调整频率存储时钟信号。 因此，动态存储器时钟切换机制用于快速改变用于独立图形处理器，集成在芯片上的图形处理器或任何其它处理器的存储器模块的频率，使得存储器时钟可以实时地降低到更低的频率 节省电力。

公开(公告)号：US20100262959A1

公开(公告)日：2010-10-14

申请号：US12422790

申请日：2009-04-13

申请人： John Bruno ,  Nathaniel Clinton ,  Kamran R. Zargahi

发明人： John Bruno ,  Nathaniel Clinton ,  Kamran R. Zargahi

IPC分类号： G06F9/44 ,  G06F17/30

CPC分类号： G06F21/6209

摘要： Embodiments related to the revocation of applications on mobile devices are disclosed. For example, one disclosed embodiment provides a method of revoking an application stored on a mobile device, wherein the method comprises receiving an application revocation request, the application revocation request comprising an instruction to revoke a selected application saved on one or more mobile devices, sending to a mobile device an application revocation instruction configured to revoke the selected application on the mobile device, and sending to another entity a request to roll back a previously-made transaction related to the selected application.

摘要翻译： 公开了关于在移动设备上撤销应用的实施例。 例如，一个公开的实施例提供了一种撤销存储在移动设备上的应用的方法，其中该方法包括接收应用撤销请求，该应用撤销请求包括撤消保存在一个或多个移动设备上的所选应用的指令，发送 向移动设备提供被配置为在所述移动设备上撤销所选择的应用的应用撤销指令，以及向另一个实体发送回滚与所选择的应用相关的先前所做的事务的请求。

公开(公告)号：US20100262958A1

公开(公告)日：2010-10-14

申请号：US12420420

申请日：2009-04-08

申请人： Nathaniel Clinton ,  John Bruno ,  Michael Christopher Connolly

发明人： Nathaniel Clinton ,  John Bruno ,  Michael Christopher Connolly

IPC分类号： G06F9/44

CPC分类号： G06F8/65 ,  H04W8/245

摘要： Embodiments related to synchronizing a state of a mobile device with a state stored of a mobile device application server are disclosed. One embodiment provides a method of synchronizing a state on a mobile device and a state on a mobile device application server comprising receiving a state change at the application server that changes a state relative to a state stored on one or more mobile devices, and storing the state change. Next, the method comprises receiving a request from a mobile device for information regarding any state changes that have occurred, sending a response notifying the mobile device of the state change, receiving from the mobile device an application manifest that gives a current state of the mobile device, updating the application manifest to form an updated application manifest that reflects the state change, and sending the updated application manifest to the mobile device.

摘要翻译： 公开了将移动设备的状态与移动设备应用服务器所存储的状态同步的实施例。 一个实施例提供了一种使移动设备上的状态与移动设备应用服务器上的状态同步的方法，包括接收在应用服务器处的相对于存储在一个或多个移动设备上的状态改变状态的状态改变，以及存储 状态变化。 接下来，该方法包括从移动设备接收关于已经发生的任何状态改变的信息的请求，发送通知移动设备状态改变的响应，从移动设备接收给出移动设备的当前状态的应用清单 设备，更新应用程序清单以形成反映状态改变的更新的应用程序清单，并将更新的应用程序清单发送到移动设备。

公开(公告)号：US20090254926A1

公开(公告)日：2009-10-08

申请号：US12099153

申请日：2008-04-08

申请人： Jacob Kim ,  John Bruno ,  Thomas Jeyaseelan

发明人： Jacob Kim ,  John Bruno ,  Thomas Jeyaseelan

IPC分类号： G06F9/46

CPC分类号： G06F9/465 ,  G06F2209/462 ,  H04L67/02 ,  H04L67/16

摘要： A method for registering a network application with an application programming interface (API) framework. In operation, a registrar may send a registration message that associates a namespace with the network application to the API framework. In one implementation, the namespace associated with the network application may be a uniform resource identifier. In another implementation, the registration message may specify a format of the standardized clients, a security policy, and the application resources associated with the network application.

摘要翻译： 一种用于使用应用程序编程接口（API）框架注册网络应用程序的方法。 在操作中，注册服务商可以发送将命名空间与网络应用程序相关联的注册消息到API框架。 在一个实现中，与网络应用相关联的命名空间可以是统一的资源标识符。 在另一实现中，注册消息可以指定标准化客户端的格式，安全策略以及与网络应用相关联的应用资源。

公开(公告)号：US20090254670A1

公开(公告)日：2009-10-08

申请号：US12099154

申请日：2008-04-08

申请人： Jacob Kim ,  John Bruno ,  Thomas Jeyaseelan

发明人： Jacob Kim ,  John Bruno ,  Thomas Jeyaseelan

IPC分类号： G06F15/16

CPC分类号： H04L67/2823 ,  H04L67/02

摘要： A method for providing access to a network application for a standardized client. A hypertext transfer protocol (HTTP) request may be received from a standardized client. A resource request based on the HTTP request may be created. The resource request may be sent to the network application. A response may be received from the network application. A client response may be created based on the response. The client response may be sent to the standardized client.

摘要翻译： 一种用于提供对标准化客户端的网络应用的访问的方法。 可以从标准化客户端接收超文本传输​​协议（HTTP）请求。 可以创建基于HTTP请求的资源请求。 资源请求可以被发送到网络应用。 可以从网络应用接收响应。 可以基于响应来创建客户端响应。 客户端响应可以发送到标准化客户端。